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Detection of Alterations in the Gut Microbiota and Intestinal Permeability in Patients With Hashimoto Thyroiditis.
Cayres LCF, de Salis LVV, Rodrigues GSP, Lengert AVH, Biondi APC, Sargentini LDB, Brisotti JL, Gomes E, de Oliveira GLV. Cayres LCF, et al. Front Immunol. 2021 Mar 5;12:579140. doi: 10.3389/fimmu.2021.579140. eCollection 2021. Front Immunol. 2021. PMID: 33746942 Free PMC article.
Hashimoto thyroiditis (HT) is the most common autoimmune disease worldwide, characterized by chronic inflammation and circulating autoantibodies against thyroid peroxidase and thyroglobulin. Patients require hormone replacement with oral levothyroxine, and if untreated, th …
Hashimoto thyroiditis (HT) is the most common autoimmune disease worldwide, characterized by chronic inflammation and circulating aut …
Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?
Knezevic J, Starchl C, Tmava Berisha A, Amrein K. Knezevic J, et al. Nutrients. 2020 Jun 12;12(6):1769. doi: 10.3390/nu12061769. Nutrients. 2020. PMID: 32545596 Free PMC article. Review.
A healthy gut microbiota not only has beneficial effects on the activity of the immune system, but also on thyroid function. Thyroid and intestinal diseases prevalently coexist-Hashimoto's thyroiditis (HT) and Graves' disease (GD) are the most common a …
A healthy gut microbiota not only has beneficial effects on the activity of the immune system, but also on thyroid function. Thyroid …
Oral Exposure to Polystyrene Microplastics of Mice on a Normal or High-Fat Diet and Intestinal and Metabolic Outcomes.
Okamura T, Hamaguchi M, Hasegawa Y, Hashimoto Y, Majima S, Senmaru T, Ushigome E, Nakanishi N, Asano M, Yamazaki M, Sasano R, Nakanishi Y, Seno H, Takano H, Fukui M. Okamura T, et al. Environ Health Perspect. 2023 Feb;131(2):27006. doi: 10.1289/EHP11072. Epub 2023 Feb 22. Environ Health Perspect. 2023. PMID: 36821708 Free PMC article.
METHODS: C57BL6/J mice were fed a normal diet (ND) or HFD with or without polystyrene MP for 4 wk to investigate differences in glucose tolerance, intestinal permeability, gut microbiota, as well as metabolites in serum, feces, and liver. ...These findings suggest t …
METHODS: C57BL6/J mice were fed a normal diet (ND) or HFD with or without polystyrene MP for 4 wk to investigate differences in glucose tole …
Children with Hashimoto's Thyroiditis Have Increased Intestinal Permeability: Results of a Pilot Study.
Küçükemre Aydın B, Yıldız M, Akgün A, Topal N, Adal E, Önal H. Küçükemre Aydın B, et al. J Clin Res Pediatr Endocrinol. 2020 Sep 2;12(3):303-307. doi: 10.4274/jcrpe.galenos.2020.2019.0186. Epub 2020 Jan 28. J Clin Res Pediatr Endocrinol. 2020. PMID: 31990165 Free PMC article.
Increased intestinal permeability (IIP) precedes several autoimmune disorders. Although Hashimoto's thyroiditis (HT) is the most common autoimmune disorder, the role of IIP in its pathogenesis had received little attention. ...
Increased intestinal permeability (IIP) precedes several autoimmune disorders. Although Hashimoto's thyroiditis …
Intestinal gammadelta T17-IL-17A signaling disrupts hippocampal mitophagy in stress-induced depression and is restored by arketamine.
Han M, Xie B, Yu Y, Xu D, Shi Y, Xu M, Wu Y, Zhang Y, Wen X, Wang X, Zhen Z, Zhang X, Sun X, Yuan Y, Shang Y, Yuan S, Hashimoto K, Zhang J. Han M, et al. J Neuroinflammation. 2025 Dec 18;23(1):24. doi: 10.1186/s12974-025-03656-4. J Neuroinflammation. 2025. PMID: 41413564 Free PMC article.
We tested the hypothesis that stress-primed small intestinal gammadelta T cells drive hippocampal mitochondrial dysfunction and depression-like behavior via interleukin-17A (IL-1A). ...Kaede tracing confirmed an intestinal origin, and CRS-associated microbiota alone …
We tested the hypothesis that stress-primed small intestinal gammadelta T cells drive hippocampal mitochondrial dysfunction and depre …
Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption.
