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13,185 results

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Page 1
Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility.
Xu H, Wang B, Ono M, Kagita A, Fujii K, Sasakawa N, Ueda T, Gee P, Nishikawa M, Nomura M, Kitaoka F, Takahashi T, Okita K, Yoshida Y, Kaneko S, Hotta A. Xu H, et al. Cell Stem Cell. 2019 Apr 4;24(4):566-578.e7. doi: 10.1016/j.stem.2019.02.005. Epub 2019 Mar 7. Cell Stem Cell. 2019. PMID: 30853558 Free article.
Here, we show two genome-editing strategies for making immunocompatible donor iPSCs. First, we generated HLA pseudo-homozygous iPSCs with allele-specific editing of HLA heterozygous iPSCs. ...HLA-C-retained iPSCs could evade T cells and NK cells in vit …
Here, we show two genome-editing strategies for making immunocompatible donor iPSCs. First, we generated HLA pseudo-homozygous iPS …
Could iPSCs Enable "Off-the-Shelf" Cell Therapy?
Crow D. Crow D. Cell. 2019 Jun 13;177(7):1667-1669. doi: 10.1016/j.cell.2019.05.043. Cell. 2019. PMID: 31199910 Free article. Review.
An "off-the-shelf" cell therapy derived from induced pluripotent stem cells (iPSCs) has entered clinical trials in the United States. Other companies are following suit, harnessing iPSCs' self-renewal ability to manufacture cell therapies that don't require customiz …
An "off-the-shelf" cell therapy derived from induced pluripotent stem cells (iPSCs) has entered clinical trials in the United States. …
Genomic Instability of iPSCs and Challenges in Their Clinical Applications.
Yoshihara M, Oguchi A, Murakawa Y. Yoshihara M, et al. Adv Exp Med Biol. 2019;1201:23-47. doi: 10.1007/978-3-030-31206-0_2. Adv Exp Med Biol. 2019. PMID: 31898780 Review.
However, the transplantation for the second patient was discontinued at least in part due to genetic aberrations detected in iPSCs. Moreover, many studies have reported genetic aberrations in iPSCs with the rapid progress in genomic technologies. ...Furthermore, we …
However, the transplantation for the second patient was discontinued at least in part due to genetic aberrations detected in iPSCs. M …
Inducing iPSCs to escape the dish.
Barrilleaux B, Knoepfler PS. Barrilleaux B, et al. Cell Stem Cell. 2011 Aug 5;9(2):103-11. doi: 10.1016/j.stem.2011.07.006. Cell Stem Cell. 2011. PMID: 21816362 Free PMC article. Review.
Induced pluripotent stem cells (iPSCs) hold great promise for autologous cell therapies, but significant roadblocks remain to translating iPSCs to the bedside. ...We discuss potential solutions to these hurdles to provide a roadmap for iPSCs to "jump the dish …
Induced pluripotent stem cells (iPSCs) hold great promise for autologous cell therapies, but significant roadblocks remain to transla …
Bioprocess Technologies that Preserve the Quality of iPSCs.
Polanco A, Kuang B, Yoon S. Polanco A, et al. Trends Biotechnol. 2020 Oct;38(10):1128-1140. doi: 10.1016/j.tibtech.2020.03.006. Epub 2020 Apr 5. Trends Biotechnol. 2020. PMID: 32941792 Review.
Large-scale production of induced pluripotent stem cells (iPSCs) is essential for the treatment of a variety of clinical indications. However, culturing enough iPSCs for clinical applications is problematic due to their sensitive pluripotent state and dependence on …
Large-scale production of induced pluripotent stem cells (iPSCs) is essential for the treatment of a variety of clinical indications. …
Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications.
Yoshihara M, Hayashizaki Y, Murakawa Y. Yoshihara M, et al. Stem Cell Rev Rep. 2017 Feb;13(1):7-16. doi: 10.1007/s12015-016-9680-6. Stem Cell Rev Rep. 2017. PMID: 27592701 Free PMC article. Review.
Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells generated directly from mature cells through the introduction of key transcription factors. iPSCs can be propagated and differentiated into many cell types in the human body, holding enormou …
Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells generated directly from mature cells through the introduc …
iPSCs as a major opportunity to understand and cure age-related diseases.
Lemey C, Milhavet O, Lemaitre JM. Lemey C, et al. Biogerontology. 2015 Aug;16(4):399-410. doi: 10.1007/s10522-015-9579-7. Epub 2015 May 17. Biogerontology. 2015. PMID: 25981448 Review.
Senescence was originally considered as a barrier to cell reprogramming, however we developed a strategy to overcome this hurdle and derive induced pluripotent stem cells (iPSCs) from senescent cells and cells from centenarians. Furthermore we showed that the newly generat …
Senescence was originally considered as a barrier to cell reprogramming, however we developed a strategy to overcome this hurdle and derive …
iPSCs-Derived Neurons and Brain Organoids from Patients.
Zhu W, Xu L, Li X, Hu H, Lou S, Liu Y. Zhu W, et al. Handb Exp Pharmacol. 2023;281:59-81. doi: 10.1007/164_2023_657. Handb Exp Pharmacol. 2023. PMID: 37306818
Induced pluripotent stem cells (iPSCs) can be differentiated into specific neurons and brain organoids by adding induction factors and small molecules in vitro, which carry human genetic information and recapitulate the development process of human brain as well as physiol …
Induced pluripotent stem cells (iPSCs) can be differentiated into specific neurons and brain organoids by adding induction factors an …
iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System.
Orqueda AJ, Giménez CA, Pereyra-Bonnet F. Orqueda AJ, et al. Stem Cells Int. 2016;2016:5934782. doi: 10.1155/2016/5934782. Epub 2016 Jan 6. Stem Cells Int. 2016. PMID: 26880972 Free PMC article. Review.
Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs) through the overexpression of four transcription factors. iPSCs are capable of originating virtually all types of cells and tissues, including a wh …
Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs) through the ov …
An insight into the iPSCs-derived two-dimensional culture and three-dimensional organoid models for neurodegenerative disorders.
Bhargava A, Sandoval Castellanos AM, Shah S, Ning K. Bhargava A, et al. Interface Focus. 2022 Aug 12;12(5):20220040. doi: 10.1098/rsfs.2022.0040. eCollection 2022 Oct 6. Interface Focus. 2022. PMID: 35992771 Free PMC article. Review.
The use of induced pluripotent stem cells (iPSCs) is a promising approach when used as models to study neurodegenerative disorders (NDDs) in vitro. iPSCs have been used in in vitro two-dimensional cultures; however, these two-dimensional cultures do not mimic the ph …
The use of induced pluripotent stem cells (iPSCs) is a promising approach when used as models to study neurodegenerative disorders (N …
13,185 results
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