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Page 1
Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer.
Lv S, Wu Z, Luo M, Zhang Y, Zhang J, Pascal LE, Wang Z, Wei Q. Lv S, et al. Cell Death Dis. 2022 Sep 1;13(9):754. doi: 10.1038/s41419-022-05182-0. Cell Death Dis. 2022. PMID: 36050295 Free PMC article.
Ivermectin is a widely used antiparasitic drug and shows promising anticancer activity in various cancer types. ...Herein, we report the pharmacological effects and targets of ivermectin in prostate cancer. Ivermectin caused G0/G1 cell cycle arr
Ivermectin is a widely used antiparasitic drug and shows promising anticancer activity in various cancer types. ...Herein, we
Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth.
Zhou S, Wu H, Ning W, Wu X, Xu X, Ma Y, Li X, Hu J, Wang C, Wang J. Zhou S, et al. Front Pharmacol. 2021 Aug 13;12:717529. doi: 10.3389/fphar.2021.717529. eCollection 2021. Front Pharmacol. 2021. PMID: 34483925 Free PMC article.
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy. ...Overall, ivermectin suppressed cell proliferation by promoting ROS-mediated mitochondrial apoptosis pathway and inducing S phase arrest in CRC cells, sugge …
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy. ...Overall, ivermectin
Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-kappaB pathway.
Jiang L, Wang P, Sun YJ, Wu YJ. Jiang L, et al. J Exp Clin Cancer Res. 2019 Jun 18;38(1):265. doi: 10.1186/s13046-019-1251-7. J Exp Clin Cancer Res. 2019. PMID: 31215501 Free PMC article.
BACKGROUND: Discovery and development of novel drugs that are capable of overcoming drug resistance in tumor cells are urgently needed clinically. In this study, we sought to explore whether ivermectin (IVM), a macrolide antiparasitic agent, could overcome the resistance o …
BACKGROUND: Discovery and development of novel drugs that are capable of overcoming drug resistance in tumor cells are urgently needed clini …
Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs.
Markowska A, Kaysiewicz J, Markowska J, Huczyński A. Markowska A, et al. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1549-1554. doi: 10.1016/j.bmcl.2019.04.045. Epub 2019 Apr 27. Bioorg Med Chem Lett. 2019. PMID: 31054863 Review.
Noteworthy, in recent years discoveries of novel anticancer agents from well-known antibiotics have opened up new treatment pathways for several cancer diseases. The aim of this review article is to describe new applications for the following antibiotics: doxycycline (DOX) …
Noteworthy, in recent years discoveries of novel anticancer agents from well-known antibiotics have opened up new treatment pathways for sev …
Outcome of Ivermectin in Cancer Treatment: An Experience in Loja-Ecuador.
Jiménez-Gaona Y, Vivanco-Galván O, Morales-Larreategui G, Cabrera-Bejarano A, Lakshminarayanan V. Jiménez-Gaona Y, et al. Nurs Rep. 2023 Feb 22;13(1):315-326. doi: 10.3390/nursrep13010030. Nurs Rep. 2023. PMID: 36976682 Free PMC article.
(1) Background: Cancer is one of the leading causes of death worldwide, and trends in cancer incidence and mortality are increasing over last years in Loja-Ecuador. ...This paper analyzed ivermectin use as cancer treatment in the rural area of the Loja …
(1) Background: Cancer is one of the leading causes of death worldwide, and trends in cancer incidence and mortality are incre …
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.
Chai JY, Jung BK, Hong SJ. Chai JY, et al. Korean J Parasitol. 2021 Jun;59(3):189-225. doi: 10.3347/kjp.2021.59.3.189. Epub 2021 Jun 21. Korean J Parasitol. 2021. PMID: 34218593 Free PMC article. Review.
It is of particular note that albendazole and mebendazole have been repositioned as promising anti-cancer drugs. These drugs have been shown to be active in vitro and in vivo (animals) against liver, lung, ovary, prostate, colorectal, breast, head and neck cancers, …
It is of particular note that albendazole and mebendazole have been repositioned as promising anti-cancer drugs. These drugs have bee …
Ivermectin, a potential anticancer drug derived from an antiparasitic drug.
Tang M, Hu X, Wang Y, Yao X, Zhang W, Yu C, Cheng F, Li J, Fang Q. Tang M, et al. Pharmacol Res. 2021 Jan;163:105207. doi: 10.1016/j.phrs.2020.105207. Epub 2020 Sep 21. Pharmacol Res. 2021. PMID: 32971268 Free PMC article.
Campbell won the 2015 Nobel Prize in Physiology or Medicine for the discovery of the excellent efficacy of ivermectin against parasitic diseases. Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signal …
Campbell won the 2015 Nobel Prize in Physiology or Medicine for the discovery of the excellent efficacy of ivermectin against parasit …
The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug.
Juarez M, Schcolnik-Cabrera A, Dueñas-Gonzalez A. Juarez M, et al. Am J Cancer Res. 2018 Feb 1;8(2):317-331. eCollection 2018. Am J Cancer Res. 2018. PMID: 29511601 Free PMC article. Review.
In this review, we summarize the in vitro and in vivo evidences demonstrating that ivermectin exerts antitumor effects in different types of cancer. Ivermectin interacts with several targets including the multidrug resistance protein (MDR), the Akt/mTOR and W …
In this review, we summarize the in vitro and in vivo evidences demonstrating that ivermectin exerts antitumor effects in different t …
Ivermectin for preventing and treating COVID-19.
Popp M, Reis S, Schießer S, Hausinger RI, Stegemann M, Metzendorf MI, Kranke P, Meybohm P, Skoetz N, Weibel S. Popp M, et al. Cochrane Database Syst Rev. 2022 Jun 21;6(6):CD015017. doi: 10.1002/14651858.CD015017.pub3. Cochrane Database Syst Rev. 2022. PMID: 35726131 Free PMC article. Review.
The molecular hypothesis of ivermectin's antiviral mode of action suggests an inhibitory effect on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in early stages of infection. ...No trial investigated ivermectin for prevention of inf …
The molecular hypothesis of ivermectin's antiviral mode of action suggests an inhibitory effect on severe acute respiratory sy …
Ivermectin Augments the Anti-Cancer Activity of Pitavastatin in Ovarian Cancer Cells.
Jawad MJ, Richardson A. Jawad MJ, et al. Diseases. 2023 Mar 14;11(1):49. doi: 10.3390/diseases11010049. Diseases. 2023. PMID: 36975598 Free PMC article.
Here, we tested combinations of pitavastatin with the anti-parasitic drug ivermectin in six ovarian cancer cell lines. When tested on its own, ivermectin inhibited the growth of the cells but only with modest potency (IC(50) = 10-20 M). ...These data suggest …
Here, we tested combinations of pitavastatin with the anti-parasitic drug ivermectin in six ovarian cancer cell lines. When te …
332 results