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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation.
Poddar S, Chauvin SD, Archer CH, Qian W, Castillo-Badillo JA, Yin X, Disbennett WM, Miner CA, Holley JA, Naismith TV, Stinson WA, Wei X, Ning Y, Fu J, Ochoa TA, Surve N, Zaver SA, Wodzanowski KA, Balka KR, Venkatraman R, Liu C, Rome K, Bailis W, Shiba Y, Cherry S, Shin S, Semenkovich CF, De Nardo D, Yoh S, Roberson EDO, Chanda SK, Kast DJ, Miner JJ. Poddar S, et al. Among authors: miner jj. Cell. 2025 Mar 20;188(6):1605-1622.e26. doi: 10.1016/j.cell.2025.01.027. Epub 2025 Feb 12. Cell. 2025. PMID: 39947179 Free PMC article.
However, components of the STING signaling pathway, such as IRF3 and IFNAR1, are not essential for autoinflammatory disease in STING gain-of-function (STING-associated vasculopathy with onset in infancy [SAVI]) mice. ...Here, we show that STING-mediate …
However, components of the STING signaling pathway, such as IRF3 and IFNAR1, are not essential for autoinflammatory disease in STI …
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.
Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N. Wu J, et al. Among authors: miner jj. J Exp Med. 2019 Apr 1;216(4):867-883. doi: 10.1084/jem.20182192. Epub 2019 Mar 18. J Exp Med. 2019. PMID: 30886058 Free PMC article.
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. ...Pharmacological inhibition of ER stress prevented Sting(N153S/+) T cell death in vivo. By crossing Sting(N153S/+) to the OT-1 mouse, we fully restored CD8( …
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. ...Pharmacological inhibition of …
TBK1 and IKKepsilon Act Redundantly to Mediate STING-Induced NF-kappaB Responses in Myeloid Cells.
Balka KR, Louis C, Saunders TL, Smith AM, Calleja DJ, D'Silva DB, Moghaddas F, Tailler M, Lawlor KE, Zhan Y, Burns CJ, Wicks IP, Miner JJ, Kile BT, Masters SL, De Nardo D. Balka KR, et al. Among authors: miner jj. Cell Rep. 2020 Apr 7;31(1):107492. doi: 10.1016/j.celrep.2020.03.056. Cell Rep. 2020. PMID: 32268090 Free article.
Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory disease. ...Our work redefines signaling events downstream of cGAS-STING. Our findings further suggest that cGAS …
Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune …
Adult-onset STING-associated vasculopathy.
Riley TR 4th, Kotzin JJ, Park DJ, Banerjee S, Takanohashi A, Vanderver A; Penn Medicine Biobank; Baker JF, Finck AV, Miner JJ. Riley TR 4th, et al. Among authors: miner jj. J Hum Immun. 2026 May 11;2(4):e20250235. doi: 10.70962/jhi.20250235. eCollection 2026 Jul 6. J Hum Immun. 2026. PMID: 42125311 Free PMC article.
As such, genetic evaluation may be more frequently pursued in pediatric rheumatology patients. Motivated by the discovery of a STING-associated vasculopathy with onset in infancy (SAVI) mutation in a patient with adult-onset relapsing polychondritis and systemic lupus eryt …
As such, genetic evaluation may be more frequently pursued in pediatric rheumatology patients. Motivated by the discovery of a STING- …
The critical role of endoplasmic reticulum stress and the stimulator of interferon genes (STING) pathway in kidney fibrosis.
Andrade-Silva M, Dhillon P, Sanchez-Navarro A, Mukhi D, Hu H, Kolligundla LP, Bergeson A, Abedini A, Levinsohn J, Dumoulin B, Câmara NOS, Miner JJ, Susztak K. Andrade-Silva M, et al. Among authors: miner jj. Kidney Int. 2025 Feb;107(2):302-316. doi: 10.1016/j.kint.2024.10.021. Epub 2024 Nov 19. Kidney Int. 2025. PMID: 39566842 Free PMC article.
