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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 2
2004 2
2005 3
2006 1
2007 1
2008 4
2009 6
2010 10
2011 9
2012 16
2013 14
2014 20
2015 31
2016 36
2017 38
2018 38
2019 44
2020 76
2021 58
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346 results
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GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.
Luan HH, Wang A, Hilliard BK, Carvalho F, Rosen CE, Ahasic AM, Herzog EL, Kang I, Pisani MA, Yu S, Zhang C, Ring AM, Young LH, Medzhitov R. Luan HH, et al. Cell. 2019 Aug 22;178(5):1231-1244.e11. doi: 10.1016/j.cell.2019.07.033. Epub 2019 Aug 8. Cell. 2019. PMID: 31402172 Free PMC article.
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. We found that inflammation induced GDF15, and that GDF1
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we inves …
A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.
Harb H, Stephen-Victor E, Crestani E, Benamar M, Massoud A, Cui Y, Charbonnier LM, Arbag S, Baris S, Cunnigham A, Leyva-Castillo JM, Geha RS, Mousavi AJ, Guennewig B, Schmitz-Abe K, Sioutas C, Phipatanakul W, Chatila TA. Harb H, et al. Nat Immunol. 2020 Nov;21(11):1359-1370. doi: 10.1038/s41590-020-0777-3. Epub 2020 Sep 14. Nat Immunol. 2020. PMID: 32929274 Free PMC article.
Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision therapies. We found that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulatory T (T(reg)) cells is necessary for allergens a …
Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision therapies. We found that interleukin-6- and …
GDF15 and Growth Control.
Emmerson PJ, Duffin KL, Chintharlapalli S, Wu X. Emmerson PJ, et al. Front Physiol. 2018 Nov 27;9:1712. doi: 10.3389/fphys.2018.01712. eCollection 2018. Front Physiol. 2018. PMID: 30542297 Free PMC article. Review.
Its expression is highly regulated and is often induced in response to conditions associated with cellular stress. GDF15 serum levels have a strong association with many diseases, including inflammation, cancer, cardiovascular diseases, and obesity, and potentially …
Its expression is highly regulated and is often induced in response to conditions associated with cellular stress. GDF15 serum levels …
GDF15, an update of the physiological and pathological roles it plays: a review.
Assadi A, Zahabi A, Hart RA. Assadi A, et al. Pflugers Arch. 2020 Nov;472(11):1535-1546. doi: 10.1007/s00424-020-02459-1. Epub 2020 Sep 16. Pflugers Arch. 2020. PMID: 32936319 Review.
In normal physiology, GDF15 is expressed in multiple tissues at a low concentration. GDF15 is overexpressed during and following many pathological conditions such as tissue injury and inflammation in order to play a protective role. However, GDF15 appe …
In normal physiology, GDF15 is expressed in multiple tissues at a low concentration. GDF15 is overexpressed during and followi …
ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation.
Zhang Z, Xu X, Tian W, Jiang R, Lu Y, Sun Q, Fu R, He Q, Wang J, Liu Y, Yu H, Sun B. Zhang Z, et al. J Hepatol. 2020 May;72(5):976-989. doi: 10.1016/j.jhep.2019.12.004. Epub 2019 Dec 16. J Hepatol. 2020. PMID: 31857195
Intriguingly, ARRB1 was found to interact with growth differentiation factor 15 (GDF15) and facilitated the transportation of GDF15 precursor (pro-GDF15) to the Golgi apparatus for cleavage and maturation. ...Re-expression of Arrb1 in the NASH models ameliora …
Intriguingly, ARRB1 was found to interact with growth differentiation factor 15 (GDF15) and facilitated the transportation of GDF1
The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases.
Tsai VWW, Husaini Y, Sainsbury A, Brown DA, Breit SN. Tsai VWW, et al. Cell Metab. 2018 Sep 4;28(3):353-368. doi: 10.1016/j.cmet.2018.07.018. Cell Metab. 2018. PMID: 30184485 Free article. Review.
MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth factor beta (TGFb) superfamily, with no close relatives. ...The best documented actions of MIC-1/GDF15 are on regulation of energy homeostasis. When MIC-1/GDF15 serum le …
MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth factor beta (TGFb) superfamily, with no clo …
Biomarkers and diagnostics in heart failure.
Gaggin HK, Januzzi JL Jr. Gaggin HK, et al. Biochim Biophys Acta. 2013 Dec;1832(12):2442-50. doi: 10.1016/j.bbadis.2012.12.014. Epub 2013 Jan 9. Biochim Biophys Acta. 2013. PMID: 23313577 Free article. Review.
An array of additional biomarkers has emerged, each reflecting different pathophysiological processes in the development and progression of HF: myocardial insult, inflammation and remodeling. Novel biomarkers, such as mid-regional pro atrial natriuretic peptide (MR-proANP) …
An array of additional biomarkers has emerged, each reflecting different pathophysiological processes in the development and progression of …
Proteomic Evaluation of the Comorbidity-Inflammation Paradigm in Heart Failure With Preserved Ejection Fraction: Results From the PROMIS-HFpEF Study.
Sanders-van Wijk S, Tromp J, Beussink-Nelson L, Hage C, Svedlund S, Saraste A, Swat SA, Sanchez C, Njoroge J, Tan RS, Fermer ML, Gan LM, Lund LH, Lam CSP, Shah SJ. Sanders-van Wijk S, et al. Circulation. 2020 Nov 24;142(21):2029-2044. doi: 10.1161/CIRCULATIONAHA.120.045810. Epub 2020 Oct 9. Circulation. 2020. PMID: 33034202
RESULTS: Comorbidity burden was associated with abnormal cardiac structure/function and with principal components/clusters of inflammation proteins. Systemic inflammation was also associated with increased mitral E velocity, E/e' ratio, and tricuspid regurgitation v …
RESULTS: Comorbidity burden was associated with abnormal cardiac structure/function and with principal components/clusters of inflammatio
GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer.
Ahmed DS, Isnard S, Lin J, Routy B, Routy JP. Ahmed DS, et al. J Cancer. 2021 Jan 1;12(4):1125-1132. doi: 10.7150/jca.50376. eCollection 2021. J Cancer. 2021. PMID: 33442410 Free PMC article. Review.
Among inflammatory proteins, growth differentiation factor-15 (GDF15), an atypical transforming growth factor-beta (TGF-beta) superfamily member, emerges as a stress-related hormone. In inflammatory conditions, cardiovascular diseases, and cancer, GDF15 is a biomark …
Among inflammatory proteins, growth differentiation factor-15 (GDF15), an atypical transforming growth factor-beta (TGF-beta) superfa …
Mitochondria, immunosenescence and inflammaging: a role for mitokines?
Conte M, Martucci M, Chiariello A, Franceschi C, Salvioli S. Conte M, et al. Semin Immunopathol. 2020 Oct;42(5):607-617. doi: 10.1007/s00281-020-00813-0. Epub 2020 Aug 5. Semin Immunopathol. 2020. PMID: 32757036 Free PMC article. Review.
In this review, we summarize the current knowledge on the role of mitokines in modulating immune response and inflammation focusing on GDF15, FGF21 and humanin and their possible involvement in the chronic age-related low-grade inflammation dubbed inflammagin …
In this review, we summarize the current knowledge on the role of mitokines in modulating immune response and inflammation focusing o …
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