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10,603 results

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Page 1
The molecular basis for cellular function of intrinsically disordered protein regions.
Holehouse AS, Kragelund BB. Holehouse AS, et al. Nat Rev Mol Cell Biol. 2024 Mar;25(3):187-211. doi: 10.1038/s41580-023-00673-0. Epub 2023 Nov 13. Nat Rev Mol Cell Biol. 2024. PMID: 37957331 Free PMC article. Review.
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable 3D structure. ...Recent work has led to major advances in understanding the link between protein sequence and conformational beha …
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a sta …
Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
Chino H, Hatta T, Natsume T, Mizushima N. Chino H, et al. Mol Cell. 2019 Jun 6;74(5):909-921.e6. doi: 10.1016/j.molcel.2019.03.033. Epub 2019 Apr 18. Mol Cell. 2019. PMID: 31006538 Free article.
Certain proteins and organelles can be selectively degraded by autophagy. Typical substrates and receptors of selective autophagy have LC3-interacting regions (LIRs) that bind to autophagosomal LC3 and GABARAP family proteins. ...ER-phagy is profoundly blocked by de …
Certain proteins and organelles can be selectively degraded by autophagy. Typical substrates and receptors of selective autophagy hav …
Intrinsically disordered protein domains in flavivirus infection.
Martins IC, Santos NC. Martins IC, et al. Arch Biochem Biophys. 2020 Apr 15;683:108298. doi: 10.1016/j.abb.2020.108298. Epub 2020 Feb 8. Arch Biochem Biophys. 2020. PMID: 32045581 Review.
Intrinsically disordered protein regions are at the core of biological processes and involved in key protein-ligand interactions. ...This is the case of many viral protein regions, as seen in the flaviviruses proteome. Given their small size, fl …
Intrinsically disordered protein regions are at the core of biological processes and involved in key protein-lig …
Intrinsically disordered protein regions at membrane contact sites.
Jamecna D, Antonny B. Jamecna D, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Nov;1866(11):159020. doi: 10.1016/j.bbalip.2021.159020. Epub 2021 Aug 2. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 34352388 Review.
In this review, we discuss the various roles of intrinsically disordered protein regions (IDPRs) in LTPs as well as in other proteins that are associated with organelle contact sites. ...These functions are added to other functions of IDPRs in membrane …
In this review, we discuss the various roles of intrinsically disordered protein regions (IDPRs) in LTPs as well as in …
AlphaFold-Multimer accurately captures interactions and dynamics of intrinsically disordered protein regions.
Omidi A, Møller MH, Malhis N, Bui JM, Gsponer J. Omidi A, et al. Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2406407121. doi: 10.1073/pnas.2406407121. Epub 2024 Oct 24. Proc Natl Acad Sci U S A. 2024. PMID: 39446390 Free PMC article.
Interactions mediated by intrinsically disordered protein regions (IDRs) pose formidable challenges in structural characterization. ...Finally, our benchmarking revealed that predictions of IDR interactions can also be successful when using full-length pro …
Interactions mediated by intrinsically disordered protein regions (IDRs) pose formidable challenges in structural chara …
Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof.
Martin EW, Holehouse AS. Martin EW, et al. Emerg Top Life Sci. 2020 Dec 11;4(3):307-329. doi: 10.1042/ETLS20190164. Emerg Top Life Sci. 2020. PMID: 33078839 Review.
Intrinsically disordered protein regions (IDRs) - regions that do not fold into a fixed three-dimensional structure but instead exist in a heterogeneous ensemble of conformations - have recently entered mainstream cell biology in the context of liquid-liquid …
Intrinsically disordered protein regions (IDRs) - regions that do not fold into a fixed three-dimensional structure but …
Principles and Properties of Stress Granules.
Protter DSW, Parker R. Protter DSW, et al. Trends Cell Biol. 2016 Sep;26(9):668-679. doi: 10.1016/j.tcb.2016.05.004. Epub 2016 Jun 9. Trends Cell Biol. 2016. PMID: 27289443 Free PMC article. Review.
Stress granules form through interactions between mRNA-binding proteins that link together populations of mRNPs. Interactions promoting stress granule formation include conventional protein-protein interactions as well as interactions involving intrinsical …
Stress granules form through interactions between mRNA-binding proteins that link together populations of mRNPs. Interactions promoti …
Self-assembling systems comprising intrinsically disordered protein polymers like elastin-like recombinamers.
Juanes-Gusano D, Santos M, Reboto V, Alonso M, Rodríguez-Cabello JC. Juanes-Gusano D, et al. J Pept Sci. 2022 Jan;28(1):e3362. doi: 10.1002/psc.3362. Epub 2021 Sep 20. J Pept Sci. 2022. PMID: 34545666 Review.
Despite lacking cooperatively folded structures under native conditions, numerous intrinsically disordered proteins (IDPs) nevertheless have great functional importance. These IDPs are hybrids containing both ordered and intrinsically disordered …
Despite lacking cooperatively folded structures under native conditions, numerous intrinsically disordered proteins (ID …
Programmability and biomedical utility of intrinsically-disordered protein polymers.
Giraldo-Castaño MC, Littlejohn KA, Avecilla ARC, Barrera-Villamizar N, Quiroz FG. Giraldo-Castaño MC, et al. Adv Drug Deliv Rev. 2024 Sep;212:115418. doi: 10.1016/j.addr.2024.115418. Epub 2024 Jul 31. Adv Drug Deliv Rev. 2024. PMID: 39094909 Free PMC article. Review.
Intrinsically disordered proteins (IDPs) exhibit molecular-level conformational dynamics that are functionally harnessed across a wide range of fascinating biological phenomena. The low sequence complexity of IDPs has led to the design and development of i …
Intrinsically disordered proteins (IDPs) exhibit molecular-level conformational dynamics that are functionally harnesse …
Toward a high-resolution mechanism of intrinsically disordered protein self-assembly.
Sekiyama N, Kobayashi R, Kodama TS. Sekiyama N, et al. J Biochem. 2023 Oct 31;174(5):391-398. doi: 10.1093/jb/mvad056. J Biochem. 2023. PMID: 37488093 Review.
Membraneless organelles formed via the self-assembly of intrinsically disordered proteins (IDPs) play a crucial role in regulating various physiological functions. ...
Membraneless organelles formed via the self-assembly of intrinsically disordered proteins (IDPs) play a crucial role in …
10,603 results
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