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Uremic pruritus.
Mettang T, Kremer AE. Mettang T, et al. Kidney Int. 2015 Apr;87(4):685-91. doi: 10.1038/ki.2013.454. Epub 2014 Jan 8. Kidney Int. 2015. PMID: 24402092 Free article. Review.
Uremic pruritus or chronic kidney disease-associated pruritus (CKD-aP) remains a frequent and compromising symptom in patients with advanced or end-stage renal disease, strongly reducing the patient's quality of life. More than 40% of patients undergoing hemo …
Uremic pruritus or chronic kidney disease-associated pruritus (CKD-aP) remains a frequent and compromising symptom in p …
Chronic Kidney Disease-Associated Pruritus: A Review.
Makar M, Smyth B, Brennan F. Makar M, et al. Kidney Blood Press Res. 2021;46(6):659-669. doi: 10.1159/000518391. Epub 2021 Sep 7. Kidney Blood Press Res. 2021. PMID: 34515143 Free article. Review.
BACKGROUND: Chronic kidney disease-associated pruritus (CKD-aP), also known as uraemic pruritus, is a disabling symptom for patients and a challenging condition for clinicians. ...The exact pathogenesis remains largely elusive, which hampers the synthesis of …
BACKGROUND: Chronic kidney disease-associated pruritus (CKD-aP), also known as uraemic pruritus, is a disabling symptom …
Nouvelles thérapies dans la prise en charge du patient avec maladie rénale chronique souffrant de prurit : une revue de la littérature New therapies in the management of chronic kidney disease associated pruritus.
Azancot S, Ureña-Torres P, Chazot C, Touzot M. Azancot S, et al. Nephrol Ther. 2022 Dec;18(6S1):6S11-6S16. doi: 10.1016/S1769-7255(22)00648-4. Nephrol Ther. 2022. PMID: 36585120 Review. French.
Chronic Kidney Disease associated Pruritus (CKD-aP) is a well-established and frequent complication observed in patient with CKD, especially in dialysis patients. ...This general review will summarize all the available treatments for the CKD-aP and wil …
Chronic Kidney Disease associated Pruritus (CKD-aP) is a well-established and frequent complication observed in patient with …
Difelikefalin: First Approval.
Deeks ED. Deeks ED. Drugs. 2021 Nov;81(16):1937-1944. doi: 10.1007/s40265-021-01619-6. Drugs. 2021. PMID: 34674115 Review.
Difelikefalin (Korsuva( )) is a synthetic peptide agonist of the kappa opioid receptor being developed by Cara Therapeutics for the treatment of pruritus. In August 2021, intravenous difelikefalin was approved in the USA for the treatment of moderate-to-severe pr …
Difelikefalin (Korsuva( )) is a synthetic peptide agonist of the kappa opioid receptor being developed by Cara Therapeutics for the t …
Pharmacological interventions for pruritus in adult palliative care patients.
Boehlke C, Joos L, Coune B, Becker C, Meerpohl JJ, Buroh S, Hercz D, Schwarzer G, Becker G. Boehlke C, et al. Cochrane Database Syst Rev. 2023 Apr 14;4(2023):CD008320. doi: 10.1002/14651858.CD008320.pub4. Cochrane Database Syst Rev. 2023. PMID: 37314034 Free PMC article.
For participants suffering from uraemic pruritus (UP; also known as chronic kidney disease (CKD)-associated pruritus (CKD-aP)), treatment with GABA-analogues compared to placebo likely resulted in a large reduction of pruritus (visual analogue s …
For participants suffering from uraemic pruritus (UP; also known as chronic kidney disease (CKD)-associated pruritus ( …
Efficacy and safety of anrikefon in patients with pruritus undergoing haemodialysis: multicentre, double blind, randomised placebo controlled phase 3 trial.
