p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer.
Cancer Res. 2009 Feb 1;69(3):1166-73. doi: 10.1158/0008-5472.CAN-08-3115. Epub 2009 Jan 27.
Cancer Res. 2009.
PMID: 19176374
Free PMC article.
Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. ...To further confirm these findings both in vitro and in …
Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 …