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Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice.
Arata S, Watanabe J, Maeda M, Yamamoto M, Matsuhashi H, Mochizuki M, Kagami N, Honda K, Inagaki M. Arata S, et al. Heliyon. 2016 May 12;2(5):e00111. doi: 10.1016/j.heliyon.2016.e00111. eCollection 2016 May. Heliyon. 2016. PMID: 27441282 Free PMC article.
The extracts of Inonotus obliquus (Chaga mushroom) demonstrate potent anti-tumor activities and have been used to treat cancer in several countries; however, the actual effect and underlying mechanisms are still unclear. ...Furthermore, I. obliquus prevented temperature drop in mice after tumor implantation. SIGNIFICANCE: Our findings suggest that the I. obliquus extract could be used as a natural remedy for cancer suppression by promoting energy metabolism....
The extracts of Inonotus obliquus (Chaga mushroom) demonstrate potent anti-tumor activities and have been used to treat can
Inonotus obliquus polysaccharides induces apoptosis of lung cancer cells and alters energy metabolism via the LKB1/AMPK axis.
Jiang S, Shi F, Lin H, Ying Y, Luo L, Huang D, Luo Z. Jiang S, et al. Int J Biol Macromol. 2019 Nov 18:S0141-8130(19)32725-4. doi: 10.1016/j.ijbiomac.2019.10.174. Online ahead of print. Int J Biol Macromol. 2019. PMID: 31751687
The present study explores the mechanisms underlying the anti-cancer action of Inonotus obliquus polysaccharides (IOP). Thus, we characterized the IOP components extracted from Chaga sclerotium and, found that the extracts contained 70% polysaccharides with an average molecular weight of 4.5 × 10(4) Da consisting of 75% glucose. ...Therefore, our study provides a solid foundation for the use of IOP as a promising alternative or supplementary medicine for cancer therapy....
The present study explores the mechanisms underlying the anti-cancer action of Inonotus obliquus polysaccharides (IOP). …
Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer.
Kang JH, Jang JE, Mishra SK, Lee HJ, Nho CW, Shin D, Jin M, Kim MK, Choi C, Oh SH. Kang JH, et al. J Ethnopharmacol. 2015 Sep 15;173:303-12. doi: 10.1016/j.jep.2015.07.030. Epub 2015 Jul 22. J Ethnopharmacol. 2015. PMID: 26210065
AIM OF THE STUDY: In this study, we examined the effect of different fractions and components of Chaga mushroom (Inonotus Obliquus) on viability and apoptosis of colon cancer cells. ...These properties of ergosterol peroxide advocate its use as a supplement in colon cancer chemoprevention....
AIM OF THE STUDY: In this study, we examined the effect of different fractions and components of Chaga mushroom (Inonotus Obliquus
Inonotus obliquus extract induces apoptosis in the human colorectal carcinoma's HCT-116 cell line.
Tsai CC, Li YS, Lin PP. Tsai CC, et al. Biomed Pharmacother. 2017 Dec;96:1119-1126. doi: 10.1016/j.biopha.2017.11.111. Epub 2017 Nov 27. Biomed Pharmacother. 2017. PMID: 29174853
This study investigated the inhibitory activity against the proliferation of human colorectal cancer HCT-116 cells by Inonotus obliquus extracts obtained from submerged fermentation. ...I. obliquus extracts decreased the expression of NF-κB p65 protein and COX-2 gene in HCT-116 cells. Taking together, I. obliquus extracts may be used as a potentially novel food material for health care to improve the treatment of colorectal cancer....
This study investigated the inhibitory activity against the proliferation of human colorectal cancer HCT-116 cells by Inonotus
Chaga ( Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B).
Géry A, Dubreule C, André V, Rioult JP, Bouchart V, Heutte N, Eldin de Pécoulas P, Krivomaz T, Garon D. Géry A, et al. Integr Cancer Ther. 2018 Sep;17(3):832-843. doi: 10.1177/1534735418757912. Epub 2018 Feb 27. Integr Cancer Ther. 2018. PMID: 29484963 Free PMC article.
