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Ivermectin as a potential therapeutic in COVID-19.
Segura-Aguilar J, Tizabi Y. Segura-Aguilar J, et al. Clin Pharmacol Transl Med. 2020;4(1):160-161. Epub 2020 Dec 29. Clin Pharmacol Transl Med. 2020. PMID: 33778414 Free PMC article. No abstract available.
Guidelines for clinical management of SARS-CoV-2 infection.
García-Álvarez JL, García-Vigil JL. García-Álvarez JL, et al. Gac Med Mex. 2020;156(6):576-583. doi: 10.24875/GMM.M21000461. Gac Med Mex. 2020. PMID: 33877121 Free article. English.
In SARS-CoV-2 infection (COVID-19), the most common manifestations involve the upper airways; in complicated cases, bilateral interstitial pneumonia, severe acute respiratory failure and multiple organ failure occur, which require hospital treat …
In SARS-CoV-2 infection (COVID-19), the most common manifestations involve the upper airways; in complica …
COVID-19: a basic approach to understanding potential treatments.
Cedillo-Alvarez C, Gallardo-Ortiz IA, López LT, Montes S, Páez-Martínez N. Cedillo-Alvarez C, et al. Gac Med Mex. 2020;156(6):570-575. doi: 10.24875/GMM.M21000459. Gac Med Mex. 2020. PMID: 33877122 Free article. Review. English.
SARS-CoV-2 virus has been identified as the causative agent of the COVID-19 pandemic. ...Pathogenicity mechanisms, as well as controlled treatments, still have to be studied in detail in order to propose a viable therapeutic option that prevents
SARS-CoV-2 virus has been identified as the causative agent of the COVID-19 pandemic. ...Pathogenicity me
COVID-19 Pandemic and Dysbiosis: Can the Ivermectin Hysteria Lead to an Increase of Autoimmune Neuroinflammatory Diseases?
Peron JPS, Nakaya HI, Schlindwein MAM, Gonçalves MVM. Peron JPS, et al. Crit Rev Immunol. 2020;40(6):537-542. doi: 10.1615/CritRevImmunol.2020036242. Crit Rev Immunol. 2020. PMID: 33900697
The pandemic caused by the SARS-CoV-2 has made new treatments a goal for the scientific community. One of these treatments is Ivermectin. Here we discuss the hypothesis of dysbiosis caused by the use of Ivermectin and the possible impacts on neu …
The pandemic caused by the SARS-CoV-2 has made new treatments a goal for the scientific community. One of these treatme …
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro.
Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. Caly L, et al. Antiviral Res. 2020 Jun;178:104787. doi: 10.1016/j.antiviral.2020.104787. Epub 2020 Apr 3. Antiviral Res. 2020. PMID: 32251768 Free PMC article.
Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown t …
Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak …
Antiviral treatment of COVID-19.
Şimşek Yavuz S, Ünal S. Şimşek Yavuz S, et al. Turk J Med Sci. 2020 Apr 21;50(SI-1):611-619. doi: 10.3906/sag-2004-145. Turk J Med Sci. 2020. PMID: 32293834 Free PMC article. Review.
Currently, there is not any specific effective antiviral treatment for COVID-19. Although most of the COVID-19 patients have mild or moderate courses, up to 5%-10% can have severe, potentially life threatening course, there is an urgent need for effect …
Currently, there is not any specific effective antiviral treatment for COVID-19. Although most of the COVID-19 p …
Ivermectin and COVID-19: Keeping Rigor in Times of Urgency.
Chaccour C, Hammann F, Ramón-García S, Rabinovich NR. Chaccour C, et al. Am J Trop Med Hyg. 2020 Jun;102(6):1156-1157. doi: 10.4269/ajtmh.20-0271. Am J Trop Med Hyg. 2020. PMID: 32314704 Free PMC article. No abstract available.
Potential use of hydroxychloroquine, ivermectin and azithromycin drugs in fighting COVID-19: trends, scope and relevance.
Choudhary R, Sharma AK. Choudhary R, et al. New Microbes New Infect. 2020 Apr 22;35:100684. doi: 10.1016/j.nmni.2020.100684. eCollection 2020 May. New Microbes New Infect. 2020. PMID: 32322397 Free PMC article. Review.
Alarming situation has been caused due to the emergence of COVID-19 infection around the world. There is an urgency of developing a therapeutic strategy in order to control the spread of COVID-19. ...However, their efficacies need to be studied in deta …
Alarming situation has been caused due to the emergence of COVID-19 infection around the world. There is an urgency of develop …
COVID-19 and Fake News in the Dominican Republic.
Tapia L. Tapia L. Am J Trop Med Hyg. 2020 Jun;102(6):1172-1174. doi: 10.4269/ajtmh.20-0234. Am J Trop Med Hyg. 2020. PMID: 32358952 Free PMC article.
The first case of novel coronavirus disease (COVID-19) in the Dominican Republic coincided with a period of political crisis. ...Having a weak public health infrastructure and a lack of public trust, the Ministry of Health (MoH) began the fight against COVID- …
The first case of novel coronavirus disease (COVID-19) in the Dominican Republic coincided with a period of political crisis. …
Nitazoxanide/azithromycin combination for COVID-19: A suggested new protocol for early management.
Kelleni MT. Kelleni MT. Pharmacol Res. 2020 Jul;157:104874. doi: 10.1016/j.phrs.2020.104874. Epub 2020 Apr 30. Pharmacol Res. 2020. PMID: 32360581 Free PMC article.
Further, BCG vaccination is being considered for clinical trials aiming to test its potential for lowering COVID-19 morbidity and mortality. This article illustrates some structural and functional relationships that may gather these drugs and the author, basing on a …
Further, BCG vaccination is being considered for clinical trials aiming to test its potential for lowering COVID-19 morbidity …
The Approved Dose of Ivermectin Alone is not the Ideal Dose for the Treatment of COVID-19.
Schmith VD, Zhou JJ, Lohmer LRL. Schmith VD, et al. Clin Pharmacol Ther. 2020 Oct;108(4):762-765. doi: 10.1002/cpt.1889. Epub 2020 Jun 7. Clin Pharmacol Ther. 2020. PMID: 32378737 Free PMC article.
Caly et al.(1) reported that ivermectin inhibited severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in vitro for up to 48 hours using ivermectin at 5 muM. The concentration resulting in 50% inhibition (IC(50) ; 2 M) was …
Caly et al.(1) reported that ivermectin inhibited severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2
In Vitro Data of Current Therapies for SARS-CoV-2.
Anastasiou IA, Eleftheriadou I, Tentolouris A, Tsilingiris D, Tentolouris N. Anastasiou IA, et al. Curr Med Chem. 2020;27(27):4542-4548. doi: 10.2174/0929867327666200513075430. Curr Med Chem. 2020. PMID: 32400323
BACKGROUND: In December 2019, a new coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), emerged from China, causing pneumonia outbreaks first in the Wuhan region and then spread worldwide. ...OBJECTIVES: The aim of this stu …
BACKGROUND: In December 2019, a new coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2
Old and re-purposed drugs for the treatment of COVID-19.
Jean SS, Hsueh PR. Jean SS, et al. Expert Rev Anti Infect Ther. 2020 Sep;18(9):843-847. doi: 10.1080/14787210.2020.1771181. Epub 2020 Jun 1. Expert Rev Anti Infect Ther. 2020. PMID: 32419524 Free PMC article. Review.
Introduction: The coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed since December 2019. ...In addition, tocilizumab might be considered as the supplementary …
Introduction: The coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2
A chronicle of SARS-CoV-2: Part-I - Epidemiology, diagnosis, prognosis, transmission and treatment.
Kumar M, Taki K, Gahlot R, Sharma A, Dhangar K. Kumar M, et al. Sci Total Environ. 2020 Sep 10;734:139278. doi: 10.1016/j.scitotenv.2020.139278. Epub 2020 May 15. Sci Total Environ. 2020. PMID: 32434058 Free PMC article. Review.
In order to benefit the public, community workers and scientific community, we hereby present a chronicle of SARS-CoV-2 that leads to the unseen precedent of social distancing and lockdown owing to coronavirus disease (COVID-19). ...We have expl …
In order to benefit the public, community workers and scientific community, we hereby present a chronicle of SARS-CoV-2
Novel 2019-coronavirus on new year's Eve.
Gupta P, Goyal K, Kanta P, Ghosh A, Singh MP. Gupta P, et al. Indian J Med Microbiol. 2019 Oct-Dec;37(4):459-477. doi: 10.4103/ijmm.IJMM_20_54. Indian J Med Microbiol. 2019. PMID: 32436867 Free PMC article. Review.
The disease caused by severe acute respiratory syndrome coronavirus (CoV)-2 (SARS-CoV-2) can prove deadlier if the so-called 'super-spreading events' emerge with time. Recent research has shown the maximum homology of 99% of SARS-CoV
The disease caused by severe acute respiratory syndrome coronavirus (CoV)-2 (SARS-CoV-2) can prove deadli …
Prioritization of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.
Arshad U, Pertinez H, Box H, Tatham L, Rajoli RKR, Curley P, Neary M, Sharp J, Liptrott NJ, Valentijn A, David C, Rannard SP, O'Neill PM, Aljayyoussi G, Pennington SH, Ward SA, Hill A, Back DJ, Khoo SH, Bray PG, Biagini GA, Owen A. Arshad U, et al. Clin Pharmacol Ther. 2020 Oct;108(4):775-790. doi: 10.1002/cpt.1909. Epub 2020 Jun 14. Clin Pharmacol Ther. 2020. PMID: 32438446 Free PMC article. Review.
Accordingly, concentration 90% (EC(90) ) values recalculated from in vitro anti-SARS-CoV-2 activity data was expressed as a ratio to the achievable maximum plasma concentration (C(max) ) at an approved dose in humans (C(max) /EC(90) ratio). ...A more in-depth …
Accordingly, concentration 90% (EC(90) ) values recalculated from in vitro anti-SARS-CoV-2 activity data was expressed …
Repurposing approved drugs as inhibitors of SARS-CoV-2 S-protein from molecular modeling and virtual screening.
de Oliveira OV, Rocha GB, Paluch AS, Costa LT. de Oliveira OV, et al. J Biomol Struct Dyn. 2021 Jul;39(11):3924-3933. doi: 10.1080/07391102.2020.1772885. Epub 2020 Jun 2. J Biomol Struct Dyn. 2021. PMID: 32448085 Free PMC article.
Herein, molecular modeling techniques were used with the main goal to obtain candidates from a drug database as potential targets to be used against SARS-CoV-2. This novel coronavirus, responsible by the COVID-19 outbreak since the end of 2019, …
Herein, molecular modeling techniques were used with the main goal to obtain candidates from a drug database as potential targets to be used …
Can Zn Be a Critical Element in COVID-19 Treatment?
Rahman MT, Idid SZ. Rahman MT, et al. Biol Trace Elem Res. 2021 Feb;199(2):550-558. doi: 10.1007/s12011-020-02194-9. Epub 2020 May 26. Biol Trace Elem Res. 2021. PMID: 32458149 Free PMC article. Review.
The current COVID-19 pandemic caused by SARS-CoV-2 has prompted investigators worldwide to search for an effective anti-viral treatment. ...Again, the effectiveness of Zn can be enhanced by using chloroquine as an ionophore while Zn inside the i …
The current COVID-19 pandemic caused by SARS-CoV-2 has prompted investigators worldwide to search for an …
Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action.
Rizzo E. Rizzo E. Naunyn Schmiedebergs Arch Pharmacol. 2020 Jul;393(7):1153-1156. doi: 10.1007/s00210-020-01902-5. Epub 2020 May 27. Naunyn Schmiedebergs Arch Pharmacol. 2020. PMID: 32462282 Free PMC article.
Ivermectin is an antiparasitic drug that has shown also an effective pharmacological activity towards various infective agents, including viruses. ...
Ivermectin is an antiparasitic drug that has shown also an effective pharmacological activity towards various infective agents, inclu
Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system.
Yuan S, Chan JFW, Chik KKH, Chan CCY, Tsang JOL, Liang R, Cao J, Tang K, Chen LL, Wen K, Cai JP, Ye ZW, Lu G, Chu H, Jin DY, Yuen KY. Yuan S, et al. Pharmacol Res. 2020 Sep;159:104960. doi: 10.1016/j.phrs.2020.104960. Epub 2020 May 28. Pharmacol Res. 2020. PMID: 32473310 Free PMC article.
Coronavirus Disease 2019 (COVID-19) caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a crude case fatality rate of about 0.5-10 % depending on locality. ...To find more immediately ava …
Coronavirus Disease 2019 (COVID-19) caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS
Ivermectin, a new candidate therapeutic against SARS-CoV-2/COVID-19.
Sharun K, Dhama K, Patel SK, Pathak M, Tiwari R, Singh BR, Sah R, Bonilla-Aldana DK, Rodriguez-Morales AJ, Leblebicioglu H. Sharun K, et al. Ann Clin Microbiol Antimicrob. 2020 May 30;19(1):23. doi: 10.1186/s12941-020-00368-w. Ann Clin Microbiol Antimicrob. 2020. PMID: 32473642 Free PMC article. No abstract available.
Ivermectin: repurposing a multipurpose drug for Venezuela's humanitarian crisis.
Perez-Garcia LA, Mejias-Carpio IE, Delgado-Noguera LA, Manzanarez-Motezuma JP, Escalona-Rodriguez MA, Sordillo EM, Mogollon-Rodriguez EA, Hernandez-Pereira CE, Marquez-Colmenarez MC, Paniz-Mondolfi AE. Perez-Garcia LA, et al. Int J Antimicrob Agents. 2020 Aug;56(2):106037. doi: 10.1016/j.ijantimicag.2020.106037. Epub 2020 May 29. Int J Antimicrob Agents. 2020. PMID: 32479893 Free PMC article. Review.
Ivermectin (IVM) is a robust antiparasitic drug with an excellent tolerance and safety profile. ...In addition, novel experimental evidence has shown that IVM is active and efficacious in vitro against Chagas disease, Leishmaniases, arboviruses, and SARS-CoV-
Ivermectin (IVM) is a robust antiparasitic drug with an excellent tolerance and safety profile. ...In addition, novel experimental ev
The SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT) to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission in low risk, non-severe COVID-19 patients in the first 48 hours after symptoms onset: A structured summary of a study protocol for a randomized control pilot trial.
Chaccour C, Ruiz-Castillo P, Richardson MA, Moncunill G, Casellas A, Carmona-Torre F, Giráldez M, Mota JS, Yuste JR, Azanza JR, Fernández M, Reina G, Dobaño C, Brew J, Sadaba B, Hammann F, Rabinovich R. Chaccour C, et al. Trials. 2020 Jun 8;21(1):498. doi: 10.1186/s13063-020-04421-z. Trials. 2020. PMID: 32513289 Free PMC article.
The secondary objectives are: 1.To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the nasopharyngeal swab at day 7 post treatment.2.To assess the efficacy of ivermectin to improve symptom progression in treated p …
The secondary objectives are: 1.To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the …
An overview on COVID-19: reality and expectation.
Hamed MA. Hamed MA. Bull Natl Res Cent. 2020;44(1):86. doi: 10.1186/s42269-020-00341-9. Epub 2020 Jun 1. Bull Natl Res Cent. 2020. PMID: 32514228 Free PMC article. Review.
