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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 2
2001 1
2003 1
2004 3
2005 1
2006 3
2007 2
2008 8
2009 3
2010 4
2011 8
2012 10
2013 12
2014 18
2015 19
2016 16
2017 20
2018 22
2019 29
2020 35
2021 42
2022 42
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271 results
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Page 1
Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies.
Fraile M, Eiro N, Costa LA, Martín A, Vizoso FJ. Fraile M, et al. Biology (Basel). 2022 Nov 18;11(11):1678. doi: 10.3390/biology11111678. Biology (Basel). 2022. PMID: 36421393 Free PMC article. Review.
Aging and frailty are complex processes implicating multifactorial mechanisms, such as replicative senescence, oxidative stress, mitochondrial dysfunction, or autophagy disorder. All of these mechanisms drive dramatic changes in the tissue environment, such as senescence-a
Aging and frailty are complex processes implicating multifactorial mechanisms, such as replicative senescence, oxidative stress, mito
Immunosenescence is a therapeutic target for frailty in older adults: a narrative review.
Jia H, Huang W, Liu C, Tang S, Zhang J, Chen C, Tian Y, Zhong W. Jia H, et al. Ann Transl Med. 2022 Oct;10(20):1142. doi: 10.21037/atm-22-4405. Ann Transl Med. 2022. PMID: 36388790 Free PMC article. Review.
METHODS: Several databases were searched with the following key words: immunosenescence, inflamm-aging, frailty, sarcopenia and skeletal muscle, etc. KEY CONTENT AND FINDINGS: Skeletal muscle is the core phenotype of frailty and sarcopenia. Immune aging and s …
METHODS: Several databases were searched with the following key words: immunosenescence, inflamm-aging, frailty, sarcopenia an …
Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux.
Tai S, Sun J, Zhou Y, Zhu Z, He Y, Chen M, Yang H, Xiao Y, Tu T, Tang L, Li X, Zeng J, Zheng X, Zhou S. Tai S, et al. J Adv Res. 2022 Nov;41:205-218. doi: 10.1016/j.jare.2021.12.009. Epub 2021 Dec 22. J Adv Res. 2022. PMID: 36328749 Free PMC article.
INTRODUCTION: Vascular smooth muscle cell (VSMC) senescence in the vasculature results in vascular aging as well as age-related diseases, while metformin improves the inflamm-aging profile by enhancing autophagy. ...METHODS: Animal models established by angio …
INTRODUCTION: Vascular smooth muscle cell (VSMC) senescence in the vasculature results in vascular aging as well as age-related disea …
DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults.
Sadarangani SP, Young BE, Lian W, Phua HP, Chen MI, Barr I, Yeo TW, Dalan R, Chow A. Sadarangani SP, et al. NPJ Vaccines. 2022 Nov 1;7(1):135. doi: 10.1038/s41541-022-00548-z. NPJ Vaccines. 2022. PMID: 36319665 Free PMC article.
Immunosenescence (age-related immune dysfunction) and inflamm-aging contribute to suboptimal immune responses in older adults to standard-dose influenza vaccines, which may be exacerbated in those with metabolic co-morbidities. ...
Immunosenescence (age-related immune dysfunction) and inflamm-aging contribute to suboptimal immune responses in older adults …
Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism.
Sze SCW, Zhang L, Zhang S, Lin K, Ng TB, Ng ML, Lee KF, Lam JKW, Zhang Z, Yung KKL. Sze SCW, et al. Int J Mol Sci. 2022 Oct 21;23(20):12689. doi: 10.3390/ijms232012689. Int J Mol Sci. 2022. PMID: 36293552 Free PMC article.
The aberrant transferrin and ferritin upregulation triggered an iron accumulation via the upregulation of an IRP2-induced TfR1. This culminates in NF-kappaB-iNOS-mediated ovarian oxi-inflamm-aging and serum estradiol decrement in naturally aging rats. ...Thes …
The aberrant transferrin and ferritin upregulation triggered an iron accumulation via the upregulation of an IRP2-induced TfR1. This culmina …
AMPK Amplifies IL2-STAT5 Signaling to Maintain Stability of Regulatory T Cells in Aged Mice.
Pokhrel RH, Kang B, Timilshina M, Chang JH. Pokhrel RH, et al. Int J Mol Sci. 2022 Oct 16;23(20):12384. doi: 10.3390/ijms232012384. Int J Mol Sci. 2022. PMID: 36293240 Free PMC article.
AMP-activated protein kinase (AMPK), an important regulator of the aging process, is expressed in various immune cells. However, its role in regulatory T cell (Treg) stability during aging is poorly understood. ...Thus, our study addressed the role of AMPK in Tregs …
AMP-activated protein kinase (AMPK), an important regulator of the aging process, is expressed in various immune cells. However, its …
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components.
Sharma R, Diwan B, Sharma A, Witkowski JM. Sharma R, et al. Biogerontology. 2022 Dec;23(6):699-729. doi: 10.1007/s10522-022-09995-6. Epub 2022 Oct 19. Biogerontology. 2022. PMID: 36261747 Free PMC article. Review.
Immunological aging is strongly associated with the observable deleterious effects of human aging. ...Evidence and opportunities related to nutritional bioactive components and immunological aging have been deliberated to augment potential nutrition-oriented …
Immunological aging is strongly associated with the observable deleterious effects of human aging. ...Evidence and opportuniti …
Profiling the Oxylipidome in Aged Mice after Chronic Ethanol Feeding: Identifying Lipid Metabolites as Drivers of Hepatocyte Stress.
Anton P, Rutt LN, Capper C, Orlicky DJ, McCullough R. Anton P, et al. Alcohol. 2022 Sep 20:S0741-8329(22)00096-9. doi: 10.1016/j.alcohol.2022.08.012. Online ahead of print. Alcohol. 2022. PMID: 36150611 Free article.
The global population of people over the age of 65 is increasing and expected to reach 1.5 billion by 2050. While aging is associated with a number of chronic illnesses including dementia, the underlying contribution of alcohol misuse in the elderly is understudied. ...Des …
The global population of people over the age of 65 is increasing and expected to reach 1.5 billion by 2050. While aging is associated …
271 results