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1990 2
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180 results

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Page 1
Indole-3-carbinol is a negative regulator of estrogen.
Auborn KJ, Fan S, Rosen EM, Goodwin L, Chandraskaren A, Williams DE, Chen D, Carter TH. Auborn KJ, et al. J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S. doi: 10.1093/jn/133.7.2470s. J Nutr. 2003. PMID: 12840226 Review.
Studies increasingly indicate that dietary indole-3-carbinol (I3C) prevents the development of estrogen-enhanced cancers including breast, endometrial and cervical cancers. Epidemiological, laboratory, animal and translational studies support the effic …
Studies increasingly indicate that dietary indole-3-carbinol (I3C) prevents the development of estrogen-enhanced …
Indole-3-carbinol as a chemopreventive and anti-cancer agent.
Weng JR, Tsai CH, Kulp SK, Chen CS. Weng JR, et al. Cancer Lett. 2008 Apr 18;262(2):153-63. doi: 10.1016/j.canlet.2008.01.033. Epub 2008 Mar 7. Cancer Lett. 2008. PMID: 18314259 Free PMC article. Review.
In light of this clinical and molecular heterogeneity of human cancers, it is desirable to concomitantly target these genetic abnormalities by using an agent with pleiotropic mode of action. Indole-3-carbinol and its metabolite 3,3'-diindoylmethane (DIM) targ …
In light of this clinical and molecular heterogeneity of human cancers, it is desirable to concomitantly target these genetic abnormalities …
Indole-3-Carbinol Inhibits the Growth of Endometriotic Lesions by Suppression of Microvascular Network Formation.
Rudzitis-Auth J, Becker M, Scheuer C, Menger MD, Laschke MW. Rudzitis-Auth J, et al. Nutrients. 2022 Nov 21;14(22):4940. doi: 10.3390/nu14224940. Nutrients. 2022. PMID: 36432626 Free PMC article.
Endometriosis represents an estrogen-dependent disorder with a complex pathophysiology. Phytochemicals are promising candidates for endometriosis therapy, because they simultaneously target different cellular processes involved in the pathogenesis of endometriosis. Herein, …
Endometriosis represents an estrogen-dependent disorder with a complex pathophysiology. Phytochemicals are promising candidates for e …
The micronutrient indole-3-carbinol: implications for disease and chemoprevention.
Shertzer HG, Senft AP. Shertzer HG, et al. Drug Metabol Drug Interact. 2000;17(1-4):159-88. doi: 10.1515/dmdi.2000.17.1-4.159. Drug Metabol Drug Interact. 2000. PMID: 11201294 Review.
This review provides a historical perspective for the development of indole-3-carbinol (I-3-C) as a chemopreventive or therapeutic agent. Early experiments in animal models clearly showed that feeding cruciferous vegetables reduced the incidence of chemical c …
This review provides a historical perspective for the development of indole-3-carbinol (I-3-C) as a chemopreventive or …
Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane.
Williams DE. Williams DE. Front Nutr. 2021 Oct 1;8:734334. doi: 10.3389/fnut.2021.734334. eCollection 2021. Front Nutr. 2021. PMID: 34660663 Free PMC article. Review.
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3,3'-diindolylmethane (DIM), are effective cancer chemopreventive agents in pre-clinical models a …
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol …
Molecular Targets, Anti-cancer Properties and Potency of Synthetic Indole-3-carbinol Derivatives.
Karimabad MN, Mahmoodi M, Jafarzadeh A, Darekordi A, Hajizadeh MR, Hassanshahi G. Karimabad MN, et al. Mini Rev Med Chem. 2019;19(7):540-554. doi: 10.2174/1389557518666181116120145. Mini Rev Med Chem. 2019. PMID: 30444199 Review.
The indole-3-carbinol (I3C) displays anti-cancer/proliferative activities against human cancer cells. ...Several signaling pathways in association with various factors specific for cellular viability, including hypoxia inducible factor 1, NF-kappaB, insulin-l …
The indole-3-carbinol (I3C) displays anti-cancer/proliferative activities against human cancer cells. ...Several signal …
Targets for indole-3-carbinol in cancer prevention.
Kim YS, Milner JA. Kim YS, et al. J Nutr Biochem. 2005 Feb;16(2):65-73. doi: 10.1016/j.jnutbio.2004.10.007. J Nutr Biochem. 2005. PMID: 15681163 Review.
Mounting preclinical and clinical evidence indicate that indole-3-carbinol (I3C), a key bioactive food component in cruciferous vegetables, has multiple anticarcinogenic and antitumorigenic properties. ...Modification of nuclear transcription factors includin …
Mounting preclinical and clinical evidence indicate that indole-3-carbinol (I3C), a key bioactive food component in cru …
Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity.
McAlindon TE, Gulin J, Chen T, Klug T, Lahita R, Nuite M. McAlindon TE, et al. Lupus. 2001;10(11):779-83. doi: 10.1177/096120330101001104. Lupus. 2001. PMID: 11789487 Clinical Trial.
Estrogen metabolism in women with SLE is weighted towards 16alpha-hydroxyestrone, an estrogenic compound that might fuel disease activity. Indole-3-carbinol (I3C) is a nutritional compound that can shift estrogen metabolism towards less …
Estrogen metabolism in women with SLE is weighted towards 16alpha-hydroxyestrone, an estrogenic compound that might fuel disea …
Indole-3-carbinol. A novel approach to breast cancer prevention.
Bradlow HL, Sepkovic DW, Telang NT, Osborne MP. Bradlow HL, et al. Ann N Y Acad Sci. 1995 Sep 30;768:180-200. doi: 10.1111/j.1749-6632.1995.tb12121.x. Ann N Y Acad Sci. 1995. PMID: 8526347 Review.
Remarkably, although PAHs are reported to induce P450-1A1, we have found them to decrease 2-hydroxylation. Finally, using indole-3-carbinol to induce 2-hydroxylation results in the chemoprevention of mammary tumors in rodents and recurrences of laryngeal papi …
Remarkably, although PAHs are reported to induce P450-1A1, we have found them to decrease 2-hydroxylation. Finally, using indole-3 …
Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs.
Safe S, Papineni S, Chintharlapalli S. Safe S, et al. Cancer Lett. 2008 Oct 8;269(2):326-38. doi: 10.1016/j.canlet.2008.04.021. Epub 2008 May 22. Cancer Lett. 2008. PMID: 18501502 Free PMC article. Review.
Indole-3-carbinol (I3C) conjugates are phytochemicals expressed in brassica vegetables and have been associated with the anticancer activities of vegetable consumption. ...
Indole-3-carbinol (I3C) conjugates are phytochemicals expressed in brassica vegetables and have been associated with th …
180 results