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2019 2
2020 0
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Inositol hexaphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target.
Liu G, Song Y, Cui L, Wen Z, Lu X. Liu G, et al. Int J Clin Exp Pathol. 2015 Feb 1;8(2):1402-10. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 25973024 Free PMC article.
BACKGROUND: Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate that is present in high amounts in almost all plants and mammalian cells. ...
BACKGROUND: Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate that is present in high amounts in almost all pl …
PI3K/Akt Pathway and miR-21 are Involved in N-Ethyl-N-Nitrosourea-Induced F1 Mouse Lung Tumorigenesis: Effect of Inositol Hexaphosphate.
Sahay S, Tiwari P, Pandey M, Gupta KP. Sahay S, et al. J Environ Pathol Toxicol Oncol. 2019;38(1):69-81. doi: 10.1615/JEnvironPatholToxicolOncol.2018026684. J Environ Pathol Toxicol Oncol. 2019. PMID: 30806292
In this study, we explored the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and microRNA-21 (miR-21) in transplacental lung tumorigenesis and its prevention by dietary compound inositol hexaphosphate (IP6) in F1 mice. ...
In this study, we explored the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and microRNA-21 (miR …
Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target.
Gu M, Roy S, Raina K, Agarwal C, Agarwal R. Gu M, et al. Cancer Res. 2009 Dec 15;69(24):9465-72. doi: 10.1158/0008-5472.CAN-09-2805. Cancer Res. 2009. PMID: 19920184 Free PMC article.
Here, we assessed the efficacy of inositol hexaphosphate (IP6) against invasive human prostate cancer PC-3 and C4-2B cells and regulation of PI3K-Akt pathway. IP6 treatment of cells suppressed proliferation, induced apoptosis along with caspase-3 and p …
Here, we assessed the efficacy of inositol hexaphosphate (IP6) against invasive human prostate cancer PC-3 and C4-2B ce …
Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase.
Huang C, Ma WY, Hecht SS, Dong Z. Huang C, et al. Cancer Res. 1997 Jul 15;57(14):2873-8. Cancer Res. 1997. PMID: 9230193 Free article.
Inositol hexaphosphate (InsP6) is the most abundant inositol phosphate found in plants. In mammalian cells, the concentrations of InsP6 are between 10 and 100 microM. ...InsP6 markedly blocks epidermal growth factor-induced phosphatidylinositol-3
Inositol hexaphosphate (InsP6) is the most abundant inositol phosphate found in plants. In mammalian cells, the concent
Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation.
Vucenik I, Ramakrishna G, Tantivejkul K, Anderson LM, Ramljak D. Vucenik I, et al. Breast Cancer Res Treat. 2005 May;91(1):35-45. doi: 10.1007/s10549-004-6456-5. Breast Cancer Res Treat. 2005. PMID: 15868430
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate with demonstrated anti-proliferative and anti-cancer activity in mammary cells. ...Treatment of MCF-7 human breast cancer cells with 2 mM IP6 for 24 h caused a 3.1-fold incr
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate with demonstrated anti-proliferative and
Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2α.
Chen KE, Tillu VA, Chandra M, Collins BM. Chen KE, et al. Structure. 2018 Dec 4;26(12):1612-1625.e4. doi: 10.1016/j.str.2018.08.010. Epub 2018 Oct 4. Structure. 2018. PMID: 30293811 Free article.
Phosphorylation of phosphoinositides by the class II phosphatidylinositol 3-kinase (PI3K) PI3K-C2α is essential for many processes, including neuroexocytosis and formation of clathrin-coated vesicles. ...Here we report the crystal structure of the C2 domain o …
Phosphorylation of phosphoinositides by the class II phosphatidylinositol 3-kinase (PI3K) PI3K-C2α is essential for man …
Pectin-encrusted gold nanocomposites containing phytic acid and jacalin: 1,2-dimethylhydrazine-induced colon carcinogenesis in Wistar rats, PI3K/Akt, COX-2, and serum metabolomics as potential targets.
Arya M, Singh P, Tripathi CB, Parashar P, Singh M, Kanoujia J, Guleria A, Kaithwas G, Gupta KP, Saraf SA. Arya M, et al. Drug Deliv Transl Res. 2019 Feb;9(1):53-65. doi: 10.1007/s13346-018-00605-y. Drug Deliv Transl Res. 2019. PMID: 30484258
Phytic acid (PA) has momentous chemotherapeutic potential. Due to the chelate formation and rapid elimination, it is not popular in cancer treatment. ...Chloroauric acid was reduced with pectin to produce pectin-gold nanoparticles (PGNPs). PGNPs were incubate
Phytic acid (PA) has momentous chemotherapeutic potential. Due to the chelate formation and rapid elimination, it is not popul
PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer.
Dong Z, Huang C, Ma WY. Dong Z, et al. Anticancer Res. 1999 Sep-Oct;19(5A):3743-7. Anticancer Res. 1999. PMID: 10625951 Review.
Phosphatidylinositol-3 kinase (PI-3 K) plays a central role in a broad range of biological effects. However, little is known about its role in phorbol ester- or epidermal growth factor (EGF)-induced signal transduction to the transcriptional machinery
Phosphatidylinositol-3 kinase (PI-3 K) plays a central role in a broad range of biological effects. However, lit
Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases.
Otto JC, Kelly P, Chiou ST, York JD. Otto JC, et al. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15653-8. doi: 10.1073/pnas.0705729104. Epub 2007 Sep 25. Proc Natl Acad Sci U S A. 2007. PMID: 17895383 Free PMC article.
In mammals, many cellular stimuli evoke a response through G protein activation of phospholipase C, which results in the lipid-derived production of inositol 1,4,5-trisphosphate (IP(3)). Although it is well established that IP(3) is converted to numerous i
In mammals, many cellular stimuli evoke a response through G protein activation of phospholipase C, which results in the lipid-derived produ …
Inositol hexaphosphate inhibits ultraviolet B-induced signal transduction.
Chen N, Ma WY, Dong Z. Chen N, et al. Mol Carcinog. 2001 Jul;31(3):139-44. doi: 10.1002/mc.1048. Mol Carcinog. 2001. PMID: 11479922
Inositol hexaphosphate (InsP6) has an effective anticancer action in many experimental models in vivo and in vitro. Ultraviolet B (UVB) radiation is believed to be responsible for many of the carcinogenic effects related to sun exposure, and alteration in UVB-induce
Inositol hexaphosphate (InsP6) has an effective anticancer action in many experimental models in vivo and in vitro. Ultraviole
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