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18 results

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Proteome reallocation enables the selective de novo biosynthesis of non-linear, branched-chain acetate esters.
Seo H, Giannone RJ, Yang YH, Trinh CT. Seo H, et al. Metab Eng. 2022 Sep;73:38-49. doi: 10.1016/j.ymben.2022.05.003. Epub 2022 May 11. Metab Eng. 2022. PMID: 35561848
By systematic manipulation of pathway gene replication and transcription, enzyme specificity of the first committed steps of these submodules, and downstream competing pathways, we demonstrated selective microbial production of isoamyl acetate over isobutyl acetate. We fou …
By systematic manipulation of pathway gene replication and transcription, enzyme specificity of the first committed steps of these submodule …
Pyruvate decarboxylase encoded by the PDC1 gene contributes, at least partially, to the decarboxylation of alpha-ketoisocaproate for isoamyl alcohol formation in Saccharomyces cerevisiae.
Yoshimoto H, Fukushige T, Yonezawa T, Sakai Y, Okawa K, Iwamatsu A, Sone H, Tamai Y. Yoshimoto H, et al. J Biosci Bioeng. 2001;92(1):83-5. doi: 10.1263/jbb.92.83. J Biosci Bioeng. 2001. PMID: 16233064
Isoamyl alcohol is an important flavor component of yeast-fermented alcoholic beverages. ...These results indicate that pyruvate decarboxylase encoded by the PDC1 gene contributes, at least partially, to the decarboxylation of alpha-KIC for isoamyl alcohol fo …
Isoamyl alcohol is an important flavor component of yeast-fermented alcoholic beverages. ...These results indicate that pyruvate …
Enhanced isoamyl acetate production upon manipulation of the acetyl-CoA node in Escherichia coli.
Vadali RV, Bennett GN, San KY. Vadali RV, et al. Biotechnol Prog. 2004 May-Jun;20(3):692-7. doi: 10.1021/bp034326y. Biotechnol Prog. 2004. PMID: 15176870
The acetyl-CoA levels also increased ( approximately 5-fold) but not as much as that of CoA, showing that the carbon flux from the pyruvate node is rate-limiting upon an increase in CoA levels. In this study, pyruvate dehydrogenase was overexpressed under elevated C …
The acetyl-CoA levels also increased ( approximately 5-fold) but not as much as that of CoA, showing that the carbon flux from the pyruva …
A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae.
Dickinson JR, Lanterman MM, Danner DJ, Pearson BM, Sanz P, Harrison SJ, Hewlins MJ. Dickinson JR, et al. J Biol Chem. 1997 Oct 24;272(43):26871-8. doi: 10.1074/jbc.272.43.26871. J Biol Chem. 1997. PMID: 9341119 Free article.
This pathway is not required for the synthesis of isoamyl alcohol because abolition of branched-chain alpha-keto acid dehydrogenase activity in an lpd1 disruption mutant did not prevent the formation of isoamyl alcohol. A second possible route was via pyru …
This pathway is not required for the synthesis of isoamyl alcohol because abolition of branched-chain alpha-keto acid dehydrog …
Microbial Community and Metabolite Dynamics During Soy Sauce Koji Making.
Tan G, Hu M, Li X, Li X, Pan Z, Li M, Li L, Wang Y, Zheng Z. Tan G, et al. Front Microbiol. 2022 Feb 25;13:841529. doi: 10.3389/fmicb.2022.841529. eCollection 2022. Front Microbiol. 2022. PMID: 35283863 Free PMC article.
Aspergillus (fungi) and Weissella (bacteria) exhibited marked abundance increases (0.98-38.45% and 0.31-30.41%, respectively) after 48 h of fermentation. Metabolite analysis revealed that aspartic acid, lysine, methyl acetate, isovaleraldehyde, and isoamyl alcohol c …
Aspergillus (fungi) and Weissella (bacteria) exhibited marked abundance increases (0.98-38.45% and 0.31-30.41%, respectively) after 48 h of …
Characterization of the flavor and nutritional value of coconut water vinegar based on metabolomics.
