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Intranasal Insulin for Alzheimer's Disease.
Hallschmid M. Hallschmid M. CNS Drugs. 2021 Jan;35(1):21-37. doi: 10.1007/s40263-020-00781-x. Epub 2021 Jan 30. CNS Drugs. 2021. PMID: 33515428 Free PMC article. Review.
Brain insulin signaling contributes to memory function and might be a viable target in the prevention and treatment of memory impairments including Alzheimer's disease. ...Proof-of-concept studies and (pilot) clinical trials in individuals with mild co …
Brain insulin signaling contributes to memory function and might be a viable target in the prevention and treatment of memory impairm …
Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial.
Craft S, Raman R, Chow TW, Rafii MS, Sun CK, Rissman RA, Donohue MC, Brewer JB, Jenkins C, Harless K, Gessert D, Aisen PS. Craft S, et al. JAMA Neurol. 2020 Sep 1;77(9):1099-1109. doi: 10.1001/jamaneurol.2020.1840. JAMA Neurol. 2020. PMID: 32568367 Free PMC article. Clinical Trial.
IMPORTANCE: Insulin modulates aspects of brain function relevant to Alzheimer disease and can be delivered to the brain using intranasal devices. To date, the use of intranasal insulin to treat persons with mild cognitive impairment and …
IMPORTANCE: Insulin modulates aspects of brain function relevant to Alzheimer disease and can be delivered to the brain …
Intranasal insulin in Alzheimer's disease: Food for thought.
Chapman CD, Schiöth HB, Grillo CA, Benedict C. Chapman CD, et al. Neuropharmacology. 2018 Jul 1;136(Pt B):196-201. doi: 10.1016/j.neuropharm.2017.11.037. Epub 2017 Nov 24. Neuropharmacology. 2018. PMID: 29180222 Free article. Review.
Accumulating evidence suggests that disrupted brain insulin signaling promotes the development and progression of Alzheimer's disease (AD), driving clinicians to target this circuitry. ...However, there remain significant open questions regarding in
Accumulating evidence suggests that disrupted brain insulin signaling promotes the development and progression of Alzheimer' …
Intranasal insulin in Alzheimer's dementia or mild cognitive impairment: a systematic review.
Avgerinos KI, Kalaitzidis G, Malli A, Kalaitzoglou D, Myserlis PG, Lioutas VA. Avgerinos KI, et al. J Neurol. 2018 Jul;265(7):1497-1510. doi: 10.1007/s00415-018-8768-0. Epub 2018 Feb 1. J Neurol. 2018. PMID: 29392460 Free PMC article. Review.
BACKGROUND AND AIMS: Due to common pathophysiological findings of Alzheimer's disease (AD) with diabetes mellitus (DM), insulin has been suggested as a possible treatment of AD or mild cognitive impairment (MCI). A safe alternative of IV insulin
BACKGROUND AND AIMS: Due to common pathophysiological findings of Alzheimer's disease (AD) with diabetes mellitus (DM), …
Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial.
Craft S, Baker LD, Montine TJ, Minoshima S, Watson GS, Claxton A, Arbuckle M, Callaghan M, Tsai E, Plymate SR, Green PS, Leverenz J, Cross D, Gerton B. Craft S, et al. Arch Neurol. 2012 Jan;69(1):29-38. doi: 10.1001/archneurol.2011.233. Epub 2011 Sep 12. Arch Neurol. 2012. PMID: 21911655 Free PMC article. Clinical Trial.
OBJECTIVE: To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD). ...MAIN OUTCOME …
OBJECTIVE: To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, an …
Altered Insulin Signaling in Alzheimer's Disease Brain - Special Emphasis on PI3K-Akt Pathway.
Gabbouj S, Ryhänen S, Marttinen M, Wittrahm R, Takalo M, Kemppainen S, Martiskainen H, Tanila H, Haapasalo A, Hiltunen M, Natunen T. Gabbouj S, et al. Front Neurosci. 2019 Jun 18;13:629. doi: 10.3389/fnins.2019.00629. eCollection 2019. Front Neurosci. 2019. PMID: 31275108 Free PMC article. Review.
Alzheimer's disease (AD) and type 2 diabetes (T2D) are both diseases with increasing prevalence in aging populations. ...Interestingly, enhancement of PI3K-Akt signaling in the CNS by intranasal insulin (IN) treatment has been shown to improve m
Alzheimer's disease (AD) and type 2 diabetes (T2D) are both diseases with increasing prevalence in aging populations. .
Intranasal insulin.
Hallschmid M. Hallschmid M. J Neuroendocrinol. 2021 Apr;33(4):e12934. doi: 10.1111/jne.12934. Epub 2021 Jan 28. J Neuroendocrinol. 2021. PMID: 33506526 Review.
"Brain insulin resistance" is an evolving concept that posits impairments in central nervous insulin signalling as a pathophysiological factor in metabolic and cognitive disorders such as obesity, type 2 diabetes and Alzheimer's disease, and, no …
"Brain insulin resistance" is an evolving concept that posits impairments in central nervous insulin signalling as a pathophys …
Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence.
Freiherr J, Hallschmid M, Frey WH 2nd, Brünner YF, Chapman CD, Hölscher C, Craft S, De Felice FG, Benedict C. Freiherr J, et al. CNS Drugs. 2013 Jul;27(7):505-14. doi: 10.1007/s40263-013-0076-8. CNS Drugs. 2013. PMID: 23719722 Free PMC article. Review.
Research in animals and humans has associated Alzheimer's disease (AD) with decreased cerebrospinal fluid levels of insulin in combination with decreased insulin sensitivity (insulin resistance) in the brain. ...With this view in mind, th …
Research in animals and humans has associated Alzheimer's disease (AD) with decreased cerebrospinal fluid levels of …
Extracellular Vesicle Biomarkers Track Cognitive Changes Following Intranasal Insulin in Alzheimer's Disease.
Mustapic M, Tran J, Craft S, Kapogiannis D. Mustapic M, et al. J Alzheimers Dis. 2019;69(2):489-498. doi: 10.3233/JAD-180578. J Alzheimers Dis. 2019. PMID: 30958348 Free PMC article. Clinical Trial.
BACKGROUND: Insulin resistance is implicated in Alzheimer's disease (AD), whereas intranasal insulin is an experimental treatment in clinical trials. ...CONCLUSION: Neuronal EV biomarkers of insulin resistance (pS312-IRS-1, pY-IRS- …
BACKGROUND: Insulin resistance is implicated in Alzheimer's disease (AD), whereas intranasal insulin
Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease.
Kellar D, Lockhart SN, Aisen P, Raman R, Rissman RA, Brewer J, Craft S. Kellar D, et al. J Prev Alzheimers Dis. 2021;8(3):240-248. doi: 10.14283/jpad.2021.14. J Prev Alzheimers Dis. 2021. PMID: 34101779 Clinical Trial.
BACKGROUND: Intranasally administered insulin has shown promise in both rodent and human studies in Alzheimer's disease; however, both effects and mechanisms require elucidation. ...CONCLUSION: Intranasal insulin treatment for 12 m …
BACKGROUND: Intranasally administered insulin has shown promise in both rodent and human studies in Alzheimer's
170 results