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Year Number of Results
1998 2
1999 1
2000 1
2001 1
2005 2
2006 4
2007 1
2008 1
2009 1
2010 1
2014 1
2015 1
2022 0
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16 results
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Page 1
Prostate cancer and inositol hexaphosphate: efficacy and mechanisms.
Singh RP, Agarwal R. Singh RP, et al. Anticancer Res. 2005 Jul-Aug;25(4):2891-903. Anticancer Res. 2005. PMID: 16080543 Free article. Review.
Several mechanisms, including overexpression of growth, survival and angiogenic factors and their receptors, together with a loss/decrease of tumor suppressor p53, retinoblastoma and cyclin-dependent kinase inhibitor, have been implicated in PCA growth and progression. The …
Several mechanisms, including overexpression of growth, survival and angiogenic factors and their receptors, together with a loss/decrease o …
Inositol hexaphosphate induces apoptosis by coordinative modulation of P53, Bcl-2 and sequential activation of caspases in 7,12 dimethylbenz[a]anthracene exposed mouse epidermis.
Singh J, Gupta KP. Singh J, et al. J Environ Pathol Toxicol Oncol. 2008;27(3):209-17. doi: 10.1615/jenvironpatholtoxicoloncol.v27.i3.50. J Environ Pathol Toxicol Oncol. 2008. PMID: 18652568
Inositol hexaphosphate (IP6) is a major constituent of most cereals, legumes, nuts, oil seeds, and soybean. ...These results suggested that topically applied IP6 directly induces apoptotic machinery by modulating the expression of mt p53, Bcl-2, and caspase a …
Inositol hexaphosphate (IP6) is a major constituent of most cereals, legumes, nuts, oil seeds, and soybean. ...These results s …
Quantitative analysis of the level of p53 and p21(WAF1) mRNA in human colon cancer HT-29 cells treated with inositol hexaphosphate.
Weglarz L, Molin I, Orchel A, Parfiniewicz B, Dzierzewicz Z. Weglarz L, et al. Acta Biochim Pol. 2006;53(2):349-56. Epub 2006 May 30. Acta Biochim Pol. 2006. PMID: 16733561 Free article.
The aim of this study was to analyze the molecular mechanism of inositol hexaphosphate (InsP(6)) action through which it may inhibit proliferation of colon cancer cells and cell cycle progression. ...The 2(-Delta Delta Ct) method was used to analyze the relative cha …
The aim of this study was to analyze the molecular mechanism of inositol hexaphosphate (InsP(6)) action through which it may i …
p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer.
Roy S, Gu M, Ramasamy K, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R. Roy S, et al. Cancer Res. 2009 Feb 1;69(3):1166-73. doi: 10.1158/0008-5472.CAN-08-3115. Epub 2009 Jan 27. Cancer Res. 2009. PMID: 19176374 Free PMC article.
Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein levels in human prostate cancer (PCa) DU145 cells lacking functional p53. ...Together, these results provide evidence, for the first …
Inositol hexaphosphate (IP6) causes G(1) arrest and increases cyclin-dependent kinase inhibitors p21/Cip1 and p27/Kip1 protein …
Metabolism and cellular functions of IP6: a review.
Shamsuddin AM. Shamsuddin AM. Anticancer Res. 1999 Sep-Oct;19(5A):3733-6. Anticancer Res. 1999. PMID: 10625949 Review.
Inositol hexaphosphate (IP6) has a demonstrably effective anti-cancer action against a variety of experimental tumors. ...The metabolized IP6, in the form of inositol and IP1 is transported via plasma and reaches distant organs as well as tumors. ...
Inositol hexaphosphate (IP6) has a demonstrably effective anti-cancer action against a variety of experimental tumors. ...The …
Effects of food factors on signal transduction pathways.
Dong Z. Dong Z. Biofactors. 2000;12(1-4):17-28. doi: 10.1002/biof.5520120104. Biofactors. 2000. PMID: 11216482 Review.
These compounds also inhibited ultraviolet B (UVB)-induced AP-1 and nuclear factor kappa B (NFkappaB)-dependent transcriptional activation; (2) resveratrol, found at high levels in grapes, inhibited cell transformation through the induction of apoptosis, mediated through JNK and …
These compounds also inhibited ultraviolet B (UVB)-induced AP-1 and nuclear factor kappa B (NFkappaB)-dependent transcriptional activation; …
Effects of inositol hexaphosphate on proliferation of HT-29 human colon carcinoma cell line.
Tian Y, Song Y. Tian Y, et al. World J Gastroenterol. 2006 Jul 14;12(26):4137-42. doi: 10.3748/wjg.v12.i26.4137. World J Gastroenterol. 2006. PMID: 16830361 Free PMC article.
AIM: To investigate the effects of inositol hexaphosphate (IP(6)) on proliferation of HT-29 human colon carcinoma cell line. ...Analysis of cell cycle regulator expression revealed that IP(6) reduced the abnormal expression of P53 and PCNA and induced the exp …
AIM: To investigate the effects of inositol hexaphosphate (IP(6)) on proliferation of HT-29 human colon carcinoma cell line. . …
Rice bran phytic acid induced apoptosis through regulation of Bcl-2/Bax and p53 genes in HepG2 human hepatocellular carcinoma cells.
Al-Fatlawi AA, Al-Fatlawi AA, Irshad M, Zafaryab M, Rizvi MM, Ahmad A. Al-Fatlawi AA, et al. Asian Pac J Cancer Prev. 2014;15(8):3731-6. doi: 10.7314/apjcp.2014.15.8.3731. Asian Pac J Cancer Prev. 2014. PMID: 24870784 Free article.
Phytic acid (PA) has been reported to have positive nutritional benefits and prevent cancer formation. ...At the IC50 (2.49 mM) of PA, the p53, Bax, Caspase-3 and-9 genes were up- regulated by 6.03, 7.37, 19.7 and 14.5 fold respectively. ...
Phytic acid (PA) has been reported to have positive nutritional benefits and prevent cancer formation. ...At the IC50 (2.49 mM …
P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis.
Panduri V, Surapureddi S, Soberanes S, Weitzman SA, Chandel N, Kamp DW. Panduri V, et al. Am J Respir Cell Mol Biol. 2006 Apr;34(4):443-52. doi: 10.1165/rcmb.2005-0352OC. Epub 2005 Dec 15. Am J Respir Cell Mol Biol. 2006. PMID: 16357363 Free PMC article.
Further, pifithrin, E6, phytic acid, or rho(0)-A549 cells (cells incapable of mitochondrial reactive oxygen species production) block asbestos-induced p53 activation. Finally, we show that asbestos augments p53 expression in cells at the bronchoalveola …
Further, pifithrin, E6, phytic acid, or rho(0)-A549 cells (cells incapable of mitochondrial reactive oxygen species production …
Up-regulation of the tumor suppressor gene p53 and WAF1 gene expression by IP6 in HT-29 human colon carcinoma cell line.
Saied IT, Shamsuddin AM. Saied IT, et al. Anticancer Res. 1998 May-Jun;18(3A):1479-84. Anticancer Res. 1998. PMID: 9673359
Inositol hexaphosphate (InsP6 or IP6) ubiquitous in various cells has a novel anti-cancer action both in vivo and in vitro. ...Since loss of p53 function enhances cancer cells' resistance to chemotherapeutic agents, the stimulating function of IP6 on p53 …
Inositol hexaphosphate (InsP6 or IP6) ubiquitous in various cells has a novel anti-cancer action both in vivo and in vitro. .. …
16 results