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120 results

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Page 1
Joint Hypermobility, Autonomic Dysfunction, Gastrointestinal Dysfunction, and Autoimmune Markers: Clinical Associations and Response to Intravenous Immunoglobulin Therapy.
Pasricha PJ, McKnight M, Villatoro L, Barahona G, Brinker J, Hui K, Polydefkis M, Burns R, McMahan ZH, Gould N, Goodman B, Hentz J, Treisman G. Pasricha PJ, et al. Am J Gastroenterol. 2024 Nov 1;119(11):2298-2306. doi: 10.14309/ajg.0000000000002910. Epub 2024 Jun 24. Am J Gastroenterol. 2024. PMID: 38912927 Free PMC article. Clinical Trial.
INTRODUCTION: We examined autoimmunity markers (AIM) and autonomic dysfunction in patients with chronic neurogastroenterological symptoms and their relationship to joint hypermobility/hypermobility spectrum disorder (JH/HSD). ...DISCUSSION: Autoimmune …
INTRODUCTION: We examined autoimmunity markers (AIM) and autonomic dysfunction in patients with chronic neurogastroenterologic …
Hypermobile Ehlers-Danlos Syndrome.
Hakim A. Hakim A. 2004 Oct 22 [updated 2024 Feb 22]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 2004 Oct 22 [updated 2024 Feb 22]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. PMID: 20301456 Free Books & Documents. Review.
Chronic fatigue, functional bowel disorders, cardiovascular autonomic dysfunction, swallow and phonation disorders, sleep disorders including apnea, migraine, entrapment and peripheral neuropathies, inflammation from mast cell activation disorders, anxiety disorders …
Chronic fatigue, functional bowel disorders, cardiovascular autonomic dysfunction, swallow and phonation disorders, sleep diso …
Fascial Pathophysiology in Hypermobility Spectrum Disorders and Hypermobile Ehlers-Danlos Syndrome: A Review of Emerging Evidence.
Wang TJ, Stecco A, Hakim AJ, Schleip R. Wang TJ, et al. Int J Mol Sci. 2025 Jun 11;26(12):5587. doi: 10.3390/ijms26125587. Int J Mol Sci. 2025. PMID: 40565051 Free PMC article. Review.
Hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are increasingly recognized as complex, multisystem connective tissue disorders characterized by joint hypermobility and instability, chronic pain, autonomic dysfunction …
Hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are increasingly recognized as complex, multisys …
Hypermobile Ehlers-Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know.
Thwaites PA, Gibson PR, Burgell RE. Thwaites PA, et al. J Gastroenterol Hepatol. 2022 Sep;37(9):1693-1709. doi: 10.1111/jgh.15927. Epub 2022 Jul 20. J Gastroenterol Hepatol. 2022. PMID: 35750466 Free PMC article.
METHODS: Literature relevant to the gastrointestinal system and hypermobile Ehlers-Danlos syndrome was systematically searched, critically appraised, and summarized. ...The pathophysiology of gut symptoms is poorly understood but may involve effects of connective tissue la …
METHODS: Literature relevant to the gastrointestinal system and hypermobile Ehlers-Danlos syndrome was systematically searched, criti …
AGA Clinical Practice Update on GI Manifestations and Autonomic or Immune Dysfunction in Hypermobile Ehlers-Danlos Syndrome: Expert Review.
Aziz Q, Harris LA, Goodman BP, Simrén M, Shin A. Aziz Q, et al. Clin Gastroenterol Hepatol. 2025 Jul;23(8):1291-1302. doi: 10.1016/j.cgh.2025.02.015. Epub 2025 May 19. Clin Gastroenterol Hepatol. 2025. PMID: 40387691 Review.
BEST PRACTICE ADVICE 3: Gastroenterologists seeing patients with DGBI should inquire about joint hypermobility and strongly consider incorporating the Beighton score for assessing joint hypermobility into their practice as a screening tool; if the screen is positive …
BEST PRACTICE ADVICE 3: Gastroenterologists seeing patients with DGBI should inquire about joint hypermobility and strongly consider …
Dysautonomia, Hypermobility Spectrum Disorders and Mast Cell Activation Syndrome as Migraine Comorbidities.
