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Low ileocecal valve pressure is significantly associated with small intestinal bacterial overgrowth (SIBO).
Roland BC, Ciarleglio MM, Clarke JO, Semler JR, Tomakin E, Mullin GE, Pasricha PJ. Roland BC, et al. Dig Dis Sci. 2014 Jun;59(6):1269-77. doi: 10.1007/s10620-014-3166-7. Epub 2014 May 3. Dig Dis Sci. 2014. PMID: 24795035
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is a significant and increasingly recognized syndrome. While the development may be multifactorial, impairment of the ileocecal valve (ICV), small bowel motility, and gastric acid secretion have been hy …
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is a significant and increasingly recognized syndrome. While the development …
Gastroduodenal "Dysbiosis": a New Clinical Entity.
Shah A, Morrison M, Holtmann GJ. Shah A, et al. Curr Treat Options Gastroenterol. 2018 Dec;16(4):591-604. doi: 10.1007/s11938-018-0207-x. Curr Treat Options Gastroenterol. 2018. PMID: 30421297 Review.
Initially believed that small intestinal dysbiosis (e.g. SIBO) is mainly due to alterations of luminal conditions (e.g. after surgical resections of the ileocecal valve), there is now enough evidence to conclude that small intestinal dysbiosis can occur witho …
Initially believed that small intestinal dysbiosis (e.g. SIBO) is mainly due to alterations of luminal conditions (e.g. after surgica …
A Prospective Evaluation of Ileocecal Valve Dysfunction and Intestinal Motility Derangements in Small Intestinal Bacterial Overgrowth.
Chander Roland B, Mullin GE, Passi M, Zheng X, Salem A, Yolken R, Pasricha PJ. Chander Roland B, et al. Dig Dis Sci. 2017 Dec;62(12):3525-3535. doi: 10.1007/s10620-017-4726-4. Epub 2017 Sep 4. Dig Dis Sci. 2017. PMID: 28871499
We hypothesized that loss of gastric acid, a delayed intestinal transit, and ileocecal valve dysfunction may contribute to the genesis of this syndrome. AIMS: Our primary aim was to assess these parameters using wireless motility capsule (WMC) testing and to correla …
We hypothesized that loss of gastric acid, a delayed intestinal transit, and ileocecal valve dysfunction may contribute to the …
Systematic review with meta-analysis: the prevalence of small intestinal bacterial overgrowth in inflammatory bowel disease.
Shah A, Morrison M, Burger D, Martin N, Rich J, Jones M, Koloski N, Walker MM, Talley NJ, Holtmann GJ. Shah A, et al. Aliment Pharmacol Ther. 2019 Mar;49(6):624-635. doi: 10.1111/apt.15133. Epub 2019 Feb 8. Aliment Pharmacol Ther. 2019. PMID: 30735254
METHODS: Electronic databases were searched up to May 2018 for studies reporting prevalence of SIBO in IBD patients. The prevalence rate of SIBO among IBD patients and the odds ratio (OR) and 95% CI of SIBO in IBD patients compared with controls were calculat …
METHODS: Electronic databases were searched up to May 2018 for studies reporting prevalence of SIBO in IBD patients. The prevalence r …
Testing and Treating Small Intestinal Bacterial Overgrowth Reduces Symptoms in Patients with Inflammatory Bowel Disease.
Cohen-Mekelburg S, Tafesh Z, Coburn E, Weg R, Malik N, Webb C, Hammad H, Scherl E, Bosworth BP. Cohen-Mekelburg S, et al. Dig Dis Sci. 2018 Sep;63(9):2439-2444. doi: 10.1007/s10620-018-5109-1. Epub 2018 May 14. Dig Dis Sci. 2018. PMID: 29761252
BACKGROUND: Common mechanisms against small intestinal bacterial overgrowth (SIBO), including an intact ileocecal valve, gastric acid secretion, intestinal motility, and an intact immune system, are compromised in inflammatory bowel disease (IBD), and therefo …
BACKGROUND: Common mechanisms against small intestinal bacterial overgrowth (SIBO), including an intact ileocecal valve …
Elevated methane levels in small intestinal bacterial overgrowth suggests delayed small bowel and colonic transit.
Suri J, Kataria R, Malik Z, Parkman HP, Schey R. Suri J, et al. Medicine (Baltimore). 2018 May;97(21):e10554. doi: 10.1097/MD.0000000000010554. Medicine (Baltimore). 2018. PMID: 29794732 Free PMC article.
Limited research exists regarding the relationship between small intestinal bacterial overgrowth (SIBO), small bowel transit (SBT), and colonic transit (CT). Furthermore, symptom analysis is limited between the subtypes of SIBO: hydrogen producing (H-SIBO) an …
Limited research exists regarding the relationship between small intestinal bacterial overgrowth (SIBO), small bowel transit (SBT), a …
Small Intestinal Bacterial Overgrowth Syndrome Prevalence in Romanian Patients with Inflammatory Bowel Disease.
Andrei M, Gologan S, Stoicescu A, Ionescu M, Nicolaie T, Diculescu M. Andrei M, et al. Curr Health Sci J. 2016 Apr-Jun;42(2):151-156. doi: 10.12865/CHSJ.42.02.06. Epub 2016 Jun 28. Curr Health Sci J. 2016. PMID: 30568826 Free PMC article.
METHOD: patients with IBD (CD - Crohn disease and UC - ulcerative colitis) in remission underwent screening for the presence of SIBO using the hydrogen breath test. RESULTS: of the 75 patients tested, the breath test was positive for SIBO in 25.3% (30.77% of patient …
METHOD: patients with IBD (CD - Crohn disease and UC - ulcerative colitis) in remission underwent screening for the presence of SIBO …
Small Intestinal Bacterial Overgrowth in Children with Short Bowel Syndrome: Risk Factors, Clinical Presentation and Management-A Single-Center Experience.
Velimirovic M, Osterman V, Prislan A, Pintar T. Velimirovic M, et al. Children (Basel). 2025 Mar 11;12(3):351. doi: 10.3390/children12030351. Children (Basel). 2025. PMID: 40150633 Free PMC article.
Results: The mean small bowel remnant was 47 cm (SD = 31.5), with an absent ileocecal valve in 61.5% (8/13). Five children (31.2%) had at least 1 episode of clinically suspected SIBO, with a total of 25 episodes. ...Symptom resolution was achieved in 56% (14/ …
Results: The mean small bowel remnant was 47 cm (SD = 31.5), with an absent ileocecal valve in 61.5% (8/13). Five children (31 …
Small Intestinal Bacterial Overgrowth.
Sorathia SJ, Chippa V, Rivas JM. Sorathia SJ, et al. 2023 Apr 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2023 Apr 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 31536241 Free Books & Documents.
The terminal ileum microbiome is intermediate between the proximal small intestine (aerobic flora) and the colon (densely anaerobic); in the absence of an ileocecal valve, the microbiome is similar to the colon, with 10 organisms/mL. When the protective mechanisms ( …
The terminal ileum microbiome is intermediate between the proximal small intestine (aerobic flora) and the colon (densely anaerobic); in the …