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L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase.
Fujigaki S, Saito K, Takemura M, Maekawa N, Yamada Y, Wada H, Seishima M. Fujigaki S, et al. Infect Immun. 2002 Feb;70(2):779-86. doi: 10.1128/iai.70.2.779-786.2002. Infect Immun. 2002. PMID: 11796611 Free PMC article.
L-Tryptophan degradation by indoleamine 2,3-dioxygenase (IDO) might have an important role in gamma interferon (IFN-gamma)-induced antimicrobial effects. ...The extent of increased mRNA expression of T. gondii surface antigen gene 2
L-Tryptophan degradation by indoleamine 2,3-dioxygenase (IDO) might have an important role in gamma interferon ( …
Huntingtons Disease Mice Infected with Toxoplasma gondii Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality.
Donley DW, Olson AR, Raisbeck MF, Fox JH, Gigley JP. Donley DW, et al. PLoS One. 2016 Sep 9;11(9):e0162404. doi: 10.1371/journal.pone.0162404. eCollection 2016. PLoS One. 2016. PMID: 27611938 Free PMC article.
Activation of the kynurenine pathway of tryptophan degradation is implicated in the pathogenesis of HD. Indoleamine-2,3-dioxygenase (IDO) catalyzes the oxidation of tryptophan to kynurenine, the first step in this pathway. ...Findings are …
Activation of the kynurenine pathway of tryptophan degradation is implicated in the pathogenesis of HD. Indoleamine-2, …
Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection.
Majumdar T, Sharma S, Kumar M, Hussain MA, Chauhan N, Kalia I, Sahu AK, Rana VS, Bharti R, Haldar AK, Singh AP, Mazumder S. Majumdar T, et al. Cell Death Dis. 2019 Feb 15;10(3):161. doi: 10.1038/s41419-019-1420-9. Cell Death Dis. 2019. PMID: 30770800 Free PMC article.
Recent studies have documented the diverse role of host immunity in infection by the protozoan parasite, Toxoplasma gondii. However, the contribution of the β-catenin pathway in this process has not been explored. Here, we show that AKT-mediated phosphorylated β-cat …
Recent studies have documented the diverse role of host immunity in infection by the protozoan parasite, Toxoplasma gondii. However, …
Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1.
Silva NM, Rodrigues CV, Santoro MM, Reis LF, Alvarez-Leite JI, Gazzinelli RT. Silva NM, et al. Infect Immun. 2002 Feb;70(2):859-68. doi: 10.1128/iai.70.2.859-868.2002. Infect Immun. 2002. PMID: 11796621 Free PMC article.
The induction of indoleamine 2,3-dioxygenase (INDO) expression and the tryptophan (Trp)-kynurenine (Kyn) metabolic pathway during in vivo infection with Toxoplasma gondii was investigated. ...These findings indicate the important role of …
The induction of indoleamine 2,3-dioxygenase (INDO) expression and the tryptophan (Trp)-kynurenine (Kyn) metabol …
Acute Toxoplasma Gondii Infection in Cats Induced Tissue-Specific Transcriptional Response Dominated by Immune Signatures.
Cong W, Dottorini T, Khan F, Emes RD, Zhang FK, Zhou CX, He JJ, Zhang XX, Elsheikha HM, Zhu XQ. Cong W, et al. Front Immunol. 2018 Oct 19;9:2403. doi: 10.3389/fimmu.2018.02403. eCollection 2018. Front Immunol. 2018. PMID: 30405608 Free PMC article.
Gene ontology and KEGG analyses identified DEGs enriched in immune pathways, such as cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, NOD-like receptor signaling pathway, NF-kappa B signaling pathway, MAPK signaling pathway, …
Gene ontology and KEGG analyses identified DEGs enriched in immune pathways, such as cytokine-cytokine receptor interaction, Jak-STAT …
Modulation of host HIF-1α activity and the tryptophan pathway contributes to the anti-Toxoplasma gondii potential of nanoparticles.
