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401 results

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Page 1
Beta-cell compensation and gestational diabetes.
Usman TO, Chhetri G, Yeh H, Dong HH. Usman TO, et al. J Biol Chem. 2023 Dec;299(12):105405. doi: 10.1016/j.jbc.2023.105405. Epub 2023 Oct 29. J Biol Chem. 2023. PMID: 38229396 Free PMC article. Review.
To overcome insulin resistance, maternal beta-cells are conditioned to release more insulin into the blood. Such an adaptive response, termed beta-cell compensation, is essential for maintaining normal maternal metabolism. beta-cell …
To overcome insulin resistance, maternal beta-cells are conditioned to release more insulin into the blood. Such an adaptive r …
What Is Gestational Diabetes-Really?
Buchanan TA, Xiang AH, Page KA, Watanabe RM. Buchanan TA, et al. Diabetes. 2025 Jul 1;74(7):1037-1046. doi: 10.2337/dbi24-0041. Diabetes. 2025. PMID: 40197830 Free PMC article. Review.
The pathogenesis of GDM has long been attributed to inadequate pancreatic beta-cell compensation for the physiological insulin resistance of pregnancy. This defect is thought to resolve after pregnancy but become manifest in later life as an increased risk of …
The pathogenesis of GDM has long been attributed to inadequate pancreatic beta-cell compensation for the physiological …
Obesity, diabetes, and inflammation: Pathophysiology and clinical implications.
Donath MY, Drucker DJ. Donath MY, et al. Immunity. 2025 Oct 14;58(10):2373-2382. doi: 10.1016/j.immuni.2025.09.011. Epub 2025 Oct 3. Immunity. 2025. PMID: 41045922 Review.
Initially adaptive, this inflammation promotes tissue remodeling and metabolic compensation, but chronic activation contributes to insulin resistance, beta cell dysfunction, and end-organ damage. ...
Initially adaptive, this inflammation promotes tissue remodeling and metabolic compensation, but chronic activation contributes to in …
METRNL represses beta-to-alpha cell trans-differentiation to maintain beta cell function under diabetic metabolic stress in mice.
Zhou Y, Hu L, Zhuang R, Song L, Chang X, Liu L, Huang Y, Zhang M, Zheng J, Xu X, Wang T, Guo B. Zhou Y, et al. Diabetologia. 2025 Aug;68(8):1769-1788. doi: 10.1007/s00125-025-06459-7. Epub 2025 Jun 10. Diabetologia. 2025. PMID: 40495021
AIMS/HYPOTHESIS: In type 2 diabetes mellitus, beta cell failure is associated with pancreatic beta cell dedifferentiation and trans-differentiation into other types of islet cells. ...CONCLUSIONS/INTERPRETATION: METRNL helps to maintain beta …
AIMS/HYPOTHESIS: In type 2 diabetes mellitus, beta cell failure is associated with pancreatic beta cell dediffer …
Reversing pancreatic beta-cell dedifferentiation in the treatment of type 2 diabetes.
Son J, Accili D. Son J, et al. Exp Mol Med. 2023 Aug;55(8):1652-1658. doi: 10.1038/s12276-023-01043-8. Epub 2023 Aug 1. Exp Mol Med. 2023. PMID: 37524865 Free PMC article. Review.
Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic beta-cell failure. The failure of beta-cells to compensate for insulin resistance results in hyperglycemia, which in turn drives altered lipid metabolism and beta …
Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic beta-cell failure. The failure of beta-c …
beta-Cell adaptation in pregnancy.
Baeyens L, Hindi S, Sorenson RL, German MS. Baeyens L, et al. Diabetes Obes Metab. 2016 Sep;18 Suppl 1(Suppl 1):63-70. doi: 10.1111/dom.12716. Diabetes Obes Metab. 2016. PMID: 27615133 Free PMC article. Review.
Pregnancy in placental mammals places unique demands on the insulin-producing beta-cells in the pancreatic islets of Langerhans. The pancreas anticipates the increase in insulin resistance that occurs late in pregnancy by increasing beta-cell numbers a …
Pregnancy in placental mammals places unique demands on the insulin-producing beta-cells in the pancreatic islets of Langerhan …
The use of animal models in diabetes research.
King AJ. King AJ. Br J Pharmacol. 2012 Jun;166(3):877-94. doi: 10.1111/j.1476-5381.2012.01911.x. Br J Pharmacol. 2012. PMID: 22352879 Free PMC article.
Type 1 diabetes is due to an autoimmune destruction of the insulin-producing pancreatic beta cells, and type 2 diabetes is caused by insulin resistance coupled by a failure of the beta cell to compensate. Animal models for type 1 diabetes range …
Type 1 diabetes is due to an autoimmune destruction of the insulin-producing pancreatic beta cells, and type 2 diabetes is cau …
Beta cell dynamics: beta cell replenishment, beta cell compensation and diabetes.
Cerf ME. Cerf ME. Endocrine. 2013 Oct;44(2):303-11. doi: 10.1007/s12020-013-9917-y. Epub 2013 Mar 13. Endocrine. 2013. PMID: 23483434 Review.
Beta cell replenishment and death primarily regulate beta cell populations. Beta cells, pancreatic cells, and extra-pancreatic cells represent the three tiers for replenishing beta cells. ...In humans, beta …
Beta cell replenishment and death primarily regulate beta cell populations. Beta cells, pancreatic …
Nutrient regulation of pancreatic beta-cell proliferation.
Moullé VS, Ghislain J, Poitout V. Moullé VS, et al. Biochimie. 2017 Dec;143:10-17. doi: 10.1016/j.biochi.2017.09.017. Epub 2017 Oct 5. Biochimie. 2017. PMID: 28987628 Free PMC article. Review.
Although a causal role of insulin resistance in compensatory beta-cell responses has received considerable experimental support, precisely how the beta cell senses changes in the metabolic environment is still unknown. ...Finally, we describe the conce …
Although a causal role of insulin resistance in compensatory beta-cell responses has received considerable experimental suppor …
401 results