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2016 19
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2018 19
2019 15
2020 23
2021 1
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Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models.
Polykovskiy D, Zhebrak A, Sanchez-Lengeling B, Golovanov S, Tatanov O, Belyaev S, Kurbanov R, Artamonov A, Aladinskiy V, Veselov M, Kadurin A, Johansson S, Chen H, Nikolenko S, Aspuru-Guzik A, Zhavoronkov A. Polykovskiy D, et al. Front Pharmacol. 2020 Dec 18;11:565644. doi: 10.3389/fphar.2020.565644. eCollection 2020. Front Pharmacol. 2020. PMID: 33390943 Free PMC article.
ARDD 2020: from aging mechanisms to interventions.
Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. Mkrtchyan GV, et al. Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. doi: 10.18632/aging.202454. Epub 2020 Dec 30. Aging (Albany NY). 2020. PMID: 33378272 Free PMC article.
PsychoAge and SubjAge: development of deep markers of psychological and subjective age using artificial intelligence.
Zhavoronkov A, Kochetov K, Diamandis P, Mitina M. Zhavoronkov A, et al. Aging (Albany NY). 2020 Dec 8;12(23):23548-23577. doi: 10.18632/aging.202344. Epub 2020 Dec 8. Aging (Albany NY). 2020. PMID: 33303702 Free PMC article.
Fetal mitochondrial DNA in maternal plasma in surrogate pregnancies: Detection and topology.
Ma ML, Yakovenko S, Zhang H, Cheng SH, Apryshko V, Zhavoronkov A, Jiang P, Chan KCA, Chiu RWK, Lo YMD. Ma ML, et al. Prenat Diagn. 2020 Nov 2. doi: 10.1002/pd.5860. Online ahead of print. Prenat Diagn. 2020. PMID: 33140416
Erratum: Addendum: Molecular Generation for Desired Transcriptome Changes With Adversarial Autoencoders.
Shayakhmetov R, Kuznetsov M, Zhebrak A, Kadurin A, Nikolenko S, Aliper A, Polykovskiy D. Shayakhmetov R, et al. Front Pharmacol. 2020 Aug 21;11:1236. doi: 10.3389/fphar.2020.01236. eCollection 2020. Front Pharmacol. 2020. PMID: 32973498 Free PMC article.
Psychological aging, depression, and well-being.
Mitina M, Young S, Zhavoronkov A. Mitina M, et al. Aging (Albany NY). 2020 Sep 18;12(18):18765-18777. doi: 10.18632/aging.103880. Online ahead of print. Aging (Albany NY). 2020. PMID: 32950973 Free PMC article.
The conundrum of human immune system "senescence".
Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, Morais JA, Nóbrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Vanhaelen Q, Witkowski J, Cohen AA. Pawelec G, et al. Mech Ageing Dev. 2020 Dec;192:111357. doi: 10.1016/j.mad.2020.111357. Epub 2020 Sep 17. Mech Ageing Dev. 2020. PMID: 32949594 Free PMC article. Review.
Artificial intelligence, drug repurposing and peer review.
Levin JM, Oprea TI, Davidovich S, Clozel T, Overington JP, Vanhaelen Q, Cantor CR, Bischof E, Zhavoronkov A. Levin JM, et al. Nat Biotechnol. 2020 Oct;38(10):1127-1131. doi: 10.1038/s41587-020-0686-x. Nat Biotechnol. 2020. PMID: 32929264 No abstract available.
The Advent of Generative Chemistry.
Vanhaelen Q, Lin YC, Zhavoronkov A. Vanhaelen Q, et al. ACS Med Chem Lett. 2020 Jul 14;11(8):1496-1505. doi: 10.1021/acsmedchemlett.0c00088. eCollection 2020 Aug 13. ACS Med Chem Lett. 2020. PMID: 32832015
ANERGY TO SYNERGY-THE ENERGY FUELING THE RXCOVEA FRAMEWORK.
Bischof E, Broek JAC, Cantor CR, Duits AJ, Ferro A, Gao HW, Li Z, de Maria SL, Maria NI, Mishra B, Mishra KI, van der Ploeg L, Rudolph L, Schlick T; RxCOVEA Framework. Bischof E, et al. Int J Multiscale Comput Eng. 2020;18(3):329-333. doi: 10.1615/intjmultcompeng.2020035097. Int J Multiscale Comput Eng. 2020. PMID: 32831809 Free PMC article.
GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.
Hayashi M, Guida E, Inokawa Y, Goldberg R, Reis LO, Ooki A, Pilli M, Sadhukhan P, Woo J, Choi W, Izumchenko E, Gonzalez LM, Marchionni L, Zhavoronkov A, Brait M, Bivalacqua T, Baras A, Netto GJ, Koch W, Singh A, Hoque MO. Hayashi M, et al. Sci Signal. 2020 Aug 18;13(645):eaba0443. doi: 10.1126/scisignal.aba0443. Sci Signal. 2020. PMID: 32817372
Radioprotectors.org: an open database of known and predicted radioprotectors.
Aliper AM, Bozdaganyan ME, Sarkisova VA, Veviorsky AP, Ozerov IV, Orekhov PS, Korzinkin MB, Moskalev A, Zhavoronkov A, Osipov AN. Aliper AM, et al. Aging (Albany NY). 2020 Aug 15;12(15):15741-15755. doi: 10.18632/aging.103815. Epub 2020 Aug 15. Aging (Albany NY). 2020. PMID: 32805729 Free PMC article.
Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.
Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaître JF, Liontis T, Liu GH, Liu M, Maier AB, Nóbrega OT, Olde Rikkert MGM, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fülöp T. Cohen AA, et al. Mech Ageing Dev. 2020 Oct;191:111316. doi: 10.1016/j.mad.2020.111316. Epub 2020 Jul 18. Mech Ageing Dev. 2020. PMID: 32693105
Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning.
Galkin F, Mamoshina P, Aliper A, Putin E, Moskalev V, Gladyshev VN, Zhavoronkov A. Galkin F, et al. iScience. 2020 Jun 26;23(6):101199. doi: 10.1016/j.isci.2020.101199. Epub 2020 May 23. iScience. 2020. PMID: 32534441 Free PMC article.
Dual Transcriptomic and Molecular Machine Learning Predicts all Major Clinical Forms of Drug Cardiotoxicity.
Mamoshina P, Bueno-Orovio A, Rodriguez B. Mamoshina P, et al. Front Pharmacol. 2020 May 21;11:639. doi: 10.3389/fphar.2020.00639. eCollection 2020. Front Pharmacol. 2020. PMID: 32508633 Free PMC article.
Medicinal Chemists versus Machines Challenge: What Will It Take to Adopt and Advance Artificial Intelligence for Drug Discovery?
Zhavoronkov A. Zhavoronkov A. J Chem Inf Model. 2020 Jun 22;60(6):2657-2659. doi: 10.1021/acs.jcim.0c00435. Epub 2020 May 29. J Chem Inf Model. 2020. PMID: 32469509
The inherent challenges of classifying senescence.
Zhavoronkov A. Zhavoronkov A. Science. 2020 May 8;368(6491):595. doi: 10.1126/science.aba0833. Science. 2020. PMID: 32381712 No abstract available.
Molecular Generation for Desired Transcriptome Changes With Adversarial Autoencoders.
Shayakhmetov R, Kuznetsov M, Zhebrak A, Kadurin A, Nikolenko S, Aliper A, Polykovskiy D. Shayakhmetov R, et al. Front Pharmacol. 2020 Apr 17;11:269. doi: 10.3389/fphar.2020.00269. eCollection 2020. Front Pharmacol. 2020. PMID: 32362822 Free PMC article.
Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities.
Galkin F, Mamoshina P, Aliper A, de Magalhães JP, Gladyshev VN, Zhavoronkov A. Galkin F, et al. Ageing Res Rev. 2020 Jul;60:101050. doi: 10.1016/j.arr.2020.101050. Epub 2020 Apr 6. Ageing Res Rev. 2020. PMID: 32272169 Free article. Review.
Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections.
Zhavoronkov A. Zhavoronkov A. Aging (Albany NY). 2020 Mar 31;12(8):6492-6510. doi: 10.18632/aging.102988. Epub 2020 Mar 31. Aging (Albany NY). 2020. PMID: 32229705 Free PMC article. Review.
Multiple features for clinical relation extraction: A machine learning approach.
