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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 3
1988 5
1989 7
1990 8
1991 7
1992 12
1993 16
1994 18
1995 26
1996 25
1997 21
1998 24
1999 33
2000 30
2001 47
2002 33
2003 50
2004 33
2005 36
2006 40
2007 38
2008 43
2009 36
2010 45
2011 42
2012 40
2013 40
2014 57
2015 59
2016 50
2017 56
2018 56
2019 54
2020 54
2021 52
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1,080 results
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Page 1
Itraconazole exerts anti-liver cancer potential through the Wnt, PI3K/AKT/mTOR, and ROS pathways.
Wang W, Dong X, Liu Y, Ni B, Sai N, You L, Sun M, Yao Y, Qu C, Yin X, Ni J. Wang W, et al. Biomed Pharmacother. 2020 Nov;131:110661. doi: 10.1016/j.biopha.2020.110661. Epub 2020 Sep 14. Biomed Pharmacother. 2020. PMID: 32942154 Free article.
However, so far, it is not clear whether itraconazole has specific anti-tumor effect on liver cancer. The purpose of this study was to investigate itraconazole resistant effect of liver cancer and to explore its potential anti-cancer mechanism. …
However, so far, it is not clear whether itraconazole has specific anti-tumor effect on liver cancer. The purpose of this stud …
"Hedgehog pathway": a potential target of itraconazole in the treatment of cancer.
Wei X, Liu W, Wang JQ, Tang Z. Wei X, et al. J Cancer Res Clin Oncol. 2020 Feb;146(2):297-304. doi: 10.1007/s00432-019-03117-5. Epub 2020 Jan 20. J Cancer Res Clin Oncol. 2020. PMID: 31960187 Review.
Moreover, its mechanism has been clarified to some degree. What deserves to be mentioned is that itraconazole acting on the Hedgehog pathway has made a new progress in the treatment of cancers. ...In any case, an in-depth study on itraconazole will bring new …
Moreover, its mechanism has been clarified to some degree. What deserves to be mentioned is that itraconazole acting on the Hedgehog …
Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.
Cornely OA, Maertens J, Winston DJ, Perfect J, Ullmann AJ, Walsh TJ, Helfgott D, Holowiecki J, Stockelberg D, Goh YT, Petrini M, Hardalo C, Suresh R, Angulo-Gonzalez D. Cornely OA, et al. N Engl J Med. 2007 Jan 25;356(4):348-59. doi: 10.1056/NEJMoa061094. N Engl J Med. 2007. PMID: 17251531 Free article. Clinical Trial.
RESULTS: A total of 304 patients were randomly assigned to receive posaconazole, and 298 patients were randomly assigned to receive fluconazole (240) or itraconazole (58). Proven or probable invasive fungal infections were reported in 7 patients (2%) in the posaconazole gr …
RESULTS: A total of 304 patients were randomly assigned to receive posaconazole, and 298 patients were randomly assigned to receive fluconaz …
Anti-fungal drug itraconazole exerts anti-cancer effects in oral squamous cell carcinoma via suppressing Hedgehog pathway.
Ban L, Mei T, Su Q, Li W, Huang Z, Liu L, Wu Y, Lv S, Wang A, Li S. Ban L, et al. Life Sci. 2020 Aug 1;254:117695. doi: 10.1016/j.lfs.2020.117695. Epub 2020 May 11. Life Sci. 2020. PMID: 32407849
MATERIALS AND METHODS: The in vitro anti-cancer effects of itraconazole was determined by CCK-8 assay and colony formation assay. ...SIGNIFICANCE: Itraconazole showed anti-cancer effects on OSCC via inhibiting the Hedgehog pathway....
MATERIALS AND METHODS: The in vitro anti-cancer effects of itraconazole was determined by CCK-8 assay and colony formation ass …
Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation.
Chen MB, Liu YY, Xing ZY, Zhang ZQ, Jiang Q, Lu PH, Cao C. Chen MB, et al. Mol Cancer Ther. 2018 Jun;17(6):1229-1239. doi: 10.1158/1535-7163.MCT-17-1094. Epub 2018 Mar 28. Mol Cancer Ther. 2018. PMID: 29592879 Free article.
