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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1976 3
1980 2
1981 1
1983 1
1984 1
1985 5
1986 1
1987 2
1989 2
1990 1
1991 1
1992 4
1993 1
1995 5
1999 3
2001 2
2002 1
2004 3
2005 2
2006 5
2007 1
2008 2
2009 3
2011 6
2012 6
2013 12
2014 10
2015 4
2016 7
2017 3
2018 5
2019 5
2020 4
2021 2
2022 5
2023 2
2024 4
2025 4
2026 5

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124 results

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Page 1
Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities.
Huang B, Song BL, Xu C. Huang B, et al. Nat Metab. 2020 Feb;2(2):132-141. doi: 10.1038/s42255-020-0174-0. Epub 2020 Feb 10. Nat Metab. 2020. PMID: 32694690 Review.
Cholesterol metabolism produces essential membrane components as well as metabolites with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell-extrinsic cues reprogram cholesterol metabolism and consequently promote tumou …
Cholesterol metabolism produces essential membrane components as well as metabolites with a variety of biological functions. I …
Mammalian IRE1α dynamically and functionally coalesces with stress granules.
Liu S, Zhang X, Yao X, Wang G, Huang S, Chen P, Tang M, Cai J, Wu Z, Zhang Y, Xu R, Liu K, He K, Wang Y, Jiang L, Wang QA, Rui L, Liu J, Liu Y. Liu S, et al. Nat Cell Biol. 2024 Jun;26(6):917-931. doi: 10.1038/s41556-024-01418-7. Epub 2024 May 7. Nat Cell Biol. 2024. PMID: 38714852
Upon endoplasmic reticulum (ER) stress, activation of the ER-resident transmembrane protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) initiates a key branch of the unfolded protein response (UPR) through unconventional splicing generation of the tra …
Upon endoplasmic reticulum (ER) stress, activation of the ER-resident transmembrane protein kinase/endoribonuclease inositol-r …
Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases.
Di Rienzo M, Romagnoli A, Refolo G, Vescovo T, Ciccosanti F, Zuchegna C, Lozzi F, Occhigrossi L, Piacentini M, Fimia GM. Di Rienzo M, et al. Autophagy. 2024 Dec;20(12):2602-2615. doi: 10.1080/15548627.2024.2389474. Epub 2024 Sep 2. Autophagy. 2024. PMID: 39113560 Free PMC article. Review.
The molecular mechanisms that regulates mitophagy levels in aging remain largely uncharacterized. AMBRA1 is an intrinsically disordered scaffold protein with a unique property of regulating the activity of both proliferation and autophagy core machineries. ...Here we summa …
The molecular mechanisms that regulates mitophagy levels in aging remain largely uncharacterized. AMBRA1 is an intrinsically disorder …
Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions.
Zhao Y, Zhang T, Huo H, Ye Y, Liu Y. Zhao Y, et al. J Biol Chem. 2016 Aug 26;291(35):18252-62. doi: 10.1074/jbc.M116.737783. Epub 2016 Jul 7. J Biol Chem. 2016. PMID: 27387505 Free PMC article.
The endoplasmic reticulum (ER) network comprises sheets and tubules that are connected by dynamic three-way junctions. ...Accordingly, Lnp purified from mammalian cells has a ubiquitin ligase activity in vitro Intriguingly, biochemical analyses show that this activi …
The endoplasmic reticulum (ER) network comprises sheets and tubules that are connected by dynamic three-way junctions. ...Acco …
Regulation of Translation, Translocation, and Degradation of Proteins at the Membrane of the Endoplasmic Reticulum.
Daverkausen-Fischer L, Draga M, Pröls F. Daverkausen-Fischer L, et al. Int J Mol Sci. 2022 May 17;23(10):5576. doi: 10.3390/ijms23105576. Int J Mol Sci. 2022. PMID: 35628387 Free PMC article. Review.
