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Anticancer Properties of Inositol Hexaphosphate and Inositol: An Overview.
Vucenik I. Vucenik I. J Nutr Sci Vitaminol (Tokyo). 2019;65(Supplement):S18-S22. doi: 10.3177/jnsv.65.S18. J Nutr Sci Vitaminol (Tokyo). 2019. PMID: 31619624 Free article. Review.
Inositol hexaphosphate (IP(6)) and its parent compound myo-inositol (Ins) are active compounds from rice and other grains, with a broad spectrum of biological activities important in health and diseases. ...IP(6) reduces cell proliferation, induces apoptosis
Inositol hexaphosphate (IP(6)) and its parent compound myo-inositol (Ins) are active compounds from rice and other grai
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Croze ML, Soulage CO. Croze ML, et al. Biochimie. 2013 Oct;95(10):1811-27. doi: 10.1016/j.biochi.2013.05.011. Epub 2013 Jun 10. Biochimie. 2013. PMID: 23764390 Review.
Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were shown to possess insulin-mimetic properties and to be efficient in lowering post-prandial blood glucose. ...Finally, the actual insights into inositol insulin …
Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were shown to possess insulin- …
Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation.
Vucenik I, Ramakrishna G, Tantivejkul K, Anderson LM, Ramljak D. Vucenik I, et al. Breast Cancer Res Treat. 2005 May;91(1):35-45. doi: 10.1007/s10549-004-6456-5. Breast Cancer Res Treat. 2005. PMID: 15868430
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate with demonstrated anti-proliferative and anti-cancer activity in mammary cells. ...In addition, IP6-induced apoptosis detected in MCF-7 cells appeared also to be PKC delta-d
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate with demonstrated anti-proliferative and
Inhibitory effect of inositol hexaphosphate on metalloproteinases transcription in colon cancer cells stimulated with phorbol-12-myristate 13-acetate.
Kapral M, Wawszczyk J, Hollek A, Dymitruk D, Weglarz L. Kapral M, et al. Acta Pol Pharm. 2012 Nov-Dec;69(6):1307-12. Acta Pol Pharm. 2012. PMID: 23285695 Free article.
Inositol hexaphosphate (IP6) is a naturally occurring phytochemical, found in abundance in cereals, legumes and other high-fiber-content diets. ...Phorbol-12-myristate 13-acetate (PMA) is a well-known inflammatory stimulator and tumor promoter that activates PKC
Inositol hexaphosphate (IP6) is a naturally occurring phytochemical, found in abundance in cereals, legumes and other high-fib
Inositol hexakisphosphate and beta-cell stimulus-secretion coupling.
Barker CJ, Berggren PO. Barker CJ, et al. Anticancer Res. 1999 Sep-Oct;19(5A):3737-41. Anticancer Res. 1999. PMID: 10625950 Review.
Inositol hexakisphosphate (InsP6) inhibits serine/threonine protein phosphatases type-1 (PP1), type-2A (PP2A) and type-3 (PP3) in a concentration-dependent manner. ...Concentrations of InsP6 above 20 microM stimulated insulin secretion at basal Ca(2+)-concentration (30 nM)
Inositol hexakisphosphate (InsP6) inhibits serine/threonine protein phosphatases type-1 (PP1), type-2A (PP2A) and type-3 (PP3) in a c
Stimulation of L-type Ca2+ channels by inositol pentakis- and hexakisphosphates in rat vascular smooth muscle cells.
Quignard JF, Rakotoarisoa L, Mironneau J, Mironneau C. Quignard JF, et al. J Physiol. 2003 Jun 15;549(Pt 3):729-37. doi: 10.1113/jphysiol.2002.037473. Epub 2003 Apr 25. J Physiol. 2003. PMID: 12717004 Free PMC article.
The electrophysiological effects of D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5) and D-myo-inositol hexakisphosphate (InsP6), which represent the main cellular inositol polyphosphates, were studied on L-type Ca2+ channels in single myocytes of rat porta …
The electrophysiological effects of D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5) and D-myo-inositol hexakisphosphate (In …
Inositol hexaphosphate reduces 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase independent of protein kinase C isoform expression in keratinocytes.
Nickel KP, Belury MA. Nickel KP, et al. Cancer Lett. 1999 Jun 1;140(1-2):105-11. doi: 10.1016/s0304-3835(99)00063-4. Cancer Lett. 1999. PMID: 10403548
High-fiber diets have been shown to have beneficial effects on preventing tumorigenesis. Inositol hexaphosphate (InsP6 or phytic acid) which is a fiber-associated component of cereals and legumes has been demonstrated to inhibit cell proliferation and …
High-fiber diets have been shown to have beneficial effects on preventing tumorigenesis. Inositol hexaphosphate (InsP6 or p
PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer.
Dong Z, Huang C, Ma WY. Dong Z, et al. Anticancer Res. 1999 Sep-Oct;19(5A):3743-7. Anticancer Res. 1999. PMID: 10625951 Review.
Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity. Inositol hexaphosphate (InsP6) is one of the most promising chemopreventive agents as demonstrated by S …
Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-in …
Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes.
Palmer RH, Dekker LV, Woscholski R, Le Good JA, Gigg R, Parker PJ. Palmer RH, et al. J Biol Chem. 1995 Sep 22;270(38):22412-6. doi: 10.1074/jbc.270.38.22412. J Biol Chem. 1995. PMID: 7673228 Free article.
As potential targets for polyphosphoinositides, activation of protein kinase C (PKC) isotypes (beta 1, epsilon, zeta, nu) and a member of the PKC-related kinase (PRK) family, PRK1, has been compared in vitro. ...Consistent with this conclusion, the effects of PtdIns …
As potential targets for polyphosphoinositides, activation of protein kinase C (PKC) isotypes (beta 1, epsilon, zeta, nu) and a membe …
Phytate hydrolysate induces circumferential F-actin ring formation at cell-cell contacts by a Rho-associated kinase-dependent mechanism in colorectal cancer HT-29 cells.
Suzuki T, Hara H. Suzuki T, et al. Mol Nutr Food Res. 2010 Dec;54(12):1807-18. doi: 10.1002/mnfr.200900606. Mol Nutr Food Res. 2010. PMID: 20626001
Phytate (inositol hexa-phosphate or IP6) possessing anticancer activity is hydrolyzed by phytase in intestinal microbes and the metabolites are distributed throughout the colon. ...Altogether, the phytate hydrolysate induces circumferential F-actin ring formation through a …
Phytate (inositol hexa-phosphate or IP6) possessing anticancer activity is hydrolyzed by phytase in intestinal microbes and the metab …
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