We here evaluated the antiesophageal cancer cell activity by the antifungal drug itraconazole. Our results show that mug/mL concentrations of itraconazole potently inhibited survival and proliferation of established (TE-1 and Eca-109) and primary human esopha …
We here evaluated the antiesophageal cancer cell activity by the antifungal drug itraconazole. Our results show that mug/mL co …
Itraconazole inhibits proliferation of pancreatic cancer cells through activation of Bak-1.
Jiang F, Xing HS, Chen WY, Du J, Ruan YL, Lin AY, Zhou CZ. Jiang F, et al. J Cell Biochem. 2019 Mar;120(3):4333-4341. doi: 10.1002/jcb.27719. Epub 2018 Sep 27. J Cell Biochem. 2019. PMID: 30260036
This study investigates the antiproliferative effects of itraconazole on pancreatic cancer cells and the molecular mechanism of its apoptosis-inducing effects. In this study, our results showed that itraconazole inhibited the growth of pancreatic cancer
This study investigates the antiproliferative effects of itraconazole on pancreatic cancer cells and the molecular mechanism o …
Itraconazole inhibits the Hedgehog signaling pathway thereby inducing autophagy-mediated apoptosis of colon cancer cells.
Deng H, Huang L, Liao Z, Liu M, Li Q, Xu R. Deng H, et al. Cell Death Dis. 2020 Jul 17;11(7):539. doi: 10.1038/s41419-020-02742-0. Cell Death Dis. 2020. PMID: 32681018 Free PMC article.
Moreover, treatment with itraconazole produced significant cancer inhibition in HCT-116-bearing mice. Thus, itraconazole may be a potential and effective therapy for the treatment of colon cancer....
Moreover, treatment with itraconazole produced significant cancer inhibition in HCT-116-bearing mice. Thus, itraconazole
The anti-cancer effects of itraconazole in epithelial ovarian cancer.
Choi CH, Ryu JY, Cho YJ, Jeon HK, Choi JJ, Ylaya K, Lee YY, Kim TJ, Chung JY, Hewitt SM, Kim BG, Bae DS, Lee JW. Choi CH, et al. Sci Rep. 2017 Jul 26;7(1):6552. doi: 10.1038/s41598-017-06510-7. Sci Rep. 2017. PMID: 28747628 Free PMC article.
In xenograft models of EOC using SKOV3ip1 or HeyA8, mice treated with the combination of itraconazole and paclitaxel had significantly decreased tumor weight than the control, paclitaxel-alone, or itraconazole-alone groups. ...We confirmed those effects in two EOC P …
In xenograft models of EOC using SKOV3ip1 or HeyA8, mice treated with the combination of itraconazole and paclitaxel had significantl …
Itraconazole targets cell cycle heterogeneity in colorectal cancer.
Buczacki SJA, Popova S, Biggs E, Koukorava C, Buzzelli J, Vermeulen L, Hazelwood L, Francies H, Garnett MJ, Winton DJ. Buczacki SJA, et al. J Exp Med. 2018 Jul 2;215(7):1891-1912. doi: 10.1084/jem.20171385. Epub 2018 May 31. J Exp Med. 2018. PMID: 29853607 Free PMC article.
Cellular dormancy and heterogeneity in cell cycle length provide important explanations for treatment failure after adjuvant therapy with S-phase cytotoxics in colorectal cancer (CRC), yet the molecular control of the dormant versus cycling state remains unknown. .. …
Cellular dormancy and heterogeneity in cell cycle length provide important explanations for treatment failure after adjuvant therapy with …
Association of Itraconazole, a Hedgehog Inhibitor, and Bladder Cancer.
Mamtani R, Yang YX, Scott FI, Lewis JD, Boursi B. Mamtani R, et al. J Urol. 2016 Aug;196(2):343-8. doi: 10.1016/j.juro.2016.01.089. Epub 2016 Jan 23. J Urol. 2016. PMID: 26812305 Free PMC article.
We evaluated whether itraconazole use is associated with bladder cancer risk or progression. ...CONCLUSIONS: Inhibition of the Hh pathway with itraconazole was not associated with a risk of bladder cancer overall but it was associated with a higher ris …
We evaluated whether itraconazole use is associated with bladder cancer risk or progression. ...CONCLUSIONS: Inhibition of the …
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