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Modeling Parkinson's disease in midbrain-like organoids.
Smits LM, Reinhardt L, Reinhardt P, Glatza M, Monzel AS, Stanslowsky N, Rosato-Siri MD, Zanon A, Antony PM, Bellmann J, Nicklas SM, Hemmer K, Qing X, Berger E, Kalmbach N, Ehrlich M, Bolognin S, Hicks AA, Wegner F, Sterneckert JL, Schwamborn JC. Smits LM, et al. Among authors: schwamborn jc. NPJ Parkinsons Dis. 2019 Apr 5;5:5. doi: 10.1038/s41531-019-0078-4. eCollection 2019. NPJ Parkinsons Dis. 2019. PMID: 30963107 Free PMC article.
Modeling Parkinson's disease (PD) using advanced experimental in vitro models is a powerful tool to study disease mechanisms and to elucidate unexplored aspects of this neurodegenerative disorder. ...Midbrain-specific organoids derived from PD p …
Modeling Parkinson's disease (PD) using advanced experimental in vitro models is a powerful tool to study disease
A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.
Boussaad I, Obermaier CD, Hanss Z, Bobbili DR, Bolognin S, Glaab E, Wołyńska K, Weisschuh N, De Conti L, May C, Giesert F, Grossmann D, Lambert A, Kirchen S, Biryukov M, Burbulla LF, Massart F, Bohler J, Cruciani G, Schmid B, Kurz-Drexler A, May P, Duga S, Klein C, Schwamborn JC, Marcus K, Woitalla D, Vogt Weisenhorn DM, Wurst W, Baralle M, Krainc D, Gasser T, Wissinger B, Krüger R. Boussaad I, et al. Among authors: schwamborn jc. Sci Transl Med. 2020 Sep 9;12(560):eaau3960. doi: 10.1126/scitranslmed.aau3960. Sci Transl Med. 2020. PMID: 32908004
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with monogenic forms representing prototypes of the underlying molecular pathology and reproducing to variable degrees the sporadic forms of the disease. ...After prioritization of
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with monogenic forms representing prototypes of
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells.
Monzel AS, Smits LM, Hemmer K, Hachi S, Moreno EL, van Wuellen T, Jarazo J, Walter J, Brüggemann I, Boussaad I, Berger E, Fleming RMT, Bolognin S, Schwamborn JC. Monzel AS, et al. Among authors: schwamborn jc. Stem Cell Reports. 2017 May 9;8(5):1144-1154. doi: 10.1016/j.stemcr.2017.03.010. Epub 2017 Apr 13. Stem Cell Reports. 2017. PMID: 28416282 Free PMC article.
These human midbrain organoids contain spatially organized groups of dopaminergic neurons, which make them an attractive model for the study of Parkinson's disease. ...The complexity of this model is further highlighted by the myelination of neurites. …
These human midbrain organoids contain spatially organized groups of dopaminergic neurons, which make them an attractive model for th …
Epitope imprinting of alpha-synuclein for sensing in Parkinson's brain organoid culture medium.
Lee MH, Thomas JL, Su ZL, Yeh WK, Monzel AS, Bolognin S, Schwamborn JC, Yang CH, Lin HY. Lee MH, et al. Among authors: schwamborn jc. Biosens Bioelectron. 2021 Mar 1;175:112852. doi: 10.1016/j.bios.2020.112852. Epub 2020 Nov 27. Biosens Bioelectron. 2021. PMID: 33288425
Parkinson's disease (PD) is a progressive nervous system disorder that affects movement, whose early signs may be mild and unnoticed. alpha-Synuclein has been identified as the major component of Lewy bodies and Lewy neurites, which are the characteristic pro
Parkinson's disease (PD) is a progressive nervous system disorder that affects movement, whose early signs may be mild
Midbrain Organoids: A New Tool to Investigate Parkinson's Disease.
Smits LM, Schwamborn JC. Smits LM, et al. Among authors: schwamborn jc. Front Cell Dev Biol. 2020 May 19;8:359. doi: 10.3389/fcell.2020.00359. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32509785 Free PMC article. Review.
