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Incidence of narcolepsy after H1N1 influenza and vaccinations: Systematic review and meta-analysis.
Sarkanen TO, Alakuijala APE, Dauvilliers YA, Partinen MM. Sarkanen TO, et al. Sleep Med Rev. 2018 Apr;38:177-186. doi: 10.1016/j.smrv.2017.06.006. Epub 2017 Jun 20. Sleep Med Rev. 2018. PMID: 28847694 Review.
An increased incidence of narcolepsy was seen in many countries after the pandemic H1N1 influenza vaccination campaign in 2009-2010. ...Benefits of immunization outweigh the risk of vaccination-associated narcolepsy, which remains a rare disease....
An increased incidence of narcolepsy was seen in many countries after the pandemic H1N1 influenza vaccination campaign in 2009 …
Narcolepsy and Pandemic Influenza Vaccination: What We Need to Know to be Ready for the Next Pandemic.
Edwards K, Lambert PH, Black S. Edwards K, et al. Pediatr Infect Dis J. 2019 Aug;38(8):873-876. doi: 10.1097/INF.0000000000002398. Pediatr Infect Dis J. 2019. PMID: 31306400 Review.
No studies have identified an increased risk of narcolepsy following the MF59-adjuvanted Focetria vaccine. For many potential pandemic influenza strains, adjuvants might be required to solicit a protective immune response. Thus, it is critical that we understand the …
No studies have identified an increased risk of narcolepsy following the MF59-adjuvanted Focetria vaccine. For many potential pandemi …
Autoimmunity in narcolepsy.
Bonvalet M, Ollila HM, Ambati A, Mignot E. Bonvalet M, et al. Curr Opin Pulm Med. 2017 Nov;23(6):522-529. doi: 10.1097/MCP.0000000000000426. Curr Opin Pulm Med. 2017. PMID: 28991006 Free PMC article. Review.
The core symptoms of narcolepsy are debilitating, extreme sleepiness, cataplexy, and abnormalities in the structure of sleep. ...Importantly, the highest environmental risk is seen with influenza-A infection and immunization. However, how the cells are destroyed is …
The core symptoms of narcolepsy are debilitating, extreme sleepiness, cataplexy, and abnormalities in the structure of sleep. ...Impo …
Narcolepsy and adjuvanted pandemic influenza A (H1N1) 2009 vaccines - Multi-country assessment.
Weibel D, Sturkenboom M, Black S, de Ridder M, Dodd C, Bonhoeffer J, Vanrolleghem A, van der Maas N, Lammers GJ, Overeem S, Gentile A, Giglio N, Castellano V, Kwong JC, Murray BJ, Cauch-Dudek K, Juhasz D, Campitelli M, Datta AN, Kallweit U, Huang WT, Huang YS, Hsu CY, Chen HC, Giner-Soriano M, Morros R, Gaig C, Tió E, Perez-Vilar S, Diez-Domingo J, Puertas FJ, Svenson LW, Mahmud SM, Carleton B, Naus M, Arnheim-Dahlström L, Pedersen L, DeStefano F, Shimabukuro TT. Weibel D, et al. Vaccine. 2018 Oct 1;36(41):6202-6211. doi: 10.1016/j.vaccine.2018.08.008. Epub 2018 Aug 16. Vaccine. 2018. PMID: 30122647 Free PMC article.
BACKGROUND: In 2010, a safety signal was detected for narcolepsy following vaccination with Pandemrix, an AS03-adjuvanted monovalent pandemic H1N1 influenza (pH1N1) vaccine. ...CONCLUSIONS: Other than elevated narcolepsy IRs in the period after vaccination ca …
BACKGROUND: In 2010, a safety signal was detected for narcolepsy following vaccination with Pandemrix, an AS03-adjuvanted monovalent …
Narcolepsy and Other Central Hypersomnias.
Dauvilliers Y, Barateau L. Dauvilliers Y, et al. Continuum (Minneap Minn). 2017 Aug;23(4, Sleep Neurology):989-1004. doi: 10.1212/CON.0000000000000492. Continuum (Minneap Minn). 2017. PMID: 28777172 Review.
