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Year Number of Results
2017 2
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2019 3
2020 3
2021 3
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2024 10
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2026 9

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58 results

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Page 1
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.
Kim H, Nguyen NP, Turner K, Wu S, Gujar AD, Luebeck J, Liu J, Deshpande V, Rajkumar U, Namburi S, Amin SB, Yi E, Menghi F, Schulte JH, Henssen AG, Chang HY, Beck CR, Mischel PS, Bafna V, Verhaak RGW. Kim H, et al. Among authors: luebeck j. Nat Genet. 2020 Sep;52(9):891-897. doi: 10.1038/s41588-020-0678-2. Epub 2020 Aug 17. Nat Genet. 2020. PMID: 32807987 Free PMC article.
ecDNA hubs drive cooperative intermolecular oncogene expression.
Hung KL, Yost KE, Xie L, Shi Q, Helmsauer K, Luebeck J, Schöpflin R, Lange JT, Chamorro González R, Weiser NE, Chen C, Valieva ME, Wong IT, Wu S, Dehkordi SR, Duffy CV, Kraft K, Tang J, Belk JA, Rose JC, Corces MR, Granja JM, Li R, Rajkumar U, Friedlein J, Bagchi A, Satpathy AT, Tjian R, Mundlos S, Bafna V, Henssen AG, Mischel PS, Liu Z, Chang HY. Hung KL, et al. Among authors: luebeck j. Nature. 2021 Dec;600(7890):731-736. doi: 10.1038/s41586-021-04116-8. Epub 2021 Nov 24. Nature. 2021. PMID: 34819668 Free PMC article.
Enhancing transcription-replication conflict targets ecDNA-positive cancers.
Tang J, Weiser NE, Wang G, Chowdhry S, Curtis EJ, Zhao Y, Wong IT, Marinov GK, Li R, Hanoian P, Tse E, Mojica SG, Hansen R, Plum J, Steffy A, Milutinovic S, Meyer ST, Luebeck J, Wang Y, Zhang S, Altemose N, Curtis C, Greenleaf WJ, Bafna V, Benkovic SJ, Pinkerton AB, Kasibhatla S, Hassig CA, Mischel PS, Chang HY. Tang J, et al. Among authors: luebeck j. Nature. 2024 Nov;635(8037):210-218. doi: 10.1038/s41586-024-07802-5. Epub 2024 Nov 6. Nature. 2024. PMID: 39506153 Free PMC article.
Circular ecDNA promotes accessible chromatin and high oncogene expression.
Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. Wu S, et al. Among authors: luebeck j. Nature. 2019 Nov;575(7784):699-703. doi: 10.1038/s41586-019-1763-5. Epub 2019 Nov 20. Nature. 2019. PMID: 31748743 Free PMC article.
Origins and impact of extrachromosomal DNA.
Bailey C, Pich O, Thol K, Watkins TBK, Luebeck J, Rowan A, Stavrou G, Weiser NE, Dameracharla B, Bentham R, Lu WT, Kittel J, Yang SYC, Howitt BE, Sharma N, Litovchenko M, Salgado R, Hung KL, Cornish AJ, Moore DA, Houlston RS, Bafna V, Chang HY, Nik-Zainal S, Kanu N, McGranahan N; Genomics England Consortium; Flanagan AM, Mischel PS, Jamal-Hanjani M, Swanton C. Bailey C, et al. Among authors: luebeck j. Nature. 2024 Nov;635(8037):193-200. doi: 10.1038/s41586-024-08107-3. Epub 2024 Nov 6. Nature. 2024. PMID: 39506150 Free PMC article.
Engineered extrachromosomal oncogene amplifications promote tumorigenesis.
Pradella D, Zhang M, Gao R, Yao MA, Gluchowska KM, Cendon-Florez Y, Mishra T, La Rocca G, Weigl M, Jiao Z, Nguyen HHM, Lisi M, Ozimek MM, Mastroleo C, Chen K, Grimm F, Luebeck J, Zhang S, Zolli AA, Sun EG, Dameracharla B, Zhao Z, Pritykin Y, Sigel C, Chang HY, Mischel PS, Bafna V, Antonescu CR, Ventura A. Pradella D, et al. Among authors: luebeck j. Nature. 2025 Jan;637(8047):955-964. doi: 10.1038/s41586-024-08318-8. Epub 2024 Dec 18. Nature. 2025. PMID: 39695225 Free PMC article.
Mapping extrachromosomal DNA amplifications during cancer progression.
Kim H, Kim S, Wade T, Yeo E, Lipsa A, Golebiewska A, Johnson KC, An S, Ko J, Nam Y, Lee HY, Kang S, Chung H, Niclou SP, Moon HE, Paek SH, Bafna V, Luebeck J, Verhaak RGW. Kim H, et al. Among authors: luebeck j. Nat Genet. 2024 Nov;56(11):2447-2454. doi: 10.1038/s41588-024-01949-7. Epub 2024 Oct 14. Nat Genet. 2024. PMID: 39402156 Free PMC article.
EcDNA-borne structural variants drive oncogenic fusion transcript amplification.
Yi H, Zhang S, Swinderman J, Wang Y, Kanakaveti V, Hung KL, Tsz-Lo Wong I, Srinivasan S, Curtis EJ, Bhargava-Shah A, Li R, Jones MG, Luebeck J, Bailey C, Zhao Y, Belk JA, Kraft K, Shi Q, Yan X, Pritchard SK, Mahajan KS, Liang F, Jamal-Hanjani M, Felsher DW, Gilbert LA, Bafna V, Mischel PS, Chang HY. Yi H, et al. Among authors: luebeck j. Cell. 2026 Feb 5;189(3):906-921.e20. doi: 10.1016/j.cell.2025.12.009. Epub 2026 Jan 7. Cell. 2026. PMID: 41506267 Free PMC article.
Coordinated inheritance of extrachromosomal DNAs in cancer cells.
Hung KL, Jones MG, Wong IT, Curtis EJ, Lange JT, He BJ, Luebeck J, Schmargon R, Scanu E, Brückner L, Yan X, Li R, Gnanasekar A, Chamorro González R, Belk JA, Liu Z, Melillo B, Bafna V, Dörr JR, Werner B, Huang W, Cravatt BF, Henssen AG, Mischel PS, Chang HY. Hung KL, et al. Among authors: luebeck j. Nature. 2024 Nov;635(8037):201-209. doi: 10.1038/s41586-024-07861-8. Epub 2024 Nov 6. Nature. 2024. PMID: 39506152 Free PMC article.
Extrachromosomal DNA-Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma.
Noorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT, Pradella D, Lisi M, Kittel J, Sharma N, Bailey C, Weeden CE, Bell DM, Joo E, Barbè V, Jones MG, Hung KL, Nye EL, Green M, Meader L, Norton EJ, Fabian M, Kanu N, Jamal-Hanjani M, Santarius T, Ventura A, Nicoll JAR, Boche D, Chang HY, Bafna V, Huang W, Mischel PS, Swanton C, Werner B. Noorani I, et al. Among authors: luebeck j. Cancer Discov. 2025 Oct 6;15(10):2078-2095. doi: 10.1158/2159-8290.CD-24-1555. Cancer Discov. 2025. PMID: 40920091 Free PMC article.
58 results