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Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation.
Wong CP, Magnusson KR, Ho E. Wong CP, et al. J Nutr Biochem. 2013 Jan;24(1):353-9. doi: 10.1016/j.jnutbio.2012.07.005. Epub 2012 Sep 13. J Nutr Biochem. 2013. PMID: 22981370 Free PMC article.
The goal of this study was to examine the contribution of age-related zinc deficiency and zinc transporter dysregulation on the inflammatory response in immune cells. The effects of zinc deficiency and age on the induction of inflammatory responses wer …
The goal of this study was to examine the contribution of age-related zinc deficiency and zinc transporter dysregulation on the inflammat …
MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity.
Asthana P, Li L, Lu L, Wu J, Zhang S, Li N, Wong SKK, Gurung S, Zhang Y, Lin Y, Peng Y, Xu Z, Chan KM, Zhai L, Lyu A, Bian ZX, Ge X, Iyaswamy A, Li M, Su Y, Zhou Z, Xu P, Wong HLX. Asthana P, et al. Cell Discov. 2025 Sep 23;11(1):76. doi: 10.1038/s41421-025-00825-w. Cell Discov. 2025. PMID: 40983624 Free PMC article.
Here, we demonstrate that MT1-MMP links neuroinflammation to cognitive decline in aging and obesity. Inflammatory responses in the brain increase MT1-MMP activation in the hippocampus of both mice and humans. ...Pharmacological inhibition of MT1-MMP, t …
Here, we demonstrate that MT1-MMP links neuroinflammation to cognitive decline in aging and obesity. Inflammatory responses in …
Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation.
Stotesbury C, Wong EB, Tang L, Montoya B, Knudson CJ, Melo-Silva CR, Sigal LJ. Stotesbury C, et al. Aging Cell. 2020 Jul;19(7):e13170. doi: 10.1111/acel.13170. Epub 2020 Jul 12. Aging Cell. 2020. PMID: 32657004 Free PMC article.
Here, we show that in aged B6 mice, the trafficking of mDCs to the dLN in response to ECTV is decreased, resulting in impaired IFN-gamma expression by G1-ILCs, reduced accumulation of iMOs, and attenuated CXCL9 production by iMOs, which likely contributes to …
Here, we show that in aged B6 mice, the trafficking of mDCs to the dLN in response to ECTV is decreased, resulting in i …
Olfactomedin 4-Positive Neutrophils Are Upregulated after Hemorrhagic Shock.
Kassam AF, Levinsky NC, Mallela JP, Angel K, Opoka A, Lahni P, Sahay RD, Fei L, Nomellini V, Wong HR, Alder MN. Kassam AF, et al. Am J Respir Cell Mol Biol. 2021 Feb;64(2):216-223. doi: 10.1165/rcmb.2020-0276OC. Am J Respir Cell Mol Biol. 2021. PMID: 33253592 Free PMC article.
To establish a potential role for OLFM4(+) neutrophils, we used a murine model of hemorrhagic shock because mice also express OLFM4 in a subset of neutrophils. These studies demonstrated that wild type mice had higher concentrations of cytokines in the plasma and my …
To establish a potential role for OLFM4(+) neutrophils, we used a murine model of hemorrhagic shock because mice also express OLFM4 i …
Age-associated vascular inflammation promotes monocytosis during atherogenesis.
Du W, Wong C, Song Y, Shen H, Mori D, Rotllan N, Price N, Dobrian AD, Meng H, Kleinstein SH, Fernandez-Hernando C, Goldstein DR. Du W, et al. Aging Cell. 2016 Aug;15(4):766-77. doi: 10.1111/acel.12488. Epub 2016 May 2. Aging Cell. 2016. PMID: 27135421 Free PMC article.
We found that aged atherosclerotic Ldlr(-/-) mice exhibited enhanced atherogenesis within the aorta. ...To delineate these stromal factors, we determined that the vasculature exhibited an age-enhanced inflammatory response consisting of elevated produc …
We found that aged atherosclerotic Ldlr(-/-) mice exhibited enhanced atherogenesis within the aorta. ...To delineate these str …
Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation.
Wong CP, Rinaldi NA, Ho E. Wong CP, et al. Mol Nutr Food Res. 2015 May;59(5):991-9. doi: 10.1002/mnfr.201400761. Epub 2015 Mar 17. Mol Nutr Food Res. 2015. PMID: 25656040 Free PMC article.
Zinc deficiency upregulated cell activation markers ICAM1, MHC class II, and CD86 in THP1 cells, which coincided with increased IL1beta and IL6 responses following LPS stimulation. A decreased zinc status in aged mice was similarly associated with i …
Zinc deficiency upregulated cell activation markers ICAM1, MHC class II, and CD86 in THP1 cells, which coincided with increased IL1be …
Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model.
Atkinson SJ, Varisco BM, Sandquist M, Daly MN, Klingbeil L, Kuethe JW, Midura EF, Harmon K, Opaka A, Lahni P, Piraino G, Hake P, Zingarelli B, Mortenson JE, Wynn JL, Wong HR. Atkinson SJ, et al. Mol Med. 2016 Oct;22:455-463. doi: 10.2119/molmed.2016.00058. Epub 2016 Aug 8. Mol Med. 2016. PMID: 27506554 Free PMC article.
In conclusion, in contrast to septic adult mice, genetic ablation of MMP8 increased mortality following bacterial peritonitis in juvenile mice. The increase in mortality in MMP8 null juvenile mice was associated with reduced bacterial clearance …
In conclusion, in contrast to septic adult mice, genetic ablation of MMP8 increased mortality following bacterial peritonitis …
Lung Imaging Reveals Stroke-Induced Impairment in Pulmonary Intravascular Neutrophil Function, a Response Exacerbated with Aging.
Wen SW, Shim R, Hall P, Bedo J, Wilson JL, Nicholls AJ, Hickey MJ, Wong CHY. Wen SW, et al. J Immunol. 2022 Apr 15;208(8):2019-2028. doi: 10.4049/jimmunol.2100997. Epub 2022 Apr 1. J Immunol. 2022. PMID: 35365565
Moreover, older stroke patients show an increased risk of developing stroke-associated infection, although the mechanisms underlying this increased susceptibility to infection are unknown. ...Intravital microscopy of the lung microvasculature revealed that in younge …
Moreover, older stroke patients show an increased risk of developing stroke-associated infection, although the mechanisms underlying …