RECENT FINDINGS: In ICSD-3, the names of some central disorders of hypersomnolence have been changed: narcolepsy with cataplexy and narcolepsy without cataplexy have been renamed narcolepsy type 1 and narcolepsy type 2, respectively. ...The epidemiolog …
RECENT FINDINGS: In ICSD-3, the names of some central disorders of hypersomnolence have been changed: narcolepsy with cataplexy and …
Narcolepsy Associated with Pandemrix Vaccine.
Sarkanen T, Alakuijala A, Julkunen I, Partinen M. Sarkanen T, et al. Curr Neurol Neurosci Rep. 2018 Jun 1;18(7):43. doi: 10.1007/s11910-018-0851-5. Curr Neurol Neurosci Rep. 2018. PMID: 29855798 Review.
PURPOSE OF REVIEW: After the connection between AS03-adjuvanted pandemic H1N1 vaccine Pandemrix and narcolepsy was recognized in 2010, research on narcolepsy has been more intensive than ever before. ...An increased risk of narcolepsy after natural H1N1 infec …
PURPOSE OF REVIEW: After the connection between AS03-adjuvanted pandemic H1N1 vaccine Pandemrix and narcolepsy was recognized in 2010 …
Epidemiology and Pathophysiology of Childhood Narcolepsy.
Dye TJ, Gurbani N, Simakajornboon N. Dye TJ, et al. Paediatr Respir Rev. 2018 Jan;25:14-18. doi: 10.1016/j.prrv.2016.12.005. Epub 2016 Dec 21. Paediatr Respir Rev. 2018. PMID: 28108192 Review.
Several recent studies have shown increased cases of narcolepsy, especially in children and adolescents in relation with H1N1 influenza. The increased cases in Europe seems to be related to a specific type of H1N1 influenza vaccination (Pandemrix), while the …
Several recent studies have shown increased cases of narcolepsy, especially in children and adolescents in relation with H1N1 infl …
Meeting report narcolepsy and pandemic influenza vaccination: What we know and what we need to know before the next pandemic? A report from the 2nd IABS meeting.
Edwards K, Hanquet G, Black S, Mignot E, Jankosky C, Shimabukuro T, Miller E, Nohynek H, Neels P. Edwards K, et al. Biologicals. 2019 Jul;60:1-7. doi: 10.1016/j.biologicals.2019.05.005. Epub 2019 May 23. Biologicals. 2019. PMID: 31130313 Free PMC article.
A group of scientific and public health experts and key stakeholders convened to discuss the state of knowledge on the relationship between adjuvanted monovalent inactivated 2009 influenza A H1N1 vaccines used during the 2009 influenza pandemic and narcolepsy …
A group of scientific and public health experts and key stakeholders convened to discuss the state of knowledge on the relationship between …
T cells in patients with narcolepsy target self-antigens of hypocretin neurons.
Latorre D, Kallweit U, Armentani E, Foglierini M, Mele F, Cassotta A, Jovic S, Jarrossay D, Mathis J, Zellini F, Becher B, Lanzavecchia A, Khatami R, Manconi M, Tafti M, Bassetti CL, Sallusto F. Latorre D, et al. Nature. 2018 Oct;562(7725):63-68. doi: 10.1038/s41586-018-0540-1. Epub 2018 Sep 19. Nature. 2018. PMID: 30232458
Narcolepsy is a chronic sleep disorder caused by the loss of neurons that produce hypocretin. The close association with HLA-DQB1*06:02, evidence for immune dysregulation and increased incidence upon influenza vaccination together suggest that this disorder has an a …
Narcolepsy is a chronic sleep disorder caused by the loss of neurons that produce hypocretin. The close association with HLA-DQB1*06: …
The narcolepsy-pandemic influenza story: can the truth ever be unraveled?
Sturkenboom MC. Sturkenboom MC. Vaccine. 2015 Jun 8;33 Suppl 2:B6-B13. doi: 10.1016/j.vaccine.2015.03.026. Vaccine. 2015. PMID: 26022571 Review.
A safety signal around Pandemrix, an AS03 adjuvanted influenza A(H1N1) pdm09 vaccine potentially causing narcolepsy in children and adolescents became public in August 2010, long after cessation of the influenza A(H1N1) pdm09 campaigns in Europe. ...Currently …
A safety signal around Pandemrix, an AS03 adjuvanted influenza A(H1N1) pdm09 vaccine potentially causing narcolepsy in childre …
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