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p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer.
Roy S, Gu M, Ramasamy K, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R. Roy S, et al. Cancer Res. 2009 Feb 1;69(3):1166-73. doi: 10.1158/0008-5472.CAN-08-3115. Epub 2009 Jan 27. Cancer Res. 2009. PMID: 19176374 Free PMC article.
Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. ...To further confirm these findings both in vitro and in …
Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 …
Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway.
Kapral M, Wawszczyk J, Jesse K, Paul-Samojedny M, Kuśmierz D, Węglarz L. Kapral M, et al. Molecules. 2017 Oct 3;22(10):1657. doi: 10.3390/molecules22101657. Molecules. 2017. PMID: 28972559 Free PMC article.
Therefore, AKT/mTOR signaling pathway has been recognized as an attractive target for anticancer therapy. Inositol hexaphosphate (InsP6), a natural occurring phytochemical, has been shown to have both preventive and therapeutic effects against various cancers, howev …
Therefore, AKT/mTOR signaling pathway has been recognized as an attractive target for anticancer therapy. Inositol hexaphosphate …
Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells.
Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R. Agarwal C, et al. Neoplasia. 2004 Sep-Oct;6(5):646-59. doi: 10.1593/neo.04232. Neoplasia. 2004. PMID: 15548374 Free PMC article.
One approach to control this malignancy is its preventive intervention by dietary agents. Inositol hexaphosphate (IP6), a dietary constituent, has shown promising efficacy against various cancers; however, limited studies have been performed with IP6 against PCA. .. …
One approach to control this malignancy is its preventive intervention by dietary agents. Inositol hexaphosphate (IP6), a diet …
Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes.
Singh RP, Agarwal C, Agarwal R. Singh RP, et al. Carcinogenesis. 2003 Mar;24(3):555-63. doi: 10.1093/carcin/24.3.555. Carcinogenesis. 2003. PMID: 12663518
Cancer chemopreventive effects of inositol hexaphosphate (IP6), a dietary constituent, have been demonstrated against a variety of experimental tumors, however, limited studies have been done against prostate cancer (PCA), and molecular mechanisms are not well defin …
Cancer chemopreventive effects of inositol hexaphosphate (IP6), a dietary constituent, have been demonstrated against a variet …
Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation.
Vucenik I, Ramakrishna G, Tantivejkul K, Anderson LM, Ramljak D. Vucenik I, et al. Breast Cancer Res Treat. 2005 May;91(1):35-45. doi: 10.1007/s10549-004-6456-5. Breast Cancer Res Treat. 2005. PMID: 15868430
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate with demonstrated anti-proliferative and anti-cancer activity in mammary cells. ...
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate with demonstrated anti-proliferative and …
Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.
Scherer PC, Ding Y, Liu Z, Xu J, Mao H, Barrow JC, Wei N, Zheng N, Snyder SH, Rao F. Scherer PC, et al. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3503-8. doi: 10.1073/pnas.1525580113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976604 Free PMC article.
We now report that inositol hexakisphosphate (IP6) is a major physiologic determinant of the CRL-CSN interface, which includes a hitherto unidentified electrostatic interaction between the N-terminal acidic tail of CSN subunit 2 (CSN2) and a conserved basic canyon on culli …
We now report that inositol hexakisphosphate (IP6) is a major physiologic determinant of the CRL-CSN interface, which includes a hith …