Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2015 1
2018 1
2019 3
2020 1
2021 5
2024 1
2025 2
2026 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

14 results

Results by year

Filters applied: . Clear all
Page 1
Entorhinal Cortex Wolframin-1-expressing neurons propagate tau to CA1 neurons and impair hippocampal memory.
Delpech JC, Kalavai SV, Pathak D, Ravula AR, Lad HV, Hays EC, Touch N, Rau A, Madore C, Medalla M, Luebke JI, Ikezu S, Ikezu T. Delpech JC, et al. Among authors: ikezu t. bioRxiv [Preprint]. 2026 Feb 20:2026.02.19.706636. doi: 10.64898/2026.02.19.706636. bioRxiv. 2026. PMID: 41757076 Free PMC article. Preprint.
Using a circuit-defined model in which P301L human tau is expressed selectively in Wolframin-1 (Wfs1 (+) ) ECII neurons and propagates to CA1, we found that the extent and proximal-distal distribution of tau-positive CA1 neurons were comparable in males and f …
Using a circuit-defined model in which P301L human tau is expressed selectively in Wolframin-1 (Wfs1 (+) ) ECII neurons and propag …
P2RX7 regulates tauopathy progression via tau and mitochondria loading in extracellular vesicles.
Ikezu T, Bodart-Santos V, Ravula AR, You Y, Abdullah M, Ruan Z, Ellison J, Radhakishun S, Ray NB, Melvin B, Kurti A, Liang Z, Sakai Y, O'Brien D, Nguyen S, Shaffer S, Fiddes L, Butovsky O, Springer W, Ikezu S. Ikezu T, et al. Res Sq [Preprint]. 2025 Jun 23:rs.3.rs-6771517. doi: 10.21203/rs.3.rs-6771517/v1. Res Sq. 2025. PMID: 40678243 Free PMC article. Preprint.
Here, we show that genetic deletion of P2rx7 mitigates brain atrophy, tau accumulation and cognitive impairment in PS19 tauopathy mice. Specific deletion of P2rx7 in microglia, but not astrocytes, significantly suppresses tau propagation from the entorhinal c …
Here, we show that genetic deletion of P2rx7 mitigates brain atrophy, tau accumulation and cognitive impairment in PS19 tauopathy mic …
Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer's disease.
Ikezu T, Zhang Z, Yu K, Bao H, Ikezu T, Ravula AR, Melvin B, Scholes C, You Y, Ellison J, Kanekiyo T, Wszolek Z, DeTure M, Dickson D, Han X, Peng J, Ikezu S. Ikezu T, et al. Res Sq [Preprint]. 2025 May 26:rs.3.rs-6508552. doi: 10.21203/rs.3.rs-6508552/v1. Res Sq. 2025. PMID: 40502793 Free PMC article. Preprint.
Here we report comprehensive analyses of BDEVs isolated from human E3/3 and E4/4 AD brains with a biological multi-omics approach. E4/4 BDEVs significantly enhanced tau propagation in aged human MAPT (Tau) knock-in and APP (NL-G-F): Tau double knock-in …
Here we report comprehensive analyses of BDEVs isolated from human E3/3 and E4/4 AD brains with a biological multi-omics approach. E4/4 BDEV …
P2RX7 plays a critical role in extracellular vesicle-mediated secretion of pathogenic molecules from microglia and astrocytes.
Abdullah M, Ruan Z, Ikezu S, Ikezu T. Abdullah M, et al. Among authors: ikezu t. J Extracell Biol. 2024 Jun 27;3(7):e155. doi: 10.1002/jex2.155. eCollection 2024 Jul. J Extracell Biol. 2024. PMID: 38947879 Free PMC article.
We have previously shown that administration of GSK1482160, a P2RX7 selective inhibitor, suppresses EV secretion from murine microglia and prevents tauopathy development, leading to the recovery of the hippocampal function in PS19 mice, expressing P301S tau mutant. It is y …
We have previously shown that administration of GSK1482160, a P2RX7 selective inhibitor, suppresses EV secretion from murine microglia and p …
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
