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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1956 2
1973 1
1975 1
1976 1
1979 2
1981 2
1982 3
1983 7
1984 2
1985 8
1986 6
1987 5
1988 2
1989 2
1990 6
1991 6
1992 6
1993 7
1994 6
1995 10
1996 18
1997 7
1998 11
1999 14
2000 13
2001 15
2002 17
2003 18
2004 15
2005 15
2006 11
2007 16
2008 19
2009 15
2010 29
2011 19
2012 17
2013 33
2014 15
2015 18
2016 16
2017 20
2018 20
2019 26
2020 17
2021 18
2022 19
2023 23
2024 26
2025 33
2026 24

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612 results

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Page 1
Mammalian IRE1α dynamically and functionally coalesces with stress granules.
Liu S, Zhang X, Yao X, Wang G, Huang S, Chen P, Tang M, Cai J, Wu Z, Zhang Y, Xu R, Liu K, He K, Wang Y, Jiang L, Wang QA, Rui L, Liu J, Liu Y. Liu S, et al. Nat Cell Biol. 2024 Jun;26(6):917-931. doi: 10.1038/s41556-024-01418-7. Epub 2024 May 7. Nat Cell Biol. 2024. PMID: 38714852
Upon endoplasmic reticulum (ER) stress, activation of the ER-resident transmembrane protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) initiates a key branch of the unfolded protein response (UPR) through unconventional splicing generation of the tra …
Upon endoplasmic reticulum (ER) stress, activation of the ER-resident transmembrane protein kinase/endoribonuclease inositol-r …
The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy.
Deneubourg C, Ramm M, Smith LJ, Baron O, Singh K, Byrne SC, Duchen MR, Gautel M, Eskelinen EL, Fanto M, Jungbluth H. Deneubourg C, et al. Autophagy. 2022 Mar;18(3):496-517. doi: 10.1080/15548627.2021.1943177. Epub 2021 Aug 19. Autophagy. 2022. PMID: 34130600 Free PMC article.
Primary dysfunction of autophagy due to Mendelian defects affecting core components of the autophagy machinery or closely related proteins have recently emerged as an important cause of genetic disease. ...The close connection with adult-onset neurodegenerative disorders h …
Primary dysfunction of autophagy due to Mendelian defects affecting core components of the autophagy machinery or closely related pro …
ER-endosome contacts generate a local environment promoting phagophore formation.
Da Graça J, Thiola C, Rouabah M, Guerrera IC, El Khallouki N, Romao M, Alemany C, Amiri D, Dubois S, Srimoorthy A, Giordano F, Raposo G, Morel E. Da Graça J, et al. Cell Rep. 2025 Jul 22;44(7):115993. doi: 10.1016/j.celrep.2025.115993. Epub 2025 Jul 10. Cell Rep. 2025. PMID: 40644301 Free article.
Autophagy starts with the formation of a double-membrane vacuole called the autophagosome, initiated by a transient structure known as the phagophore. Previous studies reported that phagophore biogenesis primarily occurs at endoplasmic reticulum (ER) omegasom …
Autophagy starts with the formation of a double-membrane vacuole called the autophagosome, initiated by a transient structure known a …
Identification of two novel endoplasmic reticulum body-specific integral membrane proteins.
Yamada K, Nagano AJ, Nishina M, Hara-Nishimura I, Nishimura M. Yamada K, et al. Plant Physiol. 2013 Jan;161(1):108-20. doi: 10.1104/pp.112.207654. Epub 2012 Nov 19. Plant Physiol. 2013. PMID: 23166355 Free PMC article.
The endoplasmic reticulum (ER) body, a large compartment specific to the Brassicales, accumulates beta-glucosidase and possibly plays a role in the defense against pathogens and herbivores. Although the ER body is a subdomain of the ER, it is unclear whether any ER …
The endoplasmic reticulum (ER) body, a large compartment specific to the Brassicales, accumulates beta-glucosidase and possibl …
Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex.