Alimova I, Tutubalina E. Alimova I, et al. J Biomed Inform. 2020 Mar;103:103382. doi: 10.1016/j.jbi.2020.103382. Epub 2020 Feb 3. J Biomed Inform. 2020. PMID: 32028051
Web-based Tools for Drug Repurposing: Successful Examples of Collaborative Research.
Vanhaelen Q. Vanhaelen Q. Curr Med Chem. 2021;28(1):181-195. doi: 10.2174/0929867327666200128111925. Curr Med Chem. 2021. PMID: 32003659
Reply to 'Assessing the impact of generative AI on medicinal chemistry'.
Zhavoronkov A, Aspuru-Guzik A. Zhavoronkov A, et al. Nat Biotechnol. 2020 Feb;38(2):146. doi: 10.1038/s41587-020-0417-3. Nat Biotechnol. 2020. PMID: 32001835 No abstract available.
Will Artificial Intelligence for Drug Discovery Impact Clinical Pharmacology?
Zhavoronkov A, Vanhaelen Q, Oprea TI. Zhavoronkov A, et al. Clin Pharmacol Ther. 2020 Apr;107(4):780-785. doi: 10.1002/cpt.1795. Epub 2020 Mar 3. Clin Pharmacol Ther. 2020. PMID: 31957003 Free PMC article. Review.
Latest advances in aging research and drug discovery.
Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner MI, Jensen MB, Calkhoven CF, Chen D, Grey ADNJ, Feige JN, Georgievskaya A, Gladyshev VN, Golato T, Gudkov AV, Hoppe T, Kaeberlein M, Katajisto P, Kennedy BK, Lal U, Martin-Villalba A, Moskalev AA, Ozerov I, Petr MA, Reason, Rubinsztein DC, Tyshkovskiy A, Vanhaelen Q, Zhavoronkov A, Scheibye-Knudsen M. Bakula D, et al. Aging (Albany NY). 2019 Nov 21;11(22):9971-9981. doi: 10.18632/aging.102487. Epub 2019 Nov 21. Aging (Albany NY). 2019. PMID: 31770722 Free PMC article.
To facilitate these trends, the Center for Healthy Aging at the University of Copenhagen and Insilico Medicine are building a community of Key Opinion Leaders (KOLs) in these areas and launched the annual conference series titled "Aging Research and Drug Discovery ( …
To facilitate these trends, the Center for Healthy Aging at the University of Copenhagen and Insilico Medicine are building a …
Deep biomarkers of aging and longevity: from research to applications.
Zhavoronkov A, Li R, Ma C, Mamoshina P. Zhavoronkov A, et al. Aging (Albany NY). 2019 Nov 25;11(22):10771-10780. doi: 10.18632/aging.102475. Epub 2019 Nov 25. Aging (Albany NY). 2019. PMID: 31767810 Free PMC article. Review.
Identification of Novel Antibacterials Using Machine Learning Techniques.
Ivanenkov YA, Zhavoronkov A, Yamidanov RS, Osterman IA, Sergiev PV, Aladinskiy VA, Aladinskaya AV, Terentiev VA, Veselov MS, Ayginin AA, Kartsev VG, Skvortsov DA, Chemeris AV, Baimiev AK, Sofronova AA, Malyshev AS, Filkov GI, Bezrukov DS, Zagribelnyy BA, Putin EO, Puchinina MM, Dontsova OA. Ivanenkov YA, et al. Front Pharmacol. 2019 Aug 27;10:913. doi: 10.3389/fphar.2019.00913. eCollection 2019. Front Pharmacol. 2019. PMID: 31507413 Free PMC article.
Deep learning enables rapid identification of potent DDR1 kinase inhibitors.
Zhavoronkov A, Ivanenkov YA, Aliper A, Veselov MS, Aladinskiy VA, Aladinskaya AV, Terentiev VA, Polykovskiy DA, Kuznetsov MD, Asadulaev A, Volkov Y, Zholus A, Shayakhmetov RR, Zhebrak A, Minaeva LI, Zagribelnyy BA, Lee LH, Soll R, Madge D, Xing L, Guo T, Aspuru-Guzik A. Zhavoronkov A, et al. Nat Biotechnol. 2019 Sep;37(9):1038-1040. doi: 10.1038/s41587-019-0224-x. Epub 2019 Sep 2. Nat Biotechnol. 2019. PMID: 31477924
Immune profiles in primary squamous cell carcinoma of the head and neck.
