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762 results

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Page 1
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.
Luan HH, Wang A, Hilliard BK, Carvalho F, Rosen CE, Ahasic AM, Herzog EL, Kang I, Pisani MA, Yu S, Zhang C, Ring AM, Young LH, Medzhitov R. Luan HH, et al. Cell. 2019 Aug 22;178(5):1231-1244.e11. doi: 10.1016/j.cell.2019.07.033. Epub 2019 Aug 8. Cell. 2019. PMID: 31402172 Free PMC article.
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. We found that inflammation induced GDF15, and that GDF1 …
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we inves …
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease.
Wang D, Day EA, Townsend LK, Djordjevic D, Jørgensen SB, Steinberg GR. Wang D, et al. Nat Rev Endocrinol. 2021 Oct;17(10):592-607. doi: 10.1038/s41574-021-00529-7. Epub 2021 Aug 11. Nat Rev Endocrinol. 2021. PMID: 34381196 Review.
These unique and distinct mechanisms for suppressing food intake and inflammation makes GDF15 an appealing candidate to treat many metabolic diseases, including obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, cardiovascular disease and cancer c …
These unique and distinct mechanisms for suppressing food intake and inflammation makes GDF15 an appealing candidate to treat …
GDF15 Ameliorates Liver Fibrosis by Metabolic Reprogramming of Macrophages to Acquire Anti-Inflammatory Properties.
Li X, Huai Q, Zhu C, Zhang X, Xu W, Dai H, Wang H. Li X, et al. Cell Mol Gastroenterol Hepatol. 2023;16(5):711-734. doi: 10.1016/j.jcmgh.2023.07.009. Epub 2023 Jul 25. Cell Mol Gastroenterol Hepatol. 2023. PMID: 37499753 Free PMC article.
In Gdf15 knockout mice, the intrahepatic microenvironment that developed during fibrosis showed relatively more inflammation, as demonstrated by enhanced infiltration of monocytes and neutrophils and increased expression of proinflammatory factors, which could be di …
In Gdf15 knockout mice, the intrahepatic microenvironment that developed during fibrosis showed relatively more inflammation, …
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Chen J, Peng H, Chen C, Wang Y, Sang T, Cai Z, Zhao Q, Chen S, Lin X, Eling T, Wang X. Chen J, et al. Life Sci. 2022 Dec 15;311(Pt A):121142. doi: 10.1016/j.lfs.2022.121142. Epub 2022 Oct 29. Life Sci. 2022. PMID: 36367498
Transcriptome study uncovered inflammation, cell adhesion, and the inflammation-related signaling pathways as major pathways suppressed in the NAG-1/GDF15 mice. ...These results were further confirmed in HG-induced HK-2 cells. SIGNIFICANCE: NAG-1/GDF15 …
Transcriptome study uncovered inflammation, cell adhesion, and the inflammation-related signaling pathways as major pathways s …
The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases.
Tsai VWW, Husaini Y, Sainsbury A, Brown DA, Breit SN. Tsai VWW, et al. Cell Metab. 2018 Sep 4;28(3):353-368. doi: 10.1016/j.cmet.2018.07.018. Cell Metab. 2018. PMID: 30184485 Free article. Review.
MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth factor beta (TGFb) superfamily, with no close relatives. ...The best documented actions of MIC-1/GDF15 are on regulation of energy homeostasis. When MIC-1/GDF15 serum le …
MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth factor beta (TGFb) superfamily, with no clo …
GDF15 ameliorates sepsis-induced lung injury via AMPK-mediated inhibition of glycolysis in alveolar macrophage.
Lu S, Li R, Deng Y, Bai J, Ji B, Chu Y, Xu Y, Qu H, Guo X, Li P, Meng M. Lu S, et al. Respir Res. 2024 May 9;25(1):201. doi: 10.1186/s12931-024-02824-z. Respir Res. 2024. PMID: 38725041 Free PMC article.
However, the regulatory role and the underlying mechanisms of GDF15 in sepsis remain poorly defined. Our study analyzed the levels of GDF15 and its correlations with the clinical prognosis of patients with sepsis. ...In the mouse model of lipopolysaccharide-induced …
However, the regulatory role and the underlying mechanisms of GDF15 in sepsis remain poorly defined. Our study analyzed the levels of …
Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.
Ren Y, Zhao H, Yin C, Lan X, Wu L, Du X, Griffiths HR, Gao D. Ren Y, et al. Front Endocrinol (Lausanne). 2022 Jul 14;13:873699. doi: 10.3389/fendo.2022.873699. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35909571 Free PMC article. Review.
Moreover, some hepatokines (Fetuin A, DPP4, FGF21, GDF15, and MANF) and myokines (irisin, IL-6, and DEL-1) also play pro- or anti-inflammatory roles in AT inflammation. ...Insights into the roles and mechanisms of these organokines could provide novel and potential …
Moreover, some hepatokines (Fetuin A, DPP4, FGF21, GDF15, and MANF) and myokines (irisin, IL-6, and DEL-1) also play pro- or anti-inf …
A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.
Harb H, Stephen-Victor E, Crestani E, Benamar M, Massoud A, Cui Y, Charbonnier LM, Arbag S, Baris S, Cunnigham A, Leyva-Castillo JM, Geha RS, Mousavi AJ, Guennewig B, Schmitz-Abe K, Sioutas C, Phipatanakul W, Chatila TA. Harb H, et al. Nat Immunol. 2020 Nov;21(11):1359-1370. doi: 10.1038/s41590-020-0777-3. Epub 2020 Sep 14. Nat Immunol. 2020. PMID: 32929274 Free PMC article.
Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision therapies. We found that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulatory T (T(reg)) cells is necessary for allergens a …
Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision therapies. We found that interleukin-6- and …
Emerging Roles of GDF15 in Metabolic and Cardiovascular Diseases.
Tian T, Liu M, Little PJ, Strijdom H, Weng J, Xu S. Tian T, et al. Research (Wash D C). 2025 Aug 19;8:0832. doi: 10.34133/research.0832. eCollection 2025. Research (Wash D C). 2025. PMID: 40837873 Free PMC article. Review.
Growth differentiation factor 15 (GDF15), a TGF-beta superfamily member and stress-responsive cytokine, plays a critical role in metabolism and regulation of inflammation. ...Finally, we outline unresolved issues in GDF15 biology and therapeutics, such as the …
Growth differentiation factor 15 (GDF15), a TGF-beta superfamily member and stress-responsive cytokine, plays a critical role in meta …
GDF15 mediates the metabolic effects of PPARbeta/delta by activating AMPK.
Aguilar-Recarte D, Barroso E, Gumà A, Pizarro-Delgado J, Peña L, Ruart M, Palomer X, Wahli W, Vázquez-Carrera M. Aguilar-Recarte D, et al. Cell Rep. 2021 Aug 10;36(6):109501. doi: 10.1016/j.celrep.2021.109501. Cell Rep. 2021. PMID: 34380027 Free article.
Here, we examine whether PPARbeta/delta activation effects depend on growth differentiation factor 15 (GDF15), a stress response cytokine that regulates energy metabolism. Pharmacological PPARbeta/delta activation increases GDF15 levels and ameliorates glucose intol …
Here, we examine whether PPARbeta/delta activation effects depend on growth differentiation factor 15 (GDF15), a stress response cyto …
762 results