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The following term was not found in PubMed: accutan
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Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice.
Li T, Lu D, Yao C, Li T, Dong H, Li Z, Xu G, Chen J, Zhang H, Yi X, Zhu H, Liu G, Wen K, Zhao H, Gao J, Zhang Y, Han Q, Li T, Zhang W, Zhao J, Li T, Bai Z, Song M, He X, Zhou T, Xia Q, Li A, Pan X. Li T, et al. Nat Commun. 2022 Feb 17;13(1):931. doi: 10.1038/s41467-022-28613-0. Nat Commun. 2022. PMID: 35177641 Free PMC article.
Kansl1(+/-) mice exhibit impairment in the autophagic clearance of damaged mitochondria and accumulation of reactive oxygen species, thereby resulting in defective neuronal and cardiac functions. ...
Kansl1(+/-) mice exhibit impairment in the autophagic clearance of damaged mitochondria and accumulation of reactive oxygen species, …
The antiestrogen 4-hydroxytamoxifen protects against isotretinoin-induced permeability transition and bioenergetic dysfunction of liver mitochondria: comparison with tamoxifen.
Silva FS, Ribeiro MP, Santos MS, Rocha-Pereira P, Santos-Silva A, Custódio JB. Silva FS, et al. J Bioenerg Biomembr. 2013 Aug;45(4):383-96. doi: 10.1007/s10863-013-9517-9. Epub 2013 Jun 19. J Bioenerg Biomembr. 2013. PMID: 23779226
Isotretinoin (5 nmol/mg protein) induced the Ca2+-dependent MPT pore opening in mitochondria energized with succinate, which was prevented by OHTAM, cyclosporine A, TAM and ANT ligands. When mitochondria were energized with glutamate/malate and in the absence …
Isotretinoin (5 nmol/mg protein) induced the Ca2+-dependent MPT pore opening in mitochondria energized with succinate, which w …
Safety of isotretinoin treatment as measured by liver parameters.
Thomazini BF, Lamas CA, Dolder MAH. Thomazini BF, et al. Histol Histopathol. 2019 Jul;34(7):755-763. doi: 10.14670/HH-18-075. Epub 2018 Dec 17. Histol Histopathol. 2019. PMID: 30556579
Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands it is often prescribed in cases of severe acne treatment. ...So, we confirm that the proposed protocol with 1mg/kg or 10 mg/kg isotretinoin did not cause important biochemical and histo …
Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands it is often prescribed in cases of severe acne treat …
Mitochondrial permeability transition and release of cytochrome c induced by retinoic acids.
Rigobello MP, Scutari G, Friso A, Barzon E, Artusi S, Bindoli A. Rigobello MP, et al. Biochem Pharmacol. 1999 Aug 15;58(4):665-70. doi: 10.1016/s0006-2952(99)00149-5. Biochem Pharmacol. 1999. PMID: 10413304
The effects of all-trans, 9-cis, and 13-cis retinoic acids were tested on mitochondria isolated from rat liver. All the compounds were able to induce the membrane permeability transition observed as swelling and decrease in membrane potential, but 13-cis retinoic acid appe …
The effects of all-trans, 9-cis, and 13-cis retinoic acids were tested on mitochondria isolated from rat liver. All the compounds wer …
Molecular mechanisms of the combination of retinoid and interferon-gamma for inducing differentiation and increasing apoptosis in human glioblastoma T98G and U87MG cells.
Das A, Banik NL, Ray SK. Das A, et al. Neurochem Res. 2009 Jan;34(1):87-101. doi: 10.1007/s11064-008-9669-x. Epub 2008 Mar 27. Neurochem Res. 2009. PMID: 18368485
Also, IFN-gamma activated caspase-8 and cleaved Bid to truncated Bid (tBid) for translocation to mitochondria. Fura-2 assay showed increases in intracellular free [Ca2+] and activation of calpain in apoptotic cells. ...
Also, IFN-gamma activated caspase-8 and cleaved Bid to truncated Bid (tBid) for translocation to mitochondria. Fura-2 assay showed in …
In vitro effects of 13-cis-retinoic acid (Ro 4-3780) and etretinate (Ro 10-9359) on DNA synthesis and fine structure of guinea pig and human lymphoid cells.
Nordlind K, Thyberg J. Nordlind K, et al. Int Arch Allergy Appl Immunol. 1983;71(4):363-7. doi: 10.1159/000233421. Int Arch Allergy Appl Immunol. 1983. PMID: 6574993
Electron microscopically, the cells exhibited swollen Golgi cisternae, enlarged mitochondria often with condensed matrix, and an increased number of autophagic vacuoles. ...
Electron microscopically, the cells exhibited swollen Golgi cisternae, enlarged mitochondria often with condensed matrix, and an incr …