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Did you mean intravenous and infusion clinical (55,081 results)?
NAD+ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence.
Gallagher C, Emmanuel OO. Gallagher C, et al. Ageing Res Rev. 2026 Apr;116:103057. doi: 10.1016/j.arr.2026.103057. Epub 2026 Feb 6. Ageing Res Rev. 2026. PMID: 41655607 Free article. Review.
An intravenous NAD+ pharmacokinetic pilot lacking eligible clinical outcomes was identified as contextual evidence only. Overall, NAD+ augmentation shows clear biological activity, but clinical effectiveness for anti-aging or wellness outcomes r …
An intravenous NAD+ pharmacokinetic pilot lacking eligible clinical outcomes was identified as contextual evidence only …
Intravenous infusion of nicotinamide adenine dinucleotide (NAD(+)) versus nicotinamide riboside (NR): a retrospective tolerability pilot study in a real-world setting.
Reyna K, Heinzen G, Patel N, Ritter M, Siojo A, Legere H, Pojednic R. Reyna K, et al. Front Aging. 2026 Feb 2;7:1652582. doi: 10.3389/fragi.2026.1652582. eCollection 2026. Front Aging. 2026. PMID: 41704678 Free PMC article.
Commercial clinical and wellness settings increasingly provide intravenous (IV) NAD(+) and nicotinamide riboside (NR) despite limited evaluation of safety and effectiveness. ...Participants receiving NR IV experienced minor tongue, jaw, and arm tingling and m …
Commercial clinical and wellness settings increasingly provide intravenous (IV) NAD(+) and nicotinamide riboside (NR) d …
A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD.
Grant R, Berg J, Mestayer R, Braidy N, Bennett J, Broom S, Watson J. Grant R, et al. Front Aging Neurosci. 2019 Sep 12;11:257. doi: 10.3389/fnagi.2019.00257. eCollection 2019. Front Aging Neurosci. 2019. PMID: 31572171 Free PMC article.
While studies have documented the efficacy of some NAD+ precursors such as nicotinamide riboside (NR) in raising plasma NAD+, no data are currently available on the fate of directly infused NAD+ in a human cohort. This study, therefore, documented chan …
While studies have documented the efficacy of some NAD+ precursors such as nicotinamide riboside (NR) in raising plasma NAD+, …
Tracing NAD(+) metabolism uncovers adaptive coordination between host and microbiome during colitis.
Alsaadi AI, Welz L, Pothakamury AA, Gilloteau C, Prasad P, Yahia MS, Sadler J, Smith JD, Jenkins BC, Diven GS, Bornhäuser J, Mekdoud T, Tian S, Rosenstiel P, Schreiber S, Bisanz JE, Aden K, McReynolds MR. Alsaadi AI, et al. Res Sq [Preprint]. 2025 Dec 4:rs.3.rs-8195970. doi: 10.21203/rs.3.rs-8195970/v1. Res Sq. 2025. PMID: 41377969 Free PMC article. Preprint.
Using multi-omics approaches and stable isotope-labeled NAD(+) precursors administered via intravenous infusion in a murine model of dextran sulfate sodium (DSS)-induced colitis, we mapped tissue- and lumen-specific NAD(+) metabolism under inflammatory …
Using multi-omics approaches and stable isotope-labeled NAD(+) precursors administered via intravenous infusion in a mu …
Solithromycin in Children and Adolescents With Community-acquired Bacterial Pneumonia.
Lang JE, Hornik CP, Elliott C, Silverstein A, Hornik C, Al-Uzri A, Bosheva M, Bradley JS, Borja-Tabora CFC, Di John D, Mendez Echevarria A, Ericson JE, Friedel D, Gonczi F, Isidro MGD, James LP, Kalocsai K, Koutroulis I, Laki I, Ong-Lim ALT, Nad M, Simon G, Syed S, Szabo E, Benjamin DK Jr, Cohen-Wolkowiez M; SOLI-PEDS Program. Lang JE, et al. Pediatr Infect Dis J. 2022 Jul 1;41(7):556-562. doi: 10.1097/INF.0000000000003559. Epub 2022 Jun 7. Pediatr Infect Dis J. 2022. PMID: 35675525 Free PMC article. Clinical Trial.
