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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1972 1
1973 4
1974 1
1975 3
1976 3
1977 5
1978 11
1979 10
1980 8
1981 8
1982 5
1983 9
1984 14
1985 14
1986 11
1987 12
1988 15
1989 16
1990 31
1991 33
1992 36
1993 29
1994 33
1995 34
1996 31
1997 38
1998 38
1999 33
2000 60
2001 39
2002 47
2003 46
2004 60
2005 54
2006 65
2007 62
2008 75
2009 67
2010 65
2011 71
2012 68
2013 79
2014 53
2015 69
2016 85
2017 109
2018 96
2019 88
2020 96
2021 103
2022 77
2023 60
2024 14

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Search Results

1,987 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus.
Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, de Vries WB, Dijkman KP, van Kaam AH, Villamor E, Kroon AA, Visser R, Mulder-de Tollenaer SM, De Bisschop B, Dijk PH, Avino D, Hocq C, Zecic A, Meeus M, de Baat T, Derriks F, Henriksen TB, Kyng KJ, Donders R, Nuytemans DHGM, Van Overmeire B, Mulder AL, de Boode WP; BeNeDuctus Trial Investigators. Hundscheid T, et al. N Engl J Med. 2023 Mar 16;388(11):980-990. doi: 10.1056/NEJMoa2207418. Epub 2022 Dec 6. N Engl J Med. 2023. PMID: 36477458 Clinical Trial.
The noninferiority of expectant management as compared with early ibuprofen treatment was defined as an absolute risk difference with an upper boundary of the one-sided 95% confidence interval of less than 10 percentage points. ...CONCLUSIONS: Expectant management for PDA …
The noninferiority of expectant management as compared with early ibuprofen treatment was defined as an absolute risk difference with …
Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis.
Tan E, Braithwaite I, McKinlay CJD, Dalziel SR. Tan E, et al. JAMA Netw Open. 2020 Oct 1;3(10):e2022398. doi: 10.1001/jamanetworkopen.2020.22398. JAMA Netw Open. 2020. PMID: 33125495 Free PMC article.
IMPORTANCE: Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children. ...Adverse events were uncommon. Acetaminophen and ibuprofen appeared to have similar seriou …
IMPORTANCE: Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for m …
Ibuprofen versus paracetamol for treating fever in preschool children in Nigeria: a randomized clinical trial of effectiveness and safety.
Alaje EO, Udoh EE, Akande PA, Odey FA, Meremikwu MM. Alaje EO, et al. Pan Afr Med J. 2020 Aug 26;36:350. doi: 10.11604/pamj.2020.36.350.21393. eCollection 2020. Pan Afr Med J. 2020. PMID: 33224416 Free PMC article. Clinical Trial.
INTRODUCTION: fever is the primary symptom of most childhood illnesses and a cause of concern to their caregivers. The antipyretics commonly used to treat fever are ibuprofen and paracetamol. Most studies on the effectiveness of ibuprofen and paracetamol in treating …
INTRODUCTION: fever is the primary symptom of most childhood illnesses and a cause of concern to their caregivers. The antipyretics commonly …
Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review.
Pierce CA, Voss B. Pierce CA, et al. Ann Pharmacother. 2010 Mar;44(3):489-506. doi: 10.1345/aph.1M332. Epub 2010 Feb 11. Ann Pharmacother. 2010. PMID: 20150507 Review.
In PubMed/MEDLINE, search terms used were ibuprofen, acetaminophen, paracetamol, clinical trials, and randomized controlled trials. EMBASE search terms included ibuprofen and acetaminophen, restricted to human and clinical trials. ...
In PubMed/MEDLINE, search terms used were ibuprofen, acetaminophen, paracetamol, clinical trials, and randomized controlled trials. E …
Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial.
Hay AD, Costelloe C, Redmond NM, Montgomery AA, Fletcher M, Hollinghurst S, Peters TJ. Hay AD, et al. BMJ. 2008 Sep 2;337:a1302. doi: 10.1136/bmj.a1302. BMJ. 2008. PMID: 18765450 Free PMC article. Clinical Trial.