Recently, severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), commonly known as coronavirus disease-2019 (COVID-19) has rapidly spread across China and around the world. ...Certain drugs that are clinically approved for other di …
Recently, severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), commonly known as coronavirus disease-20 …
Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen.
Heidary F, Gharebaghi R. Heidary F, et al. J Antibiot (Tokyo). 2020 Sep;73(9):593-602. doi: 10.1038/s41429-020-0336-z. Epub 2020 Jun 12. J Antibiot (Tokyo). 2020. PMID: 32533071 Free PMC article.
Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1. Ivermectin plays a role in several biological mechanis …
Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK poly …
Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials.
Horowitz RI, Freeman PR. Horowitz RI, et al. Med Hypotheses. 2020 Oct;143:109851. doi: 10.1016/j.mehy.2020.109851. Epub 2020 May 22. Med Hypotheses. 2020. PMID: 32534175 Free PMC article.
New ways of screening the general population for COVID-19 are urgently needed along with novel effective prevention and treatment strategies. ...Second, regarding prevention, no validated protocols except for physical distancing, hand washing, and isolation exist, a …
New ways of screening the general population for COVID-19 are urgently needed along with novel effective prevention and treatm …
The Battle against COVID 19 Pandemic: What we Need to Know Before we "Test Fire" Ivermectin.
Banerjee K, Nandy M, Dalai CK, Ahmed SN. Banerjee K, et al. Drug Res (Stuttg). 2020 Aug;70(8):337-340. doi: 10.1055/a-1185-8913. Epub 2020 Jun 19. Drug Res (Stuttg). 2020. PMID: 32559771 Free PMC article.
The world is faced with the dire challenge of finding an effective treatment against the rampaging COVID 19 pandemic. Amidst the crisis, reports of in vitro inhibitory activity of ivermectin, an approved anthelmintic, against the causative SARSCoV2 virus, hav …
The world is faced with the dire challenge of finding an effective treatment against the rampaging COVID 19 pandemic. Amidst t …
Ivermectin: potential candidate for the treatment of Covid 19.
Gupta D, Sahoo AK, Singh A. Gupta D, et al. Braz J Infect Dis. 2020 Jul-Aug;24(4):369-371. doi: 10.1016/j.bjid.2020.06.002. Epub 2020 Jun 28. Braz J Infect Dis. 2020. PMID: 32615072 Free PMC article. No abstract available.
Ivermectin in COVID-19. Argumentun ad ignorantiam?
Carlosama-Rosero Y. Carlosama-Rosero Y. Rev Clin Esp (Barc). 2020 Oct;220(7):457-458. doi: 10.1016/j.rce.2020.06.003. Epub 2020 Jun 12. Rev Clin Esp (Barc). 2020. PMID: 32616298 Free PMC article. No abstract available.
Repurposing Drugs for the Management of Patients with Confirmed Coronavirus Disease 2019 (COVID-19).
Lovato ECW, Barboza LN, Wietzikoski S, de Souza ANV, Auth PA, Junior AG, Dos Reis Lívero FA. Lovato ECW, et al. Curr Pharm Des. 2021;27(1):115-126. doi: 10.2174/1381612826666200707121636. Curr Pharm Des. 2021. PMID: 32634080 Review.
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed coronavirus disease 2019 (COVID-19) by the World Health Organization, is a newly emerging zoonotic agent that emerged in China in December 2019. No specific …
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed coronavirus disease 2019 (CO
Ecotoxic response of nematodes to ivermectin, a potential anti-COVID-19 drug treatment.
Essid N, Allouche M, Lazzem M, Harrath AH, Mansour L, Alwasel S, Mahmoudi E, Beyrem H, Boufahja F. Essid N, et al. Mar Pollut Bull. 2020 Aug;157:111375. doi: 10.1016/j.marpolbul.2020.111375. Epub 2020 Jun 11. Mar Pollut Bull. 2020. PMID: 32658716 Free PMC article.
At the end of March 2020, ivermectin was confirmed as a drug for COVID-19 treatment. A significant amount of ivermectin could deposit into sediments of the semi-closed Mediterranean Sea, where three European COVID-19 epicenters are locate …
At the end of March 2020, ivermectin was confirmed as a drug for COVID-19 treatment. A significant amount of ivermec
Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques.
Vanachayangkul P, Im-Erbsin R, Tungtaeng A, Kodchakorn C, Roth A, Adams J, Chaisatit C, Saingam P, Sciotti RJ, Reichard GA, Nolan CK, Pybus BS, Black CC, Lugo-Roman LA, Wegner MD, Smith PL, Wojnarski M, Vesely BA, Kobylinski KC. Vanachayangkul P, et al. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00741-20. doi: 10.1128/AAC.00741-20. Print 2020 Aug 20. Antimicrob Agents Chemother. 2020. PMID: 32660993 Free PMC article.
No inhibition or delay to blood-stage P. cynomolgi parasitemia was observed at any ivermectin dose (0.3, 0.6, and 1.2 mg/kg). Ivermectin (0.6 and 1.2 mg/kg) and chloroquine (10 mg/kg) in combination were well-tolerated with no adverse events and no sig …
No inhibition or delay to blood-stage P. cynomolgi parasitemia was observed at any ivermectin dose (0.3, 0.6, and 1.2 mg/kg). …
Management of crash and burn patients with SARS-CoV-2 associated ARDS.
Ghodsizad A, Grant AA, Mirsaeidi M, Sneij WC, Khalid L, Delazerda D, Auerbach JS, Alvarez RA, de Marchena EJ, Hare J, Guerra G, Vianna R, Loebe M. Ghodsizad A, et al. J Card Surg. 2020 Sep;35(9):2129-2130. doi: 10.1111/jocs.14699. Epub 2020 Jul 14. J Card Surg. 2020. PMID: 32663349 Free PMC article. No abstract available.
Reply to: Ivermectin in COVID-19. Argumentum ad ignorantiam?
López Reboiro ML, Sardiña González C, López Castro J. López Reboiro ML, et al. Rev Clin Esp (Barc). 2020 Oct;220(7):458. doi: 10.1016/j.rce.2020.06.011. Epub 2020 Jul 4. Rev Clin Esp (Barc). 2020. PMID: 32703528 Free PMC article. No abstract available.
Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 Infection.
Wang Z, Yang L. Wang Z, et al. Front Pharmacol. 2020 Jul 2;11:1013. doi: 10.3389/fphar.2020.01013. eCollection 2020. Front Pharmacol. 2020. PMID: 32714193 Free PMC article. Review.
The novel and highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become a continued focus of global attention due to the serious threat it poses to public …
The novel and highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coron …
FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy.
Drożdżal S, Rosik J, Lechowicz K, Machaj F, Kotfis K, Ghavami S, Łos MJ. Drożdżal S, et al. Drug Resist Updat. 2020 Dec;53:100719. doi: 10.1016/j.drup.2020.100719. Epub 2020 Jul 15. Drug Resist Updat. 2020. PMID: 32717568 Free PMC article. Review.
In December 2019, a novel SARS-CoV-2 coronavirus emerged, causing an outbreak of life-threatening pneumonia in the Hubei province, China, and has now spread worldwide, causing a pandemic. ...Chloroquine, remdesivir, lopinavir/ritonavir or ribavirin have all b …
In December 2019, a novel SARS-CoV-2 coronavirus emerged, causing an outbreak of life-threatening pneumonia in the Hube …
Current status and strategic possibilities on potential use of combinational drug therapy against COVID-19 caused by SARS-CoV-2.
Siddiqui AJ, Jahan S, Ashraf SA, Alreshidi M, Ashraf MS, Patel M, Snoussi M, Singh R, Adnan M. Siddiqui AJ, et al. J Biomol Struct Dyn. 2021 Oct;39(17):6828-6841. doi: 10.1080/07391102.2020.1802345. Epub 2020 Aug 5. J Biomol Struct Dyn. 2021. PMID: 32752944 Free PMC article. Review.
The spread of new coronavirus infection starting December 2019 as novel SARS-CoV-2, identified as the causing agent of COVID-19, has affected all over the world and been declared as pandemic. ...Until now, there is no specific drug therapy or va …
The spread of new coronavirus infection starting December 2019 as novel SARS-CoV-2, identified as the causing agent of …
Natural history of COVID-19 and current knowledge on treatment therapeutic options.
Dos Santos WG. Dos Santos WG. Biomed Pharmacother. 2020 Sep;129:110493. doi: 10.1016/j.biopha.2020.110493. Epub 2020 Jul 3. Biomed Pharmacother. 2020. PMID: 32768971 Free PMC article. Review.
Despite intense research there is currently no effective vaccine available against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in the later 2019 and responsible for the COVID-19 pandemic. ...Herein we will …
Despite intense research there is currently no effective vaccine available against the new severe acute respiratory syndrome coronavirus- …
What to expect from different drugs used in the treatment of COVID-19: A study on applications and in vivo and in vitro results.
Marcolino VA, Pimentel TC, Barão CE. Marcolino VA, et al. Eur J Pharmacol. 2020 Nov 15;887:173467. doi: 10.1016/j.ejphar.2020.173467. Epub 2020 Aug 8. Eur J Pharmacol. 2020. PMID: 32777212 Free PMC article.
The end of 2019 was marked by the emergence of a new type of coronavirus (SARS-CoV-2), which has killed more than 240,000 people around the world so far. Several clinical studies are being performed to test possible drugs in response to the COVID-19
The end of 2019 was marked by the emergence of a new type of coronavirus (SARS-CoV-2), which has killed more than 240,0 …
COVID-19 in pediatric cancer patients in a resource-limited setting: National data from Peru.
Montoya J, Ugaz C, Alarcon S, Maradiegue E, García J, Díaz R, Zapata A, Chávez S, Morales R, Ordoñez K, Hernandez E, Reaño R, Gutierrez C, Vargas MP, Sanchez K, Valdiviezo C, Maza I, Rojas N, Moore C, León E, Vásquez L. Montoya J, et al. Pediatr Blood Cancer. 2021 Feb;68(2):e28610. doi: 10.1002/pbc.28610. Epub 2020 Jul 22. Pediatr Blood Cancer. 2021. PMID: 32779840 Free PMC article. No abstract available.
White paper on Ivermectin as a potential therapy for COVID-19.
Vora A, Arora VK, Behera D, Tripathy SK. Vora A, et al. Indian J Tuberc. 2020 Jul;67(3):448-451. doi: 10.1016/j.ijtb.2020.07.031. Indian J Tuberc. 2020. PMID: 32825892 Free PMC article.
A group of senior doctors with vast clinical experience met on 19th July'20 under the aegis of Academy of Advanced Medical Education. The panel looked at Ivermectin, one of the old molecule and evaluated it's use in COVID 19 (Novel Coronavirus Disease …
A group of senior doctors with vast clinical experience met on 19th July'20 under the aegis of Academy of Advanced Medical Education. The pa …
Repurposing Drugs for COVID-19: An Approach for Treatment in the Pandemic.
Khadka S, Yuchi A, Shrestha DB, Budhathoki P, Al-Subari SMM, Ziad Alhouzani TM, Anwar Butt I. Khadka S, et al. Altern Ther Health Med. 2020 Aug;26(S2):100-107. Altern Ther Health Med. 2020. PMID: 32827400 Review.
CONTEXT: Drug repurposing is a relevant approach during the COVID-19 pandemic, because development of new drugs is time-consuming and costly, and the safety of new drugs is paramount. ...The search terms used included repositioning of drugs, repurposing of drugs and …
CONTEXT: Drug repurposing is a relevant approach during the COVID-19 pandemic, because development of new drugs is time-consum …
Known drugs and small molecules in the battle for COVID-19 treatment.
Panoutsopoulos AA. Panoutsopoulos AA. Genes Dis. 2020 Dec;7(4):528-534. doi: 10.1016/j.gendis.2020.06.007. Epub 2020 Jun 20. Genes Dis. 2020. PMID: 32837982 Free PMC article. Review.
COVID-19 has been declared a pandemic by the World Health Organization on March 11th and since then more than 3 million cases and a quarter million deaths have occurred due to it. ...Here, we discuss five of the most promising drugs that can potentially play a major
COVID-19 has been declared a pandemic by the World Health Organization on March 11th and since then more than 3 million cases
Pandemic COVID-19: Current status and challenges of antiviral therapies.
Chan W, He B, Wang X, He ML. Chan W, et al. Genes Dis. 2020 Dec;7(4):502-519. doi: 10.1016/j.gendis.2020.07.001. Epub 2020 Jul 7. Genes Dis. 2020. PMID: 32837984 Free PMC article.
The pandemic COVID-19, caused by a new coronavirus SARS-CoV-2 infection, has infected over 12 million individuals and caused more than 55,200 death worldwide. ...Antiviral chemotherapies have been conducted by in multiple cohorts in different co …
The pandemic COVID-19, caused by a new coronavirus SARS-CoV-2 infection, has infected over 12 million ind …
Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention.
Hussman JP. Hussman JP. Front Pharmacol. 2020 Jul 29;11:1169. doi: 10.3389/fphar.2020.01169. eCollection 2020. Front Pharmacol. 2020. PMID: 32848776 Free PMC article.
With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus with potentially informative findings from prior research literature and to promote investigation toward therapeutic response, a coherent cellular and molecular pathway …
With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus with potentially informative …
Treatment Options for COVID-19: A Review.
Ali MJ, Hanif M, Haider MA, Ahmed MU, Sundas F, Hirani A, Khan IA, Anis K, Karim AH. Ali MJ, et al. Front Med (Lausanne). 2020 Jul 31;7:480. doi: 10.3389/fmed.2020.00480. eCollection 2020. Front Med (Lausanne). 2020. PMID: 32850922 Free PMC article. Review.
Conclusion: We are currently facing one of the worst pandemics in history. Although SARS-CoV-2 is associated with a lower mortality rate than are SARS-CoV and MERS-CoV, its higher infectivity is making it a far more serious threat. Unfort …
Conclusion: We are currently facing one of the worst pandemics in history. Although SARS-CoV-2 is associated with a low …
Ivermectin: Potential Role as Repurposed Drug for COVID-19.
Dixit A, Yadav R, Singh AV. Dixit A, et al. Malays J Med Sci. 2020 Jul;27(4):154-158. doi: 10.21315/mjms2020.27.4.15. Epub 2020 Aug 19. Malays J Med Sci. 2020. PMID: 32863755 Free PMC article.
Severe acute respiratory illness caused by 2019 novel coronavirus (2019-nCoV), officially named severe acute respiratory syndrome coronavirus (SARS-CoV-2) in late December 2019 is an extremely communicable disease. ...In the meanwhile, the available practical …
Severe acute respiratory illness caused by 2019 novel coronavirus (2019-nCoV), officially named severe acute respiratory syndrome coronaviru …
Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2.
Lehrer S, Rheinstein PH. Lehrer S, et al. In Vivo. 2020 Sep-Oct;34(5):3023-3026. doi: 10.21873/invivo.12134. In Vivo. 2020. PMID: 32871846 Free PMC article.
BACKGROUND/AIM: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ...We carried out a docking study to determine if ivermectin might be able to atta …
BACKGROUND/AIM: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coron …
Off label, compassionate and irrational use of medicines in Covid-19 pandemic, health consequences and ethical issues.
Paumgartten FJR, Oliveira ACAX. Paumgartten FJR, et al. Cien Saude Colet. 2020 Sep;25(9):3413-3419. doi: 10.1590/1413-81232020259.16792020. Epub 2020 Aug 28. Cien Saude Colet. 2020. PMID: 32876249 Free article.
