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301 results
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Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs.
Markowska A, Kaysiewicz J, Markowska J, Huczyński A. Markowska A, et al. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1549-1554. doi: 10.1016/j.bmcl.2019.04.045. Epub 2019 Apr 27. Bioorg Med Chem Lett. 2019. PMID: 31054863 Review.
Noteworthy, in recent years discoveries of novel anticancer agents from well-known antibiotics have opened up new treatment pathways for several cancer diseases. The aim of this review article is to describe new applications for the following antibiotics: doxycycline (DOX) …
Noteworthy, in recent years discoveries of novel anticancer agents from well-known antibiotics have opened up new treatment pathways for sev …
Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth.
Zhou S, Wu H, Ning W, Wu X, Xu X, Ma Y, Li X, Hu J, Wang C, Wang J. Zhou S, et al. Front Pharmacol. 2021 Aug 13;12:717529. doi: 10.3389/fphar.2021.717529. eCollection 2021. Front Pharmacol. 2021. PMID: 34483925 Free PMC article.
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy. ...Overall, ivermectin suppressed cell proliferation by promoting ROS-mediated mitochondrial apoptosis pathway and inducing S phase arrest in CRC cells …
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy. ...Overall, ivermectin …
The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug.
Juarez M, Schcolnik-Cabrera A, Dueñas-Gonzalez A. Juarez M, et al. Am J Cancer Res. 2018 Feb 1;8(2):317-331. eCollection 2018. Am J Cancer Res. 2018. PMID: 29511601 Free PMC article. Review.
In this review, we summarize the in vitro and in vivo evidences demonstrating that ivermectin exerts antitumor effects in different types of cancer. Ivermectin interacts with several targets including the multidrug resistance protein (MDR), the Akt/mTOR and W …
In this review, we summarize the in vitro and in vivo evidences demonstrating that ivermectin exerts antitumor effects in different t …
Ivermectin as an inhibitor of cancer stem‑like cells.
Dominguez-Gomez G, Chavez-Blanco A, Medina-Franco JL, Saldivar-Gonzalez F, Flores-Torrontegui Y, Juarez M, Díaz-Chávez J, Gonzalez-Fierro A, Dueñas-González A. Dominguez-Gomez G, et al. Mol Med Rep. 2018 Feb;17(2):3397-3403. doi: 10.3892/mmr.2017.8231. Epub 2017 Dec 8. Mol Med Rep. 2018. PMID: 29257278
The aim of the present study was to demonstrate that ivermectin preferentially inhibited cancer stem-like cells (CSC) in breast cancer cells and downregulated the expression of 'stemness' genes. ...Ivermectin exhibited a similarity value of 0.78 in ref …
The aim of the present study was to demonstrate that ivermectin preferentially inhibited cancer stem-like cells (CSC) in breas …
Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway.
Jiang L, Wang P, Sun YJ, Wu YJ. Jiang L, et al. J Exp Clin Cancer Res. 2019 Jun 18;38(1):265. doi: 10.1186/s13046-019-1251-7. J Exp Clin Cancer Res. 2019. PMID: 31215501 Free PMC article.
BACKGROUND: Discovery and development of novel drugs that are capable of overcoming drug resistance in tumor cells are urgently needed clinically. In this study, we sought to explore whether ivermectin (IVM), a macrolide antiparasitic agent, could overcome the resistance o …
BACKGROUND: Discovery and development of novel drugs that are capable of overcoming drug resistance in tumor cells are urgently needed clini …
Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer.
Lv S, Wu Z, Luo M, Zhang Y, Zhang J, Pascal LE, Wang Z, Wei Q. Lv S, et al. Cell Death Dis. 2022 Sep 1;13(9):754. doi: 10.1038/s41419-022-05182-0. Cell Death Dis. 2022. PMID: 36050295 Free PMC article.
Ivermectin is a widely used antiparasitic drug and shows promising anticancer activity in various cancer types. ...Herein, we report the pharmacological effects and targets of ivermectin in prostate cancer. Ivermectin caused G0/G1 cell cycle arr …
Ivermectin is a widely used antiparasitic drug and shows promising anticancer activity in various cancer types. ...Herein, we …
Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes.
Li N, Zhan X. Li N, et al. EPMA J. 2020 May 28;11(2):289-309. doi: 10.1007/s13167-020-00209-y. eCollection 2020 Jun. EPMA J. 2020. PMID: 32549918 Free PMC article.
RELEVANCE: Ivermectin, as an old anti-parasite drug, can suppress almost completely the growth of various human cancers, including ovarian cancer (OC). ...CONCLUSION: Those findings provided the potential targeted lncRNA-EIF4A3-mRNA pathways of ivermectin …
RELEVANCE: Ivermectin, as an old anti-parasite drug, can suppress almost completely the growth of various human cancers, inclu …
Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen.
Heidary F, Gharebaghi R. Heidary F, et al. J Antibiot (Tokyo). 2020 Sep;73(9):593-602. doi: 10.1038/s41429-020-0336-z. Epub 2020 Jun 12. J Antibiot (Tokyo). 2020. PMID: 32533071 Free PMC article.
Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. ...In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, c …
Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer p …
Ivermectin for preventing and treating COVID-19.
Popp M, Stegemann M, Metzendorf MI, Gould S, Kranke P, Meybohm P, Skoetz N, Weibel S. Popp M, et al. Cochrane Database Syst Rev. 2021 Jul 28;7(7):CD015017. doi: 10.1002/14651858.CD015017.pub2. Cochrane Database Syst Rev. 2021. PMID: 34318930 Free PMC article. Updated.
The molecular hypothesis of ivermectin's antiviral mode of action suggests an inhibitory effect on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the early stages of infection. ...MAIN RESULTS: We found 14 studies with 1678 participants …
The molecular hypothesis of ivermectin's antiviral mode of action suggests an inhibitory effect on severe acute respiratory sy …
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial.
López-Medina E, López P, Hurtado IC, Dávalos DM, Ramirez O, Martínez E, Díazgranados JA, Oñate JM, Chavarriaga H, Herrera S, Parra B, Libreros G, Jaramillo R, Avendaño AC, Toro DF, Torres M, Lesmes MC, Rios CA, Caicedo I. López-Medina E, et al. JAMA. 2021 Apr 13;325(14):1426-1435. doi: 10.1001/jama.2021.3071. JAMA. 2021. PMID: 33662102 Free PMC article. Clinical Trial.
By day 21, 82% in the ivermectin group and 79% in the placebo group had resolved symptoms. ...The findings do not support the use of ivermectin for treatment of mild COVID-19, although larger trials may be needed to understand the effects of ivermectin on oth …
By day 21, 82% in the ivermectin group and 79% in the placebo group had resolved symptoms. ...The findings do not support the use of …
301 results

Searches related to "ivermectin cancer"