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L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase.
Fujigaki S, Saito K, Takemura M, Maekawa N, Yamada Y, Wada H, Seishima M. Fujigaki S, et al. Infect Immun. 2002 Feb;70(2):779-86. doi: 10.1128/IAI.70.2.779-786.2002. Infect Immun. 2002. PMID: 11796611 Free PMC article.
L-Tryptophan degradation by indoleamine 2,3-dioxygenase (IDO) might have an important role in gamma interferon (IFN-gamma)-induced antimicrobial effects. ...The levels of inducible nitric oxide synthase (iNOS) induction in infected IFN-gamma KO mice we …
L-Tryptophan degradation by indoleamine 2,3-dioxygenase (IDO) might have an important role in gamma interferon ( …
Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1.
Silva NM, Rodrigues CV, Santoro MM, Reis LF, Alvarez-Leite JI, Gazzinelli RT. Silva NM, et al. Infect Immun. 2002 Feb;70(2):859-68. doi: 10.1128/IAI.70.2.859-868.2002. Infect Immun. 2002. PMID: 11796621 Free PMC article.
The induction of indoleamine 2,3-dioxygenase (INDO) expression and the tryptophan (Trp)-kynurenine (Kyn) metabolic pathway during in vivo infection with Toxoplasma gondii was investigated. ...These findings indicate the important role of …
The induction of indoleamine 2,3-dioxygenase (INDO) expression and the tryptophan (Trp)-kynurenine (Kyn) metabol …
Huntingtons Disease Mice Infected with Toxoplasma gondii Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality.
Donley DW, Olson AR, Raisbeck MF, Fox JH, Gigley JP. Donley DW, et al. PLoS One. 2016 Sep 9;11(9):e0162404. doi: 10.1371/journal.pone.0162404. eCollection 2016. PLoS One. 2016. PMID: 27611938 Free PMC article.
Indoleamine-2,3-dioxygenase (IDO) catalyzes the oxidation of tryptophan to kynurenine, the first step in this pathway. ...The kynurenine pathway may therefore represent a point of synergism between HD and T. gondii infection
Indoleamine-2,3-dioxygenase (IDO) catalyzes the oxidation of tryptophan to kynurenine, the first step in this
Acute Toxoplasma Gondii Infection in Cats Induced Tissue-Specific Transcriptional Response Dominated by Immune Signatures.
Cong W, Dottorini T, Khan F, Emes RD, Zhang FK, Zhou CX, He JJ, Zhang XX, Elsheikha HM, Zhu XQ. Cong W, et al. Front Immunol. 2018 Oct 19;9:2403. doi: 10.3389/fimmu.2018.02403. eCollection 2018. Front Immunol. 2018. PMID: 30405608 Free PMC article.
Gene ontology and KEGG analyses identified DEGs enriched in immune pathways, such as cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, NOD-like receptor signaling pathway, NF-kappa B signaling pathway, MAPK signaling pathway, …
Gene ontology and KEGG analyses identified DEGs enriched in immune pathways, such as cytokine-cytokine receptor interaction, Jak-STAT …
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
Notarangelo FM, Wilson EH, Horning KJ, Thomas MA, Harris TH, Fang Q, Hunter CA, Schwarcz R. Notarangelo FM, et al. Schizophr Res. 2014 Jan;152(1):261-7. doi: 10.1016/j.schres.2013.11.011. Epub 2013 Dec 15. Schizophr Res. 2014. PMID: 24345671 Free PMC article.
In murine hosts, infection with T. gondii stimulates tryptophan degradation along the kynurenine pathway (KP), which contains several neuroactive metabolites, including 3-hydroxykynurenine (3-HK), quinolinic acid (QUIN) and kynurenic acid (KYNA) …
In murine hosts, infection with T. gondii stimulates tryptophan degradation along the kynurenine pathway (KP), which co …
Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection.
