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A genome-wide CNV association study on panic disorder in a Japanese population.
Kawamura Y, Otowa T, Koike A, Sugaya N, Yoshida E, Yasuda S, Inoue K, Takei K, Konishi Y, Tanii H, Shimada T, Tochigi M, Kakiuchi C, Umekage T, Liu X, Nishida N, Tokunaga K, Kuwano R, Okazaki Y, Kaiya H, Sasaki T. Kawamura Y, et al. Among authors: kaiya h. J Hum Genet. 2011 Dec;56(12):852-6. doi: 10.1038/jhg.2011.117. Epub 2011 Oct 20. J Hum Genet. 2011. PMID: 22011818
Family and twin studies have indicated that genetic factors have an important role in panic disorder (PD), whereas its pathogenesis has remained elusive. We conducted a genome-wide copy number variation (CNV) association study to elucidate the involvement of structu …
Family and twin studies have indicated that genetic factors have an important role in panic disorder (PD), whereas its pathogenesis h …
Genome-wide association study of panic disorder in the Japanese population.
Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Tanii H, Sasaki T, Kaiya H, Okazaki Y. Otowa T, et al. Among authors: kaiya h. J Hum Genet. 2009 Feb;54(2):122-6. doi: 10.1038/jhg.2008.17. Epub 2009 Jan 23. J Hum Genet. 2009. PMID: 19165232
Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety. Although a number of association studies have been conducted, no gene has been identified as a susceptibility locus. In this study, we conducted a genome-wide
Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety. Although a number of assoc
Meta-analysis of genome-wide association studies for panic disorder in the Japanese population.
Otowa T, Kawamura Y, Nishida N, Sugaya N, Koike A, Yoshida E, Inoue K, Yasuda S, Nishimura Y, Liu X, Konishi Y, Nishimura F, Shimada T, Kuwabara H, Tochigi M, Kakiuchi C, Umekage T, Miyagawa T, Miyashita A, Shimizu E, Akiyoshi J, Someya T, Kato T, Yoshikawa T, Kuwano R, Kasai K, Kato N, Kaiya H, Tokunaga K, Okazaki Y, Tanii H, Sasaki T. Otowa T, et al. Among authors: kaiya h. Transl Psychiatry. 2012 Nov 13;2(11):e186. doi: 10.1038/tp.2012.89. Transl Psychiatry. 2012. PMID: 23149450 Free PMC article.
Panic disorder (PD) is a moderately heritable anxiety disorder whose pathogenesis is not well understood. Due to the lack of power in previous association studies, genes that are truly associated with PD might not be detected. In this study, we conducted a genome-wi
Panic disorder (PD) is a moderately heritable anxiety disorder whose pathogenesis is not well understood. Due to the lack of power in
Discrimination between healthy participants and people with panic disorder based on polygenic scores for psychiatric disorders and for intermediate phenotypes using machine learning.
Ohi K, Tanaka Y, Otowa T, Shimada M, Kaiya H, Nishimura F, Sasaki T, Tanii H, Shioiri T, Hara T. Ohi K, et al. Among authors: kaiya h. Aust N Z J Psychiatry. 2024 Apr 6:48674241242936. doi: 10.1177/00048674241242936. Online ahead of print. Aust N Z J Psychiatry. 2024. PMID: 38581251
METHODS: Polygenic scores for 48 psychiatric disorders and intermediate phenotypes based on large-scale genome-wide association studies (n = 7556-1,131,881) were calculated for people with panic disorder (n = 718) and healthy controls (n = 1717). ...RESULTS: All fiv …
METHODS: Polygenic scores for 48 psychiatric disorders and intermediate phenotypes based on large-scale genome-wide association studi …
Evaluation of polygenic risks for narcolepsy and essential hypersomnia.
Yamasaki M, Miyagawa T, Toyoda H, Khor SS, Liu X, Kuwabara H, Kano Y, Shimada T, Sugiyama T, Nishida H, Sugaya N, Tochigi M, Otowa T, Okazaki Y, Kaiya H, Kawamura Y, Miyashita A, Kuwano R, Kasai K, Tanii H, Sasaki T, Honda Y, Honda M, Tokunaga K. Yamasaki M, et al. Among authors: kaiya h. J Hum Genet. 2016 Oct;61(10):873-878. doi: 10.1038/jhg.2016.65. Epub 2016 Jun 16. J Hum Genet. 2016. PMID: 27305985
Polygenic risks in narcolepsy were estimated to explain 58.1% (P(HLA-DQB1*06:02)=2.30 10(-48), P(whole genome without HLA-DQB1*06:02)=6.73 10(-2)) including HLA-DQB1*06:02 effects and 1.3% (P(whole genome without HLA-DQB1*06:02)=2.43 10(-2)) excluding HLA-DQB1*06:02 …
Polygenic risks in narcolepsy were estimated to explain 58.1% (P(HLA-DQB1*06:02)=2.30 10(-48), P(whole genome without HLA-DQB1*06:02) …
Immune-related pathways including HLA-DRB1()13:02 are associated with panic disorder.
Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor SS, Kashiwase K, Sugaya N, Kawamura Y, Umekage T, Kojima H, Saji H, Miyashita A, Kuwano R, Kaiya H, Kasai K, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. Shimada-Sugimoto M, et al. Among authors: kaiya h. Brain Behav Immun. 2015 May;46:96-103. doi: 10.1016/j.bbi.2015.01.002. Epub 2015 Jan 9. Brain Behav Immun. 2015. PMID: 25582808
Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety. Both genetic and environmental factors are thought to trigger PD onset. Previously, we performed a genome-wide association study (GWAS) for PD and focused on c
Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety. Both genetic and environme
Shared transethnic genetic basis of panic disorder and psychiatric and related intermediate phenotypes.
Ohi K, Otowa T, Shimada M, Sugiyama S, Muto Y, Tanahashi S, Kaiya H, Nishimura F, Sasaki T, Tanii H, Shioiri T. Ohi K, et al. Among authors: kaiya h. Eur Neuropsychopharmacol. 2021 Jan;42:87-96. doi: 10.1016/j.euroneuro.2020.11.003. Epub 2020 Nov 11. Eur Neuropsychopharmacol. 2021. PMID: 33189524
Panic disorder (PD), a common anxiety disorder, is modestly heritable. ...Here, we investigated the transethnic polygenetic features shared between Japanese PD patients and European patients with psychiatric disorders and their intermediate phenotypes by conducting polygen
Panic disorder (PD), a common anxiety disorder, is modestly heritable. ...Here, we investigated the transethnic polygenetic features
Sensitivity to gene dosage and gene expression affects genes with copy number variants observed among neuropsychiatric diseases.
Yamasaki M, Makino T, Khor SS, Toyoda H, Miyagawa T, Liu X, Kuwabara H, Kano Y, Shimada T, Sugiyama T, Nishida H, Sugaya N, Tochigi M, Otowa T, Okazaki Y, Kaiya H, Kawamura Y, Miyashita A, Kuwano R, Kasai K, Tanii H, Sasaki T, Honda M, Tokunaga K. Yamasaki M, et al. Among authors: kaiya h. BMC Med Genomics. 2020 Mar 29;13(1):55. doi: 10.1186/s12920-020-0699-9. BMC Med Genomics. 2020. PMID: 32223758 Free PMC article.
METHODS: Affymetrix Genome-Wide SNP Array 6.0 was used to detect CNVs by PennCNV and CNV Workshop. ...In addition, we utilized open data from GTEx to assess the effect of whole-genome CNVs on gene expression. We also investigated shared CNV region among neuropsychia …
METHODS: Affymetrix Genome-Wide SNP Array 6.0 was used to detect CNVs by PennCNV and CNV Workshop. ...In addition, we utilized open d …
Epigenome-wide association study of DNA methylation in panic disorder.
Shimada-Sugimoto M, Otowa T, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. Shimada-Sugimoto M, et al. Among authors: kaiya h. Clin Epigenetics. 2017 Jan 21;9:6. doi: 10.1186/s13148-016-0307-1. eCollection 2017. Clin Epigenetics. 2017. PMID: 28149334 Free PMC article.
BACKGROUND: Panic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. ...METHODS: The DNA methylation levels of CpG sites across the genome were examined with genomic DNA sam …
BACKGROUND: Panic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and e …
An epigenome-wide methylation study of healthy individuals with or without depressive symptoms.
Shimada M, Otowa T, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Ikegame T, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. Shimada M, et al. Among authors: kaiya h. J Hum Genet. 2018 Mar;63(3):319-326. doi: 10.1038/s10038-017-0382-y. Epub 2018 Jan 5. J Hum Genet. 2018. PMID: 29305581
Employing methylation-array technology, a total of 363,887 methylation sites across the genomes were investigated and several candidate CpG sites associated with depressive symptoms were identified, especially annotated to genes linked to a G-protein coupled receptor prote …
Employing methylation-array technology, a total of 363,887 methylation sites across the genomes were investigated and several candida …
16 results