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Short-Term Effects of Kefir-Fermented Milk Consumption on Bone Mineral Density and Bone Metabolism in a Randomized Clinical Trial of Osteoporotic Patients.
Tu MY, Chen HL, Tung YT, Kao CC, Hu FC, Chen CM. Tu MY, et al. PLoS One. 2015 Dec 10;10(12):e0144231. doi: 10.1371/journal.pone.0144231. eCollection 2015. PLoS One. 2015. PMID: 26655888 Free PMC article. Clinical Trial.
Milk products are good sources of calcium that may reduce bone resorption and help prevent bone loss as well as promote bone remodeling and increase bone formation. ...Bone mineral density (BMD) values at the spine, total hip, and hip fem …
Milk products are good sources of calcium that may reduce bone resorption and help prevent bone loss as well as promote bon …
Kefir improves bone mass and microarchitecture in an ovariectomized rat model of postmenopausal osteoporosis.
Chen HL, Tung YT, Chuang CH, Tu MY, Tsai TC, Chang SY, Chen CM. Chen HL, et al. Osteoporos Int. 2015 Feb;26(2):589-99. doi: 10.1007/s00198-014-2908-x. Epub 2014 Oct 3. Osteoporos Int. 2015. PMID: 25278298
SUMMARY: Kefir treatment in ovariectomized (OVX) rats could significantly decrease the levels of bone turnover markers and prevent OVX-induced bone loss, deterioration of trabecular microarchitecture, and biomechanical dysfunction that may be due to increase …
SUMMARY: Kefir treatment in ovariectomized (OVX) rats could significantly decrease the levels of bone turnover markers and pre …
Yacon (Smallanthus sonchifolius) and kefir improved intestinal and bone health but without symbiotic benefits in rats.
Gomes AF, Viana ML, Vaz-Tostes MDG, Costa NMB. Gomes AF, et al. Nutr Res. 2023 Oct;118:85-93. doi: 10.1016/j.nutres.2023.07.009. Epub 2023 Aug 2. Nutr Res. 2023. PMID: 37603903
We hypothesized that kefir and yacon can improve bone and intestinal health and that their synbiotic effects will enhance these benefits. The properties of yacon and kefir and their association were evaluated in the intestinal and bone health in rats. …
We hypothesized that kefir and yacon can improve bone and intestinal health and that their synbiotic effects will enhance thes …
Kefir Peptides Prevent Estrogen Deficiency-Induced Bone Loss and Modulate the Structure of the Gut Microbiota in Ovariectomized Mice.
Tu MY, Han KY, Chang GR, Lai GD, Chang KY, Chen CF, Lai JC, Lai CY, Chen HL, Chen CM. Tu MY, et al. Nutrients. 2020 Nov 9;12(11):3432. doi: 10.3390/nu12113432. Nutrients. 2020. PMID: 33182364 Free PMC article.
Osteoporosis is a major skeletal disease associated with estrogen deficiency in postmenopausal women. Kefir-fermented peptides (KPs) are bioactive peptides with health-promoting benefits that are produced from the degradation of dairy milk proteins by the probiotic microfl …
Osteoporosis is a major skeletal disease associated with estrogen deficiency in postmenopausal women. Kefir-fermented peptides (KPs) …
Osteoprotective effects of kefir fortified with omega-3 and vitamin C in ovariectomized rats.
Moazen M, Mazloom Z, Tanideh N, Dabbaghmanesh MH, Rahmdel S, Azarpira N, Fararouei M. Moazen M, et al. Int J Vitam Nutr Res. 2023 Jun;93(3):200-209. doi: 10.1024/0300-9831/a000718. Epub 2021 Jun 24. Int J Vitam Nutr Res. 2023. PMID: 34162225 Free article.