Majumdar T, Sharma S, Kumar M, Hussain MA, Chauhan N, Kalia I, Sahu AK, Rana VS, Bharti R, Haldar AK, Singh AP, Mazumder S. Majumdar T, et al. Cell Death Dis. 2019 Feb 15;10(3):161. doi: 10.1038/s41419-019-1420-9. Cell Death Dis. 2019. PMID: 30770800 Free PMC article.
Recent studies have documented the diverse role of host immunity in infection by the protozoan parasite, Toxoplasma gondii. However, the contribution of the beta-catenin pathway in this process has not been explored. Here, we show that AKT-mediated phosphorylated be …
Recent studies have documented the diverse role of host immunity in infection by the protozoan parasite, Toxoplasma gondii. However, …
Oxidative stress and tryptophan degradation pattern of acute Toxoplasma gondii infection in mice.
Engin AB, Dogruman-Al F, Ercin U, Celebi B, Babur C, Bukan N. Engin AB, et al. Parasitol Res. 2012 Oct;111(4):1725-30. doi: 10.1007/s00436-012-3015-6. Epub 2012 Jul 12. Parasitol Res. 2012. PMID: 22790966
Although immunomodulatory role of IFN-gamma favors tryptophan (Trp) degradation via indoleamine-2,3-dioxygenase (IDO) activity and is related with nitric oxide (NO) synthesis, the mechanism of antitoxoplasma activity is complex. ...Increased free radic …
Although immunomodulatory role of IFN-gamma favors tryptophan (Trp) degradation via indoleamine-2,3-dioxygenase
Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells.
Nagineni CN, Pardhasaradhi K, Martins MC, Detrick B, Hooks JJ. Nagineni CN, et al. Infect Immun. 1996 Oct;64(10):4188-96. doi: 10.1128/iai.64.10.4188-4196.1996. Infect Immun. 1996. PMID: 8926087 Free PMC article.
This effect was further confirmed by reverse transcription-PCR and Northern (RNA) blot analysis, which indicated induction of indoleamine 2,3-dioxygenase (IDO), an enzyme that converts tryptophan to kynurenine. ...This in vitro model of T. go
This effect was further confirmed by reverse transcription-PCR and Northern (RNA) blot analysis, which indicated induction of indoleamine
B7-H4 reduction induced by Toxoplasma gondii infection results in dysfunction of decidual dendritic cells by regulating the JAK2/STAT3 pathway.
Sun X, Xie H, Zhang H, Li Z, Qi H, Yang C, Liu X, Ren L, Jiang Y, Hu X. Sun X, et al. Parasit Vectors. 2022 May 3;15(1):157. doi: 10.1186/s13071-022-05263-1. Parasit Vectors. 2022. PMID: 35505420 Free PMC article.
The abnormal pregnancy outcomes were observed and the expression of B7-H4, functional molecules (CD80, CD86, and MHC-II or HLA-DR), indoleamine 2,3-dioxygenase (IDO), cytokines (IL-10 and IL-12), and signaling molecules JAK2/STAT3 in dDCs was detected …
The abnormal pregnancy outcomes were observed and the expression of B7-H4, functional molecules (CD80, CD86, and MHC-II or HLA-DR), indol
Modulation of host HIF-1α activity and the tryptophan pathway contributes to the anti-Toxoplasma gondii potential of nanoparticles.
Adeyemi OS, Murata Y, Sugi T, Han Y, Kato K. Adeyemi OS, et al. Biochem Biophys Rep. 2017 Jul 5;11:84-92. doi: 10.1016/j.bbrep.2017.07.004. eCollection 2017 Sep. Biochem Biophys Rep. 2017. PMID: 28955772 Free PMC article.
METHODS: In the present study, we explored the in vitro mode of action of the anti-T. gondii effect of NPs by evaluating the contributions of host cellular processes, including the tryptophan pathway and hypoxia-inducing factor activity. ...RESULTS: We found …
METHODS: In the present study, we explored the in vitro mode of action of the anti-T. gondii effect of NPs by evaluating the c …
14 results