Nanopore sequencing reveals hidden landscape of short L1 transductions in colorectal cancer.
Nummi P, Taira A, Ravantti J, Norri T, Välimäki N, Lepistö A, Renkonen-Sinisalo L, Koskensalo S, Seppälä TT, Ristimäki A, Tahkola K, Mattila A, Böhm J, Mecklin JP, Siili E, Pasanen A, Heikinheimo O, Bützow R, Karhu A, Aaltonen LA, Palin K, Cajuso T.
Nummi P, et al.
Commun Biol. 2026 Feb 12. doi: 10.1038/s42003-026-09674-z. Online ahead of print.
Commun Biol. 2026.
PMID: 41680266
Free article.
Here, we apply nanopore long-read sequencing to 56 colorectal cancer samples to comprehensively detect somatic transductions and to characterize the source L1 activity. ...Finally, we integrate DNA methylation provided by nanopore reads and show that active elements in …
Here, we apply nanopore long-read sequencing to 56 colorectal cancer samples to comprehensively detect somatic transductions and to c …