When Covid-19 emerged in December last year, there was no vaccine nor was there specific effective treatment for this fast-spreading and life-threatening viral respiratory infection. ...The rationale behind the prescription of macrolide antibiotics (azithromycin) fo …
When Covid-19 emerged in December last year, there was no vaccine nor was there specific effective treatment for this fast-spr …
A living WHO guideline on drugs for covid-19.
Agarwal A, Rochwerg B, Lamontagne F, Siemieniuk RA, Agoritsas T, Askie L, Lytvyn L, Leo YS, Macdonald H, Zeng L, Amin W, da Silva ARA, Aryal D, Barragan FAJ, Bausch FJ, Burhan E, Calfee CS, Cecconi M, Chacko B, Chanda D, Dat VQ, De Sutter A, Du B, Freedman S, Geduld H, Gee P, Gotte M, Harley N, Hashimi M, Hunt B, Jehan F, Kabra SK, Kanda S, Kim YJ, Kissoon N, Krishna S, Kuppalli K, Kwizera A, Lado Castro-Rial M, Lisboa T, Lodha R, Mahaka I, Manai H, Mendelson M, Migliori GB, Mino G, Nsutebu E, Preller J, Pshenichnaya N, Qadir N, Relan P, Sabzwari S, Sarin R, Shankar-Hari M, Sharland M, Shen Y, Ranganathan SS, Souza JP, Stegemann M, Swanstrom R, Ugarte S, Uyeki T, Venkatapuram S, Vuyiseka D, Wijewickrama A, Tran L, Zeraatkar D, Bartoszko JJ, Ge L, Brignardello-Petersen R, Owen A, Guyatt G, Diaz J, Kawano-Dourado L, Jacobs M, Vandvik PO. Agarwal A, et al. BMJ. 2020 Sep 4;370:m3379. doi: 10.1136/bmj.m3379. BMJ. 2020. PMID: 32887691 Updated.
The emerging SARS-CoV-2 variants (such as omicron) and subvariants are also changing the role of therapeutics. ...When making a strong recommendation against the use of monoclonal antibodies for patients with covid-19, the GDG considered in vitr …
The emerging SARS-CoV-2 variants (such as omicron) and subvariants are also changing the role of therapeutics. ...When …
Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing.
Jermain B, Hanafin PO, Cao Y, Lifschitz A, Lanusse C, Rao GG. Jermain B, et al. J Pharm Sci. 2020 Dec;109(12):3574-3578. doi: 10.1016/j.xphs.2020.08.024. Epub 2020 Sep 4. J Pharm Sci. 2020. PMID: 32891630 Free PMC article.
SARS-CoV-2 utilizes the IMPalpha/beta1 heterodimer to enter host cell nuclei after gaining cellular access through the ACE2 receptor. ...The simulated ivermectin lung exposures reached a maximum concentration of 772 ng/mL, far less than the estimated 1
SARS-CoV-2 utilizes the IMPalpha/beta1 heterodimer to enter host cell nuclei after gaining cellular access through the
A Review on Current Repurposing Drugs for the Treatment of COVID-19: Reality and Challenges.
Hossen MS, Barek MA, Jahan N, Safiqul Islam M. Hossen MS, et al. SN Compr Clin Med. 2020;2(10):1777-1789. doi: 10.1007/s42399-020-00485-9. Epub 2020 Aug 31. SN Compr Clin Med. 2020. PMID: 32904710 Free PMC article. Review.
The coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic with a high growth rate of confirmed cases. ...This study reviewed the most common drugs …
The coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS
Strongyloides infection manifested during immunosuppressive therapy for SARS-CoV-2 pneumonia.
Marchese V, Crosato V, Gulletta M, Castelnuovo F, Cristini G, Matteelli A, Castelli F. Marchese V, et al. Infection. 2021 Jun;49(3):539-542. doi: 10.1007/s15010-020-01522-4. Epub 2020 Sep 10. Infection. 2021. PMID: 32910321 Free PMC article.
BACKGROUND: SARS-CoV-2 pandemic has posed formidable public health and clinical challenges. ...DISCUSSION: We report the first case of S. stercoralis infection following an 11-day treatment with high-dose steroids and Tocilizumab for severe COVID
BACKGROUND: SARS-CoV-2 pandemic has posed formidable public health and clinical challenges. ...DISCUSSION: We report th …
A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction.
Taguchi YH, Turki T. Taguchi YH, et al. PLoS One. 2020 Sep 11;15(9):e0238907. doi: 10.1371/journal.pone.0238907. eCollection 2020. PLoS One. 2020. PMID: 32915876 Free PMC article.
BACKGROUND: COVID-19 is a critical pandemic that has affected human communities worldwide, and there is an urgent need to develop effective drugs. ...CONCLUSIONS: The drugs screened using our strategy may be effective candidates for treating patients with COVID
BACKGROUND: COVID-19 is a critical pandemic that has affected human communities worldwide, and there is an urgent need to deve …
Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?
Jans DA, Wagstaff KM. Jans DA, et al. Cells. 2020 Sep 15;9(9):2100. doi: 10.3390/cells9092100. Cells. 2020. PMID: 32942671 Free PMC article. Review.
Excitingly, cell culture experiments show robust antiviral action towards HIV-1, dengue virus (DENV), Zika virus, West Nile virus, Venezuelan equine encephalitis virus, Chikungunya virus, Pseudorabies virus, adenovirus, and SARS-CoV-2 (COVID-19) …
Excitingly, cell culture experiments show robust antiviral action towards HIV-1, dengue virus (DENV), Zika virus, West Nile virus, Venezuela …
Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approach.
Parvez MSA, Karim MA, Hasan M, Jaman J, Karim Z, Tahsin T, Hasan MN, Hosen MJ. Parvez MSA, et al. Int J Biol Macromol. 2020 Nov 15;163:1787-1797. doi: 10.1016/j.ijbiomac.2020.09.098. Epub 2020 Sep 17. Int J Biol Macromol. 2020. PMID: 32950529 Free PMC article.
The pandemic prevalence of COVID-19 has become a very serious global health issue. Scientists all over the world have been seriously attempting in the discovery of a drug to combat SARS-CoV-2. ...Here, comprehensive computational approaches incl …
The pandemic prevalence of COVID-19 has become a very serious global health issue. Scientists all over the world have been ser …
Identification of Main Protease of Coronavirus SARS-CoV-2 (Mpro) Inhibitors from Melissa officinalis.
Elekofehinti OO, Iwaloye O, Famusiwa CD, Akinseye O, Rocha JBT. Elekofehinti OO, et al. Curr Drug Discov Technol. 2021;18(5):e17092020186048. doi: 10.2174/1570163817999200918103705. Curr Drug Discov Technol. 2021. PMID: 32957889
BACKGROUND: The recent outbreak of Coronavirus SARS-CoV-2 (Covid-19), which has rapidly spread around the world in about three months with tens of thousands of deaths recorded so far is a global concern. ...M(pro) is an attractive druggable targ …
BACKGROUND: The recent outbreak of Coronavirus SARS-CoV-2 (Covid-19), which has rapidly spread around the …
Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment.
Li N, Zhao L, Zhan X. Li N, et al. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22. J Cell Physiol. 2021. PMID: 32959892 Free PMC article.
Pathway network analysis revealed four statistically significant antiviral pathways, including HCMV, HPV, EBV, and HIV1 infection pathways. Interestingly, compared with the reported 284 SARS-CoV-2/COVID-19-related genes from GencLip3, we identif …
Pathway network analysis revealed four statistically significant antiviral pathways, including HCMV, HPV, EBV, and HIV1 infection pathways. …
Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2.
Gupta SP. Gupta SP. Curr Top Med Chem. 2020;20(26):2362-2378. doi: 10.2174/1568026620666200922112300. Curr Top Med Chem. 2020. PMID: 32962613 Review.
The article highlights an up-to-date progress in studies on structural and the remedial aspects of novel coronavirus 2019-nCoV, renamed as SARS-CoV-2, leading to the disease COVID-19, a pandemic. In general, all CoVs including SARS-CoV
The article highlights an up-to-date progress in studies on structural and the remedial aspects of novel coronavirus 2019-nCoV, renamed as …
Recognition of Potential COVID-19 Drug Treatments through the Study of Existing Protein-Drug and Protein-Protein Structures: An Analysis of Kinetically Active Residues.
Perišić O. Perišić O. Biomolecules. 2020 Sep 21;10(9):1346. doi: 10.3390/biom10091346. Biomolecules. 2020. PMID: 32967116 Free PMC article.
We report the results of our in silico study of approved drugs as potential treatments for COVID-19. The study is based on the analysis of normal modes of proteins. The drugs studied include chloroquine, ivermectin, remdesivir, sofosbuvir, boceprevir, and alp …
We report the results of our in silico study of approved drugs as potential treatments for COVID-19. The study is based on the …
Favipiravir and the Need for Early Ambulatory Treatment of SARS-CoV-2 Infection (COVID-19).
McCullough PA. McCullough PA. Antimicrob Agents Chemother. 2020 Nov 17;64(12):e02017-20. doi: 10.1128/AAC.02017-20. Print 2020 Nov 17. Antimicrob Agents Chemother. 2020. PMID: 32967849 Free PMC article.
It is becoming increasingly clear that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like most human viral infections, will require multiple drugs in combination to treat COVID-19 illness. In this issue of the Journal, Doi …
It is becoming increasingly clear that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like most h …
Repurposing of the approved small molecule drugs in order to inhibit SARS-CoV-2 S protein and human ACE2 interaction through virtual screening approaches.
Kalhor H, Sadeghi S, Abolhasani H, Kalhor R, Rahimi H. Kalhor H, et al. J Biomol Struct Dyn. 2022 Feb;40(3):1299-1315. doi: 10.1080/07391102.2020.1824816. Epub 2020 Sep 24. J Biomol Struct Dyn. 2022. PMID: 32969333 Free PMC article.
Most recently, the new coronavirus (SARS-CoV-2) has been recognized as a pandemic by the World Health Organization (WHO) while this virus shares substantial similarity with SARS-CoV. ...It was proven that human ACE2 is the main receptor for the …
Most recently, the new coronavirus (SARS-CoV-2) has been recognized as a pandemic by the World Health Organization (WHO …
Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak.
Low ZY, Farouk IA, Lal SK. Low ZY, et al. Viruses. 2020 Sep 22;12(9):1058. doi: 10.3390/v12091058. Viruses. 2020. PMID: 32972027 Free PMC article. Review.
The greatest advantage of drug repositioning is that it breathes new life into the novel, rare, orphan, and resistant diseases, such as Cushing's syndrome, HIV infection, and pandemic outbreaks such as COVID-19. Repositioning existing drugs such as Hydroxychl …
The greatest advantage of drug repositioning is that it breathes new life into the novel, rare, orphan, and resistant diseases, such as Cush …
Overview of the First 6 Months of Clinical Trials for COVID-19 Pharmacotherapy: The Most Studied Drugs.
Idda ML, Soru D, Floris M. Idda ML, et al. Front Public Health. 2020 Aug 21;8:497. doi: 10.3389/fpubh.2020.00497. eCollection 2020. Front Public Health. 2020. PMID: 32974268 Free PMC article. Review.
SARS-CoV-2 rapidly spread from China until it was defined a pandemic by WHO in March 2020. ...Existing therapies used in several clinical trials work by affecting the biology of COVID-19 and/or counteracting the harmful host excessive immune res
SARS-CoV-2 rapidly spread from China until it was defined a pandemic by WHO in March 2020. ...Existing therapies used i
Clinical Presentation, Management and In-Hospital Outcome of Healthcare Personnel With COVID-19 Disease.
Malik FT, Ishraquzzaman M, Kalimuddin M, Choudhury S, Ahmed N, Badiuzzaman M, Ahmed MN, Banik D, Huq TS, Al Mamun MA. Malik FT, et al. Cureus. 2020 Aug 24;12(8):e10004. doi: 10.7759/cureus.10004. Cureus. 2020. PMID: 32983701 Free PMC article.
Objective Healthcare personnel (HCP) are undoubtedly one of the major frontline fighters in the coronavirus disease 2019 (COVID-19) pandemic. Therefore, it comes as no surprise that many HCP have become infected by COVID-19 globally. ...Structured inte …
Objective Healthcare personnel (HCP) are undoubtedly one of the major frontline fighters in the coronavirus disease 2019 (COVID-19
Effective Anti-SARS-CoV-2 RNA Dependent RNA Polymerase Drugs Based on Docking Methods: The Case of Milbemycin, Ivermectin, and Baloxavir Marboxil.
Daghir Janabi AH. Daghir Janabi AH. Avicenna J Med Biotechnol. 2020 Oct-Dec;12(4):246-250. Avicenna J Med Biotechnol. 2020. PMID: 33014317 Free PMC article.
BACKGROUND: Severe Acute Respiratory Syndrome-coronavirus 2 (SARS-CoV-2) is a new virus with a global pandemic. Yet, no vaccine or efficient treatments are found against the disease. The viral RNA dependent RNA Polymerase (RdRP) is a suitable target fo …
BACKGROUND: Severe Acute Respiratory Syndrome-coronavirus 2 (SARS-CoV-2) is a new virus with a global pandemic. …
Diagnostic approaches and potential therapeutic options for coronavirus disease 2019.
Khan Z, Ghafoor D, Khan A, Ualiyeva D, Khan SA, Bilal H, Khan B, Khan A, Sajjad W. Khan Z, et al. New Microbes New Infect. 2020 Nov;38:100770. doi: 10.1016/j.nmni.2020.100770. Epub 2020 Sep 30. New Microbes New Infect. 2020. PMID: 33014380 Free PMC article. Review.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city of China in late December 2019 and identified as a novel coronavirus. Due to its contagious nature, the virus spreads rapidly and causes coronavirus disease 2019 (COV
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city of China in late December 201 …
Ivermectin in COVID-19: What do we know?
Pandey S, Pathak SK, Pandey A, Salunke AA, Chawla J, Sharma A, Sharma S, Thivari P, Ratna HVK. Pandey S, et al. Diabetes Metab Syndr. 2020 Nov-Dec;14(6):1921-1922. doi: 10.1016/j.dsx.2020.09.027. Epub 2020 Sep 28. Diabetes Metab Syndr. 2020. PMID: 33032231 Free PMC article. Review. No abstract available.
Ivermectin: an award-winning drug with expected antiviral activity against COVID-19.
Formiga FR, Leblanc R, de Souza Rebouças J, Farias LP, de Oliveira RN, Pena L. Formiga FR, et al. J Control Release. 2021 Jan 10;329:758-761. doi: 10.1016/j.jconrel.2020.10.009. Epub 2020 Oct 7. J Control Release. 2021. PMID: 33038449 Free PMC article. Review.
Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite this promise, the anti
Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA
Pathophysiology and Potential Therapeutic Candidates for COVID-19: A Poorly Understood Arena.
Samaddar A, Grover M, Nag VL. Samaddar A, et al. Front Pharmacol. 2020 Sep 17;11:585888. doi: 10.3389/fphar.2020.585888. eCollection 2020. Front Pharmacol. 2020. PMID: 33041830 Free PMC article. Review.
