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Year Number of Results
2012 1
2013 1
2014 1
2016 4
2017 4
2018 3
2019 4
2020 3
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20 results
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Page 1
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
Lang C, Campbell KR, Ryan BJ, Carling P, Attar M, Vowles J, Perestenko OV, Bowden R, Baig F, Kasten M, Hu MT, Cowley SA, Webber C, Wade-Martins R. Lang C, et al. Among authors: vowles j. Cell Stem Cell. 2019 Jan 3;24(1):93-106.e6. doi: 10.1016/j.stem.2018.10.023. Epub 2018 Nov 29. Cell Stem Cell. 2019. PMID: 30503143 Free PMC article.
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.
Fernandes HJ, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang C, Ryan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R. Fernandes HJ, et al. Among authors: vowles j. Stem Cell Reports. 2016 Mar 8;6(3):342-56. doi: 10.1016/j.stemcr.2016.01.013. Epub 2016 Feb 18. Stem Cell Reports. 2016. PMID: 26905200 Free PMC article.
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.
Zambon F, Cherubini M, Fernandes HJR, Lang C, Ryan BJ, Volpato V, Bengoa-Vergniory N, Vingill S, Attar M, Booth HDE, Haenseler W, Vowles J, Bowden R, Webber C, Cowley SA, Wade-Martins R. Zambon F, et al. Among authors: vowles j. Hum Mol Genet. 2019 Jun 15;28(12):2001-2013. doi: 10.1093/hmg/ddz038. Hum Mol Genet. 2019. PMID: 30753527 Free PMC article.
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2.
Connor-Robson N, Booth H, Martin JG, Gao B, Li K, Doig N, Vowles J, Browne C, Klinger L, Juhasz P, Klein C, Cowley SA, Bolam P, Hirst W, Wade-Martins R. Connor-Robson N, et al. Among authors: vowles j. Neurobiol Dis. 2019 Jul;127:512-526. doi: 10.1016/j.nbd.2019.04.005. Epub 2019 Apr 5. Neurobiol Dis. 2019. PMID: 30954703 Free PMC article.
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Dafinca R, Scaber J, Ababneh N, Lalic T, Weir G, Christian H, Vowles J, Douglas AG, Fletcher-Jones A, Browne C, Nakanishi M, Turner MR, Wade-Martins R, Cowley SA, Talbot K. Dafinca R, et al. Among authors: vowles j. Stem Cells. 2016 Aug;34(8):2063-78. doi: 10.1002/stem.2388. Epub 2016 May 4. Stem Cells. 2016. PMID: 27097283 Free PMC article.
Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.
Haenseler W, Zambon F, Lee H, Vowles J, Rinaldi F, Duggal G, Houlden H, Gwinn K, Wray S, Luk KC, Wade-Martins R, James WS, Cowley SA. Haenseler W, et al. Among authors: vowles j. Sci Rep. 2017 Aug 21;7(1):9003. doi: 10.1038/s41598-017-09362-3. Sci Rep. 2017. PMID: 28827786 Free PMC article.
Physiological characterisation of human iPS-derived dopaminergic neurons.
Hartfield EM, Yamasaki-Mann M, Ribeiro Fernandes HJ, Vowles J, James WS, Cowley SA, Wade-Martins R. Hartfield EM, et al. Among authors: vowles j. PLoS One. 2014 Feb 21;9(2):e87388. doi: 10.1371/journal.pone.0087388. eCollection 2014. PLoS One. 2014. PMID: 24586273 Free PMC article.
Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.
Wong MMK, Hoekstra SD, Vowles J, Watson LM, Fuller G, Németh AH, Cowley SA, Ansorge O, Talbot K, Becker EBE. Wong MMK, et al. Among authors: vowles j. Acta Neuropathol Commun. 2018 Sep 24;6(1):99. doi: 10.1186/s40478-018-0600-7. Acta Neuropathol Commun. 2018. PMID: 30249303 Free PMC article.
A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells.
Watson LM, Wong MMK, Vowles J, Cowley SA, Becker EBE. Watson LM, et al. Among authors: vowles j. Cerebellum. 2018 Aug;17(4):419-427. doi: 10.1007/s12311-017-0913-2. Cerebellum. 2018. PMID: 29397531 Free PMC article.
RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes.
Booth HDE, Wessely F, Connor-Robson N, Rinaldi F, Vowles J, Browne C, Evetts SG, Hu MT, Cowley SA, Webber C, Wade-Martins R. Booth HDE, et al. Among authors: vowles j. Neurobiol Dis. 2019 Sep;129:56-66. doi: 10.1016/j.nbd.2019.05.006. Epub 2019 May 11. Neurobiol Dis. 2019. PMID: 31085228 Free article.
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