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Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan).
Li Y, Lin W, Huang J, Xie Y, Ma W. Li Y, et al. Chin Med. 2016 Sep 27;11:43. doi: 10.1186/s13020-016-0114-9. eCollection 2016. Chin Med. 2016. PMID: 27708693 Free PMC article. Review.
Gynostemma pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-can …
Gynostemma pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of severa …
Prebiotic properties of jiaogulan in the context of gut microbiome.
Huang G, Yasir M, Zheng Y, Khan I. Huang G, et al. Food Sci Nutr. 2022 Jan 22;10(3):731-739. doi: 10.1002/fsn3.2701. eCollection 2022 Mar. Food Sci Nutr. 2022. PMID: 35282005 Free PMC article. Review.
Jiaogulan (Gynostemma pentaphyllum) is a traditional Chinese medicinal herb that has been widely used in food and supplemental products. ...More recently, there has been growing interest in the prebiotic potential of jiaogulan, especially at the interface of …
Jiaogulan (Gynostemma pentaphyllum) is a traditional Chinese medicinal herb that has been widely used in food and supplemental …
Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy.
Zhu LR, Li SS, Zheng WQ, Ni WJ, Cai M, Liu HP. Zhu LR, et al. Front Immunol. 2023 Feb 2;14:1086078. doi: 10.3389/fimmu.2023.1086078. eCollection 2023. Front Immunol. 2023. PMID: 36817459 Free PMC article. Review.
The gut microbiota not only constitutes intestinal microenvironment homeostasis and human health but also exerts indispensable roles in the occurrence and progression of multiple liver diseases, including alcohol-related liver disease, nonalcoholic fatty liver disease, autoimmune …
The gut microbiota not only constitutes intestinal microenvironment homeostasis and human health but also exerts indispensable roles in the …
Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum.
Su C, Li N, Ren R, Wang Y, Su X, Lu F, Zong R, Yang L, Ma X. Su C, et al. Molecules. 2021 Oct 15;26(20):6249. doi: 10.3390/molecules26206249. Molecules. 2021. PMID: 34684830 Free PMC article. Review.
Gynostemma pentaphyllum (Thunb.) Makino (GP), also named Jiaogulan in Chinese, was known to people for its function in both health care and disease treatment. ...Both in vivo and in vitro tests, ranging from different cell lines to animals, indicated that GP possess …
Gynostemma pentaphyllum (Thunb.) Makino (GP), also named Jiaogulan in Chinese, was known to people for its function in both he …
Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and microenvironment in Apc(Min/+) mice.
Khan I, Huang G, Li XA, Liao W, Leong WK, Xia W, Bian X, Wu J, Hsiao WLW. Khan I, et al. Pharmacol Res. 2019 Oct;148:104448. doi: 10.1016/j.phrs.2019.104448. Epub 2019 Sep 6. Pharmacol Res. 2019. PMID: 31499195
The incidence of colorectal cancer (CRC) is alarming among younger peoples. While no effective chemopreventive drug available in the market, researchers have been searching for alternative strategies against CRC that are in demand. Therefore, we tested the cancer-pr …
The incidence of colorectal cancer (CRC) is alarming among younger peoples. While no effective chemopreventive drug available in the …
Gypenoside inhibits gastric cancer proliferation by suppressing glycolysis via the Hippo pathway.
Pan L, Lan B, Li S, Jin Y, Cui M, Xia Y, Wei S, Huang H. Pan L, et al. Sci Rep. 2024 Aug 16;14(1):19003. doi: 10.1038/s41598-024-69435-y. Sci Rep. 2024. PMID: 39152152 Free PMC article.
Gastric cancer (GC) remains a global disease with a high mortality rate, the lack of effective treatments and the high toxicity of side effects are primary causes for its poor prognosis. ...
Gastric cancer (GC) remains a global disease with a high mortality rate, the lack of effective treatments and the high toxicity of si …
Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum).
Wang J, Yang JL, Zhou PP, Meng XH, Shi YP. Wang J, et al. J Agric Food Chem. 2017 Jul 26;65(29):5926-5934. doi: 10.1021/acs.jafc.7b01477. Epub 2017 Jul 11. J Agric Food Chem. 2017. PMID: 28662582
Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries. ...Gypenoside 5 was found to possess protein tyrosine phosphatase 1B inhibitory activity, with an IC(50) value of 8.2 0.9 muM, and moderat …
Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries …
Gypenoside induces apoptosis by inhibiting the PI3K/AKT/mTOR pathway and enhances T-cell antitumor immunity by inhibiting PD-L1 in gastric cancer.
Wu H, Lai W, Wang Q, Zhou Q, Zhang R, Zhao Y. Wu H, et al. Front Pharmacol. 2024 Feb 28;15:1243353. doi: 10.3389/fphar.2024.1243353. eCollection 2024. Front Pharmacol. 2024. PMID: 38482051 Free PMC article.
Introduction: Gypenoside is a natural extract of Gynostemma pentaphyllum (Thunb.) Makino, a plant in the Cucurbitaceae family. It has been reported to have antitumor effects on the proliferation, migration and apoptosis of various types of cancer cells. ...Thus, the …
Introduction: Gypenoside is a natural extract of Gynostemma pentaphyllum (Thunb.) Makino, a plant in the Cucurbitaceae family. It has …
Gypenoside L inhibits hepatocellular carcinoma by targeting the SREBP2-HMGCS1 axis and enhancing immune response.
Xiao MY, Pei WJ, Li S, Li FF, Xie P, Luo HT, Hyun Yoo H, Piao XL. Xiao MY, et al. Bioorg Chem. 2024 Sep;150:107539. doi: 10.1016/j.bioorg.2024.107539. Epub 2024 Jun 8. Bioorg Chem. 2024. PMID: 38861912
Gypenoside L has inhibitory effects on liver cancer cells. However, its mechanism of action is still unclear. This study aims to investigate the inhibitory effects of gypenoside L on HCC in vitro and in vivo, and explore its potential mechanisms. ...
Gypenoside L has inhibitory effects on liver cancer cells. However, its mechanism of action is still unclear. This study aims to inve …
Gypenoside-Induced Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in Bladder Cancer.
Li X, Liu H, Lv C, Du J, Lian F, Zhang S, Wang Z, Zeng Y. Li X, et al. Biomed Res Int. 2022 Mar 29;2022:9304552. doi: 10.1155/2022/9304552. eCollection 2022. Biomed Res Int. 2022. PMID: 35402614 Free PMC article.
Gypenosides are the major active components of G. pentaphyllum, and they have been widely reported to possess antitumor effects in prostate cancer, gastric cancer, hepatocellular carcinoma, colon cancer, lung cancer, and breast cancer. ...As exp …
Gypenosides are the major active components of G. pentaphyllum, and they have been widely reported to possess antitumor effects in prostate …
125 results