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824 results

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Page 1
Neuropeptides and obesity.
Beck B. Beck B. Nutrition. 2000 Oct;16(10):916-23. doi: 10.1016/s0899-9007(00)00410-x. Nutrition. 2000. PMID: 11054597 Review.
When leptin signaling is defective, through a defect in either the receptor (Zucker fa/fa rat, cp/cp rat, and db/db mouse) or in the peptide itself (ob/ob mouse), the NPY system is upregulated as shown by mRNA overexpression and increased peptide release, whereas th …
When leptin signaling is defective, through a defect in either the receptor (Zucker fa/fa rat, cp/cp rat, and db/db mouse) or …
Unraveling the obesity of OLETF rats.
Moran TH. Moran TH. Physiol Behav. 2008 Apr 22;94(1):71-8. doi: 10.1016/j.physbeh.2007.11.035. Epub 2007 Nov 29. Physiol Behav. 2008. PMID: 18190934 Free PMC article. Review.
OLETF rats are hyperphagic with the hyperphagia expressed as a significant increase in the size of meals. ...Recent studies have examined developmental aspects of altered feeding, body weight and orexigenic signaling in OLETF rats. OLETF rats …
OLETF rats are hyperphagic with the hyperphagia expressed as a significant increase in the size of meals. ...Recent studies ha …
Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat.
Yamada T, Kose H, Ohta T, Matsumoto K. Yamada T, et al. Exp Diabetes Res. 2012;2012:582546. doi: 10.1155/2012/582546. Epub 2012 Oct 15. Exp Diabetes Res. 2012. PMID: 23118743 Free PMC article. Review.
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, noninsulin-dependent diabetes mellitus (NIDDM) in humans. NIDDM in this rat model was shown to be regulated by multiple genes. We have identified 14 quantitative trait loci ( …
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, noninsulin-dependent diabetes mellitus (N …
Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors.
Moran TH, Bi S. Moran TH, et al. Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1211-8. doi: 10.1098/rstb.2006.1857. Philos Trans R Soc Lond B Biol Sci. 2006. PMID: 16815799 Free PMC article. Review.
OLETF rats become obese and develop non-insulin dependent diabetes mellitus (NIDDM). Consistent with the absence of CCK-1 receptors, OLETF rats do not respond to exogenous CCK. ...Access to a running wheel and the resulting exercise normalizes food int …
OLETF rats become obese and develop non-insulin dependent diabetes mellitus (NIDDM). Consistent with the absence of CCK-1 rece …
Actions of CCK in the controls of food intake and body weight: lessons from the CCK-A receptor deficient OLETF rat.
Bi S, Moran TH. Bi S, et al. Neuropeptides. 2002 Apr-Jun;36(2-3):171-81. doi: 10.1054/npep.2002.0895. Neuropeptides. 2002. PMID: 12359507 Review.
OLETF rats are obese and diabetic and express deficits in the control of the size of individual meals. Meal size in OLETF rats is doubled and although meal number is decreased, the decrease is not sufficient to prevent hyperphagia. ...
OLETF rats are obese and diabetic and express deficits in the control of the size of individual meals. Meal size in OLETF …
Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts.
Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Sato T, Kuno A, Fujita Y, Ino S, Shimizu M, Toda Y, Ohwada W, Yano T, Tanno M, Miki T, Miura T. Ogawa T, et al. Physiol Rep. 2023 Feb;11(4):e15608. doi: 10.14814/phy2.15608. Physiol Rep. 2023. PMID: 36802195 Free PMC article.
Compared with control rats (Long-Evans Tokushima Otsuka [LETO] rats), OLETF rats exhibited 49% higher cardiac BCAA levels and 49% lower BCKDH activity. In the cardiac ER of the OLETF rats, BCKDH-E1alpha subunit expression was downregulate …
Compared with control rats (Long-Evans Tokushima Otsuka [LETO] rats), OLETF rats exhibited 49% higher cardiac BC …
Diabetic complications in obese type 2 diabetic rat models.
Katsuda Y, Ohta T, Miyajima K, Kemmochi Y, Sasase T, Tong B, Shinohara M, Yamada T. Katsuda Y, et al. Exp Anim. 2014;63(2):121-32. doi: 10.1538/expanim.63.121. Exp Anim. 2014. PMID: 24770637 Free PMC article. Review.
We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evans Tokushima fatty (OLETF) rat, Wistar fatty rat, Zucker diabetic fatty (ZDF) rat and Spontaneously diabetic Tori …
We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evan …
Pathoetiology and prevention of NIDDM lessons from the OLETF rat.
Shima K, Zhu M, Mizuno A. Shima K, et al. J Med Invest. 1999 Aug;46(3-4):121-9. J Med Invest. 1999. PMID: 10687306 Review.
The OLETF rat, a genetic model of spontaneous development of NIDDM, exhibits hyperglycemic obesity with hyperinsulinemia and insulin resistance similar to that in humans. ...OLETF rats following long-term caloric restriction and spontaneous exercise tr …
The OLETF rat, a genetic model of spontaneous development of NIDDM, exhibits hyperglycemic obesity with hyperinsulinemia and i …
Physical activity maintains aortic endothelium-dependent relaxation in the obese type 2 diabetic OLETF rat.
Bunker AK, Arce-Esquivel AA, Rector RS, Booth FW, Ibdah JA, Laughlin MH. Bunker AK, et al. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1889-901. doi: 10.1152/ajpheart.01252.2009. Epub 2010 Mar 19. Am J Physiol Heart Circ Physiol. 2010. PMID: 20304812 Free PMC article.
Temporal changes in the protein expression of SOD isoforms in the aortic endothelium or smooth muscle did not contribute to the temporal decline in ACh-induced endothelium-dependent relaxation in sedentary OLETF rats. A significant increase in the 40-wk-old sedentar …
Temporal changes in the protein expression of SOD isoforms in the aortic endothelium or smooth muscle did not contribute to the temporal dec …
Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: developmental aspects.
Moran TH, Bi S. Moran TH, et al. Dev Psychobiol. 2006 Jul;48(5):360-7. doi: 10.1002/dev.20149. Dev Psychobiol. 2006. PMID: 16770763 Review.
Neonatal OLETF rats also have diminished latencies to consume and higher initial ingestion rats. Adult OLETF rats are hyperphagic and obese. Although arcuate nucleus peptide gene expression is apparently normal in OLETF rats, when …
Neonatal OLETF rats also have diminished latencies to consume and higher initial ingestion rats. Adult OLETF …
824 results