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Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan).
Li Y, Lin W, Huang J, Xie Y, Ma W. Li Y, et al. Chin Med. 2016 Sep 27;11:43. doi: 10.1186/s13020-016-0114-9. eCollection 2016. Chin Med. 2016. PMID: 27708693 Free PMC article. Review.
Gynostemma pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-can …
Gynostemma pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of severa …
Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and microenvironment in Apc(Min/+) mice.
Khan I, Huang G, Li XA, Liao W, Leong WK, Xia W, Bian X, Wu J, Hsiao WLW. Khan I, et al. Pharmacol Res. 2019 Oct;148:104448. doi: 10.1016/j.phrs.2019.104448. Epub 2019 Sep 6. Pharmacol Res. 2019. PMID: 31499195
Therefore, we tested the cancer-preventive properties of Ganoderma lucidum (Lingzhi) polysaccharides (GLP), along with the saponins extracted from Gynostemma pentaphyllum (GpS), an herbal tea with prebiotic-like effects. ...G-protein coupled-receptors were significa …
Therefore, we tested the cancer-preventive properties of Ganoderma lucidum (Lingzhi) polysaccharides (GLP), along with the saponins e …
Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum).
Wang J, Yang JL, Zhou PP, Meng XH, Shi YP. Wang J, et al. J Agric Food Chem. 2017 Jul 26;65(29):5926-5934. doi: 10.1021/acs.jafc.7b01477. Epub 2017 Jul 11. J Agric Food Chem. 2017. PMID: 28662582
Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries. ...Gypenoside 5 was found to possess protein tyrosine phosphatase 1B inhibitory activity, with an IC(50) value of 8.2 ± 0.9 μM, and modera …
Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries …
Gypenoside L Inhibits Proliferation of Liver and Esophageal Cancer Cells by Inducing Senescence.
Ma J, Hu X, Liao C, Xiao H, Zhu Q, Li Y, Liu Z, Tao A, He Z, Xu C, Zheng K. Ma J, et al. Molecules. 2019 Mar 18;24(6):1054. doi: 10.3390/molecules24061054. Molecules. 2019. PMID: 30889805 Free PMC article.
In our study, we investigated the inhibitory effect of gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, on cancer cell growth. ...Moreover, Gyp-L caused cell cycle arrest at S phase, and activated senescence-related cell cycle inhibitor …
In our study, we investigated the inhibitory effect of gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, on c …
Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway.
Song L, Chen X, Wang P, Gao S, Qu C, Liu L. Song L, et al. Acta Biochim Biophys Sin (Shanghai). 2018 Jun 1;50(6):586-596. doi: 10.1093/abbs/gmy045. Acta Biochim Biophys Sin (Shanghai). 2018. PMID: 29697746
Don, Gynostemma pentaphyllum (Thunb.) Mak and Amomum cardamomum L, i.e. Qingyihuaji (QYHJ) formula, has been shown to inhibit proliferation of pancreatic CSCs by inhibiting Shh signaling pathway and thereby prolong the overall survival of pancreatic cancer patients. …
Don, Gynostemma pentaphyllum (Thunb.) Mak and Amomum cardamomum L, i.e. Qingyihuaji (QYHJ) formula, has been shown to inhibit prolife …
Medicinal Value and Potential Therapeutic Mechanisms of Gynostemma pentaphyllum (Thunb.) Makino and Its Derivatives: An Overview.
Li K, Ma C, Li H, Dev S, He J, Qu X. Li K, et al. Curr Top Med Chem. 2019;19(31):2855-2867. doi: 10.2174/1568026619666191114104718. Curr Top Med Chem. 2019. PMID: 31724506 Review.
Gynostemma pentaphyllum (Thunb.) Makino (GpM) and its derivatives, especially gypenosides (Gyps), are widely used as safe and convenient natural herbal drugs for the treatment of many diseases for a long time, and Gyps have different oral bioavailability (OB) values and lo …
Gynostemma pentaphyllum (Thunb.) Makino (GpM) and its derivatives, especially gypenosides (Gyps), are widely used as safe and conveni …
Inhibitory Effect of Damulin B from Gynostemma pentaphyllum on Human Lung Cancer Cells.
Xing SF, Liu LH, Zu ML, Lin M, Zhai XF, Piao XL. Xing SF, et al. Planta Med. 2019 Mar;85(5):394-405. doi: 10.1055/a-0810-7738. Epub 2018 Dec 18. Planta Med. 2019. PMID: 30562828
Damulin B, a dammarane-type saponin from steamed Gynostemma pentaphyllum, exhibits the strongest activity against human lung carcinoma A549 cells among the isolated active saponins. ...Hence, damulin B has potential therapeutic efficacy against lung cancer....
Damulin B, a dammarane-type saponin from steamed Gynostemma pentaphyllum, exhibits the strongest activity against human lung carcinom …
Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the Apc(Min/+) mouse model.
Tai WC, Wong WY, Lee MM, Chan BD, Lu C, Hsiao WL. Tai WC, et al. Proteomics. 2016 May;16(10):1557-69. doi: 10.1002/pmic.201500293. Epub 2016 Apr 28. Proteomics. 2016. PMID: 26970558
Gynostemma pentaphyllum saponins (GpS) have been shown to have anti-cancer activity. However, the underlying mechanisms remain unclear. ...Our findings highlight the potential of GpS as an anti-cancer agent, the potential mechanisms of its anti-cancer …
Gynostemma pentaphyllum saponins (GpS) have been shown to have anti-cancer activity. However, the underlying mechanisms remain …
Gynostemma pentaphyllum saponins induce melanogenesis and activate cAMP/PKA and Wnt/β-catenin signaling pathways.
Tsang TF, Chan B, Tai WC, Huang G, Wang J, Li X, Jiang ZH, Hsiao WLW. Tsang TF, et al. Phytomedicine. 2019 Jul;60:153008. doi: 10.1016/j.phymed.2019.153008. Epub 2019 Jul 1. Phytomedicine. 2019. PMID: 31288940
HYPOTHESIS/PURPOSE: The present study aims to investigate the molecular mechanism of hyperpigmentation induced by Gynostemma pentaphyllum saponins. STUDY DESIGN/METHODS: In this study, we investigated the melanogenic effects of triterpenoid saponins of Gynostemma pe …
HYPOTHESIS/PURPOSE: The present study aims to investigate the molecular mechanism of hyperpigmentation induced by Gynostemma pentaphy …
The inhibitory effect of gypenoside stereoisomers, gypenoside L and gypenoside LI, isolated from Gynostemma pentaphyllum on the growth of human lung cancer A549 cells.
Xing SF, Liu LH, Zu ML, Ding XF, Cui WY, Chang T, Piao XL. Xing SF, et al. J Ethnopharmacol. 2018 Jun 12;219:161-172. doi: 10.1016/j.jep.2018.03.012. Epub 2018 Mar 12. J Ethnopharmacol. 2018. PMID: 29545210
ETHNOPHARMACOLOGICAL RELEVANCE: Gypenosides are major constituents in Gynostemma pentaphyllum (Thunb.) Makino. Previous studies have shown that gypenosides isolated from G. pentaphyllum possess inhibitory effect on the growth of cancer cells, especially A549 cells, …
ETHNOPHARMACOLOGICAL RELEVANCE: Gypenosides are major constituents in Gynostemma pentaphyllum (Thunb.) Makino. Previous studies have …
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