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Page 1
Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies.
Mar PL, Raj SR. Mar PL, et al. Annu Rev Med. 2020 Jan 27;71:235-248. doi: 10.1146/annurev-med-041818-011630. Epub 2019 Aug 14. Annu Rev Med. 2020. PMID: 31412221 Review.
The approach to the treatment of POTS centers on treating the underlying pathophysiologic mechanism. Stockings, abdominal binders, and vasoconstrictors are used to enhance venous return in partial neuropathic POTS. Exercise and volume expansion are the main t …
The approach to the treatment of POTS centers on treating the underlying pathophysiologic mechanism. Stockings, abdominal binders, an …
Exercise and non-pharmacological treatment of POTS.
Fu Q, Levine BD. Fu Q, et al. Auton Neurosci. 2018 Dec;215:20-27. doi: 10.1016/j.autneu.2018.07.001. Epub 2018 Jul 4. Auton Neurosci. 2018. PMID: 30001836 Free PMC article. Review.
Recent research has demonstrated that cardiovascular deconditioning (i.e., cardiac atrophy and hypovolemia) contributes significantly to the Postural Orthostatic Tachycardia Syndrome (POTS) and its functional disability. Therefore, physical reconditioning with exerc …
Recent research has demonstrated that cardiovascular deconditioning (i.e., cardiac atrophy and hypovolemia) contributes significantly …
Pathophysiology and management of postural orthostatic tachycardia syndrome (POTS): A literature review.
Ghazal M, Akkawi AR, Fancher A, Oundo E, Tanzeem H, Sajjad L, Briasoulis A. Ghazal M, et al. Curr Probl Cardiol. 2025 Mar;50(3):102977. doi: 10.1016/j.cpcardiol.2024.102977. Epub 2024 Dec 18. Curr Probl Cardiol. 2025. PMID: 39706392 Review.
Recent studies have identified three primary POTS phenotypes-hyperadrenergic, neuropathic, and hypovolemic-each requiring tailored management strategies. ...Hypovolemic POTS, often triggered by dehydration and physical deconditioning, respond primarily …
Recent studies have identified three primary POTS phenotypes-hyperadrenergic, neuropathic, and hypovolemic-each requiring tail …
Postural tachycardia syndrome (POTS).
Low PA, Sandroni P, Joyner M, Shen WK. Low PA, et al. J Cardiovasc Electrophysiol. 2009 Mar;20(3):352-8. doi: 10.1111/j.1540-8167.2008.01407.x. Epub 2009 Jan 16. J Cardiovasc Electrophysiol. 2009. PMID: 19207771 Free PMC article. Review.
Prolonged deconditioning may also interact with these mechanisms to exacerbate symptoms. The evaluation of POTS requires a focused history and examination, followed by tests that should include HUT, some estimation of volume status and preferably some evaluation of …
Prolonged deconditioning may also interact with these mechanisms to exacerbate symptoms. The evaluation of POTS requires a focused hi …
Neuronal and hormonal perturbations in postural tachycardia syndrome.
Mar PL, Raj SR. Mar PL, et al. Front Physiol. 2014 Jun 16;5:220. doi: 10.3389/fphys.2014.00220. eCollection 2014. Front Physiol. 2014. PMID: 24982638 Free PMC article. Review.
There are multiple pathophysiological mechanisms that underlie POTS. Some patients with POTS have evidence of elevated sympathoneural tone. This hyperadrenergic state is likely a driver of the excessive orthostatic tachycardia. Another common pathophysiological mech …
There are multiple pathophysiological mechanisms that underlie POTS. Some patients with POTS have evidence of elevated sympath …
Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume.
Stewart JM, Glover JL, Medow MS. Stewart JM, et al. Clin Sci (Lond). 2006 Feb;110(2):255-63. doi: 10.1042/CS20050254. Clin Sci (Lond). 2006. PMID: 16262605 Free PMC article.
PRA correlated positively with Ang II (r = +0.76) in normal- and high-flow POTS, but negatively (r = -0.83) in low-flow POTS. Blood volume was negatively correlated with Ang II (r = -0.66) in normal- and high-flow POTS and in five low-flow POTS …
PRA correlated positively with Ang II (r = +0.76) in normal- and high-flow POTS, but negatively (r = -0.83) in low-flow POTS. …
Blood volume perturbations in the postural tachycardia syndrome.
Raj SR, Robertson D. Raj SR, et al. Am J Med Sci. 2007 Jul;334(1):57-60. doi: 10.1097/MAJ.0b013e318063c6c0. Am J Med Sci. 2007. PMID: 17630594 Review.
POTS can be associated with a high degree of functional disability. The blood volume has been found to be low in many patients with POTS. This article will review some of the data regarding blood volume perturbations in POTS, blood volume …
POTS can be associated with a high degree of functional disability. The blood volume has been found to be low in many patients …
Postural Tachycardia Syndrome: Diagnosis and Management in Adolescents and Young Adults.
Heyer GL. Heyer GL. Pediatr Ann. 2017 Apr 1;46(4):e145-e154. doi: 10.3928/19382359-20170322-01. Pediatr Ann. 2017. PMID: 28414396 Review.
Although considerable overlap exists, three subtypes of POTS have been described: neuropathic, hyperadrenergic, and hypovolemic forms. The wide spectrum of symptoms and comorbidities can make treatment particularly challenging. Volume expansion with fluid and …
Although considerable overlap exists, three subtypes of POTS have been described: neuropathic, hyperadrenergic, and hypovolemic …
Postural tachycardia syndrome: a heterogeneous and multifactorial disorder.
Benarroch EE. Benarroch EE. Mayo Clin Proc. 2012 Dec;87(12):1214-25. doi: 10.1016/j.mayocp.2012.08.013. Epub 2012 Nov 1. Mayo Clin Proc. 2012. PMID: 23122672 Free PMC article. Review.
The pathophysiology of POTS is heterogeneous and includes impaired sympathetically mediated vasoconstriction, excessive sympathetic drive, volume dysregulation, and deconditioning. ...Management of POTS includes avoidance of precipitating factors, volume …
The pathophysiology of POTS is heterogeneous and includes impaired sympathetically mediated vasoconstriction, excessive sympathetic d …
Adrenal gland response to adrenocorticotropic hormone is intact in patients with postural orthostatic tachycardia syndrome.
Laurin JKH, Oyewunmi OA, Garland EM, Gamboa A, Nwazue VC, Paranjape SY, Black BK, Okamoto LE, Shibao CA, Biaggioni I, Robertson D, Diedrich A, Dupont WD, Sheldon RS, Raj SR. Laurin JKH, et al. Auton Neurosci. 2023 Sep;248:103105. doi: 10.1016/j.autneu.2023.103105. Epub 2023 Jun 24. Auton Neurosci. 2023. PMID: 37393658 Free PMC article.
BACKGROUND: Many patients with postural orthostatic tachycardia syndrome (POTS) are hypovolemic with plasma volume deficits of 10-30 %. Some also have low levels of aldosterone and diminished aldosterone-renin ratios despite elevations in angiotensin II, poin …
BACKGROUND: Many patients with postural orthostatic tachycardia syndrome (POTS) are hypovolemic with plasma volume defi …
27 results