Xu S, Ma Z, Chen Y, Li J, Jiang H, Qu T, Zhang W, Li C, Liu S. Xu S, et al. Food Chem. 2022 Feb 1;369:130872. doi: 10.1016/j.foodchem.2021.130872. Epub 2021 Aug 16. Food Chem. 2022. PMID: 34455324
The compounds in fresh coconut water with high odor activity values (OAVs) were isovaleric acid and acetic acid, with pungent sour tastes. The compounds with high OAVs in aged coconut water vinegar were phenylethyl acetate, isoamyl acetate and benzaldehyde, w …
The compounds in fresh coconut water with high odor activity values (OAVs) were isovaleric acid and acetic acid, with pungent …
Transcriptional Profiling Reveals Adaptive Response and Tolerance to Lactic Acid Stress in Pichia kudriavzevii.
Du H, Fu Y, Deng N, Xu Y. Du H, et al. Foods. 2022 Sep 6;11(18):2725. doi: 10.3390/foods11182725. Foods. 2022. PMID: 36140854 Free PMC article.
In this study, the tolerance to lactic acid of P. kudriavzevii C-16, isolated from fermented grains, was compared with its type strain ATCC 24210. Under lactic acid stress, P. kudriavzevii C-16 showed increased biomass yields and lactic acid consumption rates …
In this study, the tolerance to lactic acid of P. kudriavzevii C-16, isolated from fermented grains, was compared with its type strai …
Branched-chain 2-keto acid decarboxylases derived from Psychrobacter.
Wei J, Timler JG, Knutson CM, Barney BM. Wei J, et al. FEMS Microbiol Lett. 2013 Sep;346(2):105-12. doi: 10.1111/1574-6968.12208. Epub 2013 Aug 12. FEMS Microbiol Lett. 2013. PMID: 23826991
The conversion of branched-chain amino acids to branched-chain acids or alcohols is an important aspect of flavor in the food industry and is dependent on the Ehrlich pathway found in certain lactic acid bacteria. A key enzyme in the pathway, the 2-keto acid decarbo …
The conversion of branched-chain amino acids to branched-chain acids or alcohols is an important aspect of flavor in the food industry and i …
Analysis of the Formation of Characteristic Aroma Compounds by Amino Acid Metabolic Pathways during Fermentation with Saccharomyces cerevisiae.
Lu X, Yang C, Yang Y, Peng B. Lu X, et al. Molecules. 2023 Mar 30;28(7):3100. doi: 10.3390/molecules28073100. Molecules. 2023. PMID: 37049863 Free PMC article.
Aroma compounds, pyruvic acid and glucose were monitored in relation to the key enzymes of leucine aminotransferase (LTR), phenylalanine aminotransferase (PAL), pyruvate kinase (PK) and acetyl-CoA in the amino acid metabolic pathways during the ferment …
Aroma compounds, pyruvic acid and glucose were monitored in relation to the key enzymes of leucine aminotransferase (LTR), phe …
Metabolic engineering of the anaerobic central metabolic pathway in Escherichia coli for the simultaneous anaerobic production of isoamyl acetate and succinic acid.
Dittrich CR, Bennett GN, San KY. Dittrich CR, et al. Biotechnol Prog. 2009 Sep-Oct;25(5):1304-9. doi: 10.1002/btpr.222. Biotechnol Prog. 2009. PMID: 19774663
The triple mutant SBS990MG was found to produce higher levels of both isoamyl acetate and succinate. At the optimal condition of 25 degrees C, the culture produced 9.4 mM isoamyl acetate and 45.5 mM succinate. ...In addition, this study demonstrated that a significa …
The triple mutant SBS990MG was found to produce higher levels of both isoamyl acetate and succinate. At the optimal condition of 25 d …
18 results