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1,726 results

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Page 1
Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma.
Yang X, Wang H, Zhang L, Yao S, Dai J, Wen G, An J, Jin H, Du Q, Hu Y, Zheng L, Chen X, Yi Z, Tuo B. Yang X, et al. Biomed Pharmacother. 2023 Jul;163:114792. doi: 10.1016/j.biopha.2023.114792. Epub 2023 Apr 28. Biomed Pharmacother. 2023. PMID: 37121148 Free article. Review.
However, the molecular mechanism underlying the progression of hepatocellular carcinoma remains unclear. Karyopherin subunit alpha 2 (KPNA2), also termed importin alpha1, is a member of the nuclear transporter family. ...
However, the molecular mechanism underlying the progression of hepatocellular carcinoma remains unclear. Karyopherin subunit alpha …
KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation.
Jia Y, Wang Q, Liang M, Huang K. Jia Y, et al. J Transl Med. 2022 Dec 28;20(1):627. doi: 10.1186/s12967-022-03841-6. J Transl Med. 2022. PMID: 36578083 Free PMC article.
PURPOSE: Angiogenesis is involved in many pathological and physiological processes and is mainly driven by hypoxia. Karyopherin subunit alpha 2 (KPNA2), a member of the nuclear transport protein family, was recently shown to be induced by hypoxia in various types of …
PURPOSE: Angiogenesis is involved in many pathological and physiological processes and is mainly driven by hypoxia. Karyopherin subun …
Karyopherin alpha deficiency contributes to human preimplantation embryo arrest.
Wang W, Miyamoto Y, Chen B, Shi J, Diao F, Zheng W, Li Q, Yu L, Li L, Xu Y, Wu L, Mao X, Fu J, Li B, Yan Z, Shi R, Xue X, Mu J, Zhang Z, Wu T, Zhao L, Wang W, Zhou Z, Dong J, Li Q, Jin L, He L, Sun X, Lin G, Kuang Y, Wang L, Sang Q. Wang W, et al. J Clin Invest. 2023 Jan 17;133(2):e159951. doi: 10.1172/JCI159951. J Clin Invest. 2023. PMID: 36647821 Free PMC article.
Here, using whole-exome sequencing data from 606 women experiencing PREMBA compared with 2,813 controls, we performed a population and gene-based burden test and identified a candidate gene, karyopherin subunit alpha7 (KPNA7). In vitro studies showed that identified sequen …
Here, using whole-exome sequencing data from 606 women experiencing PREMBA compared with 2,813 controls, we performed a population and gene- …
Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation.
Laitman BM, Mariani JN, Zhang C, Sawai S, John GR. Laitman BM, et al. PLoS One. 2017 Jan 20;12(1):e0170477. doi: 10.1371/journal.pone.0170477. eCollection 2017. PLoS One. 2017. PMID: 28107514 Free PMC article.
Nuclear import, mediated in part by a group of karyopherin alpha (Kpna) proteins, regulates transcription factor access to the genome. Understanding how canonical nuclear import functions to control genomic access in OL differentiation may aid in the creation of nov …
Nuclear import, mediated in part by a group of karyopherin alpha (Kpna) proteins, regulates transcription factor access to the …
Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer.
Ohhara Y, Kinoshita I, Suzuki A, Imagawa M, Taguchi J, Noguchi T, Takeuchi S, Shimizu Y, Seki H, Suzuki J, Dosaka-Akita H. Ohhara Y, et al. Oncology. 2022;100(12):685-695. doi: 10.1159/000526807. Epub 2022 Oct 21. Oncology. 2022. PMID: 36273446 Free PMC article.
INTRODUCTION: Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes involved in nuclear import and are significant in tumor progression. ...
INTRODUCTION: Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes …
Karyopherin Subunit Alpha 1 Enhances the Malignant Behaviors of Colon Cancer Cells via Promoting Nuclear Factor-kappaB p65 Nuclear Translocation.
Zhao L, Wu D, Qu Q, Li Z, Yin H. Zhao L, et al. Dig Dis Sci. 2023 Jul;68(7):3018-3031. doi: 10.1007/s10620-023-07936-y. Epub 2023 Apr 10. Dig Dis Sci. 2023. PMID: 37038032
BACKGROUND/AIMS: Aberrant nuclear factor-kappaB p65 (NF-kappaB p65) nuclear import commonly occurs in multiple cancers, including colon cancer. According to BioGRID, we noted that Karyopherin subunit alpha 1 (KPNA1), an important molecular transporter between the nu …
BACKGROUND/AIMS: Aberrant nuclear factor-kappaB p65 (NF-kappaB p65) nuclear import commonly occurs in multiple cancers, including colon canc …
Karyopherin alpha 2 promotes proliferation, migration and invasion through activating NF-kappaB/p65 signaling pathways in melanoma cells.
Yang F, Li S, Cheng Y, Li J, Han X. Yang F, et al. Life Sci. 2020 Jul 1;252:117611. doi: 10.1016/j.lfs.2020.117611. Epub 2020 Apr 1. Life Sci. 2020. PMID: 32243925
AIMS: Melanoma is a fatal malignancy. Karyopherin alpha 2 (KPNA2) plays an important role in many carcinogenesis. This study was aimed to study the role of KPNA2 in cellular functions and molecular mechanisms of melanoma. ...
AIMS: Melanoma is a fatal malignancy. Karyopherin alpha 2 (KPNA2) plays an important role in many carcinogenesis. This study w …
RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153.
Moroianu J, Blobel G, Radu A. Moroianu J, et al. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9699-704. doi: 10.1073/pnas.94.18.9699. Proc Natl Acad Sci U S A. 1997. PMID: 9275187 Free PMC article.
In an in vitro assay in which export of endogenous nuclear karyopherin alpha from nuclei of digitonin-permeabilized cells was quantitatively monitored by indirect immunofluorescence with anti-karyopherin alpha antibodies, we found that karyopherin …
In an in vitro assay in which export of endogenous nuclear karyopherin alpha from nuclei of digitonin-permeabilized cells was …
1,726 results