Coronavirus disease 2019 (COVID-19), an acute onset pneumonia caused by a novel Betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in the Wuhan City of China in December 2019 and evolved into a global p …
Coronavirus disease 2019 (COVID-19), an acute onset pneumonia caused by a novel Betacoronavirus, severe acute respiratory synd …
Familiar Dermatologic Drugs as Therapies for COVID-19.
Ortega-Peña M, González-Cuevas R. Ortega-Peña M, et al. Actas Dermosifiliogr (Engl Ed). 2021 Feb;112(2):118-126. doi: 10.1016/j.ad.2020.09.004. Epub 2020 Oct 10. Actas Dermosifiliogr (Engl Ed). 2021. PMID: 33045209 Free PMC article. Review. English, Spanish.
We briefly review the aforementioned dermatologic drugs and describe the most recent findings relevant to their use against COVID-19. Researchers the world over are working to find the treatments needed to reduce the negative effects of coronavirus disease 2019 ( …
We briefly review the aforementioned dermatologic drugs and describe the most recent findings relevant to their use against COVID- …
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study.
Surti M, Patel M, Adnan M, Moin A, Ashraf SA, Siddiqui AJ, Snoussi M, Deshpande S, Reddy MN. Surti M, et al. RSC Adv. 2020 Oct 13;10(62):37707-37720. doi: 10.1039/d0ra06379g. eCollection 2020 Oct 12. RSC Adv. 2020. PMID: 35515150 Free PMC article.
The outbreak of novel coronavirus, SARS-CoV-2, has infected more than 36 million people and caused approximately 1 million deaths around the globe as of 9 October 2020. ...In the present study, the inhibitory prospects of ilimaquinone (marine sponge metabolit …
The outbreak of novel coronavirus, SARS-CoV-2, has infected more than 36 million people and caused approximately 1 mill …
Nebulized ivermectin for COVID-19 and other respiratory diseases, a proof of concept, dose-ranging study in rats.
Chaccour C, Abizanda G, Irigoyen-Barrio Á, Casellas A, Aldaz A, Martínez-Galán F, Hammann F, Gil AG. Chaccour C, et al. Sci Rep. 2020 Oct 13;10(1):17073. doi: 10.1038/s41598-020-74084-y. Sci Rep. 2020. PMID: 33051517 Free PMC article.
Recent data shows significant reduction of SARS-CoV-2 replication in vitro by ivermectin concentrations not achievable with safe doses orally. ...There were no histological anomalies in the lungs of any rat. Male animals received a higher ivermectin
Recent data shows significant reduction of SARS-CoV-2 replication in vitro by ivermectin concentrations not achi …
Toward Preparing a Knowledge Base to Explore Potential Drugs and Biomedical Entities Related to COVID-19: Automated Computational Approach.
Khan JY, Khondaker MTI, Hoque IT, Al-Absi HRH, Rahman MS, Guler R, Alam T, Rahman MS. Khan JY, et al. JMIR Med Inform. 2020 Nov 10;8(11):e21648. doi: 10.2196/21648. JMIR Med Inform. 2020. PMID: 33055059 Free PMC article.
Based on our computational method, we found Remdesivir, Statins, Dexamethasone, and Ivermectin could be considered as potential effective drugs to improve clinical status and lower mortality in patients hospitalized with COVID-19. We also found that Hydroxych …
Based on our computational method, we found Remdesivir, Statins, Dexamethasone, and Ivermectin could be considered as potential effec …
Ivermectin: A Closer Look at a Potential Remedy.
Elkholy KO, Hegazy O, Erdinc B, Abowali H. Elkholy KO, et al. Cureus. 2020 Sep 11;12(9):e10378. doi: 10.7759/cureus.10378. Cureus. 2020. PMID: 33062500 Free PMC article. Review.
Numerous antivirals are being studied for the management of the coronavirus disease 2019 (COVID-19) pneumonia caused by the SARS-CoV-2. Remdesivir was the first drug to gain emergency FDA approval to be used in COVID-19. ...Additio …
Numerous antivirals are being studied for the management of the coronavirus disease 2019 (COVID-19) pneumonia caused by the …
Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019: The Ivermectin in COVID Nineteen Study.
Rajter JC, Sherman MS, Fatteh N, Vogel F, Sacks J, Rajter JJ. Rajter JC, et al. Chest. 2021 Jan;159(1):85-92. doi: 10.1016/j.chest.2020.10.009. Epub 2020 Oct 13. Chest. 2021. PMID: 33065103 Free PMC article.
RESEARCH QUESTION: Does ivermectin benefit hospitalized coronavirus disease 2019 (COVID-19) patients? ...INTERPRETATION: Ivermectin treatment was associated with lower mortality during treatment of COVID-19, especially in patients with se …
RESEARCH QUESTION: Does ivermectin benefit hospitalized coronavirus disease 2019 (COVID-19) patients? ...INTERPRETATION …
Ivermectin, Famotidine, and Doxycycline: A Suggested Combinatorial Therapeutic for the Treatment of COVID-19.
Sen Gupta PS, Rana MK. Sen Gupta PS, et al. ACS Pharmacol Transl Sci. 2020 Sep 28;3(5):1037-1038. doi: 10.1021/acsptsci.0c00140. eCollection 2020 Oct 9. ACS Pharmacol Transl Sci. 2020. PMID: 33073202 Free PMC article.
While no cure is available to date, herein we put forward with rationale and supporting evidence that if administrated simultaneously, a combination of FDA-approved drugs comprising ivermectin, famotidine, and doxycycline may provide robust chemoprophylaxis effective again …
While no cure is available to date, herein we put forward with rationale and supporting evidence that if administrated simultaneously, a com …
Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-α with in-vitro effective drug ivermectin.
Sen Gupta PS, Biswal S, Panda SK, Ray AK, Rana MK. Sen Gupta PS, et al. J Biomol Struct Dyn. 2022 Mar;40(5):2217-2226. doi: 10.1080/07391102.2020.1839564. Epub 2020 Oct 28. J Biomol Struct Dyn. 2022. PMID: 33111618 Free PMC article.
While an FDA approved drug Ivermectin was reported to dramatically reduce the cell line of SARS-CoV-2 by 5000 folds within 48 h, the precise mechanism of action and the COVID-19 molecular target involved in interaction with this in-vitro …
While an FDA approved drug Ivermectin was reported to dramatically reduce the cell line of SARS-CoV-2 by 5000 fo …
An in-silico analysis of ivermectin interaction with potential SARS-CoV-2 targets and host nuclear importin α.
Azam F, Taban IM, Eid EEM, Iqbal M, Alam O, Khan S, Mahmood D, Anwar MJ, Khalilullah H, Khan MU. Azam F, et al. J Biomol Struct Dyn. 2022 Apr;40(6):2851-2864. doi: 10.1080/07391102.2020.1841028. Epub 2020 Nov 2. J Biomol Struct Dyn. 2022. PMID: 33131430 Free PMC article.
It has also been found to hamper SARS-CoV-2 replication in vitro, and its precise mechanism of action against SARS-CoV-2 is yet to be understood. ...In silico exploration of the potential targets and their interaction profile with IVM can …
It has also been found to hamper SARS-CoV-2 replication in vitro, and its precise mechanism of action against SARS
Risk of hospitalization for Covid-19 outpatients treated with various drug regimens in Brazil: Comparative analysis.
Szente Fonseca SN, de Queiroz Sousa A, Wolkoff AG, Moreira MS, Pinto BC, Valente Takeda CF, Rebouças E, Vasconcellos Abdon AP, Nascimento ALA, Risch HA. Szente Fonseca SN, et al. Travel Med Infect Dis. 2020 Nov-Dec;38:101906. doi: 10.1016/j.tmaid.2020.101906. Epub 2020 Oct 31. Travel Med Infect Dis. 2020. PMID: 33137493 Free PMC article.
We implemented this COVID-19 protocol for outpatients and studied 717 consecutive SARS-CoV-2-positive patients age 40 years or older presenting at our emergency rooms. ...CONCLUSIONS: This work adds to the growing literature of studies that have …
We implemented this COVID-19 protocol for outpatients and studied 717 consecutive SARS-CoV-2-positive pat …
Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients.
Camprubí D, Almuedo-Riera A, Martí-Soler H, Soriano A, Hurtado JC, Subirà C, Grau-Pujol B, Krolewiecki A, Muñoz J. Camprubí D, et al. PLoS One. 2020 Nov 11;15(11):e0242184. doi: 10.1371/journal.pone.0242184. eCollection 2020. PLoS One. 2020. PMID: 33175880 Free PMC article.
Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. ...No differences were found between groups. We recommend the evaluation of high-doses of ivermectin in randomized trials against SARS-CoV-2....
Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. ...No differences were found between groups.
Ivermectin: An Anthelmintic, an Insecticide, and Much More.
Martin RJ, Robertson AP, Choudhary S. Martin RJ, et al. Trends Parasitol. 2021 Jan;37(1):48-64. doi: 10.1016/j.pt.2020.10.005. Epub 2020 Nov 11. Trends Parasitol. 2021. PMID: 33189582 Free PMC article. Review.
Here we tell the story of ivermectin, describing its anthelmintic and insecticidal actions and recent studies that have sought to reposition ivermectin for the treatment of other diseases that are not caused by helminth and insect parasites. ...Caution is required b …
Here we tell the story of ivermectin, describing its anthelmintic and insecticidal actions and recent studies that have sought to rep …
COVID-19 and nutriceutical therapies, especially using zinc to supplement antimicrobials.
Butters D, Whitehouse M. Butters D, et al. Inflammopharmacology. 2021 Feb;29(1):101-105. doi: 10.1007/s10787-020-00774-8. Epub 2020 Nov 16. Inflammopharmacology. 2021. PMID: 33196946 Free PMC article. Review.
Ultimately, this is a matter of behaviour, lifestyle, and informed choice(s). See Hetzel and McMichael 1959....
Ultimately, this is a matter of behaviour, lifestyle, and informed choice(s). See Hetzel and McMichael 1959....
Therapeutic potential of ivermectin as add on treatment in COVID 19: A systematic review and meta-analysis.
Padhy BM, Mohanty RR, Das S, Meher BR. Padhy BM, et al. J Pharm Pharm Sci. 2020;23:462-469. doi: 10.18433/jpps31457. J Pharm Pharm Sci. 2020. PMID: 33227231 Free article.
The current management of COVID-19 is mostly limited to general supportive care and symptomatic treatment. ...Hence, we conducted this systematic review and meta-analysis to assess the currently available data on the therapeutic potential of ivermectin for th …
The current management of COVID-19 is mostly limited to general supportive care and symptomatic treatment. ...Hence, we conduc …
Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19): a structured summary of a study protocol for a randomized controlled trial.
Vallejos J, Zoni R, Bangher M, Villamandos S, Bobadilla A, Plano F, Campias C, Chaparro Campias E, Achinelli F, Guglielmone HA, Ojeda J, Medina F, Farizano Salazar D, Andino G, Ruiz Diaz NE, Kawerin P, Meza E, Dellamea S, Aquino A, Flores V, Martemucci CN, Vernengo MM, Martinez SM, Segovia JE, Aguirre MG. Vallejos J, et al. Trials. 2020 Nov 24;21(1):965. doi: 10.1186/s13063-020-04813-1. Trials. 2020. PMID: 33234158 Free PMC article. Clinical Trial.
OBJECTIVES: To assess the efficacy of ivermectin in addition to standard treatment compared to standard treatment alone in reducing hospitalizations in the COVID-19 patient population. ...Over 18 years of age who reside in the province of Corrientes at the ti …
OBJECTIVES: To assess the efficacy of ivermectin in addition to standard treatment compared to standard treatment alone in reducing h …
COVID-19: Panama stockpiles unproven drugs.
Torres-Atencio I, Goodridge A, Vega S. Torres-Atencio I, et al. Nature. 2020 Nov;587(7835):548. doi: 10.1038/d41586-020-03289-y. Nature. 2020. PMID: 33235365 No abstract available.
Inhaled route and anti-inflammatory action of ivermectin: Do they hold promise in fighting against COVID-19?
Mittal N, Mittal R. Mittal N, et al. Med Hypotheses. 2021 Jan;146:110364. doi: 10.1016/j.mehy.2020.110364. Epub 2020 Nov 5. Med Hypotheses. 2021. PMID: 33246694 Free PMC article.
Due to its potential to interfere with transport of SARS-CoV-2 nucleocapsid protein to nucleus, it is being proposed to have antiviral activity against this virus as well which has been confirmed in an in-vitro study. ...In a modelling simulation study, drug …
Due to its potential to interfere with transport of SARS-CoV-2 nucleocapsid protein to nucleus, it is being proposed to …
One year update on the COVID-19 pandemic: Where are we now?
Mishra SK, Tripathi T. Mishra SK, et al. Acta Trop. 2021 Feb;214:105778. doi: 10.1016/j.actatropica.2020.105778. Epub 2020 Nov 28. Acta Trop. 2021. PMID: 33253656 Free PMC article. Review.
We are living through an unprecedented crisis with the rapid spread of the new coronavirus disease (COVID-19) worldwide within a short time. The timely availability of thousands of SARS-CoV-2 genomes has enabled the scientific community to study …
We are living through an unprecedented crisis with the rapid spread of the new coronavirus disease (COVID-19) worldwide within …
A COVID-19 prophylaxis? Lower incidence associated with prophylactic administration of ivermectin.
Hellwig MD, Maia A. Hellwig MD, et al. Int J Antimicrob Agents. 2021 Jan;57(1):106248. doi: 10.1016/j.ijantimicag.2020.106248. Epub 2020 Nov 28. Int J Antimicrob Agents. 2021. PMID: 33259913 Free PMC article.
Such a treatment would be particularly valuable if it could be used as a prophylactic against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) transmission, thereby effectively slowing the spread of the disease while we await the wide avail …
Such a treatment would be particularly valuable if it could be used as a prophylactic against SARS-CoV-2 (severe acute …
A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness.
Ahmed S, Karim MM, Ross AG, Hossain MS, Clemens JD, Sumiya MK, Phru CS, Rahman M, Zaman K, Somani J, Yasmin R, Hasnat MA, Kabir A, Aziz AB, Khan WA. Ahmed S, et al. Int J Infect Dis. 2021 Feb;103:214-216. doi: 10.1016/j.ijid.2020.11.191. Epub 2020 Dec 2. Int J Infect Dis. 2021. PMID: 33278625 Free PMC article. Clinical Trial.
Ivermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. ...There were no severe adverse drug events recorded in the stud
Ivermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to inhibit severe acute respiratory syndrome c
Ivermectin Treatment May Improve the Prognosis of Patients With COVID-19.
Khan MSI, Khan MSI, Debnath CR, Nath PN, Mahtab MA, Nabeka H, Matsuda S, Akbar SMF. Khan MSI, et al. Arch Bronconeumol (Engl Ed). 2020 Dec;56(12):828-830. doi: 10.1016/j.arbres.2020.08.007. Epub 2020 Sep 24. Arch Bronconeumol (Engl Ed). 2020. PMID: 33293006 Free PMC article. No abstract available.
Severe Coronavirus Disease 2019 That Recovered from Respiratory Failure by Treatment That Included High-dose Intravenous Immunoglobulin.
Suzuki Y, Tanino Y, Nikaido T, Minemura H, Umeda T, Rikimaru M, Onuma T, Naito S, Takiguchi Y, Tomita H, Kawamata T, Togawa R, Sato Y, Uematsu M, Morimoto J, Kitakawa K, Tsukada Y, Nakamura K, Kanemitsu K, Iseki K, Shibata Y. Suzuki Y, et al. Intern Med. 2021 Feb 1;60(3):457-461. doi: 10.2169/internalmedicine.6326-20. Epub 2020 Dec 15. Intern Med. 2021. PMID: 33328409 Free PMC article.
