Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1968 2
1969 1
1970 1
1971 2
1973 3
1974 3
1975 3
1976 6
1977 3
1978 9
1979 11
1980 5
1981 9
1982 6
1983 4
1984 2
1985 5
1986 4
1987 5
1988 3
1989 1
1990 7
1991 7
1992 5
1993 5
1994 5
1995 4
1996 8
1997 7
1998 8
1999 5
2000 7
2001 7
2002 9
2003 12
2004 9
2005 8
2006 12
2007 9
2008 13
2009 7
2010 14
2011 18
2012 18
2013 19
2014 16
2015 17
2016 21
2017 18
2018 26
2019 25
2020 40
2021 37
2022 55
2023 45
2024 49
2025 42
2026 32

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

674 results

Results by year

Filters applied: . Clear all
Page 1
Branched Chain Amino Acids: Beyond Nutrition Metabolism.
Nie C, He T, Zhang W, Zhang G, Ma X. Nie C, et al. Int J Mol Sci. 2018 Mar 23;19(4):954. doi: 10.3390/ijms19040954. Int J Mol Sci. 2018. PMID: 29570613 Free PMC article. Review.
Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut health, immunity and disease in humans and animals. ...Current evidence supports B …
Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), play critical roles in the regulatio …
How important are fatty acids in human health and can they be used in treating diseases?
Dicks LMT. Dicks LMT. Gut Microbes. 2024 Jan-Dec;16(1):2420765. doi: 10.1080/19490976.2024.2420765. Epub 2024 Oct 27. Gut Microbes. 2024. PMID: 39462280 Free PMC article. Review.
Low levels of SCFAs are associated with hypertension, cardiovascular disease (CVD), strokes, obesity, and diabetes mellitus. Cis-palmitoleic acid (C(16)H(30)O(2)), a mono-unsaturated fatty acid (MUFA), increases insulin sensitivity and reduces the risk of developing …
Low levels of SCFAs are associated with hypertension, cardiovascular disease (CVD), strokes, obesity, and diabetes mellitus. C …
Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation.
Li Y, Xiong Z, Yan W, Gao E, Cheng H, Wu G, Liu Y, Zhang L, Li C, Wang S, Fan M, Zhao H, Zhang F, Tao L. Li Y, et al. Theranostics. 2020 Apr 27;10(12):5623-5640. doi: 10.7150/thno.44836. eCollection 2020. Theranostics. 2020. PMID: 32373236 Free PMC article.
Branched chain amino acids (BCAA), consisting of valine, leucine and isoleucine, are a group of essential amino acids that are highly oxidized in the heart. Elevated levels of BCAA have been implicated in the development of cardiovascular diseases; however, t …
Branched chain amino acids (BCAA), consisting of valine, leucine and isoleucine, are a group of essential amino acids that are highly …
Blood metabolome of cardiovascular disease, diabetic kidney disease, and diabetic retinopathy in type 2 diabetes patients: A systematic review and meta-analysis.
Kuo S, Li D, Wargny M, Yoshida T, Yoshida Y. Kuo S, et al. Endocr Res. 2025 Nov;50(4):244-270. doi: 10.1080/07435800.2025.2545832. Epub 2025 Aug 20. Endocr Res. 2025. PMID: 40835231 Free PMC article.
Studies assessing the association between circulating metabolites and CVD, including coronary heart disease, strokes, heart failure, CV death, DKD, and DR in T2D were eligible for review. ...These include TMAO (OR 1.1, 95% confidence interval (CI) 0.91-1.3) and derivatives …
Studies assessing the association between circulating metabolites and CVD, including coronary heart disease, strokes, heart failure, …
Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets.
Xu Y, Jiang H, Li L, Chen F, Liu Y, Zhou M, Wang J, Jiang J, Li X, Fan X, Zhang L, Zhang J, Qiu J, Wu Y, Fang C, Sun H, Liu J. Xu Y, et al. Circulation. 2020 Jul 7;142(1):49-64. doi: 10.1161/CIRCULATIONAHA.119.043581. Epub 2020 Mar 23. Circulation. 2020. PMID: 32200651
BACKGROUND: Branched-chain amino acids (BCAAs), essential nutrients including leucine, isoleucine, and valine, serve as a resource for energy production and the regulator of important nutrient and metabolic signals. Recent studies have suggested that dysfunction of BCAA ca …
