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Inonotus obliquus polysaccharides induces apoptosis of lung cancer cells and alters energy metabolism via the LKB1/AMPK axis.
Jiang S, Shi F, Lin H, Ying Y, Luo L, Huang D, Luo Z. Jiang S, et al. Int J Biol Macromol. 2020 May 15;151:1277-1286. doi: 10.1016/j.ijbiomac.2019.10.174. Epub 2019 Nov 18. Int J Biol Macromol. 2020. PMID: 31751687
The present study explores the mechanisms underlying the anti-cancer action of Inonotus obliquus polysaccharides (IOP). Thus, we characterized the IOP components extracted from Chaga sclerotium and, found that the extracts contained 70% polysaccharides with a …
The present study explores the mechanisms underlying the anti-cancer action of Inonotus obliquus polysaccharides (IOP). …
Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice.
Arata S, Watanabe J, Maeda M, Yamamoto M, Matsuhashi H, Mochizuki M, Kagami N, Honda K, Inagaki M. Arata S, et al. Heliyon. 2016 May 12;2(5):e00111. doi: 10.1016/j.heliyon.2016.e00111. eCollection 2016 May. Heliyon. 2016. PMID: 27441282 Free PMC article.
The extracts of Inonotus obliquus (Chaga mushroom) demonstrate potent anti-tumor activities and have been used to treat cancer in several countries; however, the actual effect and underlying mechanisms are still unclear. ...SIGNIFICANCE: Our findings suggest …
The extracts of Inonotus obliquus (Chaga mushroom) demonstrate potent anti-tumor activities and have been used to treat can
The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies.
Duru KC, Kovaleva EG, Danilova IG, van der Bijl P. Duru KC, et al. Phytother Res. 2019 Aug;33(8):1966-1980. doi: 10.1002/ptr.6384. Epub 2019 Jun 17. Phytother Res. 2019. PMID: 31209936 Review.
The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties. ...The possible role of this m …
The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom …
Chaga ( Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B).
Géry A, Dubreule C, André V, Rioult JP, Bouchart V, Heutte N, Eldin de Pécoulas P, Krivomaz T, Garon D. Géry A, et al. Integr Cancer Ther. 2018 Sep;17(3):832-843. doi: 10.1177/1534735418757912. Epub 2018 Feb 27. Integr Cancer Ther. 2018. PMID: 29484963 Free PMC article.
BACKGROUND: Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine (especially by Khanty people) to treat various health problems. ...Moreover, the results highlighted a cytotoxic activity of the Chaga's
BACKGROUND: Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine …
Composition of Triterpenoids in Inonotus obliquus and Their Anti-Proliferative Activity on Cancer Cell Lines.
Kim J, Yang SC, Hwang AY, Cho H, Hwang KT. Kim J, et al. Molecules. 2020 Sep 6;25(18):4066. doi: 10.3390/molecules25184066. Molecules. 2020. PMID: 32899899 Free PMC article.
The objective of this study was to determine the composition of triterpenoids in the extracts from the inner and outer parts of Inonotus obliquus and to evaluate their anti-proliferative activity against cancer cell lines (HT-29, AGS, MCF-7, and PC3). ...Anti …
The objective of this study was to determine the composition of triterpenoids in the extracts from the inner and outer parts of Inonotus
Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells.
Baek J, Roh HS, Baek KH, Lee S, Lee S, Song SS, Kim KH. Baek J, et al. J Ethnopharmacol. 2018 Oct 5;224:63-75. doi: 10.1016/j.jep.2018.05.025. Epub 2018 May 22. J Ethnopharmacol. 2018. PMID: 29800742
ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus, also known as Chaga mushroom, is one of the most widely appreciated wild edible mushrooms in Russia and northern European countries and is renowned for its use in cancer treatment. ...CONCLUSION: These findin …
ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus, also known as Chaga mushroom, is one of the most widely appreciated wild ed …
Inonotus obliquus extract induces apoptosis in the human colorectal carcinoma's HCT-116 cell line.
Tsai CC, Li YS, Lin PP. Tsai CC, et al. Biomed Pharmacother. 2017 Dec;96:1119-1126. doi: 10.1016/j.biopha.2017.11.111. Epub 2017 Nov 27. Biomed Pharmacother. 2017. PMID: 29174853
Because of irregular dietary habits and lifestyle in Taiwan, the incidence and mortality rate of colorectal cancer have been increasing rapidly these years. This study investigated the inhibitory activity against the proliferation of human colorectal cancer HCT-116 …
Because of irregular dietary habits and lifestyle in Taiwan, the incidence and mortality rate of colorectal cancer have been increasi …
Chemical constituents from Inonotus obliquus and their antitumor activities.
Zhao F, Xia G, Chen L, Zhao J, Xie Z, Qiu F, Han G. Zhao F, et al. J Nat Med. 2016 Oct;70(4):721-30. doi: 10.1007/s11418-016-1002-4. Epub 2016 May 14. J Nat Med. 2016. PMID: 27180084
Four new lanostane-type triterpenes (inonotusanes D-G, 1-4), including a 24,25,26,27-tetranorlanostane, together with 11 known compounds (5-15), including 7 lanostane derivatives, 2 steroids and 2 aromatic compounds, were isolated from the sclerotia of Inonotus obliquus
Four new lanostane-type triterpenes (inonotusanes D-G, 1-4), including a 24,25,26,27-tetranorlanostane, together with 11 known compounds (5- …
Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus.
Zhao Y, Zheng W. Zhao Y, et al. J Ethnopharmacol. 2021 Jan 30;265:113321. doi: 10.1016/j.jep.2020.113321. Epub 2020 Aug 30. J Ethnopharmacol. 2021. PMID: 32877719 Review.
ETHNOPHARMACOLOGICAL RELEVANCE: The crude extracts of the medicinal mushroom Inonotus obliquus have been used as an effective traditional medicine to treat malicious tumors, gastritis, gastric ulcers, and other inflammatory conditions in Russia and most Baltic count …
ETHNOPHARMACOLOGICAL RELEVANCE: The crude extracts of the medicinal mushroom Inonotus obliquus have been used as an effective …
Progress on understanding the anticancer mechanisms of medicinal mushroom: inonotus obliquus.
Song FQ, Liu Y, Kong XS, Chang W, Song G. Song FQ, et al. Asian Pac J Cancer Prev. 2013;14(3):1571-8. doi: 10.7314/apjcp.2013.14.3.1571. Asian Pac J Cancer Prev. 2013. PMID: 23679238 Free article. Review.
As a white rot fungus, Inonotus obliquus is valued as an edible and medicinal resource. Chemical investigations have shown that I. obliquus produces a diverse range of secondary metabolites, including phenolic compounds, melanins, and lanostane-type triterpen …
As a white rot fungus, Inonotus obliquus is valued as an edible and medicinal resource. Chemical investigations have shown tha …
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