We herein report a case of severe coronavirus disease 2019 (COVID-19) in which high-dose intravenous immunoglobulin (IVIg) treatment achieved significant clinical improvement of deterioration of pulmonary inflammation after temporary clinical improvement. ...IVIg tr …
We herein report a case of severe coronavirus disease 2019 (COVID-19) in which high-dose intravenous immunoglobulin (IVIg) tre …
Clinically Approved Antiviral Drug in an Orally Administrable Nanoparticle for COVID-19.
Surnar B, Kamran MZ, Shah AS, Dhar S. Surnar B, et al. ACS Pharmacol Transl Sci. 2020 Dec 1;3(6):1371-1380. doi: 10.1021/acsptsci.0c00179. eCollection 2020 Dec 11. ACS Pharmacol Transl Sci. 2020. PMID: 33330844 Free PMC article.
There is urgent therapeutic need for COVID-19, a disease for which there are currently no widely effective approved treatments and the emergency use authorized drugs do not result in significant and widespread patient improvement. ...As both ACE2 targeting and the p …
There is urgent therapeutic need for COVID-19, a disease for which there are currently no widely effective approved treatments …
Possible treatment and strategies for COVID-19: review and assessment.
Trivedi N, Verma A, Kumar D. Trivedi N, et al. Eur Rev Med Pharmacol Sci. 2020 Dec;24(23):12593-12608. doi: 10.26355/eurrev_202012_24057. Eur Rev Med Pharmacol Sci. 2020. PMID: 33336780 Free article. Review.
The emergent outbreak of COVID-19 triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps propagating globally. ...Many randomized and controlled clinical trials are taking place to further validate these agent' …
The emergent outbreak of COVID-19 triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- …
Inclusion of pregnant women in COVID-19 treatment trials: a review and global call to action.
Taylor MM, Kobeissi L, Kim C, Amin A, Thorson AE, Bellare NB, Brizuela V, Bonet M, Kara E, Thwin SS, Kuganantham H, Ali M, Oladapo OT, Broutet N. Taylor MM, et al. Lancet Glob Health. 2021 Mar;9(3):e366-e371. doi: 10.1016/S2214-109X(20)30484-8. Epub 2020 Dec 16. Lancet Glob Health. 2021. PMID: 33340453 Free PMC article. Review.
Of 35 studies that evaluated high-dose vitamin treatment for COVID-19, 27 (77%) excluded pregnant women. Despite the surge in treatment studies for COVID-19, the proportion excluding pregnant women remains consistent. ...Inclusion of pregnant women in …
Of 35 studies that evaluated high-dose vitamin treatment for COVID-19, 27 (77%) excluded pregnant women. Despite the surge in …
The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?
Jans DA, Wagstaff KM. Jans DA, et al. Biochem Biophys Res Commun. 2021 Jan 29;538:163-172. doi: 10.1016/j.bbrc.2020.10.042. Epub 2020 Oct 21. Biochem Biophys Res Commun. 2021. PMID: 33341233 Free PMC article. Review.
Cell culture experiments have shown robust antiviral action towards a whole range of viruses, including HIV-1, dengue, Zika and West Nile Virus, Venezuelan equine encephalitis virus, Chikungunya, pseudorabies virus, adenovirus, and SARS-CoV-2 (COVID- …
Cell culture experiments have shown robust antiviral action towards a whole range of viruses, including HIV-1, dengue, Zika and West Nile Vi …
Challenges in COVID-19 drug treatment in patients with advanced liver diseases: A hepatology perspective.
Hanafy AS, Abd-Elsalam S. Hanafy AS, et al. World J Gastroenterol. 2020 Dec 14;26(46):7272-7286. doi: 10.3748/wjg.v26.i46.7272. World J Gastroenterol. 2020. PMID: 33362383 Free PMC article. Review.
The global incidence of coronavirus disease 2019 (COVID-19) continues to increase despite health care efforts. The disease is caused by coronavirus 2 with high transmission and mortality rates. ...Drugs suitable to manage COVID-19 in patients wi …
The global incidence of coronavirus disease 2019 (COVID-19) continues to increase despite health care efforts. The disease is …
COVID-19 in Still's disease.
de Carvalho JF. de Carvalho JF. Eur Rev Med Pharmacol Sci. 2020 Dec;24(24):12627-12629. doi: 10.26355/eurrev_202012_24158. Eur Rev Med Pharmacol Sci. 2020. PMID: 33378008 Free article. No abstract available.
Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis.
Kim MS, An MH, Kim WJ, Hwang TH. Kim MS, et al. PLoS Med. 2020 Dec 30;17(12):e1003501. doi: 10.1371/journal.pmed.1003501. eCollection 2020 Dec. PLoS Med. 2020. PMID: 33378357 Free PMC article.
We included studies investigating the effect of pharmacological management of patients hospitalized for COVID-19 management. Mild patients who do not require hospitalization or have self-limiting disease courses were not eligible for our NMA. ...Only 29% of current …
We included studies investigating the effect of pharmacological management of patients hospitalized for COVID-19 management. M …
Clinical outcomes after early ambulatory multidrug therapy for high-risk SARS-CoV-2 (COVID-19) infection.
Procter BC, Ross C, Pickard V, Smith E, Hanson C, McCullough PA. Procter BC, et al. Rev Cardiovasc Med. 2020 Dec 30;21(4):611-614. doi: 10.31083/j.rcm.2020.04.260. Rev Cardiovasc Med. 2020. PMID: 33388006 Free article.
There is an emergency need for early ambulatory treatment of Coronavirus Disease 2019 (COVID-19) in acutely ill patients in an attempt to reduce disease progression and the risks of hospitalization and death. ...Patients age 50.5 13.7 years (range 12 to 89), 61.6% w …
There is an emergency need for early ambulatory treatment of Coronavirus Disease 2019 (COVID-19) in acutely ill patients in an …
CoViTris2020 and ChloViD2020: a striking new hope in COVID-19 therapy.
Rabie AM. Rabie AM. Mol Divers. 2021 Aug;25(3):1839-1854. doi: 10.1007/s11030-020-10169-0. Epub 2021 Jan 3. Mol Divers. 2021. PMID: 33389560 Free PMC article. Retracted.
Repurposing of known active compounds against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new effective and time-saving trend in anti-COVID-19 drug discovery. ...CoViTris2020 and ChloViD2020 inhibit SARS- …
Repurposing of known active compounds against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) i …
Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes.
Kaur H, Shekhar N, Sharma S, Sarma P, Prakash A, Medhi B. Kaur H, et al. Pharmacol Rep. 2021 Jun;73(3):736-749. doi: 10.1007/s43440-020-00195-y. Epub 2021 Jan 3. Pharmacol Rep. 2021. PMID: 33389725 Free PMC article. Review.
The article discusses the evidence available for the use of Ivermectin, an anti-parasitic drug with antiviral properties, in COVID-19. ...In silico-based analysis of ivermectin's molecular interaction specificity using AI and classical mechanics …
The article discusses the evidence available for the use of Ivermectin, an anti-parasitic drug with antiviral properties, in COVID
Computational investigations of three main drugs and their comparison with synthesized compounds as potent inhibitors of SARS-CoV-2 main protease (Mpro): DFT, QSAR, molecular docking, and in silico toxicity analysis.
Mohapatra RK, Perekhoda L, Azam M, Suleiman M, Sarangi AK, Semenets A, Pintilie L, Al-Resayes SI. Mohapatra RK, et al. J King Saud Univ Sci. 2021 Mar;33(2):101315. doi: 10.1016/j.jksus.2020.101315. Epub 2020 Dec 27. J King Saud Univ Sci. 2021. PMID: 33390681 Free PMC article.
In this study, we examined five previously synthesized compounds and checked their binding affinity towards the SARS-CoV-2 main protease (M(pro)) by molecular docking study, and compared the data with three FDA approved drugs, i.e., Remdesivir, Ivermectine
In this study, we examined five previously synthesized compounds and checked their binding affinity towards the SARS-CoV-2
The efficacy and safety of Ivermectin in patients with mild and moderate COVID-19: A structured summary of a study protocol for a randomized controlled trial.
Hosseini FS, Malektojari A, Ghazizadeh S, Hassaniazad M, Davoodian P, Dadvand H, Nikpoor AR, Nikoofal-Sahlabadi S, Kahoori S, Sepandi M, Hassanipour S, Fathalipour M. Hosseini FS, et al. Trials. 2021 Jan 4;22(1):4. doi: 10.1186/s13063-020-04988-7. Trials. 2021. PMID: 33397429 Free PMC article.
OBJECTIVES: We will evaluate the efficacy and safety of Ivermectin in patients with mild and moderately severe COVID-19. TRIAL DESIGN: This is a phase 3, single-center, randomized, open-label, controlled trial with a 2-arm parallel-group design (1:1 ra …
OBJECTIVES: We will evaluate the efficacy and safety of Ivermectin in patients with mild and moderately severe COVID-19
Therapeutic options for COVID-19: a quick review.
Ismaila MS, Bande F, Ishaka A, Sani AA, Georges K. Ismaila MS, et al. J Chemother. 2021 Apr;33(2):67-84. doi: 10.1080/1120009X.2020.1868237. Epub 2021 Jan 11. J Chemother. 2021. PMID: 33427110 Review.
There is the need for a collection of information regarding the availlable therapeutic options related to COVID-19. this article therefore reviewed emerging and re-emerging therapeutic compounds/drugs used in COVID-19 management and reports of clinical …
There is the need for a collection of information regarding the availlable therapeutic options related to COVID-19. this artic …
A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin's possible mode of action against SARS-CoV-2.
Kinobe RT, Owens L. Kinobe RT, et al. Fundam Clin Pharmacol. 2021 Apr;35(2):260-276. doi: 10.1111/fcp.12644. Epub 2021 Jan 28. Fundam Clin Pharmacol. 2021. PMID: 33427370 Free PMC article. Review.
We systematically reviewed the evidence for the applicability of ivermectin against viral infections including SARS-CoV-2 regarding efficacy, mechanisms and selective toxicity. The SARS-CoV-2 genome was mined to determine potential …
We systematically reviewed the evidence for the applicability of ivermectin against viral infections including SARS-CoV
Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters.
Telbisz Á, Ambrus C, Mózner O, Szabó E, Várady G, Bakos É, Sarkadi B, Özvegy-Laczka C. Telbisz Á, et al. Pharmaceutics. 2021 Jan 9;13(1):81. doi: 10.3390/pharmaceutics13010081. Pharmaceutics. 2021. PMID: 33435273 Free PMC article.
During the COVID-19 pandemic, several repurposed drugs have been proposed to alleviate the major health effects of the disease. ...Our in vitro studies, using a variety of model systems, explored the interactions of the antimalarial agents chloroquine and hydroxychl …
During the COVID-19 pandemic, several repurposed drugs have been proposed to alleviate the major health effects of the disease …
Antivirals that target the host IMPα/β1-virus interface.
Martin AJ, Jans DA. Martin AJ, et al. Biochem Soc Trans. 2021 Feb 26;49(1):281-295. doi: 10.1042/BST20200568. Biochem Soc Trans. 2021. PMID: 33439253 Free PMC article. Review.
Of these, agents targeting IMPalpha/beta1 directly include the FDA-approved macrocyclic lactone ivermectin, which has documented broad-spectrum activity against a whole range of viruses, including HIV-1, DENV1-4, ZIKV, West Nile virus (WNV), Venezuelan equine encephalitis …
Of these, agents targeting IMPalpha/beta1 directly include the FDA-approved macrocyclic lactone ivermectin, which has documented broa …
Evaluation of the initial response in clinical trial efforts for COVID-19 in Brazil.
Ribeiro TB, Mazotti TA, Silva NAO, Stein AT, Diaz-Quijano FA, Melo DO. Ribeiro TB, et al. Rev Bras Epidemiol. 2021 Jan 6;23:e200104. doi: 10.1590/1980-549720200104. eCollection 2021. Rev Bras Epidemiol. 2021. PMID: 33439937 Free article. English, Portuguese.
OBJECTIVE: To describe the methodological characteristics and good research practices of COVID-19 interventional studies developed in Brazil in the first months of the pandemic. ...The most tested pharmacological interventions in these studies were: chloroquine/hydr …
OBJECTIVE: To describe the methodological characteristics and good research practices of COVID-19 interventional studies devel …
Antiviral treatment in COVID-19: which is the most promising?-a narrative review.
Yadav AK, Wen S, Xu X, Yu L. Yadav AK, et al. Ann Palliat Med. 2021 Jan;10(1):707-720. doi: 10.21037/apm-20-1755. Epub 2021 Jan 11. Ann Palliat Med. 2021. PMID: 33440983 Free article. Review.
However, in those clinical trials, there were some limitations which need to be overcome to find the most promising antiviral against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In conclusion, many of above-mentioned antivirals seems …
However, in those clinical trials, there were some limitations which need to be overcome to find the most promising antiviral against severe …
Deep vein thrombosis with pulmonary thromboembolism in a case of severe COVID-19 pneumonia.
Devi S, Mohakud S, Kar N, Muthuvel D. Devi S, et al. BMJ Case Rep. 2021 Jan 15;14(1):e240932. doi: 10.1136/bcr-2020-240932. BMJ Case Rep. 2021. PMID: 33452066 Free PMC article.
The frontal chest radiograph showed bilateral ground-glass opacities; he tested positive for COVID-19 with elevated D-dimer. The colour Doppler examination of the left leg revealed acute deep vein thrombosis (DVT) of the common femoral and the popliteal veins. ...Th …
The frontal chest radiograph showed bilateral ground-glass opacities; he tested positive for COVID-19 with elevated D-dimer. T …
Oral ivermectin for a scabies outbreak in a long-term care facility: potential value in preventing COVID-19 and associated mortality.
Bernigaud C, Guillemot D, Ahmed-Belkacem A, Grimaldi-Bensouda L, Lespine A, Berry F, Softic L, Chenost C, Do-Pham G, Giraudeau B, Fourati S, Chosidow O. Bernigaud C, et al. Br J Dermatol. 2021 Jun;184(6):1207-1209. doi: 10.1111/bjd.19821. Epub 2021 Mar 1. Br J Dermatol. 2021. PMID: 33454964 Free PMC article. No abstract available.
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents.
Mody V, Ho J, Wills S, Mawri A, Lawson L, Ebert MCCJC, Fortin GM, Rayalam S, Taval S. Mody V, et al. Commun Biol. 2021 Jan 20;4(1):93. doi: 10.1038/s42003-020-01577-x. Commun Biol. 2021. PMID: 33473151 Free PMC article.
Emerging outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is a major threat to public health. The morbidity is increasing due to lack of SARS-CoV-2 specific drugs. ...In summary, these molecules co …
Emerging outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is a major threat to …
From hydroxychloroquine to ivermectin: what are the anti-viral properties of anti-parasitic drugs to combat SARS-CoV-2?
Rakedzon S, Neuberger A, Domb AJ, Petersiel N, Schwartz E. Rakedzon S, et al. J Travel Med. 2021 Feb 23;28(2):taab005. doi: 10.1093/jtm/taab005. J Travel Med. 2021. PMID: 33480414 Free PMC article.
