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Year Number of Results
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18 results

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Page 1
The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity.
Fernandes SA, Pan J, Terziyska DS, Koyuncu S, Ding X, Németh IB, Wilhelm S, Nüchel J, Al-Gburi S, Gonidas C, Pasparakis M, Mosialos G, Széll M, Teleman AA, Eming SA, Vilchez D, Demetriades C. Fernandes SA, et al. Among authors: nuchel j. bioRxiv [Preprint]. 2025 Sep 2:2025.09.01.673523. doi: 10.1101/2025.09.01.673523. bioRxiv. 2025. PMID: 40950055 Free PMC article. Preprint.
TANGO1 inhibitors reduce collagen secretion and limit tissue scarring.
Raote I, Rosendahl AH, Häkkinen HM, Vibe C, Küçükaylak I, Sawant M, Keufgens L, Frommelt P, Halwas K, Broadbent K, Cunquero M, Castro G, Villemeur M, Nüchel J, Bornikoel A, Dam B, Zirmire RK, Kiran R, Carolis C, Andilla J, Loza-Alvarez P, Ruprecht V, Jamora C, Campelo F, Krüger M, Hammerschmidt M, Eckes B, Neundorf I, Krieg T, Malhotra V. Raote I, et al. Among authors: nuchel j. Nat Commun. 2024 Apr 24;15(1):3302. doi: 10.1038/s41467-024-47004-1. Nat Commun. 2024. PMID: 38658535 Free PMC article.
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor.
Nicastro R, Brohée L, Alba J, Nüchel J, Figlia G, Kipschull S, Gollwitzer P, Romero-Pozuelo J, Fernandes SA, Lamprakis A, Vanni S, Teleman AA, De Virgilio C, Demetriades C. Nicastro R, et al. Among authors: nuchel j. Nat Cell Biol. 2023 Sep;25(9):1303-1318. doi: 10.1038/s41556-023-01198-6. Epub 2023 Aug 10. Nat Cell Biol. 2023. PMID: 37563253 Free PMC article.
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.
Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA. Willenborg S, et al. Among authors: nuchel j. Cell Metab. 2021 Dec 7;33(12):2398-2414.e9. doi: 10.1016/j.cmet.2021.10.004. Epub 2021 Oct 28. Cell Metab. 2021. PMID: 34715039 Free article.
GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis.
Pothukuchi P, Agliarulo I, Pirozzi M, Rizzo R, Russo D, Turacchio G, Nüchel J, Yang JS, Gehin C, Capolupo L, Hernandez-Corbacho MJ, Biswas A, Vanacore G, Dathan N, Nitta T, Henklein P, Thattai M, Inokuchi JI, Hsu VW, Plomann M, Obeid LM, Hannun YA, Luini A, D'Angelo G, Parashuraman S. Pothukuchi P, et al. Among authors: nuchel j. EMBO J. 2021 Oct 18;40(20):e107766. doi: 10.15252/embj.2021107766. Epub 2021 Sep 13. EMBO J. 2021. PMID: 34516001 Free PMC article.
TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy.
Zehender A, Li YN, Lin NY, Stefanica A, Nüchel J, Chen CW, Hsu HH, Zhu H, Ding X, Huang J, Shen L, Györfi AH, Soare A, Rauber S, Bergmann C, Ramming A, Plomann M, Eckes B, Schett G, Distler JHW. Zehender A, et al. Among authors: nuchel j. Nat Commun. 2021 Jul 20;12(1):4404. doi: 10.1038/s41467-021-24601-y. Nat Commun. 2021. PMID: 34285225 Free PMC article.
18 results