STING and PERK were found to physically interact, and STING agonists induced PERK activation in kidney tubule cells. Mice with a STING activating mutation presented with ER stress and kidney fibroinflammation. We also generated mice with a tubule specific …
STING and PERK were found to physically interact, and STING agonists induced PERK activation in kidney tubule cells. Mice with …
Regulation of cGAS and STING signaling during inflammation and infection.
Chauvin SD, Stinson WA, Platt DJ, Poddar S, Miner JJ. Chauvin SD, et al. Among authors: miner jj. J Biol Chem. 2023 Jul;299(7):104866. doi: 10.1016/j.jbc.2023.104866. Epub 2023 May 27. J Biol Chem. 2023. PMID: 37247757 Free PMC article. Review.
Mutations leading to constitutive activation of STING cause devastating human diseases. Thus, the cGAS-STING pathway is of great interest because of its role in diverse cellular processes and because of the potential therapeutic implications of targeting cGAS and …
Mutations leading to constitutive activation of STING cause devastating human diseases. Thus, the cGAS-STING pathway is of gre …
Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage.
Li F, Poudel B, Andrade-Silva M, Wu J, Raman A, Cruz-Morales E, Wahba J, Vassalotti A, Li C, Abedini A, Klötzer KA, Ding X, Hunter CA, Miner JJ, Susztak K. Li F, et al. Among authors: miner jj. Circulation. 2026 Feb 10;153(6):396-414. doi: 10.1161/CIRCULATIONAHA.124.071351. Epub 2025 Dec 11. Circulation. 2026. PMID: 41376591 Free PMC article.
In vitro and in vivo experiments demonstrated that the APOL1 RV activates the cytosolic nucleotide sensor STING (stimulator of interferon genes), leading to increased production of endothelin 1. Notably, mice with endothelium-specific STING knockout or those treated …
In vitro and in vivo experiments demonstrated that the APOL1 RV activates the cytosolic nucleotide sensor STING (stimulator of interf …
Autoinflammatory syndromes of STING and TREX1 dysfunction.
Park DJ, Jones KM, Anderson JB, Finck AV, Miner JJ. Park DJ, et al. Among authors: miner jj. J Clin Invest. 2026 Jun 1;136(11):e204549. doi: 10.1172/JCI204549. eCollection 2026 Jun 1. J Clin Invest. 2026. PMID: 42222883 Free PMC article. Review.
Cytosolic self-DNA is a potent trigger of innate immunity, activating the DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream effector stimulator of interferon genes (STING). This pathway is negatively regulated by the DNA-degrading enzyme three-prime repair exonu …
Cytosolic self-DNA is a potent trigger of innate immunity, activating the DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream effec …
The intersection of TREX1, cGAS, STING and the DNA damage theory of aging.
Jones KM, Chauvin SD, Miner JJ. Jones KM, et al. Among authors: miner jj. Front Aging. 2025 Dec 4;6:1720372. doi: 10.3389/fragi.2025.1720372. eCollection 2025. Front Aging. 2025. PMID: 41425849 Free PMC article. Review.
First, we review mechanisms by which the DNA exonuclease TREX1 negatively regulates the cytosolic DNA sensor cGAS and its downstream effector STING, and we propose a model of TREX1-mediated DNA damage and cellular senescence that implicates age-related, inducible TREX1 exp …
First, we review mechanisms by which the DNA exonuclease TREX1 negatively regulates the cytosolic DNA sensor cGAS and its downstream effecto …
Transferrable protection by gut microbes against STING-associated lung disease.
Platt DJ, Lawrence D, Rodgers R, Schriefer L, Qian W, Miner CA, Menos AM, Kennedy EA, Peterson ST, Stinson WA, Baldridge MT, Miner JJ. Platt DJ, et al. Among authors: miner jj. Cell Rep. 2021 May 11;35(6):109113. doi: 10.1016/j.celrep.2021.109113. Cell Rep. 2021. PMID: 33979608 Free PMC article.
STING modulates immunity by responding to bacterial and endogenous cyclic dinucleotides (CDNs). Humans and mice with STING gain-of-function mutations develop a syndrome known as STING-associated vasculopathy with onset in infancy (SAVI), which is characterize …
STING modulates immunity by responding to bacterial and endogenous cyclic dinucleotides (CDNs). Humans and mice with STING gai …
18 results