BACKGROUND: Nearly a year into the COVID-19 pandemic, we still lack effective anti-SARS-CoV-2 drugs with substantial impact on mortality rates except for dexamethasone. ...As the level of evidence of these data is low, the efficacy of ivermec
BACKGROUND: Nearly a year into the COVID-19 pandemic, we still lack effective anti-SARS-CoV-2 drugs with …
A Narrative Review of Pharmacologic Treatments for COVID-19: Safety Considerations and Ototoxicity.
Little C, Cosetti MK. Little C, et al. Laryngoscope. 2021 Jul;131(7):1626-1632. doi: 10.1002/lary.29424. Epub 2021 Jan 27. Laryngoscope. 2021. PMID: 33491234 Free PMC article. Review.
OBJECTIVE/HYPOTHESIS: The purpose of this review is to summarize evidence-based data regarding the ototoxic effects of potential COVID-19 therapeutics to treat patients suffering from SARS-CoV-2. METHODS: Medications under investigation as novel …
OBJECTIVE/HYPOTHESIS: The purpose of this review is to summarize evidence-based data regarding the ototoxic effects of potential COVID
Immunosuppression in kidney transplant recipients with COVID-19 infection - where do we stand and where are we heading?
Daoud A, Alqassieh A, Alkhader D, Posadas Salas MA, Rao V, Fülöp T, Soliman KM. Daoud A, et al. Ren Fail. 2021 Dec;43(1):273-280. doi: 10.1080/0886022X.2021.1876730. Ren Fail. 2021. PMID: 33491531 Free PMC article. Review.
The appropriate immunosuppressive regimen in kidney transplant recipients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2/COVID-19) infection remains unclear. The impact of direct virus injury complicated by dysregulated …
The appropriate immunosuppressive regimen in kidney transplant recipients with severe acute respiratory syndrome coronavirus-2 (SA
Molecular docking studies of some selected gallic acid derivatives against five non-structural proteins of novel coronavirus.
Umar HI, Siraj B, Ajayi A, Jimoh TO, Chukwuemeka PO. Umar HI, et al. J Genet Eng Biotechnol. 2021 Jan 25;19(1):16. doi: 10.1186/s43141-021-00120-7. J Genet Eng Biotechnol. 2021. PMID: 33492492 Free PMC article.
Realizing the need for potent and harmless therapeutic compounds to combat COVID-19, we attempted in this study to find promising therapeutic compounds against the imminent threat of this virus. In this current study, 16 derivatives of gallic acid were docked agains …
Realizing the need for potent and harmless therapeutic compounds to combat COVID-19, we attempted in this study to find promis …
Safety and Pharmacokinetic Assessments of a Novel Ivermectin Nasal Spray Formulation in a Pig Model.
Errecalde J, Lifschitz A, Vecchioli G, Ceballos L, Errecalde F, Ballent M, Marín G, Daniele M, Turic E, Spitzer E, Toneguzzo F, Gold S, Krolewiecki A, Alvarez L, Lanusse C. Errecalde J, et al. J Pharm Sci. 2021 Jun;110(6):2501-2507. doi: 10.1016/j.xphs.2021.01.017. Epub 2021 Jan 23. J Pharm Sci. 2021. PMID: 33493479 Free PMC article.
Recently published data indicates that high ivermectin (IVM) concentrations suppress in vitro SARS-CoV-2 replication. ...These original results support the undertaking of future clinical trials to evaluate the safety/efficacy of the nasal IVM spray app …
Recently published data indicates that high ivermectin (IVM) concentrations suppress in vitro SARS-CoV-2 replica …
The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial.
Chaccour C, Casellas A, Blanco-Di Matteo A, Pineda I, Fernandez-Montero A, Ruiz-Castillo P, Richardson MA, Rodríguez-Mateos M, Jordán-Iborra C, Brew J, Carmona-Torre F, Giráldez M, Laso E, Gabaldón-Figueira JC, Dobaño C, Moncunill G, Yuste JR, Del Pozo JL, Rabinovich NR, Schöning V, Hammann F, Reina G, Sadaba B, Fernández-Alonso M. Chaccour C, et al. EClinicalMedicine. 2021 Feb;32:100720. doi: 10.1016/j.eclinm.2020.100720. Epub 2021 Jan 19. EClinicalMedicine. 2021. PMID: 33495752 Free PMC article.
BACKGROUND: Ivermectin inhibits the replication of SARS-CoV-2 in vitro at concentrations not readily achievable with currently approved doses. There is limited evidence to support its clinical use in COVID-19 patients. We conducted a Pilo …
BACKGROUND: Ivermectin inhibits the replication of SARS-CoV-2 in vitro at concentrations not readily achievable …
Molecular Docking of Azithromycin, Ritonavir, Lopinavir, Oseltamivir, Ivermectin and Heparin Interacting with Coronavirus Disease 2019 Main and Severe Acute Respiratory Syndrome Coronavirus-2 3C-Like Proteases.
Arouche TDS, Martins AY, Ramalho TC, Júnior RNC, Costa FLP, Filho TSA, Neto AMJC. Arouche TDS, et al. J Nanosci Nanotechnol. 2021 Apr 1;21(4):2075-2089. doi: 10.1166/jnn.2021.19029. J Nanosci Nanotechnol. 2021. PMID: 33500022
Here, we selected two viral proteins based on their vital role in the viral life cycle: Structure of the main protease SARS-CoV-2 and the structural base of the SARS-CoV-2 protease 3CL, both supporting the entry of the virus into the huma …
Here, we selected two viral proteins based on their vital role in the viral life cycle: Structure of the main protease SARS-CoV
What does the COVID-19 pandemic mean for the next decade of onchocerciasis control and elimination?
Hamley JID, Blok DJ, Walker M, Milton P, Hopkins AD, Hamill LC, Downs P, de Vlas SJ, Stolk WA, Basáñez MG. Hamley JID, et al. Trans R Soc Trop Med Hyg. 2021 Mar 6;115(3):269-280. doi: 10.1093/trstmh/traa193. Trans R Soc Trop Med Hyg. 2021. PMID: 33515042 Free PMC article.
BACKGROUND: Mass drug administration (MDA) of ivermectin for onchocerciasis has been disrupted by the coronavirus disease 2019 (COVID-19) pandemic. ...Biannual MDA is more effective than increasing coverage for mitigating COVID-19's impac …
BACKGROUND: Mass drug administration (MDA) of ivermectin for onchocerciasis has been disrupted by the coronavirus disease 2019 (CO
Enhanced production of camptothecin by immobilized callus of Ophiorrhiza mungos and a bioinformatic insight into its potential antiviral effect against SARS-CoV-2.
Mamkulathil Devasia R, Altaf M, Fahad Alrefaei A, Manoharadas S. Mamkulathil Devasia R, et al. J King Saud Univ Sci. 2021 Mar;33(2):101344. doi: 10.1016/j.jksus.2021.101344. Epub 2021 Jan 21. J King Saud Univ Sci. 2021. PMID: 33531790 Free PMC article.
Further docking analysis of the CPT against the exterior spike glycoprotein of SARS-CoV-2 was also done to determine their potential interaction. ...The docking analysis of CPT against the spike glycoprotein of SARS-CoV-2 showed hydrogen …
Further docking analysis of the CPT against the exterior spike glycoprotein of SARS-CoV-2 was also done to determine th …
The History of Methylprednisolone, Ascorbic Acid, Thiamine, and Heparin Protocol and I-MASK+ Ivermectin Protocol for COVID-19.
Turkia M. Turkia M. Cureus. 2020 Dec 31;12(12):e12403. doi: 10.7759/cureus.12403. Cureus. 2020. PMID: 33532161 Free PMC article.
An alliance of established experts on critical care, Front Line COVID-19 Critical Care Alliance (FLCCC), has published two protocols for treatment of COVID-19. ...According to the authors, ivermectin is considered the first agent effective for b …
An alliance of established experts on critical care, Front Line COVID-19 Critical Care Alliance (FLCCC), has published two pro …
Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs.
Badary OA. Badary OA. Pharmacogenomics J. 2021 Jun;21(3):275-284. doi: 10.1038/s41397-021-00209-9. Epub 2021 Feb 4. Pharmacogenomics J. 2021. PMID: 33542445 Free PMC article. Review.
The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global pandemic. Many drugs without established efficacy are being used to treat COVID-19 patients either as an offlabel/compassionate use or as a clinical trial. ...There …
The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global pandemic. Many drugs without establish …
Ivermectin: Panacea or true promise for COVID-19.
Heimfarth L, Santos VS, Araújo AAS, Quintans-Júnior LJ, Martins-Filho PR. Heimfarth L, et al. EXCLI J. 2020 Nov 9;19:1517-1519. doi: 10.17179/excli2020-3022. eCollection 2020. EXCLI J. 2020. PMID: 33542677 Free PMC article. No abstract available.
Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico.
Lima-Morales R, Méndez-Hernández P, Flores YN, Osorno-Romero P, Sancho-Hernández CR, Cuecuecha-Rugerio E, Nava-Zamora A, Hernández-Galdamez DR, Romo-Dueñas DK, Salmerón J. Lima-Morales R, et al. Int J Infect Dis. 2021 Apr;105:598-605. doi: 10.1016/j.ijid.2021.02.014. Epub 2021 Feb 10. Int J Infect Dis. 2021. PMID: 33578014 Free PMC article.
OBJECTIVE: There is an urgent need for effective treatments to prevent or attenuate lung and systemic inflammation, endotheliitis, and thrombosis related to COVID-19. This study aimed to assess the effectiveness of a multidrug-therapy consisting of Ivermectin
OBJECTIVE: There is an urgent need for effective treatments to prevent or attenuate lung and systemic inflammation, endotheliitis, and throm …
Small-molecule Antiviral Agents in Ongoing Clinical Trials for COVID-19.
Apaydın ÇB, Çınar G, Cihan-Üstündağ G. Apaydın ÇB, et al. Curr Drug Targets. 2021;22(17):1986-2005. doi: 10.2174/1389450122666210215112150. Curr Drug Targets. 2021. PMID: 33588727 Review.
The coronavirus disease 2019 (COVID-19) pandemic, due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in December 2019 and has rapidly spread globally. ...This review highlights the small-molecule repurp …
The coronavirus disease 2019 (COVID-19) pandemic, due to the novel severe acute respiratory syndrome coronavirus 2 ( …
In vitro assays on the susceptibility of four species of nematophagous fungi to anthelmintics and chemical fungicides/antifungal drug.
Wang B, Zhang N, Gong P, Li J, Wang X, Li X, Wang F, Cai K, Zhang X. Wang B, et al. Lett Appl Microbiol. 2021 Aug;73(2):124-131. doi: 10.1111/lam.13462. Epub 2021 Jun 15. Lett Appl Microbiol. 2021. PMID: 33590540
A modified 24-well cell culture plate assay was conducted to evaluate the susceptibility of nematophagous fungi against drugs tested by calculating the effective middle concentrations (EC(50) ) of each tested drug to inhibit the germination of fungal spores. EC(50) ranged between …
A modified 24-well cell culture plate assay was conducted to evaluate the susceptibility of nematophagous fungi against drugs tested by calc …
Effect of a combination of nitazoxanide, ribavirin, and ivermectin plus zinc supplement (MANS.NRIZ study) on the clearance of mild COVID-19.
Elalfy H, Besheer T, El-Mesery A, El-Gilany AH, Soliman MA, Alhawarey A, Alegezy M, Elhadidy T, Hewidy AA, Zaghloul H, Neamatallah MAM, Raafat D, El-Emshaty WM, Abo El Kheir NY, El-Bendary M. Elalfy H, et al. J Med Virol. 2021 May;93(5):3176-3183. doi: 10.1002/jmv.26880. Epub 2021 Mar 11. J Med Virol. 2021. PMID: 33590901 Free PMC article. Clinical Trial.
This trial compared the rate and time of viral clearance in subjects receiving a combination of nitazoxanide, ribavirin, and ivermectin plus Zinc versus those receiving supportive treatment. This non-randomized controlled trial included 62 patients on the triple combinatio …
This trial compared the rate and time of viral clearance in subjects receiving a combination of nitazoxanide, ribavirin, and ivermectin
Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study.
Behera P, Patro BK, Singh AK, Chandanshive PD, S R R, Pradhan SK, Pentapati SSK, Batmanabane G, Mohapatra PR, Padhy BM, Bal SK, Singh SR, Mohanty RR. Behera P, et al. PLoS One. 2021 Feb 16;16(2):e0247163. doi: 10.1371/journal.pone.0247163. eCollection 2021. PLoS One. 2021. PMID: 33592050 Free PMC article.
BACKGROUND: Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. ...Those involved in physical activity (AOR 3.06 95% CI, 1.18-7.93) for more than an hour/day were more likely to cont …
BACKGROUND: Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV
Ivermectin shows clinical benefits in mild to moderate COVID19: a randomized controlled double-blind, dose-response study in Lagos.
Babalola OE, Bode CO, Ajayi AA, Alakaloko FM, Akase IE, Otrofanowei E, Salu OB, Adeyemo WL, Ademuyiwa AO, Omilabu S. Babalola OE, et al. QJM. 2022 Jan 5;114(11):780-788. doi: 10.1093/qjmed/hcab035. QJM. 2022. PMID: 33599247 Free PMC article. Clinical Trial.
INTRODUCTION: In vitro studies have shown the efficacy of Ivermectin (IV) to inhibit the SARS-CoV-2 viral replication, but questions remained as to in-vivo applications. ...The DTN for Control were, = 9.1+/-5.2, for A 6.0 +/- 2.9 and for …
INTRODUCTION: In vitro studies have shown the efficacy of Ivermectin (IV) to inhibit the SARS-CoV-2 viral replic …
Multidrug treatment for COVID-19.
Ohe M, Furuya K, Goudarzi H. Ohe M, et al. Drug Discov Ther. 2021 Mar 10;15(1):39-41. doi: 10.5582/ddt.2021.01005. Epub 2021 Feb 19. Drug Discov Ther. 2021. PMID: 33612572 Free article.
The World Health Organization characterized the disease caused by SARS-CoV-2 (COVID-19) as a pandemic in March 2020. In the absence of specific treatments for the virus, treatment options are being examined. ...Moreover, multidrug therapy may pr …
The World Health Organization characterized the disease caused by SARS-CoV-2 (COVID-19) as a pandemic in …
Therapeutic Strategies in the Management of COVID-19.
Naik RR, Shakya AK. Naik RR, et al. Front Mol Biosci. 2021 Feb 4;7:636738. doi: 10.3389/fmolb.2020.636738. eCollection 2020. Front Mol Biosci. 2021. PMID: 33614709 Free PMC article. Review.
Since December 2019, SARS-CoV-2 (COVID-19), novel corona virus has caused pandemic globally, with rise in the number of cases and death of the patients. Vast majority of the countries that are dealing with rise in the active cases and death of p …
Since December 2019, SARS-CoV-2 (COVID-19), novel corona virus has caused pandemic globally, with rise in …
Community-directed distributors-The "foot soldiers" in the fight to control and eliminate neglected tropical diseases.
Amazigo UV, Leak SGA, Zoure HGM, Okoronkwo C, Diop Ly M, Isiyaku S, Crump A, Okeibunor JC, Boatin B. Amazigo UV, et al. PLoS Negl Trop Dis. 2021 Mar 4;15(3):e0009088. doi: 10.1371/journal.pntd.0009088. eCollection 2021 Mar. PLoS Negl Trop Dis. 2021. PMID: 33661903 Free PMC article. Review.