Knight BC, High S. Knight BC, et al. Biochem J. 1998 Apr 1;331 ( Pt 1)(Pt 1):161-7. doi: 10.1042/bj3310161. Biochem J. 1998. PMID: 9512475 Free PMC article.
The Sec61 complex is a central component of the endoplasmic reticulum (ER) translocation site. The complex consists of three subunits: Sec61alpha, Sec61beta and Sec61gamma, at least two of which (alpha and beta) are adjacent to nascent proteins during memb …
The Sec61 complex is a central component of the endoplasmic reticulum (ER) translocation site. The complex consists of …
Co-chaperones of the mammalian endoplasmic reticulum.
Melnyk A, Rieger H, Zimmermann R. Melnyk A, et al. Subcell Biochem. 2015;78:179-200. doi: 10.1007/978-3-319-11731-7_9. Subcell Biochem. 2015. PMID: 25487022 Review.
In mammalian cells, the rough endoplasmic reticulum or ER plays a central role in the biogenesis of most extracellular plus many organellar proteins and in cellular calcium homeostasis. ...ER-membrane integrated as well as ER-lumenal Hsp40s, which are …
In mammalian cells, the rough endoplasmic reticulum or ER plays a central role in the biogenesis of most extracellular plus ma …
Calnexin: a membrane-bound chaperone of the endoplasmic reticulum.
Bergeron JJ, Brenner MB, Thomas DY, Williams DB. Bergeron JJ, et al. Trends Biochem Sci. 1994 Mar;19(3):124-8. doi: 10.1016/0968-0004(94)90205-4. Trends Biochem Sci. 1994. PMID: 8203019 Review.
Calnexin is a new type of molecular chaperone that interacts with many nascent membrane and soluble proteins of the secretory pathway. Calnexin is unrelated to molecular chaperones of the Hsp60, Hsp70 and Hsp90 families, and is further distinguished from them in that it is …
Calnexin is a new type of molecular chaperone that interacts with many nascent membrane and soluble proteins of the secretory pathway …
Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy.
Nakamura M. Nakamura M. J Pharm Pharm Sci. 2024 Apr 19;27:12568. doi: 10.3389/jpps.2024.12568. eCollection 2024. J Pharm Pharm Sci. 2024. PMID: 38706718 Free PMC article. Review.
Unhealthy sources of fats, ultra-processed foods with added sugars, and a sedentary lifestyle make humans more susceptible to developing overweight and obesity. While lipids constitute an integral component of the organism, excessive and abnormal lipid accumulation …
Unhealthy sources of fats, ultra-processed foods with added sugars, and a sedentary lifestyle make humans more susceptible to developing ove …
Endoplasmic Reticulum Stress and Obesity.
Yilmaz E. Yilmaz E. Adv Exp Med Biol. 2024;1460:373-390. doi: 10.1007/978-3-031-63657-8_13. Adv Exp Med Biol. 2024. PMID: 39287859 Review.
A shift in energy balance alters systemic metabolic regulation and the important role that chronic inflammation, endoplasmic reticulum (ER) dysfunction, and activation of the unfolded protein response (UPR) plays in this process.Why obesity is so closely associated …
A shift in energy balance alters systemic metabolic regulation and the important role that chronic inflammation, endoplasmic retic …
Regulation of protein biogenesis at the endoplasmic reticulum membrane.
Hegde RS, Lingappa VR. Hegde RS, et al. Trends Cell Biol. 1999 Apr;9(4):132-7. doi: 10.1016/s0962-8924(99)01504-4. Trends Cell Biol. 1999. PMID: 10203789 Review.
The biogenesis of most secretory and membrane proteins involves targeting the nascent protein to the endoplasmic reticulum (ER), translocation across or integration into the ER membrane and maturation into a functional product. The essential mac …
The biogenesis of most secretory and membrane proteins involves targeting the nascent protein to the endoplasmic reticulum …
612 results