The sham group also received 1ml/day of distilled water. Subsequently, bone mineral content (BMC) and bone mineral density (BMD) of various bones were assessed. ...Ovariectomy resulted in significant reduction in bone density (P<0.05). Kef …
The sham group also received 1ml/day of distilled water. Subsequently, bone mineral content (BMC) and bone mineral density …
Milk kefir therapy improves the skeletal response to resistance exercise in rats submitted to glucocorticoid-induced osteoporosis.
de Vasconcelos RF, Costa V, Araujo B, Maia TAC, Dias R, Vasconcelos L, Silveira H, Carneiro B, Thiers D, Costa FWG, Kurita L, Ayala A, Leitão R, Pereira KMA, Gondim DV, Goes P. de Vasconcelos RF, et al. Exp Gerontol. 2022 Oct 1;167:111921. doi: 10.1016/j.exger.2022.111921. Epub 2022 Aug 11. Exp Gerontol. 2022. PMID: 35964897
Exercise has been an important non-pharmacological option, while medications modulate bone remodeling despite adverse effects. In this way, milk Kefir (MK) therapy stands out as a safe alternative to improve bone metabolism. ...MK was administered daily (1 /d …
Exercise has been an important non-pharmacological option, while medications modulate bone remodeling despite adverse effects. In thi …
Microbial Strains in Fermented Dairy: Unlocking Biofunctional Properties and Health Benefits.
Wijesekara A, Weerasingha V, Jayarathna S, Vidanarachchi JK, Priyashantha H. Wijesekara A, et al. Int J Food Sci. 2025 Aug 19;2025:6672700. doi: 10.1155/ijfo/6672700. eCollection 2025. Int J Food Sci. 2025. PMID: 40881058 Free PMC article. Review.
Fermented dairy products like yoghurt, cheese, and kefir are essential for human nutrition and health. They offer a wide range of biofunctional properties, providing unique flavors along with substantial nutritional and therapeutic benefits. ...This review explores the imp …
Fermented dairy products like yoghurt, cheese, and kefir are essential for human nutrition and health. They offer a wide range of bio …
Kefir peptides attenuate atherosclerotic vascular calcification and osteoporosis in atherogenic diet-fed ApoE (-/-) knockout mice.
Chang GR, Cheng WY, Fan HC, Chen HL, Lan YW, Chen MS, Yen CC, Chen CM. Chang GR, et al. Front Cell Dev Biol. 2023 Apr 6;11:1158812. doi: 10.3389/fcell.2023.1158812. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37091976 Free PMC article.
KPs exerted osteoprotective effects in AD-fed ApoE (-/-) mice, which was evidenced by lower levels of the bone resorption marker CTX-1 and higher levels of the bone formation marker P1NP. KPs improved cortical bone mineral density and bone volum …
KPs exerted osteoprotective effects in AD-fed ApoE (-/-) mice, which was evidenced by lower levels of the bone resorption marker CTX- …
Kefir peptides ameliorate osteoporosis in AKR1A1 knockout mice with vitamin C deficiency by promoting osteoblastogenesis and inhibiting osteoclastogenesis.
Chang GR, Lin WY, Fan HC, Tu MY, Liu YH, Yen CC, Cidem A, Chen W, Chen CM. Chang GR, et al. Biomed Pharmacother. 2022 Dec;156:113859. doi: 10.1016/j.biopha.2022.113859. Epub 2022 Oct 14. Biomed Pharmacother. 2022. PMID: 36252352 Free article.
We previously demonstrated that AKR1A1 knockout mice (AKR1A1(eGFP/eGFP)) with Vit C deficiency exhibited aberrant bone formation and osteoporosis. In this study, we aimed to evaluate the osteoprotective effects of kefir peptides (KPs) in AKR1A1(eGFP/eGFP) mice and u …
We previously demonstrated that AKR1A1 knockout mice (AKR1A1(eGFP/eGFP)) with Vit C deficiency exhibited aberrant bone formation and …
Therapeutic Effects of Kefir Peptides on Hemophilia-Induced Osteoporosis in Mice With Deficient Coagulation Factor VIII.
Yen CC, Liu YW, Chang GR, Lan YW, Kao YT, Cheng SN, Chen W, Chen CM. Yen CC, et al. Front Cell Dev Biol. 2022 Feb 18;10:794198. doi: 10.3389/fcell.2022.794198. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35252176 Free PMC article.
Osteoporosis is a clinically prevalent comorbidity in patients with hemophilia. A preventive effect of kefir peptides (KPs) on postmenopausal osteoporosis has been proved. The aim of this study was to evaluate the therapeutic effect of KPs for the treatment of osteoporosis …
Osteoporosis is a clinically prevalent comorbidity in patients with hemophilia. A preventive effect of kefir peptides (KPs) on postme …