Liu BC, Li ZL, Zhang P, Zhong AM, Bai YL, Xu Y, Gao BH, Li YL, Wang Y, Zhou LH, Yao L, Wang JX, Yan R, Wang L, Liao B, Xie DQ, Yi XM, Guan TJ, Wang CL, Li GS, Li FQ, Chen JH; Anrikefon-302 study collaborator group. Liu BC, et al. BMJ. 2025 Aug 19;390:e085208. doi: 10.1136/bmj-2025-085208. BMJ. 2025. PMID: 40829896 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the efficacy and safety of anrikefon (formerly known as HSK21542), a novel selective peripherally restricted kappa opioid receptor agonist, in patients with chronic kidney disease associated pruritus. DESIGN: Multicentre, double blind, randomi …
OBJECTIVE: To evaluate the efficacy and safety of anrikefon (formerly known as HSK21542), a novel selective peripherally restricted kappa op …
Nemolizumab for chronic pruritus beyond atopic dermatitis and prurigo nodularis: a systematic review and synthesis of emerging evidence.
Shanshal M, Uthayakumar A. Shanshal M, et al. J Dermatolog Treat. 2026 Dec;37(1):2612882. doi: 10.1080/09546634.2026.2612882. Epub 2026 Jan 8. J Dermatolog Treat. 2026. PMID: 41504136 Free article.
BACKGROUND: Nemolizumab, an anti-IL-31 receptor A antibody, is licensed for atopic dermatitis and prurigo nodularis; its role in other chronic pruritus (CP) syndromes is uncertain. ...Across indications, nemolizumab was well tolerated, but certainty was low for C …
BACKGROUND: Nemolizumab, an anti-IL-31 receptor A antibody, is licensed for atopic dermatitis and prurigo nodularis; its role in othe …
Randomized controlled trial of nalfurafine for refractory pruritus in hemodialysis patients.
Zhang P, Xiang S, Liu B, Wang X, Yang X, Ye C, Wang Z, Li Y, Zhou L, Wang C, Li H, Huang J, Peng A, Wang X, Wang D, Xiao J, Chen W, Cheng H, Mao N, Wang J, Yang L, Chen J. Zhang P, et al. Ren Fail. 2023 Dec;45(1):2175590. doi: 10.1080/0886022X.2023.2175590. Ren Fail. 2023. PMID: 36856148 Free PMC article. Clinical Trial.
Background: Chronic kidney disease-associated pruritus (CKD-aP) is very common and sometimes refractory to treatment in hemodialysis patients. In a trial conducted in Japan, nalfurafine, effectively reduced itching of treatment-resistant CKD-aP. Our present b …
Background: Chronic kidney disease-associated pruritus (CKD-aP) is very common and sometimes refractory to treatment in hemodi …
Pruritus in Uremic Patients: Approaches to Alleviating a Common Symptom in Chronic Kidney Disease.
Cîrstea Ș, Orzan OA, Zilișteanu DS. Cîrstea Ș, et al. Life (Basel). 2025 Jun 24;15(7):1001. doi: 10.3390/life15071001. Life (Basel). 2025. PMID: 40724504 Free PMC article. Review.
Chronic kidney disease-associated pruritus (CKD-aP) is a distressing symptom that affects both dialysis and non-dialysis patients, significantly impairing their quality of life. ...By integrating new pharmacologic and nonpharmacologic options, CKD-aP manageme …
Chronic kidney disease-associated pruritus (CKD-aP) is a distressing symptom that affects both dialysis and non-dialysis patie …
Chronic kidney disease and itch.
Azimi SZ, Lerner EA. Azimi SZ, et al. Itch (Phila). 2024 Jul-Sep;9(3):e0076. doi: 10.1097/itx.0000000000000076. Epub 2024 Sep 20. Itch (Phila). 2024. PMID: 41450907 Free PMC article.
Chronic kidney disease-associated pruritus (CKD-aP) is a prevalent and challenging symptom in patients with CKD and end-stage renal disease (ESRD). ...A developing area is that altered hemoglobin metabolism may lead to the activation of mas-related G protein- …
Chronic kidney disease-associated pruritus (CKD-aP) is a prevalent and challenging symptom in patients with CKD and end …
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