BACKGROUND: Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine (especially by Khanty people) to treat various health problems. ...Moreover, the results highlighted a cytotoxic activity of the Chaga's aqueous extract after 48 and 72 hours of exposure with a higher effect on cancer-derived cells A549 than on normal transformed cells BEAS-2B ( P = 0.025 after 48 hours of exposure and P = 0.004 after 72 hours of exposure)....
BACKGROUND: Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine …
Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells.
Baek J, Roh HS, Baek KH, Lee S, Lee S, Song SS, Kim KH. Baek J, et al. J Ethnopharmacol. 2018 Oct 5;224:63-75. doi: 10.1016/j.jep.2018.05.025. Epub 2018 May 22. J Ethnopharmacol. 2018. PMID: 29800742
ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus, also known as Chaga mushroom, is one of the most widely appreciated wild edible mushrooms in Russia and northern European countries and is renowned for its use in cancer treatment. ...RESULTS: The MeOH extract of I. obliquus reduced cell viability in all lung cancer cell lines tested through induction of apoptosis accompanied by caspase-3 cleavage. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus, also known as Chaga mushroom, is one of the most widely appreciated wild ed …
Chemical constituents from Inonotus obliquus and their antitumor activities.
Zhao F, Xia G, Chen L, Zhao J, Xie Z, Qiu F, Han G. Zhao F, et al. J Nat Med. 2016 Oct;70(4):721-30. doi: 10.1007/s11418-016-1002-4. Epub 2016 May 14. J Nat Med. 2016. PMID: 27180084
Four new lanostane-type triterpenes (inonotusanes D-G, 1-4), including a 24,25,26,27-tetranorlanostane, together with 11 known compounds (5-15), including 7 lanostane derivatives, 2 steroids and 2 aromatic compounds, were isolated from the sclerotia of Inonotus obliquus. ...Compounds 1, 8, 12 and 13 exhibited strong cytotoxicity against the 4T1 (mouse breast cancer) cell line, with IC50 9.40, 7.79, 9.06 and 9.31 μM, respectively. 8, 12 and 13 also exhibited strong cytotoxicity against the the MCF-7 (human breast cancer) cell line, with IC50 8.35-9.01 μM....
Four new lanostane-type triterpenes (inonotusanes D-G, 1-4), including a 24,25,26,27-tetranorlanostane, together with 11 known compounds (5- …
[Composition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga)].
Nikitina SA, Khabibrakhmanova VR, Sysoeva MA. Nikitina SA, et al. Biomed Khim. 2016 May;62(4):369-75. doi: 10.18097/PBMC20166204369. Biomed Khim. 2016. PMID: 27562990 Review. Russian.
Special attention has been paid to the biological activity of chaga mushroom extracts and these particular compounds against various cancer cell lines in vitro and in vivo. ...
Special attention has been paid to the biological activity of chaga mushroom extracts and these particular compounds against various canc
The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies.
Duru KC, Kovaleva EG, Danilova IG, van der Bijl P. Duru KC, et al. Phytother Res. 2019 Aug;33(8):1966-1980. doi: 10.1002/ptr.6384. Epub 2019 Jun 17. Phytother Res. 2019. PMID: 31209936 Review.
Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties. ...The possible role of this mushroom as a therapeutic agent in addressing the pathogenesis of diabetes and cancer has also been suggested....
Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglyce
Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses.
Tian J, Hu X, Liu D, Wu H, Qu L. Tian J, et al. Int J Biol Macromol. 2017 Feb;95:160-167. doi: 10.1016/j.ijbiomac.2016.11.054. Epub 2016 Nov 16. Int J Biol Macromol. 2017. PMID: 27865960
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. ...
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy,
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