Saloura V, Izumchenko E, Zuo Z, Bao R, Korzinkin M, Ozerov I, Zhavoronkov A, Sidransky D, Bedi A, Hoque MO, Koeppen H, Keck MK, Khattri A, London N, Kotlov N, Fatima A, Vougiouklakis T, Nakamura Y, Lingen M, Agrawal N, Savage PA, Kron S, Kline J, Kowanetz M, Seiwert TY. Saloura V, et al. Oral Oncol. 2019 Sep;96:77-88. doi: 10.1016/j.oraloncology.2019.06.032. Epub 2019 Jul 12. Oral Oncol. 2019. PMID: 31422218
Deep Aging Clocks: The Emergence of AI-Based Biomarkers of Aging and Longevity.
Zhavoronkov A, Mamoshina P. Zhavoronkov A, et al. Trends Pharmacol Sci. 2019 Aug;40(8):546-549. doi: 10.1016/j.tips.2019.05.004. Epub 2019 Jul 3. Trends Pharmacol Sci. 2019. PMID: 31279569 Free article. Review.
The Advent of Human Life Data Economics.
Zhavoronkov A, Church G. Zhavoronkov A, et al. Trends Mol Med. 2019 Jul;25(7):566-570. doi: 10.1016/j.molmed.2019.05.002. Epub 2019 Jun 27. Trends Mol Med. 2019. PMID: 31257078 Review.
Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity.
Moskalev AA, Shaposhnikov MV, Zemskaya NV, Koval LА, Schegoleva EV, Guvatova ZG, Krasnov GS, Solovev IA, Sheptyakov MA, Zhavoronkov A, Kudryavtseva AV. Moskalev AA, et al. Sci Rep. 2019 Jun 24;9(1):9151. doi: 10.1038/s41598-019-45714-x. Sci Rep. 2019. PMID: 31235842 Free PMC article.
Are We Opening the Door to a New Era of Medicinal Chemistry or Being Collapsed to a Chemical Singularity?
Ivanenkov YA, Zagribelnyy BA, Aladinskiy VA. Ivanenkov YA, et al. J Med Chem. 2019 Nov 27;62(22):10026-10043. doi: 10.1021/acs.jmedchem.9b00004. Epub 2019 Jun 26. J Med Chem. 2019. PMID: 31188596
The Neuronal Overexpression of Gclc in Drosophila melanogaster Induces Life Extension With Longevity-Associated Transcriptomic Changes in the Thorax.
Moskalev A, Guvatova Z, Shaposhnikov M, Lashmanova E, Proshkina E, Koval L, Zhavoronkov A, Krasnov G, Kudryavtseva A. Moskalev A, et al. Front Genet. 2019 Mar 5;10:149. doi: 10.3389/fgene.2019.00149. eCollection 2019. Front Genet. 2019. PMID: 30891062 Free PMC article.
Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster.
Moskalev A, Proshkina E, Zhavoronkov A, Shaposhnikov M. Moskalev A, et al. BMC Syst Biol. 2019 Mar 5;13(Suppl 1):16. doi: 10.1186/s12918-019-0687-x. BMC Syst Biol. 2019. PMID: 30836998 Free PMC article.
PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40).
Subbannayya T, Leal-Rojas P, Zhavoronkov A, Ozerov IV, Korzinkin M, Babu N, Radhakrishnan A, Chavan S, Raja R, Pinto SM, Patil AH, Barbhuiya MA, Kumar P, Guerrero-Preston R, Navani S, Tiwari PK, Kumar RV, Prasad TSK, Roa JC, Pandey A, Sidransky D, Gowda H, Izumchenko E, Chatterjee A. Subbannayya T, et al. J Cell Commun Signal. 2019 Jun;13(2):163-177. doi: 10.1007/s12079-018-00503-5. Epub 2019 Jan 21. J Cell Commun Signal. 2019. PMID: 30666556 Free PMC article.
Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers.
Mamoshina P, Kochetov K, Cortese F, Kovalchuk A, Aliper A, Putin E, Scheibye-Knudsen M, Cantor CR, Skjodt NM, Kovalchuk O, Zhavoronkov A. Mamoshina P, et al. Sci Rep. 2019 Jan 15;9(1):142. doi: 10.1038/s41598-018-35704-w. Sci Rep. 2019. PMID: 30644411 Free PMC article.
