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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1972 1
1973 4
1974 1
1975 3
1976 3
1977 5
1978 11
1979 10
1980 8
1981 8
1982 5
1983 9
1984 14
1985 14
1986 11
1987 12
1988 15
1989 16
1990 31
1991 33
1992 36
1993 29
1994 33
1995 34
1996 31
1997 38
1998 38
1999 33
2000 60
2001 39
2002 46
2003 46
2004 60
2005 54
2006 63
2007 62
2008 75
2009 66
2010 65
2011 70
2012 68
2013 79
2014 52
2015 67
2016 84
2017 108
2018 95
2019 88
2020 97
2021 104
2022 79
2023 63
2024 78
2025 9

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2,047 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis.
Tan E, Braithwaite I, McKinlay CJD, Dalziel SR. Tan E, et al. JAMA Netw Open. 2020 Oct 1;3(10):e2022398. doi: 10.1001/jamanetworkopen.2020.22398. JAMA Netw Open. 2020. PMID: 33125495 Free PMC article.
OBJECTIVE: To compare acetaminophen with ibuprofen for the short-term treatment of fever or pain in children younger than 2 years. ...Adverse events were uncommon. Acetaminophen and ibuprofen appeared to have similar serious adverse event profiles (7 studies with 27 …
OBJECTIVE: To compare acetaminophen with ibuprofen for the short-term treatment of fever or pain in children younger than 2 years. .. …
Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus.
Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, de Vries WB, Dijkman KP, van Kaam AH, Villamor E, Kroon AA, Visser R, Mulder-de Tollenaer SM, De Bisschop B, Dijk PH, Avino D, Hocq C, Zecic A, Meeus M, de Baat T, Derriks F, Henriksen TB, Kyng KJ, Donders R, Nuytemans DHGM, Van Overmeire B, Mulder AL, de Boode WP; BeNeDuctus Trial Investigators. Hundscheid T, et al. N Engl J Med. 2023 Mar 16;388(11):980-990. doi: 10.1056/NEJMoa2207418. Epub 2022 Dec 6. N Engl J Med. 2023. PMID: 36477458 Clinical Trial.
The noninferiority of expectant management as compared with early ibuprofen treatment was defined as an absolute risk difference with an upper boundary of the one-sided 95% confidence interval of less than 10 percentage points. ...CONCLUSIONS: Expectant management for PDA …
The noninferiority of expectant management as compared with early ibuprofen treatment was defined as an absolute risk difference with …
Ibuprofen versus paracetamol for treating fever in preschool children in Nigeria: a randomized clinical trial of effectiveness and safety.
Alaje EO, Udoh EE, Akande PA, Odey FA, Meremikwu MM. Alaje EO, et al. Pan Afr Med J. 2020 Aug 26;36:350. doi: 10.11604/pamj.2020.36.350.21393. eCollection 2020. Pan Afr Med J. 2020. PMID: 33224416 Free PMC article. Clinical Trial.
The antipyretics commonly used to treat fever are ibuprofen and paracetamol. Most studies on the effectiveness of ibuprofen and paracetamol in treating fever in under-fives were conducted in Europe and North America with very few in African children. ...RESULTS: the …
The antipyretics commonly used to treat fever are ibuprofen and paracetamol. Most studies on the effectiveness of ibuprofen an …
Analgesic effect of oral ibuprofen 400, 600, and 800 mg; paracetamol 500 and 1000 mg; and paracetamol 1000 mg plus 60 mg codeine in acute postoperative pain: a single-dose, randomized, placebo-controlled, and double-blind study.
Lyngstad G, Skjelbred P, Swanson DM, Skoglund LA. Lyngstad G, et al. Eur J Clin Pharmacol. 2021 Dec;77(12):1843-1852. doi: 10.1007/s00228-021-03231-9. Epub 2021 Oct 16. Eur J Clin Pharmacol. 2021. PMID: 34655316 Free PMC article. Clinical Trial.
Paracetamol 1000/codeine 60 mg gives similar analgesia as ibuprofen from 400 mg, but has a shorter time to analgesic onset. Active drugs show no significant difference in maximal analgesic effect. ...NNT and NTTp values did not coincide well with PROMs. CONCLUSION: Ibup
Paracetamol 1000/codeine 60 mg gives similar analgesia as ibuprofen from 400 mg, but has a shorter time to analgesic onset. Active dr …
Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.
Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8. Cochrane Database Syst Rev. 2020. PMID: 32045960 Free PMC article.
Early versus expectant administration of IV ibuprofen, echocardiographically-guided IV ibuprofen treatment versus standard IV ibuprofen treatment, continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, and rectal ibuprofen
Early versus expectant administration of IV ibuprofen, echocardiographically-guided IV ibuprofen treatment versus standard IV …
Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review.
Pierce CA, Voss B. Pierce CA, et al. Ann Pharmacother. 2010 Mar;44(3):489-506. doi: 10.1345/aph.1M332. Epub 2010 Feb 11. Ann Pharmacother. 2010. PMID: 20150507 Review.
In PubMed/MEDLINE, search terms used were ibuprofen, acetaminophen, paracetamol, clinical trials, and randomized controlled trials. ...The combined odds ratio for the proportion of adult subjects experiencing at least 1 AE slightly favored ibuprofen; however, the di …
In PubMed/MEDLINE, search terms used were ibuprofen, acetaminophen, paracetamol, clinical trials, and randomized controlled trials. . …
Short-term Dual Therapy or Mono Therapy With Acetaminophen and Ibuprofen for Fever: A Network Meta-Analysis.
De la Cruz-Mena JE, Veroniki AA, Acosta-Reyes J, Estupiñán-Bohorquez A, Ibarra JA, Pana MC, Sierra JM, Florez ID. De la Cruz-Mena JE, et al. Pediatrics. 2024 Oct 1;154(4):e2023065390. doi: 10.1542/peds.2023-065390. Pediatrics. 2024. PMID: 39318339
CONTEXT: There is uncertainty whether acetaminophen and ibuprofen are similar in their effects and safety when used as single or dual (alternating or combined) therapies. ...Acetaminophen may be inferior to combined or alternating therapies to get children afebrile at 4 an …
CONTEXT: There is uncertainty whether acetaminophen and ibuprofen are similar in their effects and safety when used as single or dual …
Single-Blind Randomized Controlled Trial: Comparative Efficacy of Dark Chocolate, Coconut Water, and Ibuprofen in Managing Primary Dysmenorrhea.
Nuha K, Rusmil K, Ganiem AR, Permadi W, Diah Herawati DM. Nuha K, et al. Int J Environ Res Public Health. 2023 Aug 21;20(16):6619. doi: 10.3390/ijerph20166619. Int J Environ Res Public Health. 2023. PMID: 37623203 Free PMC article. Clinical Trial.
Various pharmacological and non-pharmacological treatments are available for pain relief, but information on their effectiveness, particularly regarding green coconut water, dark chocolate, and Ibuprofen, remains limited. This study aimed to compare the effectiveness of gr …
Various pharmacological and non-pharmacological treatments are available for pain relief, but information on their effectiveness, particular …
Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration.
Atkinson HC, Stanescu I, Frampton C, Salem II, Beasley CP, Robson R. Atkinson HC, et al. Clin Drug Investig. 2015 Oct;35(10):625-32. doi: 10.1007/s40261-015-0320-8. Clin Drug Investig. 2015. PMID: 26334726 Free PMC article. Clinical Trial.
BACKGROUND AND OBJECTIVES: Previously published studies have suggested the lack of a pharmacokinetic interaction between ibuprofen and paracetamol when they are delivered as a fixed-dose oral combination. The aim of this study was to determine the pharmacokinetic profile a …
BACKGROUND AND OBJECTIVES: Previously published studies have suggested the lack of a pharmacokinetic interaction between ibuprofen an …
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study.
Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S. Kuptniratsaikul V, et al. Clin Interv Aging. 2014 Mar 20;9:451-8. doi: 10.2147/CIA.S58535. eCollection 2014. Clin Interv Aging. 2014. PMID: 24672232 Free PMC article. Clinical Trial.
RESULTS: 185 and 182 patients were randomly assigned into C. domestica extracts and ibuprofen groups, respectively. The baseline characteristics were no different between groups. ...CONCLUSION: C. domestica extracts are as effective as ibuprofen for the treatment of …
RESULTS: 185 and 182 patients were randomly assigned into C. domestica extracts and ibuprofen groups, respectively. The baseline char …
2,047 results