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Effect of prebiotic fiber on physical function and gut microbiota in adults, mostly women, with knee osteoarthritis and obesity: a randomized controlled trial.
Fortuna R, Wang W, Mayengbam S, Tuplin EWN, Sampsell K, Sharkey KA, Hart DA, Reimer RA. Fortuna R, et al. Eur J Nutr. 2024 Sep;63(6):2149-2161. doi: 10.1007/s00394-024-03415-w. Epub 2024 May 7. Eur J Nutr. 2024. PMID: 38713231 Clinical Trial.
PURPOSE: Obesity is a primary risk factor for knee osteoarthritis (OA). Prebiotics enhance beneficial gut microbes and can reduce body fat and inflammation. ...CONCLUSION: Prebiotics may hold promise for conservative management of knee osteoarthritis in adults with …
PURPOSE: Obesity is a primary risk factor for knee osteoarthritis (OA). Prebiotics enhance beneficial gut microbes and can reduce bod …
Effect of Prebiotic Supplementation With and Without Physiotherapy on Pain and Pain Sensitivity in People with Knee Osteoarthritis.
Kouraki A, Franks S, Vijay A, Kurien T, Taylor MA, Smith SL, Smith B, Kelly A, Valdes AM. Kouraki A, et al. Nutrients. 2026 Feb 24;18(5):714. doi: 10.3390/nu18050714. Nutrients. 2026. PMID: 41829888 Free PMC article. Clinical Trial.
We evaluated the effects of inulin supplementation with and without PSE on knee osteoarthritis (OA) pain. Methods: In a 2 2 factorial RCT, 117 community-dwelling adults with knee OA received 6 weeks of: (A) 20 g/day inulin, (B) digital PSE (Joint Academy ), …
We evaluated the effects of inulin supplementation with and without PSE on knee osteoarthritis (OA) pain. Methods: In a 2 2 …
A new strategy for enhancing S-Adenosyl-L-Methionine (SAMe) oral bioavailability: Preparation of SAMe loaded inulin nanoparticles for colon targeting with in vivo validation.
Ergin AD, Bayindir ZS, Gumustas M, Ozcelikay AT, Yuksel N. Ergin AD, et al. Int J Biol Macromol. 2025 Feb;289:138818. doi: 10.1016/j.ijbiomac.2024.138818. Epub 2024 Dec 16. Int J Biol Macromol. 2025. PMID: 39694359
This study sought to improve SAMe's bioavailability by encapsulating it in inulin nanoparticles, utilizing a colon-targeted delivery system. Inulin, a prebiotic that promotes gut health by encouraging beneficial gut bacteria, is an ideal carrier for colon-specific d …
This study sought to improve SAMe's bioavailability by encapsulating it in inulin nanoparticles, utilizing a colon-targeted delivery …
Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial.
Fortuna R, Hart DA, Sharkey KA, Schachar RA, Johnston K, Reimer RA. Fortuna R, et al. Trials. 2021 Apr 7;22(1):255. doi: 10.1186/s13063-021-05212-w. Trials. 2021. PMID: 33827639 Free PMC article.
BACKGROUND: Osteoarthritis (OA) is a chronic and painful condition where the articular cartilage surfaces progressively degenerate, resulting in loss of function and progressive disability. ...METHODS: Adults (n = 60) with co-morbid obesity (BMI > 30 kg/m(2)) and knee O …
BACKGROUND: Osteoarthritis (OA) is a chronic and painful condition where the articular cartilage surfaces progressively degenerate, r …
Maternal Dietary Supplementation with Oligofructose-Enriched Inulin in Gestating/Lactating Rats Preserves Maternal Bone and Improves Bone Microarchitecture in Their Offspring.
Bueno-Vargas P, Manzano M, Diaz-Castro J, López-Aliaga I, Rueda R, López-Pedrosa JM. Bueno-Vargas P, et al. PLoS One. 2016 Apr 26;11(4):e0154120. doi: 10.1371/journal.pone.0154120. eCollection 2016. PLoS One. 2016. PMID: 27115490 Free PMC article.
This study was performed in rats to assess the relationship between maternal dietary intake of prebiotic oligofructose-enriched inulin and its role in bone turnover during gestation and lactation, as well as its effect on offspring peak bone mass/architecture during early …
This study was performed in rats to assess the relationship between maternal dietary intake of prebiotic oligofructose-enriched inulin
Comparative effects of nabumetone, sulindac, and ibuprofen on renal function.
Cook ME, Wallin JD, Thakur VD, Kadowitz PJ, McNamara DB, Garcia MM, Lipani JA, Poland M. Cook ME, et al. J Rheumatol. 1997 Jun;24(6):1137-44. J Rheumatol. 1997. PMID: 9195523 Clinical Trial.
METHODS: Seventeen women over age 56 receiving hydrochlorothiazide and fosinopril for hypertension who had osteoarthritis requiring NSAID received 3 different NSAID to evaluate potential varying renal effects. ...After each period renal function was assessed by inulin
METHODS: Seventeen women over age 56 receiving hydrochlorothiazide and fosinopril for hypertension who had osteoarthritis requiring N …
Evaluation of the renal protective effect of misoprostol in elderly, osteoarthritic patients at risk for nonsteroidal anti-inflammatory drug-induced renal dysfunction.
Fullerton T, Sica DA, Blum RA. Fullerton T, et al. J Clin Pharmacol. 1993 Dec;33(12):1225-32. doi: 10.1002/j.1552-4604.1993.tb03924.x. J Clin Pharmacol. 1993. PMID: 8126257 Clinical Trial.
Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) studies using inulin and PAH plasma clearance, urinary prostaglandin E2 (PGE2) and protein excretion, and serum electrolytes were obtained at baseline, after the first dose, and on day 7 and 14 of each …
Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) studies using inulin and PAH plasma clearance, urinary prosta …