Here, we review the contributions of 4.8 million community-directed distributors (CDDs) of medicines over 2 decades in 146,000 communities in 27 sub-Saharan African countries to control or eliminate onchocerciasis and lymphatic filariasis (LF). ...We are of the opinion tha …
Here, we review the contributions of 4.8 million community-directed distributors (CDDs) of medicines over 2 decades in 146,000 commun …
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial.
López-Medina E, López P, Hurtado IC, Dávalos DM, Ramirez O, Martínez E, Díazgranados JA, Oñate JM, Chavarriaga H, Herrera S, Parra B, Libreros G, Jaramillo R, Avendaño AC, Toro DF, Torres M, Lesmes MC, Rios CA, Caicedo I. López-Medina E, et al. JAMA. 2021 Apr 13;325(14):1426-1435. doi: 10.1001/jama.2021.3071. JAMA. 2021. PMID: 33662102 Free PMC article. Clinical Trial.
IMPORTANCE: Ivermectin is widely prescribed as a potential treatment for COVID-19 despite uncertainty about its clinical benefit. ...The findings do not support the use of ivermectin for treatment of mild COVID-19, although larger trials …
IMPORTANCE: Ivermectin is widely prescribed as a potential treatment for COVID-19 despite uncertainty about its clinica …
Phase 2 randomized study on chloroquine, hydroxychloroquine or ivermectin in hospitalized patients with severe manifestations of SARS-CoV-2 infection.
Galan LEB, Santos NMD, Asato MS, Araújo JV, de Lima Moreira A, Araújo AMM, Paiva ADP, Portella DGS, Marques FSS, Silva GMA, de Sousa Resende J, Tizolim MR, Santos PL, Buttenbender SF, de Andrade SB, Carbonell RCC, Da Rocha JG, de Souza RGS, da Fonseca AJ. Galan LEB, et al. Pathog Glob Health. 2021 Jun;115(4):235-242. doi: 10.1080/20477724.2021.1890887. Epub 2021 Mar 8. Pathog Glob Health. 2021. PMID: 33682640 Free PMC article. Clinical Trial.
Objective: Given the urgent need for strategies to minimize the damage caused by this pandemic, this study performed a randomized, double-blind phase 2 study to assess the safety of the effectiveness of chloroquine (CQ), hydroxychloroquine (HCQ) or ivermectin in sev …
Objective: Given the urgent need for strategies to minimize the damage caused by this pandemic, this study performed a randomized, double-bl …
Ivermectin also inhibits the replication of bovine respiratory viruses (BRSV, BPIV-3, BoHV-1, BCoV and BVDV) in vitro.
Yesilbag K, Toker EB, Ates O. Yesilbag K, et al. Virus Res. 2021 May;297:198384. doi: 10.1016/j.virusres.2021.198384. Epub 2021 Mar 10. Virus Res. 2021. PMID: 33713753 Free PMC article.
Moreover, since it is identified as an inhibitor for importin alpha/beta-mediated nuclear localization signal (NLS), IVM is also reported to have antiviral potential against several RNA and DNA viruses. Since therapeutic use of IVM in COVID-19 cases has recently bee …
Moreover, since it is identified as an inhibitor for importin alpha/beta-mediated nuclear localization signal (NLS), IVM is also reported to …
Dexamethasone and COVID-19: Strategies in Low- and Middle-Income Countries to Tackle Steroid-Related Strongyloides Hyperinfection.
Olivera MJ. Olivera MJ. Am J Trop Med Hyg. 2021 Mar 15;104(5):1611-1612. doi: 10.4269/ajtmh.20-1085. Am J Trop Med Hyg. 2021. PMID: 33720844 Free PMC article.
COVID-19 can trigger a systemic inflammatory response that in some cases leads to severe lung involvement, multisystem dysfunction, and death. Dexamethasone therapy, because of its potent anti-inflammatory effects, has been proposed for the management of hospitalize
COVID-19 can trigger a systemic inflammatory response that in some cases leads to severe lung involvement, multisystem dysfunc
The time to offer treatments for COVID-19.
Ngo BT, Marik P, Kory P, Shapiro L, Thomadsen R, Iglesias J, Ditmore S, Rendell M, Varon J, Dubé M, Nanda N, In G, Arkfeld D, Chaudhary P, Campese VM, Hanna DL, Sawcer DE, Ehresmann G, Peng D, Smogorewski M, Armstrong A, Dasgupta R, Sattler F, Brennan-Rieder D, Mussini C, Mitja O, Soriano V, Peschanski N, Hayem G, Confalonieri M, Piccirillo MC, Lobo-Ferreira A, Bello Rivero I, Turkia M, Vinjevoll EH, Griffin D, Hung IF. Ngo BT, et al. Expert Opin Investig Drugs. 2021 May;30(5):505-518. doi: 10.1080/13543784.2021.1901883. Epub 2021 Apr 23. Expert Opin Investig Drugs. 2021. PMID: 33721548 Free PMC article. Review.
Remdesivir and high titer convalescent plasma have emergency use authorization for hospitalized patients in the U.S.A. There is also support for glucocorticoid treatment of the COVID-19 respiratory distress syndrome. Monoclonal antibodies are authorized for o …
Remdesivir and high titer convalescent plasma have emergency use authorization for hospitalized patients in the U.S.A. There is also …
Environmental impact assessment of COVID-19 therapeutic solutions. A prospective analysis.
Tarazona JV, Martínez M, Martínez MA, Anadón A. Tarazona JV, et al. Sci Total Environ. 2021 Jul 15;778:146257. doi: 10.1016/j.scitotenv.2021.146257. Epub 2021 Mar 10. Sci Total Environ. 2021. PMID: 33721651 Free PMC article.
Several medicinal products for human use are currently under consideration as potential treatment for COVID-19 pandemic. As proposals cover also prophylactic use, the treatment could be massive, resulting in unprecedent levels of antiviral emissions to the aquatic e …
Several medicinal products for human use are currently under consideration as potential treatment for COVID-19 pandemic. As pr …
Use of ivermectin in the treatment of Covid-19: A pilot trial.
Pott-Junior H, Paoliello MMB, Miguel AQC, da Cunha AF, de Melo Freire CC, Neves FF, da Silva de Avó LR, Roscani MG, Dos Santos SS, Chachá SGF. Pott-Junior H, et al. Toxicol Rep. 2021;8:505-510. doi: 10.1016/j.toxrep.2021.03.003. Epub 2021 Mar 9. Toxicol Rep. 2021. PMID: 33723507 Free PMC article. Retracted.
RESULTS: A total of 32 patients were enrolled and randomized to treatment. SOC treatment together with ivermectin did not result in any serious adverse events. All patients exhibited a reduction in SARS-CoV-2 viral load within 7 days; however, those wh …
RESULTS: A total of 32 patients were enrolled and randomized to treatment. SOC treatment together with ivermectin did not result in a …
Cancer vs. SARS-CoV-2 induced inflammation, overlapping functions, and pharmacological targeting.
Amere Subbarao S. Amere Subbarao S. Inflammopharmacology. 2021 Apr;29(2):343-366. doi: 10.1007/s10787-021-00796-w. Epub 2021 Mar 15. Inflammopharmacology. 2021. PMID: 33723711 Free PMC article. Review.
It is established that the cytokine storm induced in response to SARS-CoV-2 infection contributes to disease-associated mortality. ...In this review, we emphasise on various possibilities to reduce SARS-CoV-2 induced cytokine storm....
It is established that the cytokine storm induced in response to SARS-CoV-2 infection contributes to disease-associated …
Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2.
Eweas AF, Alhossary AA, Abdel-Moneim AS. Eweas AF, et al. Front Microbiol. 2021 Jan 25;11:592908. doi: 10.3389/fmicb.2020.592908. eCollection 2020. Front Microbiol. 2021. PMID: 33746908 Free PMC article.
SARS-CoV-2 is a newly emerged coronavirus that causes a respiratory disease with variable severity and fatal consequences. ...Our results suggest that both these drugs utilize different mechanisms at the entry and post-entry stages and could be considered pot
SARS-CoV-2 is a newly emerged coronavirus that causes a respiratory disease with variable severity and fatal consequenc
Potential of CRISPR/Cas13 System in Treatment and Diagnosis of COVID-19.
Khodavirdipour A, Piri M, Jabbari S, Khalaj-Kondori M. Khodavirdipour A, et al. Glob Med Genet. 2021 Mar;8(1):7-10. doi: 10.1055/s-0041-1723086. Epub 2021 Feb 25. Glob Med Genet. 2021. PMID: 33748818 Free PMC article. Review.
The novel coronavirus disease 2019 (COVID-19) belongs to coronaviridae families like sarbecovirus (SARS), and causes pyrexia, pertussis, and acute respiratory distress syndrome (ARDS) in major. Started from Wuhan, China, COVID-19 now forced the …
The novel coronavirus disease 2019 (COVID-19) belongs to coronaviridae families like sarbecovirus (SARS), and causes py …
Modeling of SARS-CoV-2 Treatment Effects for Informed Drug Repurposing.
Kern C, Schöning V, Chaccour C, Hammann F. Kern C, et al. Front Pharmacol. 2021 Mar 10;12:625678. doi: 10.3389/fphar.2021.625678. eCollection 2021. Front Pharmacol. 2021. PMID: 33776767 Free PMC article. Review.
Several repurposed drugs are currently under investigation in the fight against coronavirus disease 2019 (COVID-19). Candidates are often selected solely by their effective concentrations in vitro, an approach that has largely not lived up to expectations in COVI
Several repurposed drugs are currently under investigation in the fight against coronavirus disease 2019 (COVID-19). Candidate …
The association between the use of ivermectin and mortality in patients with COVID-19: a meta-analysis.
Kow CS, Merchant HA, Mustafa ZU, Hasan SS. Kow CS, et al. Pharmacol Rep. 2021 Oct;73(5):1473-1479. doi: 10.1007/s43440-021-00245-z. Epub 2021 Mar 29. Pharmacol Rep. 2021. PMID: 33779964 Free PMC article.
OBJECTIVE: The effect of ivermectin on mortality in patients with novel coronavirus disease 2019 (COVID-19) has been investigated in many studies. ...CONCLUSION: We observed a preliminary beneficial effect on mortality associated with ivermectin use in …
OBJECTIVE: The effect of ivermectin on mortality in patients with novel coronavirus disease 2019 (COVID-19) has been in …
Ivermectin reduces in vivo coronavirus infection in a mouse experimental model.
Arévalo AP, Pagotto R, Pórfido JL, Daghero H, Segovia M, Yamasaki K, Varela B, Hill M, Verdes JM, Duhalde Vega M, Bollati-Fogolín M, Crispo M. Arévalo AP, et al. Sci Rep. 2021 Mar 30;11(1):7132. doi: 10.1038/s41598-021-86679-0. Sci Rep. 2021. PMID: 33785846 Free PMC article.
The objective of this study was to test the effectiveness of ivermectin for the treatment of mouse hepatitis virus (MHV), a type 2 family RNA coronavirus similar to SARS-CoV-2. Female BALB/cJ mice were infected with 6,000 PFU of MHV-A59 (group i …
The objective of this study was to test the effectiveness of ivermectin for the treatment of mouse hepatitis virus (MHV), a type 2
In silico studies of selected multi-drug targeting against 3CLpro and nsp12 RNA-dependent RNA-polymerase proteins of SARS-CoV-2 and SARS-CoV.
Udofia IA, Gbayo KO, Oloba-Whenu OA, Ogunbayo TB, Isanbor C. Udofia IA, et al. Netw Model Anal Health Inform Bioinform. 2021;10(1):22. doi: 10.1007/s13721-021-00299-2. Epub 2021 Mar 25. Netw Model Anal Health Inform Bioinform. 2021. PMID: 33786291 Free PMC article.
Also, SARS-CoV-2 and SARS-CoV 3CLpro gave deltaG values ranging from - 5.1 to - 8.4 kcal/mol and - 5.5 to - 8.6 kcal/mol, respectively. Interesting results are obtained for ivermectin, an antiparasitic agent with broad spectrum activity, …
Also, SARS-CoV-2 and SARS-CoV 3CLpro gave deltaG values ranging from - 5.1 to - 8.4 kcal/mol and - 5.5 to …
Antiviral Drug Ivermectin at Nanomolar Concentrations Inhibits Glycine-Induced Chloride Current in Rat Hippocampal Neurons.
Bukanova JV, Solntseva EI, Kondratenko RV, Skrebitsky VG. Bukanova JV, et al. Bull Exp Biol Med. 2021 Mar;170(5):649-653. doi: 10.1007/s10517-021-05125-3. Epub 2021 Mar 31. Bull Exp Biol Med. 2021. PMID: 33788116 Free PMC article.
Ivermectin (IVM) belongs to the class of macrocyclic lactones, which is used as an antiparasitic agent. At present, the researchers focus on possibility to use IVM in treatment of certain forms of cancer and viral diseases such as COVID-19. The mechanisms of
Ivermectin (IVM) belongs to the class of macrocyclic lactones, which is used as an antiparasitic agent. At present, the researchers f
Treatment of COVID-19: a review of current and prospective pharmacotherapies.
Quek E, Tahir H, Kumar P, Hastings R, Jha R. Quek E, et al. Br J Hosp Med (Lond). 2021 Mar 2;82(3):1-9. doi: 10.12968/hmed.2021.0112. Epub 2021 Mar 12. Br J Hosp Med (Lond). 2021. PMID: 33792391 Review.
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread and have grave health and socioeconomic consequences worldwide. Researchers have raced to understa …
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS
COVID-19: The Ivermectin African Enigma.
Guerrero R, Bravo LE, Muñoz E, Ardila EKG, Guerrero E. Guerrero R, et al. Colomb Med (Cali). 2020 Dec 30;51(4):e2014613. doi: 10.25100/cm.v51i4.4613. Colomb Med (Cali). 2020. PMID: 33795896 Free PMC article.
INTRODUCTION: The low frequency of cases and deaths from the SARS-CoV-2 COVID-19 virus in some countries of Africa has called our attention about the unusual behavior of this disease. The ivermectin is considered a drug of choice for vari …
INTRODUCTION: The low frequency of cases and deaths from the SARS-CoV-2 COVID-19 virus in some countries …
Pharmacogenetics Approach for the Improvement of COVID-19 Treatment.
Fricke-Galindo I, Falfán-Valencia R. Fricke-Galindo I, et al. Viruses. 2021 Mar 5;13(3):413. doi: 10.3390/v13030413. Viruses. 2021. PMID: 33807592 Free PMC article. Review.
Pharmacogenetics could explain this variation and improve patients' outcomes with this complex disease; nevertheless, several disease-related issues must be carefully reviewed in the pharmacogenetic study of COVID-19 treatment. We aimed to describe the pharmacogenet …
Pharmacogenetics could explain this variation and improve patients' outcomes with this complex disease; nevertheless, several disease-relate …
Drugs intervention study in COVID-19 management.
Taher M, Tik N, Susanti D. Taher M, et al. Drug Metab Pers Ther. 2021 Apr 5. doi: 10.1515/dmdi-2020-0173. Online ahead of print. Drug Metab Pers Ther. 2021. PMID: 33818031 Free article. Review.