Blitshteyn S. Blitshteyn S. Curr Neurol Neurosci Rep. 2023 Nov;23(11):769-776. doi: 10.1007/s11910-023-01307-w. Epub 2023 Oct 17. Curr Neurol Neurosci Rep. 2023. PMID: 37847487 Review.
PURPOSE OF REVIEW: Dysautonomia refers to the dysfunction of the autonomic nervous system and encompasses a wide variety of autonomic symptoms and disorders. The most common autonomic disorders are postural orthostatic tachycardia syndrom …
PURPOSE OF REVIEW: Dysautonomia refers to the dysfunction of the autonomic nervous system and encompasses a wide …
Autonomic and sensory dysfunction in hypermobile Ehlers-Danlos syndrome: How do small fibers contribute?
Kersebaum D, Baron R, Gierthmühlen J, Forstenpointner J. Kersebaum D, et al. Auton Neurosci. 2025 Aug;260:103306. doi: 10.1016/j.autneu.2025.103306. Epub 2025 May 29. Auton Neurosci. 2025. PMID: 40460600 Free article.
Hypermobile EDS (hEDS) is associated with joint hypermobility, early-onset osteoarthritis, chronic pain, and dysautonomia. This study explored sensory-vascular profiles, as both nociceptive and autonomic nerve fibers are part of the small-fiber group. ...Findings in …
Hypermobile EDS (hEDS) is associated with joint hypermobility, early-onset osteoarthritis, chronic pain, and dysautonomia. This study …
The Relationship Between Hypermobile Ehlers-Danlos Syndrome (hEDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS).
Kucharik AH, Chang C. Kucharik AH, et al. Clin Rev Allergy Immunol. 2020 Jun;58(3):273-297. doi: 10.1007/s12016-019-08755-8. Clin Rev Allergy Immunol. 2020. PMID: 31267471 Review.
Patients previously diagnosed with EDS hypermobility type may not meet the new, stricter criteria for hEDS but may for a less severe hypermobility spectrum disorder (HSD). ...
Patients previously diagnosed with EDS hypermobility type may not meet the new, stricter criteria for hEDS but may for a less severe …
Complex Genetics and Regulatory Drivers of Hypermobile Ehlers-Danlos Syndrome: Insights from Genome-Wide Association Study Meta-analysis.
Petrucci-Nelson T, Guilhaumou S, Berrandou TE, Gensemer C, Georges A, Huff M, Fustier MA, Esmael A, Henry J, Jaye O, Phookan R, Dooley S, Byerly K, Loizzi B, Fenner R, Mach E, Weintraub A, Daylor V, Weninger J, Koren N, Bistran E, Griggs C, Griggs M, Severance S, Byrd R, Patel S, Kautz SA, Maitland A, Bouatia-Naji N, Norris RA. Petrucci-Nelson T, et al. medRxiv [Preprint]. 2025 Sep 21:2025.09.19.25336146. doi: 10.1101/2025.09.19.25336146. medRxiv. 2025. PMID: 41001447 Free PMC article. Preprint.
Clinically, hEDS is defined by generalized joint hypermobility and chronic musculoskeletal pain, but its impact extends beyond the musculoskeletal system. ...Gene-based and transcriptome-wide analyses identified common variants in a locus containing multiple candida …
Clinically, hEDS is defined by generalized joint hypermobility and chronic musculoskeletal pain, but its impact extends beyond the mu …
Functional Gastrointestinal Disorders, Autonomic Nervous System Dysfunction, and Joint Hypermobility in Children: Are They Related?
Velasco-Benitez CA, Axelrod C, Fernandez Valdes L, Saps M. Velasco-Benitez CA, et al. J Pediatr. 2020 Mar;218:114-120.e3. doi: 10.1016/j.jpeds.2019.11.009. Epub 2020 Jan 16. J Pediatr. 2020. PMID: 31955876
OBJECTIVES: To evaluate the prevalence of orthostatic intolerance and joint hypermobility in schoolchildren with and without functional gastrointestinal disorders (FGIDs) and to assess autonomic nervous system dysfunction in children with FGIDs …
OBJECTIVES: To evaluate the prevalence of orthostatic intolerance and joint hypermobility in schoolchildren with and without function …
120 results