Reversibility of irreversible aging.
Galkin F, Zhang B, Dmitriev SE, Gladyshev VN. Galkin F, et al. Ageing Res Rev. 2019 Jan;49:104-114. doi: 10.1016/j.arr.2018.11.008. Epub 2018 Dec 1. Ageing Res Rev. 2019. PMID: 30513346 Review.
Artificial intelligence for aging and longevity research: Recent advances and perspectives.
Zhavoronkov A, Mamoshina P, Vanhaelen Q, Scheibye-Knudsen M, Moskalev A, Aliper A. Zhavoronkov A, et al. Ageing Res Rev. 2019 Jan;49:49-66. doi: 10.1016/j.arr.2018.11.003. Epub 2018 Nov 22. Ageing Res Rev. 2019. PMID: 30472217 Free article. Review.
Aging and drug discovery.
Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M. Bakula D, et al. Aging (Albany NY). 2018 Nov 13;10(11):3079-3088. doi: 10.18632/aging.101646. Aging (Albany NY). 2018. PMID: 30425188 Free PMC article.
PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging.
Bobrov E, Georgievskaya A, Kiselev K, Sevastopolsky A, Zhavoronkov A, Gurov S, Rudakov K, Del Pilar Bonilla Tobar M, Jaspers S, Clemann S. Bobrov E, et al. Aging (Albany NY). 2018 Nov 9;10(11):3249-3259. doi: 10.18632/aging.101629. Aging (Albany NY). 2018. PMID: 30414596 Free PMC article.
Overexpression of CBS and CSE genes affects lifespan, stress resistance and locomotor activity in Drosophila melanogaster.
Shaposhnikov M, Proshkina E, Koval L, Zemskaya N, Zhavoronkov A, Moskalev A. Shaposhnikov M, et al. Aging (Albany NY). 2018 Nov 8;10(11):3260-3272. doi: 10.18632/aging.101630. Aging (Albany NY). 2018. PMID: 30408770 Free PMC article.
Artificial Intelligence for Drug Discovery, Biomarker Development, and Generation of Novel Chemistry.
Zhavoronkov A. Zhavoronkov A. Mol Pharm. 2018 Oct 1;15(10):4311-4313. doi: 10.1021/acs.molpharmaceut.8b00930. Mol Pharm. 2018. PMID: 30269508 No abstract available.
Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 Drosophila species with different lifespans.
Shaposhnikov MV, Zemskaya NV, Koval LA, Schegoleva EV, Zhavoronkov A, Moskalev AA. Shaposhnikov MV, et al. Aging (Albany NY). 2018 Sep 20;10(9):2428-2458. doi: 10.18632/aging.101561. Aging (Albany NY). 2018. PMID: 30243020 Free PMC article.
Entangled Conditional Adversarial Autoencoder for de Novo Drug Discovery.
Polykovskiy D, Zhebrak A, Vetrov D, Ivanenkov Y, Aladinskiy V, Mamoshina P, Bozdaganyan M, Aliper A, Zhavoronkov A, Kadurin A. Polykovskiy D, et al. Mol Pharm. 2018 Oct 1;15(10):4398-4405. doi: 10.1021/acs.molpharmaceut.8b00839. Epub 2018 Sep 19. Mol Pharm. 2018. PMID: 30180591 Free article.
Machine Learning on Human Muscle Transcriptomic Data for Biomarker Discovery and Tissue-Specific Drug Target Identification.
Mamoshina P, Volosnikova M, Ozerov IV, Putin E, Skibina E, Cortese F, Zhavoronkov A. Mamoshina P, et al. Front Genet. 2018 Jul 12;9:242. doi: 10.3389/fgene.2018.00242. eCollection 2018. Front Genet. 2018. PMID: 30050560 Free PMC article.
Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1.
Maldonado L, Brait M, Izumchenko E, Begum S, Chatterjee A, Sen T, Loyo M, Barbosa A, Poeta ML, Makarev E, Zhavoronkov A, Fazio VM, Angioli R, Rabitti C, Ongenaert M, Van Criekinge W, Noordhuis MG, de Graeff P, Wisman GBA, van der Zee AGJ, Hoque MO. Maldonado L, et al. Cancer Lett. 2018 Oct 1;433:242-251. doi: 10.1016/j.canlet.2018.06.030. Epub 2018 Jun 28. Cancer Lett. 2018. PMID: 29964205
Medical concept normalization in social media posts with recurrent neural networks.
