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Repurposing Ivermectin as an Anti-dengue Drug.
Ooi EE. Ooi EE. Clin Infect Dis. 2021 May 18;72(10):e594-e595. doi: 10.1093/cid/ciaa1341. Clin Infect Dis. 2021. PMID: 33124646 No abstract available.
An ivermectin - atorvastatin combination impairs nuclear transport inhibiting dengue infection in vitro and in vivo.
Palacios-Rápalo SN, Farfan-Morales CN, Cordero-Rivera CD, De Jesús-González LA, Reyes-Ruiz JM, Meraz-Ríos MA, Del Ángel RM. Palacios-Rápalo SN, et al. iScience. 2023 Oct 27;26(12):108294. doi: 10.1016/j.isci.2023.108294. eCollection 2023 Dec 15. iScience. 2023. PMID: 38034354 Free PMC article.
Dengue virus (DENV) uses cellular nuclear transport machinery to import some proteins into the nucleus. Recently, the non-structural protein 3 (NS3) of DENV was localized in the nucleus of infected cells; however, its nuclear import mechanism is still unknown. In this stud …
Dengue virus (DENV) uses cellular nuclear transport machinery to import some proteins into the nucleus. Recently, the non-structural …
In-host modeling of dengue virus and non-structural protein 1 and the effects of ivermectin in patients with acute dengue fever.
Ding J, Mairiang D, Prayongkul D, Puttikhunt C, Noisakran S, Kaewjiw N, Songjaeng A, Prommool T, Tangthawornchaikul N, Angkasekwinai N, Suputtamongkol Y, Lapphra K, Chokephaibulkit K, White NJ, Avirutnan P, Tarning J. Ding J, et al. CPT Pharmacometrics Syst Pharmacol. 2024 Dec;13(12):2196-2209. doi: 10.1002/psp4.13233. Epub 2024 Sep 23. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 39308445 Free PMC article.
Ivermectin, an old anti-parasitic drug, had no effect on dengue viremia, but reduced the dengue non-structural protein 1 (NS1) in a clinical trial. This is potentially important, as NS1 may play a causal role in the pathogenesis of severe dengue. This …
Ivermectin, an old anti-parasitic drug, had no effect on dengue viremia, but reduced the dengue non-structural protein …
Ivermectin Accelerates Circulating Nonstructural Protein 1 (NS1) Clearance in Adult Dengue Patients: A Combined Phase 2/3 Randomized Double-blinded Placebo Controlled Trial.
Suputtamongkol Y, Avirutnan P, Mairiang D, Angkasekwinai N, Niwattayakul K, Yamasmith E, Saleh-Arong FA, Songjaeng A, Prommool T, Tangthawornchaikul N, Puttikhunt C, Hunnangkul S, Komoltri C, Thammapalo S, Malasit P. Suputtamongkol Y, et al. Clin Infect Dis. 2021 May 18;72(10):e586-e593. doi: 10.1093/cid/ciaa1332. Clin Infect Dis. 2021. PMID: 33462580 Clinical Trial.
The antiparasitic drug ivermectin efficiently inhibits the replication of all 4 dengue virus serotypes in vitro. ...Dengue hemorrhagic fever occurred in 24 (24.0%) of ivermectin-treated patients and 32 (31.1%) patients receiving placebo (P = .260). ...
The antiparasitic drug ivermectin efficiently inhibits the replication of all 4 dengue virus serotypes in vitro. ...Dengue …
Dengue virus NS1 secretion is regulated via importin-subunit beta1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin.
Denolly S, Guo H, Martens M, Płaszczyca A, Scaturro P, Prasad V, Kongmanas K, Punyadee N, Songjaeng A, Mairiang D, Pichlmair A, Avirutnan P, Bartenschlager R. Denolly S, et al. mBio. 2023 Oct 31;14(5):e0144123. doi: 10.1128/mbio.01441-23. Epub 2023 Sep 13. mBio. 2023. PMID: 37702492 Free PMC article.
Dengue virus (DENV) is a major human pathogen that can cause hemorrhagic fever and shock syndrome. ...These results reveal a novel mode of action of ivermectin that might apply to other flaviviruses as well....
Dengue virus (DENV) is a major human pathogen that can cause hemorrhagic fever and shock syndrome. ...These results reveal a novel mo …
Ivermectin: An Anthelmintic, an Insecticide, and Much More.
Martin RJ, Robertson AP, Choudhary S. Martin RJ, et al. Trends Parasitol. 2021 Jan;37(1):48-64. doi: 10.1016/j.pt.2020.10.005. Epub 2020 Nov 11. Trends Parasitol. 2021. PMID: 33189582 Free PMC article. Review.
Here we tell the story of ivermectin, describing its anthelmintic and insecticidal actions and recent studies that have sought to reposition ivermectin for the treatment of other diseases that are not caused by helminth and insect parasites. ...In addition, in tissu …
Here we tell the story of ivermectin, describing its anthelmintic and insecticidal actions and recent studies that have sought to rep …
Antivirus effectiveness of ivermectin on dengue virus type 2 in Aedes albopictus.
Xu TL, Han Y, Liu W, Pang XY, Zheng B, Zhang Y, Zhou XN. Xu TL, et al. PLoS Negl Trop Dis. 2018 Nov 19;12(11):e0006934. doi: 10.1371/journal.pntd.0006934. eCollection 2018 Nov. PLoS Negl Trop Dis. 2018. PMID: 30452439 Free PMC article.
Dengue vector control is a key component for the dengue control strategy, since no absolutely effective vaccine or drug is available yet. ...This study aims to confirm the antivirus effectiveness of ivermectin on dengue virus type 2 (DENV-2) in Aedes a …
Dengue vector control is a key component for the dengue control strategy, since no absolutely effective vaccine or drug is ava …
Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?
Jans DA, Wagstaff KM. Jans DA, et al. Cells. 2020 Sep 15;9(9):2100. doi: 10.3390/cells9092100. Cells. 2020. PMID: 32942671 Free PMC article. Review.
The small molecule macrocyclic lactone ivermectin, approved by the US Food and Drug Administration for parasitic infections, has received renewed attention in the last eight years due to its apparent exciting potential as an antiviral. ...This mini-review discusses the cas …
The small molecule macrocyclic lactone ivermectin, approved by the US Food and Drug Administration for parasitic infections, has rece …
Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen.
Heidary F, Gharebaghi R. Heidary F, et al. J Antibiot (Tokyo). 2020 Sep;73(9):593-602. doi: 10.1038/s41429-020-0336-z. Epub 2020 Jun 12. J Antibiot (Tokyo). 2020. PMID: 32533071 Free PMC article.
Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Sy …
Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, …
36 results