Yoshitomo A, Asano S, Hozuki S, Tamemoto Y, Shibata Y, Hashimoto N, Takahashi K, Sasaki Y, Ozawa N, Kageyama M, Iijima T, Kazuki Y, Sato H, Hisaka A. Yoshitomo A, et al. Drug Metab Dispos. 2023 Mar;51(3):318-328. doi: 10.1124/dmd.122.000907. Epub 2022 Dec 7. Drug Metab Dispos. 2023. PMID: 36810197
The membrane permeability ratios for B to A (R(BA)) and f(ent) varied by 8.8-fold and by more than 3000-fold, respectively, among the drugs. ...These parameters were used to predict overall intestinal availability (F(A)F(G)) by applying an intestinal pharmaco …
The membrane permeability ratios for B to A (R(BA)) and f(ent) varied by 8.8-fold and by more than 3000-fold, respectively, among the …
HLA-B27-associated gut microbiota and amino acid perturbations promote ankylosing spondylitis through M1 macrophage activation.
Huang T, Yang H, Zhang L, Wang X, Chen Y, Dai H, Hashimoto K, Luo Y, Pu Y, Liu Y. Huang T, et al. Gut Microbes. 2026 Dec 31;18(1):2630561. doi: 10.1080/19490976.2026.2630561. Epub 2026 Feb 16. Gut Microbes. 2026. PMID: 41698880 Free PMC article.
To explore causality, fecal microbiota transplantation (FMT) from clinical donors into antibiotic-treated mice recapitulated key disease-relevant features, including impaired intestinal barrier function, systemic inflammation, trabecular bone loss, and polari …
To explore causality, fecal microbiota transplantation (FMT) from clinical donors into antibiotic-treated mice recapitulated key disease-rel …
The impact of thyroid disorders on the gut microbiome: emerging mechanisms and clinical relevance.
Silva IB, Puig-Domingo M. Silva IB, et al. Arch Endocrinol Metab. 2025 Dec 3;70(Spe1):e250075. doi: 10.20945/2359-4292-2025-0075. Arch Endocrinol Metab. 2025. PMID: 41337660 Free PMC article. Review.
The thyroid-gut axis represents a dynamic interaction between the intestinal microbiota and thyroid function, with growing evidence linking gut dysbiosis to thyroid diseases. ...Alterations in gut microbiota composition have been associated with autoimmune thyroid d …
The thyroid-gut axis represents a dynamic interaction between the intestinal microbiota and thyroid function, with growing evi …
Reframing type 1 diabetes through the endocannabinoidome-microbiota axis: a systems biology perspective.
Łukowski W. Łukowski W. Front Endocrinol (Lausanne). 2025 May 29;16:1576419. doi: 10.3389/fendo.2025.1576419. eCollection 2025. Front Endocrinol (Lausanne). 2025. PMID: 40510476 Free PMC article. Review.
The proposed Endocannabinoidome-Microbiota (ECBoM) model highlights a shared hallmark of autoimmunity-SCFA depletion, increased intestinal permeability, and ECS dysregulation-as key drivers of chronic inflammation and immune dysfunction. These disturbances, observed …
The proposed Endocannabinoidome-Microbiota (ECBoM) model highlights a shared hallmark of autoimmunity-SCFA depletion, increased intestina …
Gut microbiota in hypothyroidism: pathogenic mechanisms and opportunities for precision microbiome interventions.
Jiang T, Yang X, Wu B, Tao R, Chen R, Jin L, Sun D, Weng H. Jiang T, et al. Front Microbiol. 2025 Oct 1;16:1661211. doi: 10.3389/fmicb.2025.1661211. eCollection 2025. Front Microbiol. 2025. PMID: 41103764 Free PMC article. Review.
Hypothyroidism is a common endocrine disorder characterized by insufficient thyroid hormone synthesis or secretion, most frequently caused by Hashimoto's thyroiditis, an autoimmune condition that leads to chronic thyroid gland damage. ...Recent studies indicate that …
Hypothyroidism is a common endocrine disorder characterized by insufficient thyroid hormone synthesis or secretion, most frequently caused b …
48 results