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2019 2
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Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase.
Huang C, Ma WY, Hecht SS, Dong Z. Huang C, et al. Cancer Res. 1997 Jul 15;57(14):2873-8. Cancer Res. 1997. PMID: 9230193
Inositol hexaphosphate (InsP6) is the most abundant inositol phosphate found in plants. ...InsP6 markedly blocks epidermal growth factor-induced phosphatidylinositol-3 (PI-3) kinase activity in a dose-dependent manner in JB6 cells …
Inositol hexaphosphate (InsP6) is the most abundant inositol phosphate found in plants. ...InsP6 markedly blocks epider …
Inositol hexaphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target.
Liu G, Song Y, Cui L, Wen Z, Lu X. Liu G, et al. Int J Clin Exp Pathol. 2015 Feb 1;8(2):1402-10. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 25973024 Free PMC article.
BACKGROUND: Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate that is present in high amounts in almost all plants and mammalian cells. ...
BACKGROUND: Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate that is present in high amounts in almost all pl …
PI3K/Akt Pathway and miR-21 are Involved in N-Ethyl-N-Nitrosourea-Induced F1 Mouse Lung Tumorigenesis: Effect of Inositol Hexaphosphate.
Sahay S, Tiwari P, Pandey M, Gupta KP. Sahay S, et al. J Environ Pathol Toxicol Oncol. 2019;38(1):69-81. doi: 10.1615/JEnvironPatholToxicolOncol.2018026684. J Environ Pathol Toxicol Oncol. 2019. PMID: 30806292
The risk of cancer development in offspring due to carcinogen exposure during pregnancy is a serious issue. In this study, we explored the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and microRNA-21 (miR-21) in transplacental lung tumo …
The risk of cancer development in offspring due to carcinogen exposure during pregnancy is a serious issue. In this study, we explored the i …
Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target.
Gu M, Roy S, Raina K, Agarwal C, Agarwal R. Gu M, et al. Cancer Res. 2009 Dec 15;69(24):9465-72. doi: 10.1158/0008-5472.CAN-09-2805. Cancer Res. 2009. PMID: 19920184 Free PMC article.
Here, we assessed the efficacy of inositol hexaphosphate (IP6) against invasive human prostate cancer PC-3 and C4-2B cells and regulation of PI3K-Akt pathway. IP6 treatment of cells suppressed proliferation, induced apoptosis along with caspase-3 and p …
Here, we assessed the efficacy of inositol hexaphosphate (IP6) against invasive human prostate cancer PC-3 and C4-2B ce …
Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation.
Vucenik I, Ramakrishna G, Tantivejkul K, Anderson LM, Ramljak D. Vucenik I, et al. Breast Cancer Res Treat. 2005 May;91(1):35-45. doi: 10.1007/s10549-004-6456-5. Breast Cancer Res Treat. 2005. PMID: 15868430
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate with demonstrated anti-proliferative and anti-cancer activity in mammary cells. ...The effects of both pharmacological (2 mM) and physiological (100 microM) doses of IP6 on major P …
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate with demonstrated anti-proliferative and …
Effects of food factors on signal transduction pathways.
Dong Z. Dong Z. Biofactors. 2000;12(1-4):17-28. doi: 10.1002/biof.5520120104. Biofactors. 2000. PMID: 11216482 Review.
These compounds also inhibited ultraviolet B (UVB)-induced AP-1 and nuclear factor kappa B (NFkappaB)-dependent transcriptional activation; (2) resveratrol, found at high levels in grapes, inhibited cell transformation through the induction of apoptosis, mediated through JNK and …
These compounds also inhibited ultraviolet B (UVB)-induced AP-1 and nuclear factor kappa B (NFkappaB)-dependent transcriptional activation; …
Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2α.
Chen KE, Tillu VA, Chandra M, Collins BM. Chen KE, et al. Structure. 2018 Dec 4;26(12):1612-1625.e4. doi: 10.1016/j.str.2018.08.010. Epub 2018 Oct 4. Structure. 2018. PMID: 30293811 Free article.
Phosphorylation of phosphoinositides by the class II phosphatidylinositol 3-kinase (PI3K) PI3K-C2alpha is essential for many processes, including neuroexocytosis and formation of clathrin-coated vesicles. ...Here we report the crystal structure of the C2 doma …
Phosphorylation of phosphoinositides by the class II phosphatidylinositol 3-kinase (PI3K) PI3K-C2alpha is essential for …
PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer.
Dong Z, Huang C, Ma WY. Dong Z, et al. Anticancer Res. 1999 Sep-Oct;19(5A):3743-7. Anticancer Res. 1999. PMID: 10625951 Review.
Phosphatidylinositol-3 kinase (PI-3 K) plays a central role in a broad range of biological effects. ...Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K act …
Phosphatidylinositol-3 kinase (PI-3 K) plays a central role in a broad range of biological effects. ...Overexpre …
Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases.
Otto JC, Kelly P, Chiou ST, York JD. Otto JC, et al. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15653-8. doi: 10.1073/pnas.0705729104. Epub 2007 Sep 25. Proc Natl Acad Sci U S A. 2007. PMID: 17895383 Free PMC article.
In mammals, many cellular stimuli evoke a response through G protein activation of phospholipase C, which results in the lipid-derived production of inositol 1,4,5-trisphosphate (IP(3)). Although it is well established that IP(3) is converted to numerous i …
In mammals, many cellular stimuli evoke a response through G protein activation of phospholipase C, which results in the lipid-derived produ …
Molecular mechanisms for the antitumor activity of inositol hexakisphosphate (IP6).
Bozsik A, Kökény S, Olah E. Bozsik A, et al. Cancer Genomics Proteomics. 2007 Jan-Feb;4(1):43-51. Cancer Genomics Proteomics. 2007. PMID: 17726240 Free article.
BACKGROUND: Inositol hexakisphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has been reported to have significant in vivo and in vitro anticancer activity against numerous tumors. ...Through microarray analysis, the anticancer effect of IP6 in K-562 …
BACKGROUND: Inositol hexakisphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has been reported to have signifi …
15 results