The proportion achieving clinical cure was 60% (95% CI, 47%-72%) and 68% (95% CI, 43%-87%) for the solithromycin and comparator groups, respectively. CONCLUSIONS: Intravenous and oral solithromycin were generally well-tolerated and associated with clinical im …
The proportion achieving clinical cure was 60% (95% CI, 47%-72%) and 68% (95% CI, 43%-87%) for the solithromycin and comparator group …
Treatment of Parkinson's disease with NADH.
Dizdar N, Kågedal B, Lindvall B. Dizdar N, et al. Acta Neurol Scand. 1994 Nov;90(5):345-7. doi: 10.1111/j.1600-0404.1994.tb02735.x. Acta Neurol Scand. 1994. PMID: 7887134 Clinical Trial.
This has to be verified by double-blind, clinical studies and measurement of biochemical effects of the treatment. In a double blind study five patients with clinically moderate Parkinson's disease were treated with NADH, 25 mg, given intravenously once a day …
This has to be verified by double-blind, clinical studies and measurement of biochemical effects of the treatment. In a double blind …
The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury.
Prins ML, Matsumoto JH. Prins ML, et al. J Lipid Res. 2014 Dec;55(12):2450-7. doi: 10.1194/jlr.R046706. Epub 2014 Apr 10. J Lipid Res. 2014. PMID: 24721741 Free PMC article. Review.
The postinjury period of glucose metabolic depression is accompanied by adenosine triphosphate decreases, increased flux of glucose through the pentose phosphate pathway, free radical production, activation of poly-ADP ribose polymerase via DNA damage, and inhibition of glycerald …
The postinjury period of glucose metabolic depression is accompanied by adenosine triphosphate decreases, increased flux of glucose through …
Renal haemodynamics and natriuretic responses to intravenous administration of diadenosine tetraphosphate (Ap4A) and nicotinamide adenine dinucleotide (NAD) in rat.
Szczepańska-Konkel M, Langner G, Bednarczuk G, Stiepanow-Trzeciak A, Jankowski M, Angielski S. Szczepańska-Konkel M, et al. J Physiol Pharmacol. 2003 Jun;54(2):163-73. J Physiol Pharmacol. 2003. PMID: 12832719 Free article.
Effects of Ap4A and NAD--precursor of adenosine, on renal plasma flow (RPF), glomerular filtration rate (GFR) and urine excretion were determined in the anaesthetised rats. Infusion of Ap4A or NAD (i.v., bolus--1 micromol/kg followed by 10 nmol/min/kg) decrea …
Effects of Ap4A and NAD--precursor of adenosine, on renal plasma flow (RPF), glomerular filtration rate (GFR) and urine excretion wer …
A Post Hoc Analysis of Older Patients with Metastatic Colorectal Cancer Receiving Oxaliplatin-Based Chemotherapy Plus Bevacizumab: The Randomized Obelics Study.
Rosati G, Piccirillo MC, Nasti G, De Stefano A, Carlomagno C, Romano C, Cassata A, Silvestro L, Nappi A, Perrone F, Budillon A, Avallone A. Rosati G, et al. Drugs Aging. 2025 Apr;42(4):353-362. doi: 10.1007/s40266-025-01191-8. Epub 2025 Mar 16. Drugs Aging. 2025. PMID: 40089969 Clinical Trial.
BACKGROUND: Phase II trials and subgroup analyses of clinical studies suggest that bevacizumab plus an oxaliplatin-based chemotherapy doublet is effective and tolerable in fit older patients with metastatic colorectal cancer (mCRC). ...They received bevacizumab 5 mg/kg adm …
BACKGROUND: Phase II trials and subgroup analyses of clinical studies suggest that bevacizumab plus an oxaliplatin-based chemotherapy …
35 results