Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 2
1995 11
1996 21
1997 41
1998 40
1999 44
2000 56
2001 58
2002 61
2003 78
2004 75
2005 71
2006 70
2007 74
2008 71
2009 83
2010 91
2011 88
2012 67
2013 76
2014 74
2015 92
2016 64
2017 64
2018 61
2019 69
2020 76
2021 58
2022 57
2023 48
2024 38
2025 48
2026 19

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,791 results

Results by year

Filters applied: . Clear all
Page 1
Karyopherin-mediated nucleocytoplasmic transport.
Wing CE, Fung HYJ, Chook YM. Wing CE, et al. Nat Rev Mol Cell Biol. 2022 May;23(5):307-328. doi: 10.1038/s41580-021-00446-7. Epub 2022 Jan 20. Nat Rev Mol Cell Biol. 2022. PMID: 35058649 Free PMC article. Review.
The majority of the macromolecular traffic across the nuclear pores is mediated by the Karyopherin-beta (or Kap) family of nuclear transport receptors. Work over more than two decades has shed considerable light on how the different Kap family members bring their re …
The majority of the macromolecular traffic across the nuclear pores is mediated by the Karyopherin-beta (or Kap) family of nuc …
Nuclear localization signals for four distinct karyopherin-beta nuclear import systems.
Soniat M, Chook YM. Soniat M, et al. Biochem J. 2015 Jun 15;468(3):353-62. doi: 10.1042/BJ20150368. Biochem J. 2015. PMID: 26173234 Review.
The Karyopherin-beta family of proteins mediates nuclear transport of macromolecules. Nuclear versus cytoplasmic localization of proteins is often suggested by the presence of NLSs (nuclear localization signals) or NESs (nuclear export signals). ...Until recently, o …
The Karyopherin-beta family of proteins mediates nuclear transport of macromolecules. Nuclear versus cytoplasmic localization …
Recognition of nuclear targeting signals by Karyopherin-beta proteins.
Xu D, Farmer A, Chook YM. Xu D, et al. Curr Opin Struct Biol. 2010 Dec;20(6):782-90. doi: 10.1016/j.sbi.2010.09.008. Epub 2010 Oct 13. Curr Opin Struct Biol. 2010. PMID: 20951026 Free PMC article. Review.
The Karyopherin-beta family of nuclear transport factors mediates the majority of nucleocytoplasmic transport. ...We review recent findings relating to how these three classes of nuclear targeting signals are recognized by their Karyopherin-beta nuclea …
The Karyopherin-beta family of nuclear transport factors mediates the majority of nucleocytoplasmic transport. ...We review re …
Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer.
Ohhara Y, Kinoshita I, Suzuki A, Imagawa M, Taguchi J, Noguchi T, Takeuchi S, Shimizu Y, Seki H, Suzuki J, Dosaka-Akita H. Ohhara Y, et al. Oncology. 2022;100(12):685-695. doi: 10.1159/000526807. Epub 2022 Oct 21. Oncology. 2022. PMID: 36273446 Free PMC article.
INTRODUCTION: Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes involved in nuclear import and are significant in tumor progression. ...
INTRODUCTION: Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes …
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
Hofweber M, Hutten S, Bourgeois B, Spreitzer E, Niedner-Boblenz A, Schifferer M, Ruepp MD, Simons M, Niessing D, Madl T, Dormann D. Hofweber M, et al. Cell. 2018 Apr 19;173(3):706-719.e13. doi: 10.1016/j.cell.2018.03.004. Cell. 2018. PMID: 29677514 Free article.
A key step that is disrupted in these patients is nuclear import of FUS mediated by the import receptor Transportin/Karyopherin-beta2. In ALS-FUS patients, this is caused by mutations in the nuclear localization signal (NLS) of FUS that weaken Transportin binding. ...
A key step that is disrupted in these patients is nuclear import of FUS mediated by the import receptor Transportin/Karyopherin-beta2 …
Inhibition of Karyopherin beta 1 suppresses prostate cancer growth.
Yang J, Guo Y, Lu C, Zhang R, Wang Y, Luo L, Zhang Y, Chu CH, Wang KJ, Obbad S, Yan W, Li X. Yang J, et al. Oncogene. 2019 Jun;38(24):4700-4714. doi: 10.1038/s41388-019-0745-2. Epub 2019 Feb 11. Oncogene. 2019. PMID: 30742095 Free PMC article.
Nuclear-cytoplasmic transport of oncogenic factors is mediated by Karyopherin proteins during cell transformation. However, the role of nuclear transporter proteins in PCa progression has not been well defined. Here, we report that the KPNB1, a key member of Karyopherin …
Nuclear-cytoplasmic transport of oncogenic factors is mediated by Karyopherin proteins during cell transformation. However, the role …
Distinct nuclear import and export pathways mediated by members of the karyopherin beta family.
Moroianu J. Moroianu J. J Cell Biochem. 1998 Aug 1;70(2):231-9. J Cell Biochem. 1998. PMID: 9671229 Review.
Two other beta karyopherin family members, CRM1 and CAS, mediate export of proteins containing leucine-rich nuclear export signals (NES) and reexport of karyopherin alpha, respectively. ...The challenge for the future will be to identify the distinct or, perh …
Two other beta karyopherin family members, CRM1 and CAS, mediate export of proteins containing leucine-rich nuclear export sig …
Importin-beta/karyopherin-beta1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region.
Verrico A, Rovella P, Di Francesco L, Damizia M, Staid DS, Le Pera L, Schininà ME, Lavia P. Verrico A, et al. Oncogene. 2020 Jan;39(2):454-468. doi: 10.1038/s41388-019-0989-x. Epub 2019 Sep 6. Oncogene. 2020. PMID: 31492900
The nuclear transport receptor importin-beta/karyopherin-beta1 is overexpressed in cancers that display genomic instability. It is regarded as a promising cancer target and inhibitors are being developed. ...To unravel importin-beta's mitotic functions we hav …
The nuclear transport receptor importin-beta/karyopherin-beta1 is overexpressed in cancers that display genomic instability. I …
Karyopherins and condensates.
Springhower CE, Rosen MK, Chook YM. Springhower CE, et al. Curr Opin Cell Biol. 2020 Jun;64:112-123. doi: 10.1016/j.ceb.2020.04.003. Epub 2020 May 28. Curr Opin Cell Biol. 2020. PMID: 32474299 Free PMC article. Review.
The nuclear-cytoplasmic distribution of these proteins is controlled by proteins in the karyopherin family of nuclear transport factors (Kaps). Recent studies have shown that Kaps not only transport these proteins but also inhibit their self-association/aggregation, acting …
The nuclear-cytoplasmic distribution of these proteins is controlled by proteins in the karyopherin family of nuclear transport facto …
The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence.
Moroianu J, Blobel G, Radu A. Moroianu J, et al. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6572-6. doi: 10.1073/pnas.93.13.6572. Proc Natl Acad Sci U S A. 1996. PMID: 8692858 Free PMC article.
The NLS of karyopherin alpha overlaps with the binding site of karyopherin alpha for karyopherin beta. Hence, binding of karyopherin beta to karyopherin alpha covers the NLS of karyopherin alpha. This prevents autologous lig …
The NLS of karyopherin alpha overlaps with the binding site of karyopherin alpha for karyopherin beta. Hence, bi …
1,791 results