The endoplasmic reticulum (ER) of mammalian cells is the central organelle for the maturation and folding of transmembrane proteins and for proteins destined to be secreted into the extracellular space. ...A variety of metabolic diseases are known to date, which are …
The endoplasmic reticulum (ER) of mammalian cells is the central organelle for the maturation and folding of transmembrane pro …
STRIPAK complexes: structure, biological function, and involvement in human diseases.
Hwang J, Pallas DC. Hwang J, et al. Int J Biochem Cell Biol. 2014 Feb;47:118-48. doi: 10.1016/j.biocel.2013.11.021. Epub 2013 Dec 11. Int J Biochem Cell Biol. 2014. PMID: 24333164 Free PMC article. Review.
The mammalian striatin family consists of three proteins, striatin, S/G2 nuclear autoantigen, and zinedin. Striatin family members have no intrinsic catalytic activity, but rather function as scaffolding proteins. Remarkably, they organize multiple diverse, large signaling …
The mammalian striatin family consists of three proteins, striatin, S/G2 nuclear autoantigen, and zinedin. Striatin family members have no …
TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit.
Roca FJ, Whitworth LJ, Redmond S, Jones AA, Ramakrishnan L. Roca FJ, et al. Cell. 2019 Sep 5;178(6):1344-1361.e11. doi: 10.1016/j.cell.2019.08.004. Epub 2019 Aug 29. Cell. 2019. PMID: 31474371 Free PMC article.
In zebrafish infected with Mycobacterium marinum or Mycobacterium tuberculosis, excess tumor necrosis factor triggers programmed necrosis of infected macrophages through the production of mitochondrial reactive oxygen species (ROS) and the participation of cyclophilin D, a com …
In zebrafish infected with Mycobacterium marinum or Mycobacterium tuberculosis, excess tumor necrosis factor triggers programmed necrosis of …
Dynamic phase microscopy reveals periodic oscillations of endoplasmic reticulum during network formation.
Vyshenskaya TV, Tychinsky VP, Weiss DG, Kuznetsov SA. Vyshenskaya TV, et al. Biochemistry (Mosc). 2014 Sep;79(9):907-16. doi: 10.1134/S0006297914090077. Biochemistry (Mosc). 2014. PMID: 25385018 Free article. Review.
Dynamic phase microscopy was used to study the dynamic events of formation of the endoplasmic reticulum (ER) in interphase-arrested Xenopus egg extract. We have shown that the ER periodically oscillated in an ATP-dependent manner in the frequency range of 1.6-2.2 Hz …
Dynamic phase microscopy was used to study the dynamic events of formation of the endoplasmic reticulum (ER) in interphase-arr …
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies.
Luo B, Lee AS. Luo B, et al. Oncogene. 2013 Feb 14;32(7):805-18. doi: 10.1038/onc.2012.130. Epub 2012 Apr 16. Oncogene. 2013. PMID: 22508478 Free PMC article. Review.
Cancer progression is characterized by rapidly proliferating cancer cells that are in need of increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is required to facilitate the folding, assembly and transportation of membrane a …
Cancer progression is characterized by rapidly proliferating cancer cells that are in need of increased protein synthesis. Therefore, enhanc …
TEX264 is a major receptor for mammalian reticulophagy.
Delorme-Axford E, Popelka H, Klionsky DJ. Delorme-Axford E, et al. Autophagy. 2019 Oct;15(10):1677-1681. doi: 10.1080/15548627.2019.1646540. Epub 2019 Jul 30. Autophagy. 2019. PMID: 31362563 Free PMC article.
The endoplasmic reticulum (ER) is the main site of cellular protein and calcium homeostasis, as well as lipid synthesis in eukaryotic cells. Reticulophagy is the selective clearance and degradation of ER components and membranes by the cellular autopha …
The endoplasmic reticulum (ER) is the main site of cellular protein and calcium homeostasis, as well as lipid synthesis in euk …
124 results