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Table representation of search results timeline featuring number of search results per year.

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1971 1
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1980 16
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1982 11
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1988 13
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1990 14
1991 14
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1994 11
1995 16
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1997 13
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1999 12
2000 19
2001 16
2002 16
2003 6
2004 14
2005 14
2006 9
2007 29
2008 16
2009 16
2010 28
2011 26
2012 16
2013 26
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925 results

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Page 1
Mechanism of auxin perception by the TIR1 ubiquitin ligase.
Tan X, Calderon-Villalobos LI, Sharon M, Zheng C, Robinson CV, Estelle M, Zheng N. Tan X, et al. Nature. 2007 Apr 5;446(7136):640-5. doi: 10.1038/nature05731. Nature. 2007. PMID: 17410169
These structures show that the leucine-rich repeat domain of TIR1 contains an unexpected inositol hexakisphosphate co-factor and recognizes auxin and the Aux/IAA polypeptide substrate through a single surface pocket. Anchored to the base of the TIR1 pocket, auxin …
These structures show that the leucine-rich repeat domain of TIR1 contains an unexpected inositol hexakisphosphate co-factor a …
Inositol hexakisphosphate binding sites in rat heart and brain.
Rowley KG, Gundlach AL, Cincotta M, Louis WJ. Rowley KG, et al. Br J Pharmacol. 1996 Aug;118(7):1615-20. doi: 10.1111/j.1476-5381.1996.tb15582.x. Br J Pharmacol. 1996. PMID: 8842422 Free PMC article.
1. Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol hexakisphosphate (InsP6) are produced in response to stimulation of cardiac alpha 1-adrenoceptors. ...Inositol phosphates inhibited binding of [3H]-InsP6 with the order of potency: InsP …
1. Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol hexakisphosphate (InsP6) are produced in response to stimul …
Inositol hexakisphosphate is required for Integrator function.
Lin MH, Jensen MK, Elrod ND, Huang KL, Welle KA, Wagner EJ, Tong L. Lin MH, et al. Nat Commun. 2022 Sep 30;13(1):5742. doi: 10.1038/s41467-022-33506-3. Nat Commun. 2022. PMID: 36180473 Free PMC article.
Here we report a cryo-EM structure of the Drosophila ICM, at 2.74 A resolution, revealing stable association of an inositol hexakisphosphate (IP(6)) molecule. The IP(6) binding site is located in a highly electropositive pocket at an interface among all three …
Here we report a cryo-EM structure of the Drosophila ICM, at 2.74 A resolution, revealing stable association of an inositol hexaki …
Specific binding of inositol hexakisphosphate (phytic acid) to adrenal chromaffin cell membranes and effects on calcium-dependent catecholamine release.
Regunathan S, Reis DJ, Wahlestedt C. Regunathan S, et al. Biochem Pharmacol. 1992 Mar 17;43(6):1331-6. doi: 10.1016/0006-2952(92)90510-p. Biochem Pharmacol. 1992. PMID: 1562283 Free article.
In a membrane preparation of cultured bovine adrenal chromaffin cells, [3H]inositol hexakisphosphate ([3H]InsP6) was shown to bind specifically with a Kd of 90 nM and a Bmax of 700 fmol/mg protein. ...In [3H]InsP6 competition binding experiments, we found tha …
In a membrane preparation of cultured bovine adrenal chromaffin cells, [3H]inositol hexakisphosphate ([3H]InsP6) was shown to …
Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs.
Ma Y, Lieber MR. Ma Y, et al. J Biol Chem. 2002 Mar 29;277(13):10756-9. doi: 10.1074/jbc.C200030200. Epub 2002 Jan 30. J Biol Chem. 2002. PMID: 11821378 Free article.
It was recently shown that myo-inositol hexakisphosphate (IP(6)) stimulates the joining of complementary DNA ends in a cell free system. ...Furthermore, the binding of DNA ends and IP(6) to Ku are independent of each other. The possible relationship between …
It was recently shown that myo-inositol hexakisphosphate (IP(6)) stimulates the joining of complementary DNA ends in a cell fr …
Inositol hexakisphosphate increases the size of platelet aggregates.
Brehm MA, Klemm U, Rehbach C, Erdmann N, Kolšek K, Lin H, Aponte-Santamaría C, Gräter F, Rauch BH, Riley AM, Mayr GW, Potter BVL, Windhorst S. Brehm MA, et al. Biochem Pharmacol. 2019 Mar;161:14-25. doi: 10.1016/j.bcp.2018.12.011. Epub 2018 Dec 14. Biochem Pharmacol. 2019. PMID: 30557554 Free PMC article.
The inositol phosphates, InsP(5) and InsP(6), have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. ...By employing blind docking studies we predic …
The inositol phosphates, InsP(5) and InsP(6), have recently been identified as binding partners of fibrinogen, which is critic …
Signalling Properties of Inositol Polyphosphates.
Maffucci T, Falasca M. Maffucci T, et al. Molecules. 2020 Nov 12;25(22):5281. doi: 10.3390/molecules25225281. Molecules. 2020. PMID: 33198256 Free PMC article. Review.
Several studies have identified specific signalling functions for inositol polyphosphates (IPs) in different cell types and have led to the accumulation of new information regarding their cellular roles as well as new insights into their cellular production. ...
Several studies have identified specific signalling functions for inositol polyphosphates (IPs) in different cell types and have led …
Human XPR1 structures reveal phosphate export mechanism.
Yan R, Chen H, Liu C, Zhao J, Wu D, Jiang J, Gong J, Jiang D. Yan R, et al. Nature. 2024 Sep;633(8031):960-967. doi: 10.1038/s41586-024-07852-9. Epub 2024 Aug 21. Nature. 2024. PMID: 39169184
However, the mechanisms underpinning XPR1-mediated Pi efflux and regulation by the intracellular inositol polyphosphate (InsPP) sensor SPX domain remain poorly understood. Here we present cryo-electron microscopy structures of human XPR1 in Pi-bound closed, open and InsP(6 …
However, the mechanisms underpinning XPR1-mediated Pi efflux and regulation by the intracellular inositol polyphosphate (InsPP) senso …
Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate.
Egerer M, Giesemann T, Herrmann C, Aktories K. Egerer M, et al. J Biol Chem. 2009 Feb 6;284(6):3389-95. doi: 10.1074/jbc.M806002200. Epub 2008 Dec 1. J Biol Chem. 2009. PMID: 19047051 Free article.
Processing of the toxin occurs by autocatalytic cleavage and is activated by inositol hexakisphosphate (InsP6). Here we studied the inherent protease activity in fragments of toxin B and determined the site of toxin B that interacts with InsP6. ...Lysine 600 of toxi …
Processing of the toxin occurs by autocatalytic cleavage and is activated by inositol hexakisphosphate (InsP6). Here we studie …
Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins.
Egerer M, Satchell KJ. Egerer M, et al. PLoS Pathog. 2010 Jul 8;6(7):e1000942. doi: 10.1371/journal.ppat.1000942. PLoS Pathog. 2010. PMID: 20628577 Free PMC article. Review.
These toxins carry an embedded cysteine protease domain (CPD) that is activated for autoprocessing by binding inositol hexakisphosphate (InsP(6)), a molecule found exclusively in eukaryotic cells. ...
These toxins carry an embedded cysteine protease domain (CPD) that is activated for autoprocessing by binding inositol hexa …
925 results