Findings also indicated that both hydroxychloroquine and favipiravir were effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, lopinavir-ritonavir combination was not effective against COVID-19. Finally …
Findings also indicated that both hydroxychloroquine and favipiravir were effective against severe acute respiratory syndrome coronavirus …
Randomized clinical trial to compare the efficacy of ivermectin versus placebo to negativize nasopharyngeal PCR in patients with early COVID-19 in Peru (SAINT-Peru): a structured summary of a study protocol for randomized controlled trial.
Garcia PJ, Mundaca H, Ugarte-Gil C, Leon P, Malaga G, Chaccour C, Carcamo CP. Garcia PJ, et al. Trials. 2021 Apr 9;22(1):262. doi: 10.1186/s13063-021-05236-2. Trials. 2021. PMID: 33836826 Free PMC article.
The secondary objectives are: 1. To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the nasopharyngeal swab on days 4, 7, 14 and 21 post-treatment initiation 2. ...To assess the safety of ivermectin at the propose …
The secondary objectives are: 1. To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the …
Elucidation of the inhibitory activity of ivermectin with host nuclear importin α and several SARS-CoV-2 targets.
Bello M. Bello M. J Biomol Struct Dyn. 2022 Nov;40(18):8375-8383. doi: 10.1080/07391102.2021.1911857. Epub 2021 Apr 10. J Biomol Struct Dyn. 2022. PMID: 33843474 Free PMC article.
IVM inhibits the formation of the importin-alpha/beta1 heterodimeric complex responsible for the translocation and replication of various viral species proteins. Also, IVM hampers SARS-CoV-2 replication in vitro; however, the molecular mechanism through which …
IVM inhibits the formation of the importin-alpha/beta1 heterodimeric complex responsible for the translocation and replication of various vi …
Repurposing Ivermectin for COVID-19: Molecular Aspects and Therapeutic Possibilities.
Wehbe Z, Wehbe M, Iratni R, Pintus G, Zaraket H, Yassine HM, Eid AH. Wehbe Z, et al. Front Immunol. 2021 Mar 30;12:663586. doi: 10.3389/fimmu.2021.663586. eCollection 2021. Front Immunol. 2021. PMID: 33859652 Free PMC article. Review.
As of January 2021, SARS-CoV-2 has killed over 2 million individuals across the world. ...One of these drugs is ivermectin (IVM), an antiparasitic drug created in the 1970s. IVM later exerted antiviral activity against various viruses including …
As of January 2021, SARS-CoV-2 has killed over 2 million individuals across the world. ...One of these drugs is …
Safety and Efficacy of Ivermectin and Doxycycline Monotherapy and in Combination in the Treatment of COVID-19: A Scoping Review.
Bhowmick S, Dang A, Vallish BN, Dang S. Bhowmick S, et al. Drug Saf. 2021 Jun;44(6):635-644. doi: 10.1007/s40264-021-01066-y. Epub 2021 Apr 16. Drug Saf. 2021. PMID: 33864232 Free PMC article.
INTRODUCTION AND OBJECTIVE: Ivermectin (IVM) and doxycycline (DOXY) have demonstrated in-vitro activity against SARS-CoV-2, and have a reasonable safety profile. ...CONCLUSIONS: Evidence is not sufficiently strong to either promote or refute the effica …
INTRODUCTION AND OBJECTIVE: Ivermectin (IVM) and doxycycline (DOXY) have demonstrated in-vitro activity against SARS-CoV
Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: An open-label randomized trial.
Seet RCS, Quek AML, Ooi DSQ, Sengupta S, Lakshminarasappa SR, Koo CY, So JBY, Goh BC, Loh KS, Fisher D, Teoh HL, Sun J, Cook AR, Tambyah PA, Hartman M. Seet RCS, et al. Int J Infect Dis. 2021 May;106:314-322. doi: 10.1016/j.ijid.2021.04.035. Epub 2021 Apr 20. Int J Infect Dis. 2021. PMID: 33864917 Free PMC article. Clinical Trial.
The primary outcome was laboratory evidence of SARS-CoV-2 infection as shown by either: (1) a positive serologic test for SARS-CoV-2 antibody on day 42, or (2) a positive PCR test for SARS-CoV-2 at any time bet …
The primary outcome was laboratory evidence of SARS-CoV-2 infection as shown by either: (1) a positive serologic test f …
A fatal case of COVID-19-associated invasive pulmonary aspergillosis.
Iwanaga Y, Kawanami T, Yamasaki K, Sakakibara H, Ikushima I, Ikegami H, Tahara M, Akata K, Mukae H, Yatera K. Iwanaga Y, et al. J Infect Chemother. 2021 Jul;27(7):1102-1107. doi: 10.1016/j.jiac.2021.03.024. Epub 2021 Apr 1. J Infect Chemother. 2021. PMID: 33867266 Free PMC article.
A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. ...Aspergillus fumigatus was cultured from the tracheal a …
A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admiss …
The binding mechanism of ivermectin and levosalbutamol with spike protein of SARS-CoV-2.
Saha JK, Raihan MJ. Saha JK, et al. Struct Chem. 2021;32(5):1985-1992. doi: 10.1007/s11224-021-01776-0. Epub 2021 Apr 12. Struct Chem. 2021. PMID: 33867777 Free PMC article.
In this study, we have investigated the binding mechanism of two FDA-approved drugs (ivermectin and levosalbutamol) with the spike protein of SARs-CoV-2 using three different computational modeling techniques. ...Therefore, ivermectin can be a s …
In this study, we have investigated the binding mechanism of two FDA-approved drugs (ivermectin and levosalbutamol) with the spike pr …
Ivermectin & COVID-19: Let's keep a One Health perspective.
Domingo-Echaburu S, Orive G, Lertxundi U. Domingo-Echaburu S, et al. Sustain Chem Pharm. 2021 Jun;21:100438. doi: 10.1016/j.scp.2021.100438. Epub 2021 Apr 18. Sustain Chem Pharm. 2021. PMID: 33898692 Free PMC article.
Despite uncertainty about its clinical benefit, ivermectin has been used for COVID 19, even in prophylaxis. The European Medicines Agency (EMA) has advised against its use for the prevention or treatment of COVID-19 outside randomised clinical t …
Despite uncertainty about its clinical benefit, ivermectin has been used for COVID 19, even in prophylaxis. The Europea …
Prophylaxis against covid-19: living systematic review and network meta-analysis.
Bartoszko JJ, Siemieniuk RAC, Kum E, Qasim A, Zeraatkar D, Ge L, Han MA, Sadeghirad B, Agarwal A, Agoritsas T, Chu DK, Couban R, Darzi AJ, Devji T, Ghadimi M, Honarmand K, Izcovich A, Khamis A, Lamontagne F, Loeb M, Marcucci M, McLeod SL, Motaghi S, Murthy S, Mustafa RA, Neary JD, Pardo-Hernandez H, Rada G, Rochwerg B, Switzer C, Tendal B, Thabane L, Vandvik PO, Vernooij RWM, Viteri-García A, Wang Y, Yao L, Ye Z, Guyatt GH, Brignardello-Petersen R. Bartoszko JJ, et al. BMJ. 2021 Apr 26;373:n949. doi: 10.1136/bmj.n949. BMJ. 2021. PMID: 33903131 Free PMC article.
OBJECTIVE: To determine and compare the effects of drug prophylaxis on SARS-CoV-2 infection and covid-19. DESIGN: Living systematic review and network meta-analysis. ...CONCLUSIONS: Hydroxychloroquine prophylaxis has trivial to no effect on hosp …
OBJECTIVE: To determine and compare the effects of drug prophylaxis on SARS-CoV-2 infection and covid-19. …
Pediatric inflammatory multisystem syndrome associated with COVID-19: A report of 10 cases in a Peruvian hospital.
Luna-Muñoz C, Reyes-Florian G, Seminario-Aliaga M, Stapleton-Herbozo A, Correa-López LE, Quiñones-Laveriano DM. Luna-Muñoz C, et al. Medwave. 2021 Mar 30;21(2):e8142. doi: 10.5867/medwave.2021.02.8142. Medwave. 2021. PMID: 33905406 English, Spanish.
Pediatric inflammatory multisystem syndrome temporally associated with COVID-19 is a potentially severe and rare condition that still needs a better understanding to guide its management. ...This report presents ten cases of pediatric inflammatory multisystem syndro …
Pediatric inflammatory multisystem syndrome temporally associated with COVID-19 is a potentially severe and rare condition tha …
Ivermectin for COVID-19: Promising but not yet conclusive.
Van Rensburg R, Decloedt EH, Reuter H, Parker A, Schrueder N, Lahri S. Van Rensburg R, et al. S Afr Med J. 2021 Jan 12;111(3):13187. doi: 10.7196/SAMJ.2021.v111i3.15522. S Afr Med J. 2021. PMID: 33944732 Free article. No abstract available.
A qualitative analysis of seven ivermectin formulations in South Africa.
Bhorat QE, Bhorat AE. Bhorat QE, et al. S Afr Med J. 2021 Feb 18;111(4):288-290. doi: 10.7196/SAMJ.2021.v111i4.15630. S Afr Med J. 2021. PMID: 33944756 Free article.
Some South African (SA) healthcare practitioners are promoting the prescription and use of products claiming to contain ivermectin for the treatment and/or prevention of COVID-19 in SA. This study qualitatively analysed seven samples of ivermectin form …
Some South African (SA) healthcare practitioners are promoting the prescription and use of products claiming to contain ivermectin fo …
Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients.
Okumuş N, Demirtürk N, Çetinkaya RA, Güner R, Avcı İY, Orhan S, Konya P, Şaylan B, Karalezli A, Yamanel L, Kayaaslan B, Yılmaz G, Savaşçı Ü, Eser F, Taşkın G. Okumuş N, et al. BMC Infect Dis. 2021 May 4;21(1):411. doi: 10.1186/s12879-021-06104-9. BMC Infect Dis. 2021. PMID: 33947344 Free PMC article. Clinical Trial.
BACKGROUND AND OBJECTIVES: An effective treatment option is not yet available for SARS-CoV2, which causes the COVID-19 pandemic and whose effects are felt more and more every day. ...Consequently, ivermectin should be considered as an alternative drug …
BACKGROUND AND OBJECTIVES: An effective treatment option is not yet available for SARS-CoV2, which causes the COVID-19
Antivirals virtual screening to SARS-CoV-2 non-structural proteins.
Nunes VS, Paschoal DFS, Costa LAS, Santos HFD. Nunes VS, et al. J Biomol Struct Dyn. 2021 May 5:1-15. doi: 10.1080/07391102.2021.1921033. Online ahead of print. J Biomol Struct Dyn. 2021. PMID: 33949279 Free PMC article.
In March 2020, the World Health Organization (WHO) declared coronavirus disease-19 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a pandemic. ...Herein, we performed a virtual screening usin …
In March 2020, the World Health Organization (WHO) declared coronavirus disease-19 (COVID-19), caused by the severe acu …
Mechanistic insights into the inhibitory activity of FDA approved ivermectin against SARS-CoV-2: old drug with new implications.
Qureshi U, Mir S, Naz S, Nur-E-Alam M, Ahmed S, Ul-Haq Z. Qureshi U, et al. J Biomol Struct Dyn. 2022 Oct;40(17):8100-8111. doi: 10.1080/07391102.2021.1906750. Epub 2021 May 5. J Biomol Struct Dyn. 2022. PMID: 33950784 Free PMC article.
The novel corona virus (Covid-19) has become a great challenge worldwide since 2019, as no drug has been reported yet. ...Altogether, these results recommended the worth of IVM as a possible drug to limit the SARS-CoV-2 viral load and consequent …
The novel corona virus (Covid-19) has become a great challenge worldwide since 2019, as no drug has been reported yet. ...Alto …
Drug Repurposing Approach, Potential Drugs, and Novel Drug Targets for COVID-19 Treatment.
Kifle ZD, Ayele AG, Enyew EF. Kifle ZD, et al. J Environ Public Health. 2021 Apr 22;2021:6631721. doi: 10.1155/2021/6631721. eCollection 2021. J Environ Public Health. 2021. PMID: 33953756 Free PMC article. Review.
Some medications which are used to treat other diseases seem to be effective in treating COVID-19 even without explicit support. The existing drugs that are summarized in this review primarily focused on therapeutic agents that possessed activity against other RNA v …
Some medications which are used to treat other diseases seem to be effective in treating COVID-19 even without explicit suppor …
Ivermectin and COVID-19.
Wiwanitkit V. Wiwanitkit V. Malays J Med Sci. 2021 Apr;28(2):177. doi: 10.21315/mjms2021.28.2.17. Epub 2021 Apr 21. Malays J Med Sci. 2021. PMID: 33958972 Free PMC article. No abstract available.
Standard Dose Ivermectin for COVID-19.
Buonfrate D, Bisoffi Z. Buonfrate D, et al. Chest. 2021 May;159(5):2111-2112. doi: 10.1016/j.chest.2021.03.003. Chest. 2021. PMID: 33965138 Free PMC article. No abstract available.
Response.
Rajter JJ, Rajter JC, Sherman M. Rajter JJ, et al. Chest. 2021 May;159(5):2112-2113. doi: 10.1016/j.chest.2020.11.017. Chest. 2021. PMID: 33965139 No abstract available.
Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial.
Mahmud R, Rahman MM, Alam I, Ahmed KGU, Kabir AKMH, Sayeed SKJB, Rassel MA, Monayem FB, Islam MS, Islam MM, Barshan AD, Hoque MM, Mallik MU, Yusuf MA, Hossain MZ. Mahmud R, et al. J Int Med Res. 2021 May;49(5):3000605211013550. doi: 10.1177/03000605211013550. J Int Med Res. 2021. PMID: 33983065 Free PMC article. Clinical Trial.
OBJECTIVE: We evaluated whether ivermectin combined with doxycycline reduced the clinical recovery time in adults with COVID-19 infection. ...The proportion of patients who remained RT-PCR positive on day 14 and whose disease did not progress was significantl …
OBJECTIVE: We evaluated whether ivermectin combined with doxycycline reduced the clinical recovery time in adults with COVID- …
[Ivermectin in COVID-19. Argumentun ad ignorantiam?].
Carlosama-Rosero Y. Carlosama-Rosero Y. Rev Clin Esp. 2020 Oct;220(7):457-458. doi: 10.1016/j.rce.2020.06.003. Epub 2020 Jun 12. Rev Clin Esp. 2020. PMID: 33994568 Free PMC article. Spanish. No abstract available.
[Reply to: Ivermectin in COVID-19. Argumentum ad ignorantiam?].
López Reboiro ML, Sardiña González C, López Castro J. López Reboiro ML, et al. Rev Clin Esp. 2020 Oct;220(7):458. doi: 10.1016/j.rce.2020.06.011. Epub 2020 Jul 4. Rev Clin Esp. 2020. PMID: 33994569 Free PMC article. Spanish. No abstract available.
Ivermectin Treatment May Improve the Prognosis of Patients With COVID-19.
Khan MSI, Khan MSI, Debnath CR, Nath PN, Mahtab MA, Nabeka H, Matsuda S, Akbar SMF. Khan MSI, et al. Arch Bronconeumol (Engl Ed). 2020 Dec;56(12):828-830. doi: 10.1016/j.arbr.2020.08.011. Epub 2020 Dec 14. Arch Bronconeumol (Engl Ed). 2020. PMID: 33994641 Free PMC article. No abstract available.
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