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1,734 results

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Page 1
Karyopherin-mediated nucleocytoplasmic transport.
Wing CE, Fung HYJ, Chook YM. Wing CE, et al. Nat Rev Mol Cell Biol. 2022 May;23(5):307-328. doi: 10.1038/s41580-021-00446-7. Epub 2022 Jan 20. Nat Rev Mol Cell Biol. 2022. PMID: 35058649 Free PMC article. Review.
The majority of the macromolecular traffic across the nuclear pores is mediated by the Karyopherin-beta (or Kap) family of nuclear transport receptors. Work over more than two decades has shed considerable light on how the different Kap family members bring their re …
The majority of the macromolecular traffic across the nuclear pores is mediated by the Karyopherin-beta (or Kap) family of nuc …
Nuclear localization signals for four distinct karyopherin-beta nuclear import systems.
Soniat M, Chook YM. Soniat M, et al. Biochem J. 2015 Jun 15;468(3):353-62. doi: 10.1042/BJ20150368. Biochem J. 2015. PMID: 26173234 Review.
The Karyopherin-beta family of proteins mediates nuclear transport of macromolecules. Nuclear versus cytoplasmic localization of proteins is often suggested by the presence of NLSs (nuclear localization signals) or NESs (nuclear export signals). ...Until recently, o …
The Karyopherin-beta family of proteins mediates nuclear transport of macromolecules. Nuclear versus cytoplasmic localization …
Recognition of nuclear targeting signals by Karyopherin-beta proteins.
Xu D, Farmer A, Chook YM. Xu D, et al. Curr Opin Struct Biol. 2010 Dec;20(6):782-90. doi: 10.1016/j.sbi.2010.09.008. Epub 2010 Oct 13. Curr Opin Struct Biol. 2010. PMID: 20951026 Free PMC article. Review.
The Karyopherin-beta family of nuclear transport factors mediates the majority of nucleocytoplasmic transport. ...We review recent findings relating to how these three classes of nuclear targeting signals are recognized by their Karyopherin-beta nuclea …
The Karyopherin-beta family of nuclear transport factors mediates the majority of nucleocytoplasmic transport. ...We review re …
Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer.
Ohhara Y, Kinoshita I, Suzuki A, Imagawa M, Taguchi J, Noguchi T, Takeuchi S, Shimizu Y, Seki H, Suzuki J, Dosaka-Akita H. Ohhara Y, et al. Oncology. 2022;100(12):685-695. doi: 10.1159/000526807. Epub 2022 Oct 21. Oncology. 2022. PMID: 36273446 Free PMC article.
INTRODUCTION: Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes involved in nuclear import and are significant in tumor progression. ...
INTRODUCTION: Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes …
Inhibition of Karyopherin beta 1 suppresses prostate cancer growth.
Yang J, Guo Y, Lu C, Zhang R, Wang Y, Luo L, Zhang Y, Chu CH, Wang KJ, Obbad S, Yan W, Li X. Yang J, et al. Oncogene. 2019 Jun;38(24):4700-4714. doi: 10.1038/s41388-019-0745-2. Epub 2019 Feb 11. Oncogene. 2019. PMID: 30742095 Free PMC article.
Nuclear-cytoplasmic transport of oncogenic factors is mediated by Karyopherin proteins during cell transformation. However, the role of nuclear transporter proteins in PCa progression has not been well defined. Here, we report that the KPNB1, a key member of Karyopherin …
Nuclear-cytoplasmic transport of oncogenic factors is mediated by Karyopherin proteins during cell transformation. However, the role …
Karyopherin-betas play a key role as a phase separation regulator.
Yoshizawa T, Guo L. Yoshizawa T, et al. J Biochem. 2021 Sep 22;170(1):15-23. doi: 10.1093/jb/mvab072. J Biochem. 2021. PMID: 34223614 Free PMC article. Review.
The nucleus is a well-known membrane-bound organelle surrounded by the nuclear envelope; the nuclear pore complex on the nuclear envelope likely applies LLPS in the central channel to facilitate selective biological macromolecule exchange. Karyopherin-beta family pr …
The nucleus is a well-known membrane-bound organelle surrounded by the nuclear envelope; the nuclear pore complex on the nuclear envelope li …
Importin-beta/karyopherin-beta1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region.
Verrico A, Rovella P, Di Francesco L, Damizia M, Staid DS, Le Pera L, Schininà ME, Lavia P. Verrico A, et al. Oncogene. 2020 Jan;39(2):454-468. doi: 10.1038/s41388-019-0989-x. Epub 2019 Sep 6. Oncogene. 2020. PMID: 31492900
The nuclear transport receptor importin-beta/karyopherin-beta1 is overexpressed in cancers that display genomic instability. It is regarded as a promising cancer target and inhibitors are being developed. ...To unravel importin-beta's mitotic functions we hav …
The nuclear transport receptor importin-beta/karyopherin-beta1 is overexpressed in cancers that display genomic instability. I …
Distinct nuclear import and export pathways mediated by members of the karyopherin beta family.
Moroianu J. Moroianu J. J Cell Biochem. 1998 Aug 1;70(2):231-9. J Cell Biochem. 1998. PMID: 9671229 Review.
The common features of the members of karyopherin beta family are the ability to bind RanGTP and the ability to interact directly with nucleoporins at the NPC. The challenge for the future will be to identify the distinct or, perhaps, overlapping cargo(es) for each …
The common features of the members of karyopherin beta family are the ability to bind RanGTP and the ability to interact direc …
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.
Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J. Guo L, et al. Cell. 2018 Apr 19;173(3):677-692.e20. doi: 10.1016/j.cell.2018.03.002. Cell. 2018. PMID: 29677512 Free PMC article.
Here, we establish that nuclear-import receptors (NIRs) specifically chaperone and potently disaggregate wild-type and disease-linked RBPs bearing a NLS. Karyopherin-beta2 (also called Transportin-1) engages PY-NLSs to inhibit and reverse FUS, TAF15, EWSR1, hnRNPA1, and hn …
Here, we establish that nuclear-import receptors (NIRs) specifically chaperone and potently disaggregate wild-type and disease-linked RBPs b …
Nuclear import by karyopherin-betas: recognition and inhibition.
Chook YM, Süel KE. Chook YM, et al. Biochim Biophys Acta. 2011 Sep;1813(9):1593-606. doi: 10.1016/j.bbamcr.2010.10.014. Epub 2010 Oct 26. Biochim Biophys Acta. 2011. PMID: 21029754 Free PMC article. Review.
Proteins in the karyopherin-beta family mediate the majority of macromolecular transport between the nucleus and the cytoplasm. ...Knowledge of karyopherin-beta-cargo interactions is also critical for the development of nuclear import inhibitors and th …
Proteins in the karyopherin-beta family mediate the majority of macromolecular transport between the nucleus and the cytoplasm …
1,734 results