For less time with fever over 24 hours, paracetamol plus ibuprofen were superior to paracetamol (4.4 hours, 2.4 to 6.3; P<0.001) and to ibuprofen (2.5 hours, 0.6 to 4.4; P=0.008). ...CONCLUSION: Parents, nurses, pharmacists, and doctors wanting to use medicines t …
For less time with fever over 24 hours, paracetamol plus ibuprofen were superior to paracetamol (4.4 hours, 2.4 to 6.3; P<0.001) a …
Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.
Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8. Cochrane Database Syst Rev. 2020. PMID: 32045960 Free PMC article.
Early versus expectant administration of IV ibuprofen, echocardiographically-guided IV ibuprofen treatment versus standard IV ibuprofen treatment, continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, and rectal ibuprofen
Early versus expectant administration of IV ibuprofen, echocardiographically-guided IV ibuprofen treatment versus standard IV …
Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration.
Atkinson HC, Stanescu I, Frampton C, Salem II, Beasley CP, Robson R. Atkinson HC, et al. Clin Drug Investig. 2015 Oct;35(10):625-32. doi: 10.1007/s40261-015-0320-8. Clin Drug Investig. 2015. PMID: 26334726 Free PMC article. Clinical Trial.
Serial plasma samples were assayed for both paracetamol and ibuprofen concentrations, using validated liquid chromatography-tandem mass spectrometry methods. ...CONCLUSION: Concomitant administration of 3 mg/mL ibuprofen and 10 mg/mL paracetamol in a fixed-dose IV c …
Serial plasma samples were assayed for both paracetamol and ibuprofen concentrations, using validated liquid chromatography-tandem ma …
Analgesic effect of oral ibuprofen 400, 600, and 800 mg; paracetamol 500 and 1000 mg; and paracetamol 1000 mg plus 60 mg codeine in acute postoperative pain: a single-dose, randomized, placebo-controlled, and double-blind study.
Lyngstad G, Skjelbred P, Swanson DM, Skoglund LA. Lyngstad G, et al. Eur J Clin Pharmacol. 2021 Dec;77(12):1843-1852. doi: 10.1007/s00228-021-03231-9. Epub 2021 Oct 16. Eur J Clin Pharmacol. 2021. PMID: 34655316 Free PMC article. Clinical Trial.
NNT and NTTp values did not coincide well with PROMs. CONCLUSION: Ibuprofen doses above 400 mg for acute pain offer limited analgesic gain. Paracetamol 1000 mg/codeine 60 mg is comparable to ibuprofen doses from 400 mg. Calculated effect size estimates and PROM in o …
NNT and NTTp values did not coincide well with PROMs. CONCLUSION: Ibuprofen doses above 400 mg for acute pain offer limited analgesic …
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study.
Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S. Kuptniratsaikul V, et al. Clin Interv Aging. 2014 Mar 20;9:451-8. doi: 10.2147/CIA.S58535. eCollection 2014. Clin Interv Aging. 2014. PMID: 24672232 Free PMC article. Clinical Trial.
METHODS: 367 primary knee osteoarthritis patients with a pain score of 5 or higher were randomized to receive ibuprofen 1,200 mg/day or C. domestica extracts 1,500 mg/day for 4 weeks. ...However, the number of events of abdominal pain/discomfort was significantly higher in …
METHODS: 367 primary knee osteoarthritis patients with a pain score of 5 or higher were randomized to receive ibuprofen 1,200 mg/day …
Ibuprofen with or without an antiemetic for acute migraine headaches in adults.
Rabbie R, Derry S, Moore RA. Rabbie R, et al. Cochrane Database Syst Rev. 2013 Apr 30;2013(4):CD008039. doi: 10.1002/14651858.CD008039.pub3. Cochrane Database Syst Rev. 2013. PMID: 23633348 Free PMC article. Review.
Nine included studies (4373 participants, 5223 attacks) compared ibuprofen with placebo or other active comparators; none combined ibuprofen with a self-administered antiemetic. ...The higher dose was significantly better than the lower dose for 2-hour headache reli …
Nine included studies (4373 participants, 5223 attacks) compared ibuprofen with placebo or other active comparators; none combined …
1,987 results