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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 2
1982 5
1983 1
1984 5
1985 13
1986 32
1987 38
1988 85
1989 109
1990 118
1991 133
1992 146
1993 191
1994 172
1995 195
1996 199
1997 193
1998 231
1999 247
2000 303
2001 303
2002 298
2003 322
2004 380
2005 397
2006 385
2007 396
2008 421
2009 383
2010 460
2011 459
2012 388
2013 450
2014 426
2015 416
2016 379
2017 355
2018 336
2019 326
2020 362
2021 322
2022 265
2023 7
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Search Results

9,800 results
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Page 1
The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.
Anisimov VN, Bartke A. Anisimov VN, et al. Crit Rev Oncol Hematol. 2013 Sep;87(3):201-23. doi: 10.1016/j.critrevonc.2013.01.005. Epub 2013 Feb 21. Crit Rev Oncol Hematol. 2013. PMID: 23434537 Free PMC article. Review.
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. GH/Insulin/insulin-like growth factor-1 (IGF-1) signaling molecules that have been linked to longevity inc …
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. GH/Insulin/i …
Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer.
Kasprzak A. Kasprzak A. Int J Mol Sci. 2021 Jun 16;22(12):6434. doi: 10.3390/ijms22126434. Int J Mol Sci. 2021. PMID: 34208601 Free PMC article. Review.
High glycemic index diets, which chronically raise post-prandial blood glucose, may at least in part increase colon cancer risk via the insulin/insulin-like growth factor 1 (IGF-1) signaling pathway. ...This review de …
High glycemic index diets, which chronically raise post-prandial blood glucose, may at least in part increase colon cancer risk via t …
Starvation, Stress Resistance, and Cancer.
Buono R, Longo VD. Buono R, et al. Trends Endocrinol Metab. 2018 Apr;29(4):271-280. doi: 10.1016/j.tem.2018.01.008. Epub 2018 Feb 17. Trends Endocrinol Metab. 2018. PMID: 29463451 Free PMC article. Review.
Fasting and fasting-mimicking diets (FMDs) provide a particularly promising intervention to promote differential effects in normal and malignant cells. These effects are caused in part by the reduction in IGF-1, insulin, and glucose and the increase in IGFBP1 …
Fasting and fasting-mimicking diets (FMDs) provide a particularly promising intervention to promote differential effects in normal and malig …
IGF-1 and BRCA1 signalling pathways in familial cancer.
Werner H, Bruchim I. Werner H, et al. Lancet Oncol. 2012 Dec;13(12):e537-44. doi: 10.1016/S1470-2045(12)70362-5. Lancet Oncol. 2012. PMID: 23182194 Review.
The insulin-like growth factor (IGF) system has a direct effect on cellular proliferation and survival, and interacts with genetic and environmental factors implicated in causing cancer. ...BRCA1 and BRCA2 have an important role in the de …
The insulin-like growth factor (IGF) system has a direct effect on cellular proliferation and survival, a …
The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development.
Wagner K, Hemminki K, Försti A. Wagner K, et al. Breast Cancer Res Treat. 2007 Sep;104(3):233-48. doi: 10.1007/s10549-006-9411-9. Epub 2006 Nov 2. Breast Cancer Res Treat. 2007. PMID: 17082888 Review.
The growth hormone 1/insulin-like growth factor-1 (GH1/IGF-1) axis plays an essential role in the development of the breast by regulating cell proliferation, differentiation and apoptosis. ...Here, we discuss the infl …
The growth hormone 1/insulin-like growth factor-1 (GH1/IGF-1) axis plays an e …
Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence.
Kaaks R. Kaaks R. Novartis Found Symp. 2004;262:247-60; discussion 260-68. Novartis Found Symp. 2004. PMID: 15562834 Review.
Insulin regulates energy metabolism and increases the bio-activity of IGF-1 by enhancing its synthesis and by decreasing several of its binding proteins (IGFBP-1 and 2). ...Epidemiological evidence is accumulating and suggests that the risk of cance …
Insulin regulates energy metabolism and increases the bio-activity of IGF-1 by enhancing its synthesis and by decreasin …
Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention.
Anisimov VN. Anisimov VN. Exp Gerontol. 2003 Oct;38(10):1041-9. doi: 10.1016/s0531-5565(03)00169-4. Exp Gerontol. 2003. PMID: 14580857 Review.
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecu …
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the develop …
[GH/IGF-1 and cancer: what's new in this association].
Castro AM, Guerra-Júnior G. Castro AM, et al. Arq Bras Endocrinol Metabol. 2005 Oct;49(5):833-42. doi: 10.1590/s0004-27302005000500026. Epub 2006 Jan 23. Arq Bras Endocrinol Metabol. 2005. PMID: 16444368 Review. Portuguese.
Evidence from in vitro and animal studies suggests that members of the insulin-like growth factors (IGFs) system, including IGF-I, IGF-II, the IGF-I receptor (IGF-IR), and the IGF-binding proteins (IGFBPs) play a central rol …
Evidence from in vitro and animal studies suggests that members of the insulin-like growth factors (IGFs) system, inclu …
IGF-1 and prostate cancer.
Roberts CT Jr. Roberts CT Jr. Novartis Found Symp. 2004;262:193-9; discussion 199-204, 265-8. Novartis Found Symp. 2004. PMID: 15562830 Review.
Thus, IGF-1 action appears to be important for prostate cancer initiation. ...This decrease in IGF-1 receptor may confer a survival advantage to prostate cancer cells that have entered the circulation by making them resistant to the diffe …
Thus, IGF-1 action appears to be important for prostate cancer initiation. ...This decrease in IGF-1 rece …
Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53.
Salvioli S, Capri M, Bucci L, Lanni C, Racchi M, Uberti D, Memo M, Mari D, Govoni S, Franceschi C. Salvioli S, et al. Cancer Immunol Immunother. 2009 Dec;58(12):1909-17. doi: 10.1007/s00262-008-0639-6. Epub 2009 Jan 13. Cancer Immunol Immunother. 2009. PMID: 19139887 Review.
RESULTS: Centenarians appear to be characterised by low IGF-1-mediated responses and high levels of anti-inflammatory cytokines such as IL-10 and TGF-beta, a condition that results in protection from cancer. Both inflammation and IGF-1 pathway c …
RESULTS: Centenarians appear to be characterised by low IGF-1-mediated responses and high levels of anti-inflammatory cytokine …
9,800 results