Adeyemi OS, Murata Y, Sugi T, Han Y, Kato K. Adeyemi OS, et al. Biochem Biophys Rep. 2017 Jul 5;11:84-92. doi: 10.1016/j.bbrep.2017.07.004. eCollection 2017 Sep. Biochem Biophys Rep. 2017. PMID: 28955772 Free PMC article.
METHODS: In the present study, we explored the in vitro mode of action of the anti-T. gondii effect of NPs by evaluating the contributions of host cellular processes, including the tryptophan pathway and hypoxia-inducing factor activity. ...RESULTS: We found …
METHODS: In the present study, we explored the in vitro mode of action of the anti-T. gondii effect of NPs by evaluating the c …
Mechanisms of interferon-beta-induced inhibition of Toxoplasma gondii growth in murine macrophages and embryonic fibroblasts: role of immunity-related GTPase M1.
Mahmoud ME, Ui F, Salman D, Nishimura M, Nishikawa Y. Mahmoud ME, et al. Cell Microbiol. 2015 Jul;17(7):1069-83. doi: 10.1111/cmi.12423. Epub 2015 Feb 23. Cell Microbiol. 2015. PMID: 25628099
Treatment of these cells with IFN-β or IFN-γ inhibited T. gondii (type II PLK strain) growth. Priming macrophages with IFN-β had no effect on inflammatory cytokine expression, inducible nitric oxide synthase or indoleamine 2,3-dioxygenase
Treatment of these cells with IFN-β or IFN-γ inhibited T. gondii (type II PLK strain) growth. Priming macrophages with IFN-β h …
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
Notarangelo FM, Wilson EH, Horning KJ, Thomas MA, Harris TH, Fang Q, Hunter CA, Schwarcz R. Notarangelo FM, et al. Schizophr Res. 2014 Jan;152(1):261-7. doi: 10.1016/j.schres.2013.11.011. Epub 2013 Dec 15. Schizophr Res. 2014. PMID: 24345671 Free PMC article.
In murine hosts, infection with T. gondii stimulates tryptophan degradation along the kynurenine pathway (KP), which contains several neuroactive metabolites, including 3-hydroxykynurenine (3-HK), quinolinic acid (QUIN) and kynurenic acid (KYNA) …
In murine hosts, infection with T. gondii stimulates tryptophan degradation along the kynurenine pathway (KP), which co …
Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells.
Nagineni CN, Pardhasaradhi K, Martins MC, Detrick B, Hooks JJ. Nagineni CN, et al. Infect Immun. 1996 Oct;64(10):4188-96. doi: 10.1128/IAI.64.10.4188-4196.1996. Infect Immun. 1996. PMID: 8926087 Free PMC article.
Treatment of the cultures with IFN-gamma from day 1 or 2 postinoculation with T. gondii also offered protection against the parasite. ...This effect was further confirmed by reverse transcription-PCR and Northern (RNA) blot analysis, which indicated induction …
Treatment of the cultures with IFN-gamma from day 1 or 2 postinoculation with T. gondii also offered protection against …
Replication of Toxoplasma gondii, but not Trypanosoma cruzi, is regulated in human fibroblasts activated with gamma interferon: requirement of a functional JAK/STAT pathway.
Cerávolo IP, Chaves AC, Bonjardim CA, Sibley D, Romanha AJ, Gazzinelli RT. Cerávolo IP, et al. Infect Immun. 1999 May;67(5):2233-40. doi: 10.1128/IAI.67.5.2233-2240.1999. Infect Immun. 1999. PMID: 10225879 Free PMC article.
To study the role of tryptophan degradation by indoleamine 2, 3-dioxygenase (INDO) in the control of Trypanosoma cruzi or Toxoplasma gondii replication, we used human fibroblasts and a fibrosarcoma cell line (2C4). ...The replication of T
To study the role of tryptophan degradation by indoleamine 2, 3-dioxygenase (INDO) in the control of Trypanosoma …
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