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The Relationship Between Hypermobile Ehlers-Danlos Syndrome (hEDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS).
Kucharik AH, Chang C. Kucharik AH, et al. Clin Rev Allergy Immunol. 2020 Jun;58(3):273-297. doi: 10.1007/s12016-019-08755-8. Clin Rev Allergy Immunol. 2020. PMID: 31267471 Review.
Patients previously diagnosed with EDS hypermobility type may not meet the new, stricter criteria for hEDS but may for a less severe hypermobility spectrum disorder (HSD). ...The reason behind the purported association of these entities stems from an overlapping …
Patients previously diagnosed with EDS hypermobility type may not meet the new, stricter criteria for hEDS but may for a less severe …
Long COVID and hypermobility spectrum disorders have shared pathophysiology.
Ganesh R, Munipalli B. Ganesh R, et al. Front Neurol. 2024 Sep 5;15:1455498. doi: 10.3389/fneur.2024.1455498. eCollection 2024. Front Neurol. 2024. PMID: 39301475 Free PMC article.
Hypermobility has been detected in up to 30-57% of patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia, postural orthostatic tachycardia syndrome (POTS), and long COVID (LC) compared to the general population. ...Persistent inflam …
Hypermobility has been detected in up to 30-57% of patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibr …
High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities.
Fairweather D, Bruno KA, Darakjian AA, Bruce BK, Gehin JM, Kotha A, Jain A, Peng Z, Hodge DO, Rozen TD, Munipalli B, Rivera FA, Malavet PA, Knight DRT. Fairweather D, et al. Front Med (Lausanne). 2023 Apr 25;10:1096180. doi: 10.3389/fmed.2023.1096180. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37181352 Free PMC article.
BACKGROUND: Joint pain is a common symptom in patients with hypermobile Ehlers-Danlos Syndrome (hEDS), hypermobility spectrum disorders (HSD) and fibromyalgia. The goal of this study was to determine whether symptoms and comorbidities overlap in patients diag …
BACKGROUND: Joint pain is a common symptom in patients with hypermobile Ehlers-Danlos Syndrome (hEDS), hypermobility spectrum disorde …
Beyond bones: The relevance of variants of connective tissue (hypermobility) to fibromyalgia, ME/CFS and controversies surrounding diagnostic classification: an observational study.
Eccles JA, Thompson B, Themelis K, Amato ML, Stocks R, Pound A, Jones AM, Cipinova Z, Shah-Goodwin L, Timeyin J, Thompson CR, Batty T, Harrison NA, Critchley HD, Davies KA. Eccles JA, et al. Clin Med (Lond). 2021 Jan;21(1):53-58. doi: 10.7861/clinmed.2020-0743. Clin Med (Lond). 2021. PMID: 33479068 Free PMC article.
Patients were assessed for symptomatic hypermobility. RESULTS: Evaluations showed exceptional overlap in patients between fibromyalgia and ME/CFS, plus 81% met Brighton criteria for hypermobility syndrome (odds ratio 7.08) and 18% met 2017 hypermobile …
Patients were assessed for symptomatic hypermobility. RESULTS: Evaluations showed exceptional overlap in patients between f …
The concomitant diagnosis of fibromyalgia and connective tissue disorders: A systematic review.
Alsiri N, Alhadhoud M, Alkatefi T, Palmer S. Alsiri N, et al. Semin Arthritis Rheum. 2023 Feb;58:152127. doi: 10.1016/j.semarthrit.2022.152127. Epub 2022 Nov 17. Semin Arthritis Rheum. 2023. PMID: 36462303
BACKGROUND: Anecdotally, fibromyalgia syndrome (FMS) and connective tissue disorders (hypermobile Ehlers-Danlos Syndrome (hEDS), Hypermobility Spectrum disorders (HSD) and Generalized Joint Hypermobility (GJH)) manifest overlap in their diagnostic appr …
BACKGROUND: Anecdotally, fibromyalgia syndrome (FMS) and connective tissue disorders (hypermobile Ehlers-Danlos Syndrome (hEDS), H …
The challenges of chronic pain and fatigue.
Eccles JA, Davies KA. Eccles JA, et al. Clin Med (Lond). 2021 Jan;21(1):19-27. doi: 10.7861/clinmed.2020-1009. Clin Med (Lond). 2021. PMID: 33479064 Free PMC article. Review.
Both pain and fatigue are common, troubling and frequently overlapping symptoms, and we describe both the clinical burden and the 'clinical problem'. We explore commonly associated symptoms and possible pathological associations, including variant connective tissue (joint …
Both pain and fatigue are common, troubling and frequently overlapping symptoms, and we describe both the clinical burden and the 'cl …
Pain in fibromyalgia and related conditions.
Cassisi G, Sarzi-Puttini P, Casale R, Cazzola M, Boccassini L, Atzeni F, Stisi S. Cassisi G, et al. Reumatismo. 2014 Jun 6;66(1):72-86. doi: 10.4081/reumatismo.2014.767. Reumatismo. 2014. PMID: 24938199 Free article. Review.
Pain is the hallmark symptom of fibromyalgia (FM) and other related syndromes, but quite different from that of other rheumatic diseases, which depends on the degree of damage or inflammation in peripheral tissues. ...FM is probably the most important and extensively descr …
Pain is the hallmark symptom of fibromyalgia (FM) and other related syndromes, but quite different from that of other rheumatic disea …
Neurovisceral phenotypes in the expression of psychiatric symptoms.
Eccles JA, Owens AP, Mathias CJ, Umeda S, Critchley HD. Eccles JA, et al. Front Neurosci. 2015 Feb 10;9:4. doi: 10.3389/fnins.2015.00004. eCollection 2015. Front Neurosci. 2015. PMID: 25713509 Free PMC article. Review.
Joint hypermobility is over-represented in people with anxiety, mood and neurodevelopmental disorders. It is also linked to stress-sensitive medical conditions such as irritable bowel syndrome, chronic fatigue syndrome and fibromyalgia. Structural differences in "em …
Joint hypermobility is over-represented in people with anxiety, mood and neurodevelopmental disorders. It is also linked to stress-se …
Joint hypermobility and anxiety: the state of the art.
Garcia-Campayo J, Asso E, Alda M. Garcia-Campayo J, et al. Curr Psychiatry Rep. 2011 Feb;13(1):18-25. doi: 10.1007/s11920-010-0164-0. Curr Psychiatry Rep. 2011. PMID: 20963520 Review.
Joint hypermobility (JH) is considered a common benign, hereditary, overlap, connective tissue disorder with a prevalence in the general population of about 10% in European populations and 25% in other ethnic groups. JH shows an association with mitral valve prolaps …
Joint hypermobility (JH) is considered a common benign, hereditary, overlap, connective tissue disorder with a prevalence in t …
Ehlers-Danlos Syndrome: Immunologic contrasts and connective tissue comparisons.
Islam M, Chang C, Gershwin ME. Islam M, et al. J Transl Autoimmun. 2020 Dec 20;4:100077. doi: 10.1016/j.jtauto.2020.100077. eCollection 2021. J Transl Autoimmun. 2020. PMID: 33437956 Free PMC article. Review.
Clinical presentation of this disease can range from mild manifestations including skin hyperextensibility and joint hypermobility, to more severe complications such as vascular and organ rupture. While there may be accompanying inflammation in some of the subtypes of EDS, …
Clinical presentation of this disease can range from mild manifestations including skin hyperextensibility and joint hypermobility, t …
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