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Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation.
Wong CP, Magnusson KR, Ho E. Wong CP, et al. J Nutr Biochem. 2013 Jan;24(1):353-9. doi: 10.1016/j.jnutbio.2012.07.005. Epub 2012 Sep 13. J Nutr Biochem. 2013. PMID: 22981370 Free PMC article.
The effects of zinc deficiency and age on the induction of inflammatory responses were determined using an in vitro cell culture system and an aged mouse model. ...Furthermore, reduced Zip 6 expression enhanced proinflammatory response, and age-specifi …
The effects of zinc deficiency and age on the induction of inflammatory responses were determined using an in vitro cell cultu …
Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation.
Stotesbury C, Wong EB, Tang L, Montoya B, Knudson CJ, Melo-Silva CR, Sigal LJ. Stotesbury C, et al. Aging Cell. 2020 Jul;19(7). doi: 10.1111/acel.13170. Epub 2020 Jul 12. Aging Cell. 2020. PMID: 32657004 Free article.
In response to the IFN-γ, the incoming uninfected iMOs secret CXCL9 to recruit the critical NK cells. Here, we show that in aged B6 mice, the trafficking of mDCs to the dLN in response to ECTV is decreased, resulting in impaired IFN-γ expression by G1- …
In response to the IFN-γ, the incoming uninfected iMOs secret CXCL9 to recruit the critical NK cells. Here, we show that in aged
Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model.
Atkinson SJ, Varisco BM, Sandquist M, Daly MN, Klingbeil L, Kuethe JW, Midura EF, Harmon K, Opaka A, Lahni P, Piraino G, Hake P, Zingarelli B, Mortenson JE, Wynn JL, Wong HR. Atkinson SJ, et al. Mol Med. 2016 Oct;22:455-463. doi: 10.2119/molmed.2016.00058. Epub 2016 Aug 8. Mol Med. 2016. PMID: 27506554 Free PMC article.
Because developmental age influences the host inflammatory response, we hypothesized that developmental age influences the role of MMP8 in sepsis. ...The increase in mortality in MMP8 null juvenile mice was associated with reduced bacterial clearance a …
Because developmental age influences the host inflammatory response, we hypothesized that developmental age influences the rol …
Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation.
Wong CP, Rinaldi NA, Ho E. Wong CP, et al. Mol Nutr Food Res. 2015 May;59(5):991-9. doi: 10.1002/mnfr.201400761. Epub 2015 Mar 17. Mol Nutr Food Res. 2015. PMID: 25656040 Free PMC article.
A decreased zinc status in aged mice was similarly associated with increased ICAM1 and IL6 gene expression. Reduced IL6 promoter methylation was observed in zinc-deficient THP1 cells, as well as in aged mice and human lymphoblastoid cell lines d …
A decreased zinc status in aged mice was similarly associated with increased ICAM1 and IL6 gene expression. Reduced IL6 …
Age-associated vascular inflammation promotes monocytosis during atherogenesis.
Du W, Wong C, Song Y, Shen H, Mori D, Rotllan N, Price N, Dobrian AD, Meng H, Kleinstein SH, Fernandez-Hernando C, Goldstein DR. Du W, et al. Aging Cell. 2016 Aug;15(4):766-77. doi: 10.1111/acel.12488. Epub 2016 May 2. Aging Cell. 2016. PMID: 27135421 Free PMC article.
Here, we examined how aging impacts atherosclerosis using Ldlr(-/-) mice, an established murine model of atherosclerosis. We found that aged atherosclerotic Ldlr(-/-) mice exhibited enhanced atherogenesis within the aorta. ...To delineate these stromal factor …
Here, we examined how aging impacts atherosclerosis using Ldlr(-/-) mice, an established murine model of atherosclerosis. We found th …
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