In addition to electrophysiologically functional neurons producing and secreting dopamine, responsive neuronal subtypes, such as GABAergic and glutamatergic neurons were also detected. In order to model disorders like Parkinson's disease (PD) in vitro, …
In addition to electrophysiologically functional neurons producing and secreting dopamine, responsive neuronal subtypes, such as GABAergic a …
Machine learning-assisted neurotoxicity prediction in human midbrain organoids.
Monzel AS, Hemmer K, Kaoma T, Smits LM, Bolognin S, Lucarelli P, Rosety I, Zagare A, Antony P, Nickels SL, Krueger R, Azuaje F, Schwamborn JC. Monzel AS, et al. Among authors: schwamborn jc. Parkinsonism Relat Disord. 2020 Jun;75:105-109. doi: 10.1016/j.parkreldis.2020.05.011. Epub 2020 May 8. Parkinsonism Relat Disord. 2020. PMID: 32534431 Free article.
INTRODUCTION: Brain organoids are highly complex multi-cellular tissue proxies, which have recently risen as novel tools to study neurodegenerative diseases such as Parkinson's disease (PD). ...OBJECTIVES: The primary objective of this study was to dev …
INTRODUCTION: Brain organoids are highly complex multi-cellular tissue proxies, which have recently risen as novel tools to study neu …
Is Parkinson's Disease a Neurodevelopmental Disorder and Will Brain Organoids Help Us to Understand It?
Schwamborn JC. Schwamborn JC. Stem Cells Dev. 2018 Jul 15;27(14):968-975. doi: 10.1089/scd.2017.0289. Epub 2018 Mar 12. Stem Cells Dev. 2018. PMID: 29415619 Review.
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. ...Furthermore, these developmental defects might not causally lead to the disease but increase the susceptibility for disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease.
Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson's disease.
Nickels SL, Modamio J, Mendes-Pinheiro B, Monzel AS, Betsou F, Schwamborn JC. Nickels SL, et al. Among authors: schwamborn jc. Stem Cell Res. 2020 Jul;46:101870. doi: 10.1016/j.scr.2020.101870. Epub 2020 Jun 6. Stem Cell Res. 2020. PMID: 32534166 Free article.
The study of human midbrain development and midbrain related diseases, like Parkinson's disease (PD), is limited by deficiencies in the currently available and validated laboratory models. Three dimensional midbrain organoids represent an innovative st …
The study of human midbrain development and midbrain related diseases, like Parkinson's disease (PD), is limited by def …
Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations.
Kano M, Takanashi M, Oyama G, Yoritaka A, Hatano T, Shiba-Fukushima K, Nagai M, Nishiyama K, Hasegawa K, Inoshita T, Ishikawa KI, Akamatsu W, Imai Y, Bolognin S, Schwamborn JC, Hattori N. Kano M, et al. Among authors: schwamborn jc. NPJ Parkinsons Dis. 2020 Nov 13;6(1):33. doi: 10.1038/s41531-020-00137-8. NPJ Parkinsons Dis. 2020. PMID: 33298969 Free PMC article.
Few glial fibrillary acidic protein- and vimentin-positive astrocytes were observed in the substantia nigra in PRKN-mutated subjects compared with subjects with idiopathic Parkinson's disease. We also differentiated patient-specific induced pluripotent stem c …
Few glial fibrillary acidic protein- and vimentin-positive astrocytes were observed in the substantia nigra in PRKN-mutated subjects compare …
Millifluidic culture improves human midbrain organoid vitality and differentiation.
Berger E, Magliaro C, Paczia N, Monzel AS, Antony P, Linster CL, Bolognin S, Ahluwalia A, Schwamborn JC. Berger E, et al. Among authors: schwamborn jc. Lab Chip. 2018 Oct 9;18(20):3172-3183. doi: 10.1039/c8lc00206a. Lab Chip. 2018. PMID: 30204191
Human midbrain-specific organoids (hMOs) serve as an experimental in vitro model for studying the pathogenesis of Parkinson's disease (PD). ...In agreement with the computational model, a significantly smaller "dead core" was observed in hMOs cultured …
Human midbrain-specific organoids (hMOs) serve as an experimental in vitro model for studying the pathogenesis of Parkinson' …
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