Tutubalina E, Miftahutdinov Z, Nikolenko S, Malykh V. Tutubalina E, et al. J Biomed Inform. 2018 Aug;84:93-102. doi: 10.1016/j.jbi.2018.06.006. Epub 2018 Jun 12. J Biomed Inform. 2018. PMID: 29906585 Free article.
Reinforced Adversarial Neural Computer for de Novo Molecular Design.
Putin E, Asadulaev A, Ivanenkov Y, Aladinskiy V, Sanchez-Lengeling B, Aspuru-Guzik A, Zhavoronkov A. Putin E, et al. J Chem Inf Model. 2018 Jun 25;58(6):1194-1204. doi: 10.1021/acs.jcim.7b00690. Epub 2018 Jun 12. J Chem Inf Model. 2018. PMID: 29762023 Free article.
Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.
Cortese F, Klokov D, Osipov A, Stefaniak J, Moskalev A, Schastnaya J, Cantor C, Aliper A, Mamoshina P, Ushakov I, Sapetsky A, Vanhaelen Q, Alchinova I, Karganov M, Kovalchuk O, Wilkins R, Shtemberg A, Moreels M, Baatout S, Izumchenko E, de Magalhães JP, Artemov AV, Costes SV, Beheshti A, Mao XW, Pecaut MJ, Kaminskiy D, Ozerov IV, Scheibye-Knudsen M, Zhavoronkov A. Cortese F, et al. Oncotarget. 2018 Feb 12;9(18):14692-14722. doi: 10.18632/oncotarget.24461. eCollection 2018 Mar 6. Oncotarget. 2018. PMID: 29581875 Free PMC article. Review.
Adversarial Threshold Neural Computer for Molecular de Novo Design.
Putin E, Asadulaev A, Vanhaelen Q, Ivanenkov Y, Aladinskaya AV, Aliper A, Zhavoronkov A. Putin E, et al. Mol Pharm. 2018 Oct 1;15(10):4386-4397. doi: 10.1021/acs.molpharmaceut.7b01137. Epub 2018 Mar 30. Mol Pharm. 2018. PMID: 29569445 Free article.
Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor.
Solanki HS, Raja R, Zhavoronkov A, Ozerov IV, Artemov AV, Advani J, Radhakrishnan A, Babu N, Puttamallesh VN, Syed N, Nanjappa V, Subbannayya T, Sahasrabuddhe NA, Patil AH, Prasad TSK, Gaykalova D, Chang X, Sathyendran R, Mathur PP, Rangarajan A, Sidransky D, Pandey A, Izumchenko E, Gowda H, Chatterjee A. Solanki HS, et al. Oncoscience. 2018 Feb 23;5(1-2):21-38. doi: 10.18632/oncoscience.395. eCollection 2018 Jan. Oncoscience. 2018. PMID: 29556515 Free PMC article.
Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression of COX7A1 in embryonic and cancer cells.
West MD, Labat I, Sternberg H, Larocca D, Nasonkin I, Chapman KB, Singh R, Makarev E, Aliper A, Kazennov A, Alekseenko A, Shuvalov N, Cheskidova E, Alekseev A, Artemov A, Putin E, Mamoshina P, Pryanichnikov N, Larocca J, Copeland K, Izumchenko E, Korzinkin M, Zhavoronkov A. West MD, et al. Oncotarget. 2017 Dec 28;9(8):7796-7811. doi: 10.18632/oncotarget.23748. eCollection 2018 Jan 30. Oncotarget. 2017. PMID: 29487692 Free PMC article.
3D Molecular Representations Based on the Wave Transform for Convolutional Neural Networks.
Kuzminykh D, Polykovskiy D, Kadurin A, Zhebrak A, Baskov I, Nikolenko S, Shayakhmetov R, Zhavoronkov A. Kuzminykh D, et al. Mol Pharm. 2018 Oct 1;15(10):4378-4385. doi: 10.1021/acs.molpharmaceut.7b01134. Epub 2018 Mar 5. Mol Pharm. 2018. PMID: 29473756 Free article.
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.
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