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1994 5
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1,660 results

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Page 1
Karyopherin alpha deficiency contributes to human preimplantation embryo arrest.
Wang W, Miyamoto Y, Chen B, Shi J, Diao F, Zheng W, Li Q, Yu L, Li L, Xu Y, Wu L, Mao X, Fu J, Li B, Yan Z, Shi R, Xue X, Mu J, Zhang Z, Wu T, Zhao L, Wang W, Zhou Z, Dong J, Li Q, Jin L, He L, Sun X, Lin G, Kuang Y, Wang L, Sang Q. Wang W, et al. J Clin Invest. 2023 Jan 17;133(2):e159951. doi: 10.1172/JCI159951. J Clin Invest. 2023. PMID: 36647821 Free PMC article.
Here, using whole-exome sequencing data from 606 women experiencing PREMBA compared with 2,813 controls, we performed a population and gene-based burden test and identified a candidate gene, karyopherin subunit alpha7 (KPNA7). In vitro studies showed that identified sequen …
Here, using whole-exome sequencing data from 606 women experiencing PREMBA compared with 2,813 controls, we performed a population and gene- …
Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma.
Yang X, Wang H, Zhang L, Yao S, Dai J, Wen G, An J, Jin H, Du Q, Hu Y, Zheng L, Chen X, Yi Z, Tuo B. Yang X, et al. Biomed Pharmacother. 2023 Jul;163:114792. doi: 10.1016/j.biopha.2023.114792. Epub 2023 Apr 28. Biomed Pharmacother. 2023. PMID: 37121148 Free article. Review.
However, the molecular mechanism underlying the progression of hepatocellular carcinoma remains unclear. Karyopherin subunit alpha 2 (KPNA2), also termed importin alpha1, is a member of the nuclear transporter family. ...
However, the molecular mechanism underlying the progression of hepatocellular carcinoma remains unclear. Karyopherin subunit alpha …
Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation.
Laitman BM, Mariani JN, Zhang C, Sawai S, John GR. Laitman BM, et al. PLoS One. 2017 Jan 20;12(1):e0170477. doi: 10.1371/journal.pone.0170477. eCollection 2017. PLoS One. 2017. PMID: 28107514 Free PMC article.
Nuclear import, mediated in part by a group of karyopherin alpha (Kpna) proteins, regulates transcription factor access to the genome. Understanding how canonical nuclear import functions to control genomic access in OL differentiation may aid in the creation of nov …
Nuclear import, mediated in part by a group of karyopherin alpha (Kpna) proteins, regulates transcription factor access to the …
Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer.
Ohhara Y, Kinoshita I, Suzuki A, Imagawa M, Taguchi J, Noguchi T, Takeuchi S, Shimizu Y, Seki H, Suzuki J, Dosaka-Akita H. Ohhara Y, et al. Oncology. 2022;100(12):685-695. doi: 10.1159/000526807. Epub 2022 Oct 21. Oncology. 2022. PMID: 36273446 Free PMC article.
INTRODUCTION: Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes involved in nuclear import and are significant in tumor progression. ...
INTRODUCTION: Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes …
The functional role of the novel biomarker karyopherin alpha 2 (KPNA2) in cancer.
Christiansen A, Dyrskjøt L. Christiansen A, et al. Cancer Lett. 2013 Apr 30;331(1):18-23. doi: 10.1016/j.canlet.2012.12.013. Epub 2012 Dec 23. Cancer Lett. 2013. PMID: 23268335 Free PMC article. Review.
In recent years, Karyopherin alpha 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. ...
In recent years, Karyopherin alpha 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. ...
Karyopherin alpha 2 promotes proliferation, migration and invasion through activating NF-kappaB/p65 signaling pathways in melanoma cells.
Yang F, Li S, Cheng Y, Li J, Han X. Yang F, et al. Life Sci. 2020 Jul 1;252:117611. doi: 10.1016/j.lfs.2020.117611. Epub 2020 Apr 1. Life Sci. 2020. PMID: 32243925
AIMS: Melanoma is a fatal malignancy. Karyopherin alpha 2 (KPNA2) plays an important role in many carcinogenesis. This study was aimed to study the role of KPNA2 in cellular functions and molecular mechanisms of melanoma. ...
AIMS: Melanoma is a fatal malignancy. Karyopherin alpha 2 (KPNA2) plays an important role in many carcinogenesis. This study w …
Karyopherin Alpha 2 Is an Adverse Prognostic Factor in Clear-Cell and Papillary Renal-Cell Carcinoma.
Müller T, Tolkach Y, Stahl D, Steiner S, Hauser S, Ellinger J, Rabien A, Ralla B, Jung K, Stephan C, Kristiansen G. Müller T, et al. Clin Genitourin Cancer. 2019 Feb;17(1):e167-e175. doi: 10.1016/j.clgc.2018.10.008. Epub 2018 Oct 23. Clin Genitourin Cancer. 2019. PMID: 30448104
BACKGROUND: Karyopherin alpha2 (KPNA2) is involved in the nucleocytoplasmic transport system and is functionally involved in the pathogenesis of various solid tumors by the translocation of cancer associated cargo proteins. ...
BACKGROUND: Karyopherin alpha2 (KPNA2) is involved in the nucleocytoplasmic transport system and is functionally involved in the path …
Karyopherin alpha-2 Mediates MDC1 Nuclear Import through a Functional Nuclear Localization Signal in the tBRCT Domain of MDC1.
Radhakrishnan K, Park SJ, Kim SW, Hariharasudhan G, Jeong SY, Chang IY, Lee JH. Radhakrishnan K, et al. Int J Mol Sci. 2020 Apr 10;21(7):2650. doi: 10.3390/ijms21072650. Int J Mol Sci. 2020. PMID: 32290222 Free PMC article.
Here, we identified a novel interaction between MDC1 and karyopherin alpha-2 (KPNA2), a nucleocytoplasmic transport adaptor, and showed that KPNA2 is necessary for MDC1 nuclear import. ...
Here, we identified a novel interaction between MDC1 and karyopherin alpha-2 (KPNA2), a nucleocytoplasmic transport adaptor, a …
Decreased Expression of Karyopherin-alpha 1 is Related to the Malignant Degree of Cervical Cancer and is Critical for the Proliferation of Hela Cells.
Jiang L, Li D, Wang C, Liao J, Liu J, Wei Q, Wang Y. Jiang L, et al. Pathol Oncol Res. 2022 Aug 4;28:1610518. doi: 10.3389/pore.2022.1610518. eCollection 2022. Pathol Oncol Res. 2022. PMID: 35991835 Free PMC article.
Karyopherin alpha (KPNA) proteins are involved in nucleocytoplasmic trafficking and are critical for protein subcellular localization. ...
Karyopherin alpha (KPNA) proteins are involved in nucleocytoplasmic trafficking and are critical for protein subcellular local …
Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice.
Okano S, Yasui A, Kanno SI, Satoh K, Igarashi M, Nakajima O. Okano S, et al. J Diabetes Res. 2019 Apr 24;2019:7234549. doi: 10.1155/2019/7234549. eCollection 2019. J Diabetes Res. 2019. PMID: 31179341 Free PMC article.
Numerous reports have described that karyopherin alpha 2 (KPNA2) is highly expressed in cancers of different kinds. However, details of the expression of KPNA2 in pancreatic ductal atypia and in normal pancreatic tissues remain unclear. ...
Numerous reports have described that karyopherin alpha 2 (KPNA2) is highly expressed in cancers of different kinds. However, d …
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