BACKGROUND: Branched-chain amino acids (BCAAs), essential nutrients including leucine, isoleucine, and valine, serve as a resource fo …
Association of circulating branched-chain amino acids with risk of cardiovascular disease: A systematic review and meta-analysis.
Wang Y, Huang K, Liu F, Lu X, Huang J, Gu D. Wang Y, et al. Atherosclerosis. 2022 Jun;350:90-96. doi: 10.1016/j.atherosclerosis.2022.04.026. Epub 2022 Apr 25. Atherosclerosis. 2022. PMID: 35576716
BACKGROUND AND AIMS: We conducted a systematic review with meta-analysis of non-prospective and prospective clinical studies to assess the effects of circulating branched-chain amino acids (BCAA), including Isoleucine, Valine and Leucine, on cardiovascular diseas …
BACKGROUND AND AIMS: We conducted a systematic review with meta-analysis of non-prospective and prospective clinical studies to assess the e …
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging.
Yeh CY, Chini LCS, Davidson JW, Garcia GG, Gallagher MS, Freichels IT, Calubag MF, Rodgers AC, Green CL, Babygirija R, Sonsalla MM, Pak HH, Trautman ME, Hacker TA, Miller RA, Simcox JA, Lamming DW. Yeh CY, et al. Nat Aging. 2024 Dec;4(12):1760-1771. doi: 10.1038/s43587-024-00744-7. Epub 2024 Nov 27. Nat Aging. 2024. PMID: 39604703 Free PMC article.
Restricting the intake of protein or the branched-chain amino acid isoleucine promotes healthspan and extends lifespan in young or adult mice. However, their effects when initiated in aged animals are unknown. Here we investigate the consequences of consuming a diet with 6 …
Restricting the intake of protein or the branched-chain amino acid isoleucine promotes healthspan and extends lifespan in young or ad …
Metabolic annotation of 2-ethylhydracrylic acid.
Ryan RO. Ryan RO. Clin Chim Acta. 2015 Aug 25;448:91-7. doi: 10.1016/j.cca.2015.06.012. Epub 2015 Jun 23. Clin Chim Acta. 2015. PMID: 26115894 Free PMC article. Review.
Increased levels of the organic acid, 2-ethylhydracrylic acid (2-EHA) occur in urine of subjects with impaired L(+)-isoleucine metabolism. Chiral intermediates formed during isoleucine degradation are (S) enantiomers. ...In these cases, a block in (S) pathway iso …
Increased levels of the organic acid, 2-ethylhydracrylic acid (2-EHA) occur in urine of subjects with impaired L(+)-isoleucine metabo …
BCAA Metabolic Dyshomeostasis in Cardiovascular Disease: Pathogenic Mechanisms and Intervention.
Yin Y, Li H, Hu Q, Wu D. Yin Y, et al. Am J Cardiovasc Drugs. 2026 Mar;26(2):179-191. doi: 10.1007/s40256-025-00775-4. Epub 2025 Nov 5. Am J Cardiovasc Drugs. 2026. PMID: 41193903 Review.
Branched-chain amino acids (BCAAs), comprising leucine, isoleucine, and valine, are essential nutrients whose metabolic homeostasis is critical to cardiovascular health. ...We highlight the regulatory impact of BCAAs and their metabolites on cardiovascular …
Branched-chain amino acids (BCAAs), comprising leucine, isoleucine, and valine, are essential nutrients whose metabolic homeostasis i …
Effects of serum branched-chain amino acids on nonalcoholic fatty liver disease and subsequent cardiovascular disease.
Guo F, Chen R, Kong L, Wei P, Liu Z, Wang X, Hao H, Lu Y, Hu W. Guo F, et al. Hepatol Int. 2022 Dec;16(6):1424-1434. doi: 10.1007/s12072-022-10387-8. Epub 2022 Jul 18. Hepatol Int. 2022. PMID: 35849258
BACKGROUND: To reveal the role of branched-chain amino acids (BCAAs) in the development and progression of nonalcoholic fatty liver disease (NAFLD) and the effect on the incidence of subsequent cardiovascular disease. METHODS: A total of 1302 subjects in the …
BACKGROUND: To reveal the role of branched-chain amino acids (BCAAs) in the development and progression of nonalcoholic fatty liver disea …
674 results