Delpech JC, Pathak D, Varghese M, Kalavai SV, Hays EC, Hof PR, Johnson WE, Ikezu S, Medalla M, Luebke JI, Ikezu T. Delpech JC, et al. Among authors: ikezu t. Sci Transl Med. 2021 Sep 15;13(611):eabe8455. doi: 10.1126/scitranslmed.abe8455. Epub 2021 Sep 15. Sci Transl Med. 2021. PMID: 34524859 Free PMC article.
Animal models of tau propagation aiming to recapitulate this phenomenon mostly show tau transfer from ECII stellate neurons to the dentate gyrus, but tau pathology in the dentate gyrus does not appear until advanced stages of AD. ...Here, we report tha …
Animal models of tau propagation aiming to recapitulate this phenomenon mostly show tau transfer from ECII stellate neu …
Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons.
Podvin S, Jones A, Liu Q, Aulston B, Mosier C, Ames J, Winston C, Lietz CB, Jiang Z, O'Donoghue AJ, Ikezu T, Rissman RA, Yuan SH, Hook V. Podvin S, et al. Among authors: ikezu t. ACS Omega. 2021 May 13;6(20):13033-13056. doi: 10.1021/acsomega.1c00660. eCollection 2021 May 25. ACS Omega. 2021. PMID: 34056454 Free PMC article.
The accumulation and propagation of hyperphosphorylated tau (p-Tau) is a neuropathological hallmark occurring with neurodegeneration of Alzheimer's disease (AD). ...Notably, mPS1 neuron-derived exosomes displayed altered profiles of protein phosphatases and k …
The accumulation and propagation of hyperphosphorylated tau (p-Tau) is a neuropathological hallmark occurring with neur …
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Clayton K, et al. Among authors: ikezu t. Mol Neurodegener. 2021 Mar 22;16(1):18. doi: 10.1186/s13024-021-00440-9. Mol Neurodegener. 2021. PMID: 33752701 Free PMC article.
Administration of PLX5622 depleted nearly all microglia in mouse brains and dramatically reduced propagation of p-tau in WT and to a greater extent in App(NL-G-F) mice, although it increased plaque burden and plaque-associated p-tau(+) dystrophic neurites. .. …
Administration of PLX5622 depleted nearly all microglia in mouse brains and dramatically reduced propagation of p-tau in WT an …
Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons.
Ruan Z, Pathak D, Venkatesan Kalavai S, Yoshii-Kitahara A, Muraoka S, Bhatt N, Takamatsu-Yukawa K, Hu J, Wang Y, Hersh S, Ericsson M, Gorantla S, Gendelman HE, Kayed R, Ikezu S, Luebke JI, Ikezu T. Ruan Z, et al. Among authors: ikezu t. Brain. 2021 Feb 12;144(1):288-309. doi: 10.1093/brain/awaa376. Brain. 2021. PMID: 33246331 Free PMC article.
Strikingly, the inoculation of Alzheimer's disease or prodromal Alzheimer's disease extracellular vesicles containing only 300 pg of tau into the outer molecular layer of the dentate gyrus of 18-month-old C57BL/6 mice resulted in the accumulation of abnormally phosphorylat …
Strikingly, the inoculation of Alzheimer's disease or prodromal Alzheimer's disease extracellular vesicles containing only 300 pg of tau …
Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses.
Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. Podvin S, et al. Among authors: ikezu t. Mol Cell Proteomics. 2020 Jun;19(6):1017-1034. doi: 10.1074/mcp.RA120.002079. Epub 2020 Apr 15. Mol Cell Proteomics. 2020. PMID: 32295833 Free PMC article.
Accumulation and propagation of hyperphosphorylated Tau (p-Tau) is a common neuropathological hallmark associated with neurodegeneration of Alzheimer's disease (AD), frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and related tauop …
Accumulation and propagation of hyperphosphorylated Tau (p-Tau) is a common neuropathological hallmark associated with …
14 results