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430 results

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Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
Patel Y, Chawla J, Parmar MS. Patel Y, et al. Curr Oncol Rep. 2025 Sep;27(9):1070-1079. doi: 10.1007/s11912-025-01704-z. Epub 2025 Jul 26. Curr Oncol Rep. 2025. PMID: 40715995 Review.
RECENT FINDINGS: Preclinical studies (in vitro and animal studies) demonstrate Ivermectin's anticancer effects, including inhibition of cancer cell proliferation, induction of apoptosis, and modulation of signaling pathways (e.g., Wnt/beta-catenin, Akt/mTOR) …
RECENT FINDINGS: Preclinical studies (in vitro and animal studies) demonstrate Ivermectin's anticancer effects, including inhi …
Ivermectin Inhibits Bladder Cancer Cell Growth and Induces Oxidative Stress and DNA Damage.
Fan N, Zhang L, Wang Z, Ding H, Yue Z. Fan N, et al. Anticancer Agents Med Chem. 2024;24(5):348-357. doi: 10.2174/0118715206274095231106042833. Anticancer Agents Med Chem. 2024. PMID: 38375808
Xenograft tumor models in nude mice were used to investigate the anti-cancer effect of Ivermectin in vivo. RESULTS: Our study showed that in vitro and in vivo, Ivermectin inhibited the growth of bladder cancer cells. ...CONCLUSIONS: According to these …
Xenograft tumor models in nude mice were used to investigate the anti-cancer effect of Ivermectin in vivo. RESULTS: Our study …
Ivermectin as an inhibitor of cancer stem-like cells.
Dominguez-Gomez G, Chavez-Blanco A, Medina-Franco JL, Saldivar-Gonzalez F, Flores-Torrontegui Y, Juarez M, Díaz-Chávez J, Gonzalez-Fierro A, Dueñas-González A. Dominguez-Gomez G, et al. Mol Med Rep. 2018 Feb;17(2):3397-3403. doi: 10.3892/mmr.2017.8231. Epub 2017 Dec 8. Mol Med Rep. 2018. PMID: 29257278
The aim of the present study was to demonstrate that ivermectin preferentially inhibited cancer stem-like cells (CSC) in breast cancer cells and downregulated the expression of 'stemness' genes. ...Ivermectin exhibited a similarity value of 0.78 in ref …
The aim of the present study was to demonstrate that ivermectin preferentially inhibited cancer stem-like cells (CSC) in breas …
Ivermectin, a potential anticancer drug derived from an antiparasitic drug.
Tang M, Hu X, Wang Y, Yao X, Zhang W, Yu C, Cheng F, Li J, Fang Q. Tang M, et al. Pharmacol Res. 2021 Jan;163:105207. doi: 10.1016/j.phrs.2020.105207. Epub 2020 Sep 21. Pharmacol Res. 2021. PMID: 32971268 Free PMC article.
Campbell won the 2015 Nobel Prize in Physiology or Medicine for the discovery of the excellent efficacy of ivermectin against parasitic diseases. Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signal …
Campbell won the 2015 Nobel Prize in Physiology or Medicine for the discovery of the excellent efficacy of ivermectin against parasit …
Ivermectin and gynecologic cancer: What's the data?
Mujumdar V, Huang M, Smith LC, Musa F. Mujumdar V, et al. Gynecol Oncol Rep. 2025 Jul 11;60:101803. doi: 10.1016/j.gore.2025.101803. eCollection 2025 Aug. Gynecol Oncol Rep. 2025. PMID: 40851910 Free PMC article. Review.
The data on ivermectin as a gynecologic cancer-fighting compound is lacking. Clinical studies on ivermectin use in cancer are limited to effects observed in cell lines. We have not assessed ivermectin's safety and efficacy in gynecologic …
The data on ivermectin as a gynecologic cancer-fighting compound is lacking. Clinical studies on ivermectin use in c …
Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth.
Zhou S, Wu H, Ning W, Wu X, Xu X, Ma Y, Li X, Hu J, Wang C, Wang J. Zhou S, et al. Front Pharmacol. 2021 Aug 13;12:717529. doi: 10.3389/fphar.2021.717529. eCollection 2021. Front Pharmacol. 2021. PMID: 34483925 Free PMC article.
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy. ...Overall, ivermectin suppressed cell proliferation by promoting ROS-mediated mitochondrial apoptosis pathway and inducing S phase arrest in CRC cells, sugge …
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy. ...Overall, ivermectin …
Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer.
Lv S, Wu Z, Luo M, Zhang Y, Zhang J, Pascal LE, Wang Z, Wei Q. Lv S, et al. Cell Death Dis. 2022 Sep 1;13(9):754. doi: 10.1038/s41419-022-05182-0. Cell Death Dis. 2022. PMID: 36050295 Free PMC article.
Ivermectin is a widely used antiparasitic drug and shows promising anticancer activity in various cancer types. ...Herein, we report the pharmacological effects and targets of ivermectin in prostate cancer. Ivermectin caused G0/G1 cell cycle arr …
Ivermectin is a widely used antiparasitic drug and shows promising anticancer activity in various cancer types. ...Herein, we …
Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-kappaB pathway.
Jiang L, Wang P, Sun YJ, Wu YJ. Jiang L, et al. J Exp Clin Cancer Res. 2019 Jun 18;38(1):265. doi: 10.1186/s13046-019-1251-7. J Exp Clin Cancer Res. 2019. PMID: 31215501 Free PMC article.
In this study, we sought to explore whether ivermectin (IVM), a macrolide antiparasitic agent, could overcome the resistance of cancer cells to the therapeutic drugs. ...Thus, ivermectin, a FDA-approved antiparasitic drug, could potentially be used in combina …
In this study, we sought to explore whether ivermectin (IVM), a macrolide antiparasitic agent, could overcome the resistance of ca …
Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction.
Lee DE, Kang HW, Kim SY, Kim MJ, Jeong JW, Hong WC, Fang S, Kim HS, Lee YS, Kim HJ, Park JS. Lee DE, et al. Front Pharmacol. 2022 Aug 26;13:934746. doi: 10.3389/fphar.2022.934746. eCollection 2022. Front Pharmacol. 2022. PMID: 36091811 Free PMC article.
Ivermectin, an antiparasitic drug, exerts antitumor effects in various cancer types. This is the first study to evaluate the anticancer effects of the combination of ivermectin and gemcitabine in pancreatic cancer. ...These results indicate that ive …
Ivermectin, an antiparasitic drug, exerts antitumor effects in various cancer types. This is the first study to evaluate the a …
Ivermectin as a potential therapeutic strategy for glioma.
Hu X, Ju Y, Zhang YK. Hu X, et al. J Neurosci Res. 2024 Jan;102(1):e25254. doi: 10.1002/jnr.25254. Epub 2023 Oct 10. J Neurosci Res. 2024. PMID: 37814994 Review.
Ivermectin (IVM), a semi-synthetic macrolide parasiticide, has demonstrated considerable effectiveness in combating internal and external parasites, particularly nematodes and arthropods. ...In recent years, investigations have revealed that IVM possesses antitumor propert …
Ivermectin (IVM), a semi-synthetic macrolide parasiticide, has demonstrated considerable effectiveness in combating internal and exte …
430 results