Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2012 1
2013 1
2015 1
2016 2
2020 1
2021 1
2022 1
2023 0

Text availability

Article attribute

Article type

Publication date

Search Results

7 results

Results by year

Filters applied: . Clear all
Page 1
Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation.
Wong CP, Magnusson KR, Ho E. Wong CP, et al. J Nutr Biochem. 2013 Jan;24(1):353-9. doi: 10.1016/j.jnutbio.2012.07.005. Epub 2012 Sep 13. J Nutr Biochem. 2013. PMID: 22981370 Free PMC article.
The goal of this study was to examine the contribution of age-related zinc deficiency and zinc transporter dysregulation on the inflammatory response in immune cells. The effects of zinc deficiency and age on the induction of inflammatory responses wer …
The goal of this study was to examine the contribution of age-related zinc deficiency and zinc transporter dysregulation on the inflammat …
Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation.
Stotesbury C, Wong EB, Tang L, Montoya B, Knudson CJ, Melo-Silva CR, Sigal LJ. Stotesbury C, et al. Aging Cell. 2020 Jul;19(7):e13170. doi: 10.1111/acel.13170. Epub 2020 Jul 12. Aging Cell. 2020. PMID: 32657004 Free PMC article.
Here, we show that in aged B6 mice, the trafficking of mDCs to the dLN in response to ECTV is decreased, resulting in impaired IFN-gamma expression by G1-ILCs, reduced accumulation of iMOs, and attenuated CXCL9 production by iMOs, which likely contributes to …
Here, we show that in aged B6 mice, the trafficking of mDCs to the dLN in response to ECTV is decreased, resulting in i …
Olfactomedin 4-Positive Neutrophils Are Upregulated after Hemorrhagic Shock.
Kassam AF, Levinsky NC, Mallela JP, Angel K, Opoka A, Lahni P, Sahay RD, Fei L, Nomellini V, Wong HR, Alder MN. Kassam AF, et al. Am J Respir Cell Mol Biol. 2021 Feb;64(2):216-223. doi: 10.1165/rcmb.2020-0276OC. Am J Respir Cell Mol Biol. 2021. PMID: 33253592 Free PMC article.
In addition, we used an anti-OLFM4 antibody, which when given to wild type mice led to the reduction of myeloperoxidase in the lungs of mice. These findings suggest that OLFM4(+) neutrophils are a unique subset of neutrophils that affect the inflammatory r …
In addition, we used an anti-OLFM4 antibody, which when given to wild type mice led to the reduction of myeloperoxidase in the lungs …
Lung Imaging Reveals Stroke-Induced Impairment in Pulmonary Intravascular Neutrophil Function, a Response Exacerbated with Aging.
Wen SW, Shim R, Hall P, Bedo J, Wilson JL, Nicholls AJ, Hickey MJ, Wong CHY. Wen SW, et al. J Immunol. 2022 Apr 15;208(8):2019-2028. doi: 10.4049/jimmunol.2100997. Epub 2022 Apr 1. J Immunol. 2022. PMID: 35365565
Intravital microscopy of the lung microvasculature revealed that in younger mice, stroke promoted neutrophil arrest in pulmonary microvessels, but this response was not seen in older poststroke mice. In addition, bacterial phagocytosis by neutrophils in the l …
Intravital microscopy of the lung microvasculature revealed that in younger mice, stroke promoted neutrophil arrest in pulmonary micr …
Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model.
Atkinson SJ, Varisco BM, Sandquist M, Daly MN, Klingbeil L, Kuethe JW, Midura EF, Harmon K, Opaka A, Lahni P, Piraino G, Hake P, Zingarelli B, Mortenson JE, Wynn JL, Wong HR. Atkinson SJ, et al. Mol Med. 2016 Oct;22:455-463. doi: 10.2119/molmed.2016.00058. Epub 2016 Aug 8. Mol Med. 2016. PMID: 27506554 Free PMC article.
Leukocyte counts and cytokine concentrations in the peritoneal fluid were increased in the MMP8 null mice, relative to the wild type mice. Peritoneal macrophages from MMP8 null mice had reduced phagocytic capacity compared to WT macrophages. ...The …
Leukocyte counts and cytokine concentrations in the peritoneal fluid were increased in the MMP8 null mice, relative to the wil …
Age-associated vascular inflammation promotes monocytosis during atherogenesis.
Du W, Wong C, Song Y, Shen H, Mori D, Rotllan N, Price N, Dobrian AD, Meng H, Kleinstein SH, Fernandez-Hernando C, Goldstein DR. Du W, et al. Aging Cell. 2016 Aug;15(4):766-77. doi: 10.1111/acel.12488. Epub 2016 May 2. Aging Cell. 2016. PMID: 27135421 Free PMC article.
We found that aged atherosclerotic Ldlr(-/-) mice exhibited enhanced atherogenesis within the aorta. ...To delineate these stromal factors, we determined that the vasculature exhibited an age-enhanced inflammatory response consisting of elevated produc …
We found that aged atherosclerotic Ldlr(-/-) mice exhibited enhanced atherogenesis within the aorta. ...To delineate these str …
Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation.
Wong CP, Rinaldi NA, Ho E. Wong CP, et al. Mol Nutr Food Res. 2015 May;59(5):991-9. doi: 10.1002/mnfr.201400761. Epub 2015 Mar 17. Mol Nutr Food Res. 2015. PMID: 25656040 Free PMC article.
Zinc deficiency upregulated cell activation markers ICAM1, MHC class II, and CD86 in THP1 cells, which coincided with increased IL1beta and IL6 responses following LPS stimulation. A decreased zinc status in aged mice was similarly associated with i …
Zinc deficiency upregulated cell activation markers ICAM1, MHC class II, and CD86 in THP1 cells, which coincided with increased IL1be …